Works Published in 2010
Displaying works 41 - 60 of 209 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Rapid signaling actions of environmental estrogens in developing granule cell neurons are mediated by estrogen receptor β
Endocrinology, 151(12), 5689–5699.
Contributors: H. Le* & S. Belcher*
MeSH headings : Animals; Cell Death; Endocrine Disruptors / chemistry; Endocrine Disruptors / pharmacology; Environmental Pollutants; Estrogen Receptor beta / metabolism; Estrogens / chemistry; Estrogens / pharmacology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Molecular Structure; Neurons / cytology; Neurons / drug effects; Neurons / physiology; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction
TL;DR:
The utility of estrogen sensitive developing granule cells as an in vitro assay for elucidating rapid estrogen-signaling mechanisms and to detect EDCs that act at ERβ to rapidly regulate intracellular signaling is demonstrated.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
Source: ORCID
Added: March 5, 2021
2010 journal article
Defining hormesis: Evaluation of a complex concentration response phenomenon
International Journal of Toxicology, 29(3), 235–246.
Contributors: E. Kendig*, H. Le* & S. Belcher*
author keywords: hormesis; dose-response relationship; threshold model; beta-curve; biphasic effects; nonmonotonic; low-dose effects; subthreshold response
MeSH headings : Animals; Dose-Response Relationship, Drug; History, 16th Century; History, 19th Century; History, Ancient; Humans; Models, Biological; Nonlinear Dynamics; Pharmacokinetics; Pharmacology / methods; Terminology as Topic; Toxicology / history; Toxicology / methods
TL;DR:
By examining the history of this dose-response theory, it is clear that both pharmacological and toxicological studies provide evidence for hormetic dose responses, but retrospective examination of studies can be problematic at best.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2010 chapter
Cockroaches
In A. Mallis (Ed.), Handbook of Pest Control (10th ed, pp. 150–291). Richfield, Ohio: The Mallis Handbook Company.
Ed(s): A. Mallis
Source: NC State University Libraries
Added: January 23, 2021
2010 journal article
Framework for traits-based assessment in ecotoxicology
Integrated Environmental Assessment and Management, 7(2), 172–186.
MeSH headings : Animals; Ecotoxicology / methods; Environmental Pollutants; Risk Assessment / methods
TL;DR:
A framework for the application of traits‐based assessment based on the population vulnerability conceptual model of Van Straalen, in which vulnerability is determined by traits that can be grouped into 3 major categories, i.e., external exposure, intrinsic sensitivity, and population sustainability is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2010 journal article
Detection of Alternative Splice Variants at the Proteome Level inAspergillus flavus
Journal of Proteome Research, 9(3), 1209–1217.
author keywords: mass spectrometry; proteomics; alternative splicing; database; Aspergillus flavus
MeSH headings : Alternative Splicing; Aspergillus flavus / genetics; Aspergillus flavus / metabolism; Computer Simulation; Cytochrome-B(5) Reductase / chemistry; Cytochrome-B(5) Reductase / genetics; Databases, Protein; Fungal Proteins / biosynthesis; Fungal Proteins / chemistry; Fungal Proteins / genetics; Isotope Labeling; Mass Spectrometry; Models, Genetic; Protein Isoforms / biosynthesis; Protein Isoforms / chemistry; Protein Isoforms / genetics; Proteomics; Pyruvate Carboxylase / chemistry; Pyruvate Carboxylase / genetics; RNA Splice Sites; Reproducibility of Results
TL;DR:
The introduction of an alternative splicing database helps identify more proteins and unveils more information about a proteome, and shows potential to improve genome annotation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 18, 2021
2010 journal article
Abundance and distribution of major groups of diazotrophic cyanobacteria and their potential contribution to N2 fixation in the tropical Atlantic Ocean
Environmental Microbiology, 12, 3272–3289.
MeSH headings : Atlantic Ocean; Cabo Verde; Cyanobacteria / classification; Cyanobacteria / enzymology; Cyanobacteria / genetics; Cyanobacteria / isolation & purification; DNA, Bacterial / isolation & purification; Geography; Models, Biological; Nitrogen Fixation; Oxidoreductases / genetics; Seawater / analysis; Seawater / microbiology; Temperature; Water Microbiology
TL;DR:
Overall, highest diazotroph abundances were observed at the surface and declined with depth, except for some subsurface peaks in Trichodesmium,UCYN-B and UCYN-A, which suggested that Trichodemium had the largest input to N₂ fixation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 26, 2020
2010 journal article
Spanning boundaries in an Arizona watershed partnership: information networks as tools for entrenchment or ties for cooperation?
