Works (15)
Updated: October 16th, 2024 05:03
2024 journal article
Engineering ethanologenicity into the extremely thermophilic bacterium Anaerocellum<i> (</i> f. Caldicellulosiriuptor) bescii
METABOLIC ENGINEERING, 86, 99–114.
author keywords: Anaerocellum bescii; Ethanol; Extreme thermophile; Cellulose
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2024
2022 journal article
<p>Plant biomass fermentation by the extreme thermophile Caldicellulosiruptor bescii for co-production of green hydrogen and acetone: Technoeconomic analysis</p>
BIORESOURCE TECHNOLOGY, 348.
author keywords: Acetone; Green hydrogen; Caldicellulosiruptor bescii; Extreme thermophiles; Technoeconomic analysis
MeSH headings : Acetone; Biomass; Caldicellulosiruptor; Fermentation; Hydrogen; Lignin / chemistry
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 25, 2022
2020 journal article
Metabolically engineeredCaldicellulosiruptor besciias a platform for producing acetone and hydrogen from lignocellulose
BIOTECHNOLOGY AND BIOENGINEERING, 117(12), 3799–3808.
author keywords: acetone; Caldicellulosiruptor bescii; extreme thermophiles; metabolic engineering
MeSH headings : Acetone / metabolism; Biomass; Caldicellulosiruptor / genetics; Caldicellulosiruptor / metabolism; Hydrogen / metabolism; Lignin / metabolism; Metabolic Engineering
TL;DR:
C. bescii can be engineered with balanced pathways in which renewable carbohydrate sources are converted to useful metabolites, primarily acetone and H2, without net production of its native fermentation products, acetate and lactate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2020
2020 journal article
Modification of the glycolytic pathway in Pyrococcus furiosus and the implications for metabolic engineering
EXTREMOPHILES, 24(4), 511–518.
author keywords: Pyrococcus; Thermophile; Central metabolism; Glycolysis
MeSH headings : Fermentation; Glyceraldehyde 3-Phosphate; Glycolysis; Metabolic Engineering; Pyrococcus furiosus
TL;DR:
Insertion of a single gene encoding the thermostable NADPH-dependent primary alcohol dehydrogenase (adhA) from Caldanaerobacter subterraneus resulted in a strain producing ethanol via the previously established aldehyde oxidoreductase (AOR) pathway, and demonstrated a high ratio of ethanol over acetate at 80 °C and enabled ethanol production up to 85 °C, the highest temperature for bio-ethanol production reported to date.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2020 journal article
Use of the lignocellulose-degrading bacterium Caldicellulosiruptor bescii to assess recalcitrance and conversion of wild-type and transgenic poplar
BIOTECHNOLOGY FOR BIOFUELS, 13(1).
author keywords: Caldicellulosiruptor; Extreme thermophiles; Lignocellulose; Biofuel; Poplar
TL;DR:
Utilizing C. bescii as a screening assay for recalcitrance, poplar lines with down-regulation of coumarate 3-hydroxylase 3 (C3H3) resulted in the highest degrees of solubilization and conversion by C. Bescii, suggesting that excellent digestibility can be achieved without compromising fitness of the tree.
(via Semantic Scholar)
open access via biotechnologyforbiofuels.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 6, 2020
2019 journal article
Extreme thermophiles as emerging metabolic engineering platforms
Current Opinion in Biotechnology, 59, 55–64.
MeSH headings : Archaea; Biotechnology; Genetic Engineering; Metabolic Engineering; Waste Products
TL;DR:
If non-model platforms are successfully deployed, new avenues for production of fuels and chemicals from renewable feedstocks or waste materials will emerge.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: November 25, 2019
2019 journal article
Lignocellulose solubilization and conversion by extremely thermophilic Caldicellulosiruptor bescii improves by maintaining metabolic activity
BIOTECHNOLOGY AND BIOENGINEERING, 116(8), 1901–1908.
author keywords: biofuels; bioreactor; Caldicellulosiruptor bescii; lignocellulose; switchgrass
MeSH headings : Biofuels / microbiology; Bioreactors; Caldicellulosiruptor; Fermentation; Firmicutes / growth & development; Firmicutes / metabolism; Lignin / metabolism; Panicum / metabolism; Solubility
TL;DR:
The extreme thermophile Caldicellulosiruptor bescii solubilized carbohydrate conversion to fermentation products increased from 40% in batch to over 80% in the purged system, an improvement attributed to maintaining the bioreactor culture in a metabolically active state.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2019
2019 journal article
Quantitative fermentation of unpretreated transgenic poplar by Caldicellulosiruptor bescii
NATURE COMMUNICATIONS, 10(1).
