Works Published in 2012
Displaying works 61 - 80 of 260 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
The Drosophila melanogaster Genetic Reference Panel
Nature, 482(7384), 173–178.
MeSH headings : Alleles; Animals; Centromere / genetics; Chromosomes, Insect / genetics; Drosophila melanogaster / genetics; Genome-Wide Association Study; Genomics; Genotype; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics; Selection, Genetic / genetics; Starvation / genetics; Telomere / genetics; X Chromosome / genetics
TL;DR:
The Drosophila melanogaster Genetic Reference Panel is described, a community resource for analysis of population genomics and quantitative traits, which reveals reduced polymorphism in centromeric autosomal regions and the X chromosomes, evidence for positive and negative selection, and rapid evolution of the X chromosome.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2012 journal article
The genetic basis for natural variation in alcohol sensitivity in drosophila
Neurotoxicology and Teratology, 34(3), 377.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2012 journal article
Abundance, survival and temporary emigration of bottlenose dolphins (Tursiops sp.) off Useless Loop in the western gulf of Shark Bay, Western Australia
Marine and Freshwater Research, 63(11), 1059.
author keywords: capture-recapture; demographic parameters; photo-identification; Pollock's closed robust design
TL;DR:
This study provides a robust baseline for future comparisons of dolphin demographics, which may be of importance should climate change or increasing anthropogenic activity affect this population of bottlenose dolphins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Source: Crossref
Added: February 24, 2020
2012 journal article
Risk of Total and Aggressive Prostate Cancer and Pesticide Use in the Agricultural Health Study
American Journal of Epidemiology, 177(1), 59–74.
author keywords: aggressive prostate cancer; cohort study; farming; organophosphate insecticides; pesticide exposure; prostate cancer
MeSH headings : Age Factors; Aged; Agriculture / statistics & numerical data; Health Behavior; Herbicides / toxicity; Humans; Insecticides / toxicity; Male; Middle Aged; Organophosphorus Compounds / toxicity; Prostatic Neoplasms / chemically induced; Prostatic Neoplasms / physiopathology; Racial Groups; Severity of Illness Index
TL;DR:
This analysis has overcome several limitations of previous studies with the inclusion of a large number of cases with relevant exposure and detailed information on use of specific pesticides at 2 points in time, and for the first time specific pesticides are implicated as risk factors for aggressive prostate cancer.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Pesticide use and fatal injury among farmers in the Agricultural Health Study
International Archives of Occupational and Environmental Health, 86(2), 177–187.
author keywords: Pesticides; Mortality; Wounds and injuries
MeSH headings : Accidents, Occupational / mortality; Accidents, Occupational / statistics & numerical data; Adult; Aged; Agriculture; Confidence Intervals; Gloves, Protective; Health Surveys; Humans; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Occupational Exposure / statistics & numerical data; Pesticides / adverse effects; Proportional Hazards Models; Risk Factors; Surveys and Questionnaires; Time Factors
TL;DR:
The association between application of pesticides, particularly certain herbicides, and fatal injuries among farmers should be interpreted cautiously but deserves further evaluation, with particular focus on understanding timing of pesticide use and fatal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Seasonal Changes in Patterns of Gene Expression in Avian Song Control Brain Regions
PLoS ONE, 7(4), e35119.
Ed(s): S. Yamazaki
MeSH headings : Animals; Brain / metabolism; Breeding; Cluster Analysis; Gene Expression Profiling; Gene Expression Regulation; Hormones / blood; Male; Molecular Sequence Annotation; Molecular Sequence Data; Reproducibility of Results; Seasons; Sparrows / genetics; Telencephalon / metabolism; Vocalization, Animal
TL;DR:
Changing the hormonal and photoperiodic conditions in seasonally-breeding Gambel's white-crowned sparrows and extracting RNA from the telencephalic song control nuclei reveals categorical differences in the kinds of genes regulated in HVC and RA, and provides insights into the complex molecular pathways that underlie adult neural plasticity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
The Organizational and Aromatization Hypotheses Apply to Rapid, Nonclassical Hormone Action: Neonatal Masculinization Eliminates Rapid Estradiol Action in Female Hippocampal Neurons
Endocrinology, 153(10), 4616–4621.
MeSH headings : Animals; Aromatase / metabolism; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / metabolism; Dihydrotestosterone / metabolism; Dihydrotestosterone / pharmacology; Estradiol / metabolism; Estradiol / pharmacology; Female; Hippocampus / cytology; Hippocampus / drug effects; Hippocampus / metabolism; Neurons / cytology; Neurons / drug effects; Neurons / metabolism; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate / metabolism; Signal Transduction / drug effects; Testosterone / metabolism; Testosterone / pharmacology
TL;DR:
Findings indicate that testosterone aromatization to estradiol leads to a masculinization/defeminization process whereby hippocampal neurons fail to exhibit rapidEstradiol signaling to CREB, extending the organizational and aromatized hypotheses to rapid, nonclassical hormone action.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
A Small Number of Genes Underlie Male Pigmentation Traits in Lake Malawi Cichlid Fishes
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 318(3), 199–208.