Ecology & Society, 15(3), 22. http://www.ecologyandsociety.org/vol15/iss3/art22/
Source: NC State University Libraries
Added: December 24, 2020
2010 journal article
Structural Basis for Feedback and Pharmacological Inhibition of Saccharomyces cerevisiae Glutamate Cysteine Ligase
Journal of Biological Chemistry, 285(19), 14459–14466.
MeSH headings : Adenosine Triphosphate / metabolism; Binding Sites; Buthionine Sulfoximine / metabolism; Crystallization; Crystallography, X-Ray; Enzyme Inhibitors / metabolism; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / genetics; Glutamate-Cysteine Ligase / metabolism; Glutathione / metabolism; Kinetics; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation / genetics; Protein Conformation; Saccharomyces cerevisiae / enzymology; Saccharomyces cerevisiae / genetics
TL;DR:
The structures of two inhibited forms of Saccharomyces cerevisiae GCL are determined, which shares significant sequence identity with the human enzyme and provide additional details of the catalytic mechanism of the enzyme.
(via Semantic Scholar)
Source: Crossref
Added: October 29, 2020
2010 journal article
Pesticide Exposures and Uterine Fibroid Risk Among Farming Women
Annals of Epidemiology, 20(9), 707.
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2010 journal article
Functional characterization of pheromone receptors in the tobacco budworm Heliothis virescens
Insect Molecular Biology, 20(1), 125–133.
author keywords: odorant receptors; pheromone receptors; Heliothis virescens; Xenopus oocytes
MeSH headings : Animal Communication; Animals; Arthropod Antennae / metabolism; Behavior, Animal; DNA, Complementary / genetics; Female; Genes, Insect; Male; Moths / genetics; Moths / metabolism; Oocytes / metabolism; Receptors, Pheromone / genetics; Receptors, Pheromone / metabolism; Sex Attractants / genetics; Sex Attractants / metabolism; Xenopus / genetics
TL;DR:
Functional analyses of candidate Heliothis virescens pheromone odorant receptors (HvORs) were conducted using heterologous expression in Xenopus oocytes, finding HvOR6 was found to be highly tuned to Z9‐14:Ald, while Hv OR13, HVOR14 and Hvor16 showed specificity for Z11‐16: ald, Z11-16:OAc and Z11•16:OH,
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2010 journal article
Evidence for viable, non-clonal but fatherless Boa constrictors
Biology Letters, 7(2), 253–256.
author keywords: facultative parthenogenesis; asexual reproduction; Boidae; WW female; microsatellite DNA fingerprinting
MeSH headings : Animals; Boidae / genetics; Boidae / physiology; DNA Fingerprinting; Female; Male; Microsatellite Repeats; Parthenogenesis; Sex Determination Processes
TL;DR:
Through microsatellite DNA fingerprinting, this work provides the first evidence of facultative parthenogenesis in a Boa constrictor, identifying multiple, viable, non-experimentally induced females for the first time in any vertebrate lineage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Crossref
Added: September 5, 2020
2010 journal article
Mortality in the Agricultural Health Study, 1993-2007
American Journal of Epidemiology, 173(1), 71–83.
author keywords: agriculture; healthy worker effect; mortality; neoplasms; pesticides; wounds and injuries
MeSH headings : Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / mortality; Cause of Death / trends; Female; Humans; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Retrospective Studies; Survival Rate / trends
TL;DR:
Using data from the Agricultural Health Study, a cohort of 89,656 pesticide applicators and their spouses in North Carolina and Iowa, standardized mortality ratios (SMRs) were computed comparing deaths from time of the enrollment through 2007 to state-specific rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2010 journal article
A Genetic Strategy for Graded and Dynamic Control of Cell-Matrix Mechanobiology
Biophysical Journal, 98(3), 730a.
TL;DR:
Genetically engineered stable cell lines are engineered in which they can precisely and dynamically alter the mechanobiological behavior of living cells by varying the activity of signal transduction proteins, such as RhoA GTPase, using constitutively active and dominant negative mutants under the control of a tetracycline-repressible promoter.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Mechanotransductive Engineering of Neural Stem Cell Behavior
Biophysical Journal, 98(3), 404a–405a.
TL;DR:
It is demonstrated that ECM-derived mechanical signals can act with Rho GTPases to regulate NSC stiffness and differentiation, establishing RhoGTPase-based mechanotransduction and cellular stiffness as novel regulators of NSC behavior.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Biophysics and dynamics of natural and engineered stem cell microenvironments
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2(1), 49–64.
