Works Published in 2008
Displaying all 6 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 chapter
CD4+CD25+ Regulatory T Cells in Viral Infections
In Regulatory T Cells and Clinical Application (pp. 407–422).
TL;DR:
It is clear from the studies described herein that chronic viral infections are characterized by an early and sustained activation of immunosuppressiveCD4+CD25+ Treg cells capable of inhibiting anti-viral CD4+ and CD8+ immune responses, which allows for the establishment of long-term infection.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2008 journal article
CD4(+)CD25(+) regulatory T cells are infected and activated during acute FIV infection
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 126(3-4), 263–272.
author keywords: FIV; HIV; Regulatory T cells; Acute infection
MeSH headings : Animals; Cat Diseases / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Flow Cytometry / veterinary; Forkhead Transcription Factors / metabolism; Gene Expression Regulation / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary; T-Lymphocytes, Regulatory / virology; Viremia / veterinary
TL;DR:
The hypothesis that early activation of Treg immunosuppressor function may limit an effective anti-FIV response is supported, contributing to the establishment of chronic infection and the immunodeficiency caused by this virus.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains
BMC EVOLUTIONARY BIOLOGY, 8.
MeSH headings : Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Fish Proteins / genetics; Fish Proteins / immunology; Genetic Variation; Immunoglobulin Variable Region / genetics; Models, Genetic; Molecular Sequence Data; Multigene Family; Oryzias / genetics; Phylogeny; Protein Structure, Tertiary / genetics; Receptors, Immunologic / genetics; Species Specificity; Synteny; Zebrafish / genetics; Zebrafish / immunology
TL;DR:
Comprehensive phylogenetic analyses between the complete datasets of NITRs from medaka and zebrafish indicate multiple species-specific expansions of different families of NITS, consistent with recent birth-and-death events.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust
TOXICOLOGY AND APPLIED PHARMACOLOGY, 229(3), 310–319.
author keywords: diesel exhaust; inflammation; lung; surfactant proteins; clara cell; mice
MeSH headings : Air Pollutants / toxicity; Animals; Cytokines / drug effects; Cytokines / metabolism; Female; Intercellular Adhesion Molecule-1 / drug effects; Intercellular Adhesion Molecule-1 / metabolism; Lung / drug effects; Lung / pathology; Mice; Mice, Inbred BALB C; Neutrophils / drug effects; Neutrophils / metabolism; Occupational Exposure / adverse effects; Pneumonia / chemically induced; Pulmonary Surfactant-Associated Protein A / drug effects; Pulmonary Surfactant-Associated Protein A / metabolism; Pulmonary Surfactant-Associated Protein D / drug effects; Pulmonary Surfactant-Associated Protein D / metabolism; Respiratory Tract Infections / etiology; Time Factors; Up-Regulation / drug effects; Uteroglobin / drug effects; Uteroglobin / metabolism; Vehicle Emissions / toxicity
TL;DR:
Exposure to moderate and high occupational levels of DE caused an increase in lung injury and inflammation, and a decrease in host defense molecules, which could result in increased susceptibility to respiratory pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Tonic protein kinase A activity maintains inactive beta 2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase
JOURNAL OF LEUKOCYTE BIOLOGY, 83(4), 964–971.
author keywords: PMN; PKA; ROCK; avidity; adhesion; cytoskeleton
MeSH headings : Adult; CD18 Antigens / blood; CD18 Antigens / drug effects; Carbazoles / pharmacology; Cell Adhesion; Cyclic AMP-Dependent Protein Kinases / antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases / blood; Homeostasis; Humans; Indoles / pharmacology; Myosin-Light-Chain Kinase / blood; Neutrophils / enzymology; Neutrophils / physiology; Oligopeptides / pharmacology; Phosphorylation; Pyrroles / pharmacology; rho-Associated Kinases / blood
TL;DR:
It is demonstrated that tonic PKA activity prevents activation of β2 integrins and adhesion by inhibiting MLC phosphorylation via a MLCK‐dependent but ROCK‐independent pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
In vivo depletion of CD4(+)CD25(+) regulatory T cells in cats
JOURNAL OF IMMUNOLOGICAL METHODS, 329(1-2), 81–91.
author keywords: regulatory T cell; FOXP3; feline immunodeficiency virus; monoclonal antibody
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Formation; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / drug effects; CD8-Positive T-Lymphocytes / immunology; Cats; Cell Proliferation; Cells, Cultured; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Products, gag / pharmacology; Immunoglobulin G / blood; Immunologic Memory; Interleukin-2 Receptor alpha Subunit / immunology; Interleukin-2 Receptor alpha Subunit / metabolism; Lymphocyte Activation; Lymphocyte Depletion / methods; RNA, Messenger / metabolism; Recombinant Proteins / pharmacology; T-Lymphocytes, Regulatory / drug effects; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism; Time Factors
TL;DR:
It is concluded that despite alterations in CD25+ cell levels during depletion, the feline immune system remains functional and a model for the study of disease pathogenesis in the context of reduced numbers of immunosuppressive CD4+CD25+ Tregs throughout the f cat system is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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