MeSH headings : Animals; Cichlids / genetics; Male; Pigmentation / genetics
TL;DR:
This work quantified the number of pigment cells on the body and fins of two species of the genus Metriaclima and their hybrids and used the Castle-Wright equation to estimate that differences in individual pigmentation traits between these species are controlled by one to four genes each.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Origins of Shared Genetic Variation in African Cichlids
Molecular Biology and Evolution, 30(4), 906–917.
author keywords: cichlid; evolution; hybridization; ancestral polymorphism; single nucleotide polymorphism; genetic differentiation
MeSH headings : Adaptation, Biological / genetics; Africa; Animals; Bayes Theorem; Cichlids / genetics; Genetic Loci; Genetic Speciation; Genotype; Lakes; Models, Genetic; Phylogeny; Phylogeography; Polymorphism, Single Nucleotide; Principal Component Analysis; Rivers; Selection, Genetic; Sequence Analysis, DNA
TL;DR:
Bayesian and principal component analyses of genetic structure in the data demonstrate that the Lake Malawi endemic flock is not monophyletic and that river species have likely contributed significantly to Malawi genomes, and coalescent simulations support the hypothesis that river cichlids have transported polymorphism between lake assemblages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Consequences of a poecilogonous life history for genetic structure in coastal populations of the polychaete Streblospio benedicti
Molecular Ecology, 21(22), 5447–5460.
MeSH headings : Animals; Gene Flow; Genetics, Population; Genotyping Techniques; Geography; Larva / genetics; Larva / growth & development; Phenotype; Polychaeta / genetics; Polychaeta / growth & development; Polymorphism, Single Nucleotide; United States
TL;DR:
It is found that in their native East Coast distribution, populations of S. benedicti have high‐population genetic structure, but this structure is associated primarily with geographic separation rather than developmental differences, suggesting that this is a true case of poecilogony.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Asymmetric Dispersal Can Maintain Larval Polymorphism: A Model Motivated by Streblospio benedicti
Integrative and Comparative Biology, 52(1), 197–212.
MeSH headings : Alleles; Animals; Body Size / physiology; Computer Simulation; Ecosystem; Female; Fertility; Gene Frequency; Genetic Variation; Genotype; Haploidy; Larva / genetics; Larva / growth & development; Larva / physiology; Male; Models, Biological; Phenotype; Polychaeta / genetics; Polychaeta / growth & development; Polychaeta / physiology; Population Dynamics; Selection, Genetic; Species Specificity
TL;DR:
This study uses analytical models of dispersal to determine the conditions necessary for a stable dispersal polymorphism to exist and shows that in asexual haploid, sexual haploids, and in sexual diploids in the absence of overdominance, asymmetric dispersal is required in order to maintain a dispersed polymorphism when patches do not vary in intrinsic quality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Transcriptome Analysis and SNP Development Can Resolve Population Differentiation of Streblospio benedicti, a Developmentally Dimorphic Marine Annelid
PLoS ONE, 7(2), e31613.
Ed(s): M. Zwick
MeSH headings : Animals; Annelida / genetics; Annelida / growth & development; Biological Evolution; Gene Expression Profiling; Genetic Markers; Genotype; Larva; Life Cycle Stages / genetics; Polymorphism, Single Nucleotide
TL;DR:
A novel approach for evaluating the site frequency spectrum across the transcriptome to identify potential signatures of selection and 84 novel single nucleotide polymorphism (SNP) markers for this species that are used to distinguish coastal populations of S. benedicti.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Comparing behavioral responses across multiple assays of stress and anxiety in zebrafish (Danio rerio)
Behaviour, 149(10-12), 1205–1240.
author keywords: stress; anxiety; coping style; Danio
TL;DR:
This study demonstrates that selectively bred lines from wild-caught zebrafish exhibit consistent and divergent behavioral stress responses across multiple distinct assays, which may prove useful in understanding the proximate and ultimate mechanisms of coping with stress and anxiety.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 3, 2020
2012 chapter
Adapting the Open Field Test to Assess Anxiety-Related Behavior in Zebrafish
In Neuromethods (pp. 181–189).
Sources: Crossref, NC State University Libraries
Added: January 3, 2020
2012 journal article
Polyploidy and the Evolution of Complex Traits
International Journal of Evolutionary Biology, 2012, 1–12.
TL;DR:
It is argued that the evolutionary importance of WGD may require updating certain aspects of modern evolutionary theory, perhaps helping to synthesize a new evolutionary systems biology.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 17, 2019
2012 chapter
Chemical Analyses of Fossil Bone
In Methods in Molecular Biology (pp. 153–172).
MeSH headings : Animals; Blotting, Western; Bone Demineralization Technique / methods; Bone and Bones / chemistry; Bone and Bones / cytology; Bone and Bones / ultrastructure; Dinosaurs / anatomy & histology; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Fossils; Immunohistochemistry; Silver Staining
TL;DR:
To test this hypothesis, and to characterize these materials at a molecular level, multiple independent chemical, molecular, and microscopic analyses were applied to identify the presence of original components produced by the extinct organisms.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 17, 2019
2012 journal article
Supplementary material for: Empirical Pathway Analysis, Without Permutation
Source: ORCID
Added: October 7, 2019
2012 journal article
Simple and accurate trend tests using a permutation approximation
Source: ORCID
Added: October 7, 2019
2012 journal article
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model
Toxicological Sciences.
Source: ORCID
Added: October 7, 2019
2012 journal article
Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data
Statistics in Biosciences, 1–23.
Source: ORCID
Added: October 7, 2019
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