MeSH headings : Adult; Animals; Biomechanical Phenomena / physiology; Biophysics / methods; Biophysics / trends; Cell Culture Techniques / methods; Environment; Humans; Kinetics; Models, Biological; Stem Cells / cytology; Stem Cells / metabolism; Stem Cells / physiology; Tissue Engineering / methods
TL;DR:
How microenvironmental characteristics of the microenvironment have been shown to regulate stem cell fate are reviewed and future research directions that may help expand the current understanding of stem cell biology and aid its application to regenerative medicine are discussed.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice
Hormones and Behavior, 58(5), 754–761.
author keywords: Endocrine disruptive compounds; Estrogens; Epigenetic; Environment; Methylation; Sex differences; Bisphenol A
MeSH headings : Air Pollutants / toxicity; Animal Husbandry; Animals; Animals, Newborn; Anxiety / chemically induced; Behavior, Animal / drug effects; Behavior, Animal / physiology; Benzhydryl Compounds; Exploratory Behavior / drug effects; Exploratory Behavior / physiology; Female; Male; Maternal Deprivation; Maternal Exposure / adverse effects; Maze Learning / drug effects; Maze Learning / physiology; Mice; Mice, Inbred C57BL; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / physiopathology; Prenatal Exposure Delayed Effects / psychology
TL;DR:
The results show that prenatal BPA exposure affects social behavior and anxiety in the EPM, and some facet(s) of the infant-maternal interaction may modify these effects.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Of mice and rats: Key species variations in the sexual differentiation of brain and behavior
Frontiers in Neuroendocrinology, 31(3), 341–358.
author keywords: Hypothalamus; Calbindin D28k; Progestin receptor; Estrogen receptor; Nitric oxide; Sexual dimorphism
MeSH headings : Animals; Behavior, Animal / physiology; Brain / growth & development; Brain / physiology; Humans; Mice; Models, Animal; Rats; Sex Differentiation / physiology; Sexual Behavior, Animal / physiology; Species Specificity
TL;DR:
Neural and behavioral sexual dimorphisms in rats and mice are reviewed, which highlight species differences and experimental gaps in the literature, that are needed for direct species comparisons.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Critical periods of susceptibility to short-term energy challenge during pregnancy: Impact on fertility and offspring development
Physiology & Behavior, 99(1), 100–108.
author keywords: Reproduction; Pregnancy; Fertility; Gestation; Delayed implantation; Energy balance; Food restriction; Sexual behavior; Development
MeSH headings : Analysis of Variance; Animals; Body Weight; Disease Susceptibility; Eating / physiology; Fasting / physiology; Female; Fertility / physiology; Fetal Development / physiology; Litter Size; Male; Nutritional Status; Pregnancy / physiology; Pregnancy Outcome; Pregnancy, Animal; Sexual Behavior, Animal; Shrews; Time Factors
TL;DR:
There are critical periods of pregnancy, particularly after implantation, when short-term, mild energetic challenges have significant impacts on fertility and offspring postnatal development, and delayed implantation may have evolved, in part, as a buffering mechanism to prevent pregnancy failure during impaired energy balance in early gestation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Maternally-inherited Grb10 reduces placental size and efficiency
Developmental Biology, 337(1), 1–8.
author keywords: Adapter protein; Cell signalling; Epigenetics; Genomic imprinting; Growth factor receptor-bound protein; Growth regulation; IGF; Insulin-like growth factor; Mouse; Placenta
MeSH headings : Alleles; Animals; Endothelium / metabolism; Female; GRB10 Adaptor Protein / analysis; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / physiology; Genomic Imprinting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Placenta / pathology; Placenta / physiology; Pregnancy
TL;DR:
It is shown that following disruption of the maternal allele in mice, the labyrinthine volume was increased in a manner consistent with a cell-autonomous function of Grb10 and the enlarged placenta was more efficient in supporting foetal growth, becoming the first example of a gene that acts to limit placental size and efficiency.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2010 journal article
Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus
Proceedings of the National Academy of Sciences, 107(10), 4693–4698.
author keywords: epithelial growth factor receptor; host pathogen; microarray; Streptococcus pyogenes; transcriptome
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Clathrin-Coated Vesicles / metabolism; Cytokines / metabolism; GTP Phosphohydrolases / genetics; GTP Phosphohydrolases / metabolism; Gene Expression Profiling; Host-Pathogen Interactions; Hyaluronic Acid / metabolism; Macaca fascicularis / genetics; Macaca fascicularis / metabolism; Macaca fascicularis / microbiology; Neutrophils / metabolism; Neutrophils / microbiology; Neutrophils / pathology; Oligonucleotide Array Sequence Analysis; Pharyngitis / genetics; Pharyngitis / microbiology; Pharynx / metabolism; Pharynx / microbiology; Pharynx / pathology; Reverse Transcriptase Polymerase Chain Reaction; Streptococcus pyogenes / genetics; Streptococcus pyogenes / metabolism; Streptococcus pyogenes / physiology
TL;DR:
These results are unique in providing a comprehensive understanding of the host–pathogen interactome during mucosal infection by a bacterial pathogen.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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