Works Published in 2000
Displaying all 11 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2000 journal article
Direct quantitation of rapid elimination of viral antigen-positive lymphocytes by antiviral CD8+ T cellsin vivo
European Journal of Immunology, 30(5), 1356–1363.
Contributors: W. Barchet *, S. Oehen*, P. Klenerman *, D. Wodarz *, G. Bocharov *, A. Lloyd* , M. Nowak*, H. Hengartner*, R. Zinkernagel*, S. Ehl *
author keywords: CD8(+) T cell; virus; cytotoxicity; perforin; CD95
TL;DR:
It is illustrated how effectively CD8+ T cell‐mediated elimination of target cells can potentially contribute to virus control and immunosuppression for viruses with a particular tropism for lymphocytes, such as Epstein‐Barr virus or HIV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 8, 2020
2000 journal article
Fluctuations in HIV-1 Viral Load Are Correlated to CD4+ T-Lymphocyte Count During the Natural Course of Infection
JAIDS Journal of Acquired Immune Deficiency Syndromes, 23(5), 375–379.
Contributors: J. Masel, R. Arnaout, . TR O'Brien, J. Goedert & A. Lloyd*
TL;DR:
Using longitudinal data, whether fluctuations in viral load can be better explained by changes in CD4 + T-cell count than by a set point or trend of exponential growth was tested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 27, 2019
2000 journal article
Local stability analysis of spatially homogeneous solutions of multi-patch systems
Journal of Mathematical Biology, 41(3), 232–252.
author keywords: diffusive instability; symmetry breaking; metapopulation model; coupled map lattice
MeSH headings : Animals; Mathematics; Models, Biological; Population Dynamics; Predatory Behavior
TL;DR:
A bookkeeping scheme is presented that facilitates stability analyses by reducing the analysis of a k-species, n-patch system to that of n uncoupled k-dimensional single-patch systems and is used to analyse the stability of the equilibrium of a predator–prey system with a pool of dispersers and of the periodic solutions of the spatial Lotka–Volterra model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, ORCID
Added: July 27, 2019
2000 journal article
The Influence of HLA Class I Alleles and Heterozygosity on the Outcome of Human T Cell Lymphotropic Virus Type I Infection
The Journal of Immunology, 165(12), 7278–7284.
MeSH headings : Alleles; Disease Progression; Female; Genes, MHC Class I / immunology; Genetic Carrier Screening; Genetic Predisposition to Disease / etiology; HLA Antigens / genetics; HLA-A2 Antigen / genetics; HLA-B Antigens / genetics; HLA-C Antigens / genetics; Human T-lymphotropic virus 1 / immunology; Humans; Linkage Disequilibrium / immunology; Paraparesis, Tropical Spastic / etiology; Paraparesis, Tropical Spastic / genetics; Paraparesis, Tropical Spastic / immunology; Paraparesis, Tropical Spastic / virology; Proviruses / immunology; Risk Factors; Viral Load
TL;DR:
Evidence is presented that HLA-Cw*08 was also associated with disease protection and with a lower provirus load in healthy carriers of HTLV-I and this results are consistent with the proposal that a strong class I-restricted CTL response to HT LVI reduces the proviral load and hence the risk of disease.
(via Semantic Scholar)
www.jimmunol.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: July 27, 2019
2000 journal article
Rabbit pigmented ciliary epithelium produces interleukin-6 in response to inflammatory cytokines
EXPERIMENTAL EYE RESEARCH, 70(3), 271–279.
author keywords: interleukin-6; pigmented ciliary epithelium; interleukin-1; tumor necrosis factor-alpha; adenosine 3 ',5 '-cyclic monophosphate
MeSH headings : Animals; Cell Culture Techniques; Ciliary Body / immunology; Ciliary Body / metabolism; Cyclic AMP / metabolism; Cytokines / immunology; Endotoxins / immunology; Interleukin-1 / immunology; Interleukin-6 / biosynthesis; Pigment Epithelium of Eye / immunology; Pigment Epithelium of Eye / metabolism; Rabbits; Tumor Necrosis Factor-alpha / immunology
TL;DR:
The results indicate that the pigmented ciliary epithelium is one potential source of interleukin-6 and may contribute to the elevation in intraocular fluid interleucin- 6 levels observed during various intraocular inflammatory episodes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Ex vivo canine lens capsular sac explants
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 238(8), 708–714.