Contributors: n, P. Khatibi n, J. Wang n , J. Conway n, A. Williams-Rhaesa *, I. Peszlen n , V. Chiang n, M. Adams *, R. Kelly n
MeSH headings : Biomass; Cellulose / metabolism; Clostridiales / genetics; Clostridiales / metabolism; Ethanol / metabolism; Fermentation; Industrial Microbiology; Lignin / metabolism; Metabolic Engineering; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Polysaccharides / metabolism; Populus / chemistry; Populus / genetics; Populus / metabolism
TL;DR:
The authors pair transgenic lignin modified poplar lines with engineered Caldicellusiruptor bescii to achieve biomass solubilization and ethanol conversion without pretreatment and the nearly quantitative microbial conversion of the carbohydrate content of unpretreated transgen lignocellulosic biomass bodes well for full utilization of renewable biomass feedstocks.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 26, 2019
2019 article
The biology and biotechnology of the genus Caldicellulosiruptor: recent developments in 'Caldi World'
Lee, L. L., Crosby, J. R., Rubinstein, G. M., Laemthong, T., Bing, R. G., Straub, C. T., … Kelly, R. M. (2020, January). EXTREMOPHILES, Vol. 24, pp. 1–15.
author keywords: Caldicellulosiruptor; Extreme thermophiles; Lignocellulose
MeSH headings : Biomass; Biotechnology; Clostridiales; Glycoside Hydrolases; Hot Springs
TL;DR:
Improvements in the amount of carbohydrate released and in the production of bio-based chemicals are required to successfully realize the biotechnological potential of Caldicellulosiruptor organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 27, 2020
2018 journal article
A synthetic enzymatic pathway for extremely thermophilic acetone production based on the unexpectedly thermostable acetoacetate decarboxylase from Clostridium acetobutylicum
BIOTECHNOLOGY AND BIOENGINEERING, 115(12), 2951–2961.
author keywords: acetone; biotransformations; extreme thermophiles
MeSH headings : Acetone / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Carboxy-Lyases / genetics; Carboxy-Lyases / metabolism; Clostridium acetobutylicum / enzymology; Clostridium acetobutylicum / genetics; Clostridium acetobutylicum / metabolism; Enzyme Stability; Hot Temperature; Metabolic Engineering; Metabolic Networks and Pathways / genetics; Synthetic Biology / methods
TL;DR:
A synthetic enzymatic pathway for acetone production that functions up to at least 70°C in vitro, made possible by the unusual thermostability of Adc from the mesophile C. acetobutylicum, paving the way for bio‐reactive distillation of acetone using a metabolically engineered extreme thermophile as a production host.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018
2018 review
Biotechnology of extremely thermophilic archaea
[Review of ]. FEMS MICROBIOLOGY REVIEWS, 42(5), 543–578.
author keywords: extremely thermophilic archaea; biotechnology; biocatalysis; biooxidation
MeSH headings : Archaea / genetics; Archaea / physiology; Biotechnology / trends; Hot Temperature; Industrial Microbiology / trends; Metabolic Engineering / trends
TL;DR:
There are barriers and challenges to these organisms reaching their full potential as industrial microorganisms but, if these can be overcome, a new dimension for biotechnology will be forthcoming that strategically exploits biology at high temperatures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018
2017 journal article
Bioavailability of Carbohydrate Content in Natural and Transgenic Switchgrasses for the Extreme Thermophile Caldicellulosiruptor bescii
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 83(17).
author keywords: Caldicellulosiruptor; switchgrass; lignocellulose deconstruction and conversion; extreme thermophiles; lignocellulose
MeSH headings : Biomass; Fermentation; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Hot Temperature; Lignin / chemistry; Lignin / metabolism; Panicum / chemistry; Panicum / genetics; Panicum / metabolism; Panicum / microbiology; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Plants, Genetically Modified / microbiology; Polysaccharides / chemistry; Polysaccharides / metabolism
TL;DR:
While C. bescii could significantly solubilize the transgenic switchgrass lines and natural variant tested here, additional or alternative strategies (physical, chemical, enzymatic, and/or genetic) are needed to eliminate recalcitrance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 review
Extremely thermophilic energy metabolisms: biotechnological prospects
[Review of ]. CURRENT OPINION IN BIOTECHNOLOGY, 45, 104–112.
MeSH headings : Archaea / classification; Archaea / genetics; Archaea / metabolism; Biotechnology / methods; Carbon Dioxide / metabolism; Chemoautotrophic Growth; Energy Metabolism; Hot Temperature; Lignin / metabolism; Metabolic Engineering
TL;DR:
This review considers recent developments in extreme thermophile biology as they relate to new horizons for energy biotechnology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 review
Physiological, metabolic and biotechnological features of extremely thermophilic microorganisms
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 9(3).
MeSH headings : Biocatalysis; Carbohydrate Metabolism; Carbon Dioxide / metabolism; Glycolysis; Metabolic Engineering; Metals / chemistry; Metals / metabolism; Sulfolobales / metabolism; Sulfur / metabolism; Thermoanaerobacter / metabolism; Thermococcales / metabolism; Thermus / metabolism
TL;DR:
The bacterial genera Caldicellulosiruptor, Thermotoga and Thermus, and the archaea belonging to the orders Thermococcales and Sulfolobales, are among the most studied extreme thermophiles to date.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 review
Extremely thermophilic microorganisms as metabolic engineering platforms for production of fuels and industrial chemicals
[Review of ]. FRONTIERS IN MICROBIOLOGY, 6.
author keywords: extreme thermophiles; metabolic engineering; bio-based chemicals; genetics; biotechnology
TL;DR:
The issues and opportunities for extremely thermophilic metabolic engineering platforms are considered with an eye toward potential technological advantages for high temperature industrial biotechnology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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