MeSH headings : Actins / metabolism; Animals; Biomarkers; Cataract / metabolism; Cataract / pathology; Cell Division; Cells, Cultured; Dogs; Enzyme-Linked Immunosorbent Assay; Insulin-Like Growth Factor I / metabolism; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / growth & development; Lens Capsule, Crystalline / metabolism; Transferrin / metabolism; Transforming Growth Factor beta / metabolism; Transforming Growth Factor beta2; Vimentin / metabolism
TL;DR:
Canine lens sac explants appear to be a useful alternative tissue source for this model when human cadaver eyes are unavailable and may influence the proliferation and metaplasia of LEC during the development of PCO.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Hydrodynamic models of line-driven accretion disk winds. II. Adiabatic winds from nonisothermal disks
ASTROPHYSICAL JOURNAL, 532(1), 563–580.
author keywords: accretion, accretion disks; hydrodynamics; novae, cataclysmic variables; stars : mass loss
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Tidally-driven transport in accretion disks in close binary systems
NEW ASTRONOMY, 5(1), 53–68.
author keywords: accretion, accretion disks; hydrodynamics; shock waves; novae, cataclysmic variables; binaries : close
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1497(1), 51–60.
author keywords: ferritin; Fe metabolism; lens; cataract; lens epithelial cell; tempol; oxidative damage; peroxide; free radical
MeSH headings : Animals; Antioxidants / pharmacology; Cyclic N-Oxides / pharmacology; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Female; Ferritins / biosynthesis; Ferritins / drug effects; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Male; Spin Labels; Time Factors; tert-Butylhydroperoxide / pharmacology
TL;DR:
The redistribution of Fe within the cell after 20 h of Tempol treatment appears to render the cells more vulnerable to oxidative stress, likely due to its effects on Fe metabolism, perhaps by reducing the availability of Fe for incorporation into ferritin and Fe-dependent enzymes as well as enlarging a low molecular weight pool of Fe which may be capable of catalyzing damaging free radical reactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts
AMERICAN JOURNAL OF VETERINARY RESEARCH, 61(2), 139–143.
MeSH headings : Actins / analysis; Animals; Cataract / pathology; Cataract / veterinary; Cataract Extraction / veterinary; Dog Diseases / pathology; Dogs; Fibronectins / analysis; Histocytochemistry; Humans; Immunohistochemistry / methods; Lens, Crystalline / pathology; Lens, Crystalline / ultrastructure; Tenascin / analysis; Transforming Growth Factor beta / analysis
TL;DR:
Canine lens capsular plaques are histologically and immunohistochemically similar to posterior capsule opacification and subcapsular cataracts in humans, which suggests that the canine condition, like the human conditions, is associated with fibrous metaplasia of lens epithelial cells.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2000 article
Effect of surgical technique on in vitro posterior capsule opacification
Davidson, M. G., Morgan, D. K., & McGahan, M. C. (2000, October). JOURNAL OF CATARACT AND REFRACTIVE SURGERY, Vol. 26, pp. 1550–1554.
MeSH headings : Animals; Cataract / etiology; Cataract / pathology; Cataract / prevention & control; Cell Count; Cells, Cultured; Culture Media, Serum-Free; Dogs; Lens Capsule, Crystalline / pathology; Lens Capsule, Crystalline / surgery; Phacoemulsification / methods; Postoperative Complications / etiology; Postoperative Complications / pathology; Postoperative Complications / prevention & control
TL;DR:
Phacoemulsification with and without anterior and equatorial capsular vacuuming led to less initial LEC density in the capsular bag than ECCE, however, because cell proliferation rates among the 3 groups were only marginally affected, near 100% removal of LEC at the time of cataract extraction may be necessary to prevent PCO.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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