Christopher Straub

Works (17)

Updated: May 14th, 2025 21:08

2025 article

Structural and kinetic characterization of an acetoacetyl-Coenzyme A: acetate Coenzyme A transferase from the extreme thermophile Thermosipho melanesiensis

Bing, R. G., Buhrman, G. K., Ford, K. C., Straub, C. T., Laemthong, T., Rose, R. B., … Kelly, R. M. (2025, January 27). Biochemical Journal, Vol. 482, pp. 225–240.

By: R. Bing n , G. Buhrman n, K. Ford n, C. Straub n, T. Laemthong n, R. Rose n , M. Adams, R. Kelly n 

MeSH headings : Kinetics; Acyl Coenzyme A / metabolism; Acyl Coenzyme A / chemistry; Coenzyme A-Transferases / chemistry; Coenzyme A-Transferases / metabolism; Coenzyme A-Transferases / genetics; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / genetics; Crystallography, X-Ray; Acetyl Coenzyme A / metabolism; Acetyl Coenzyme A / chemistry; Acetates / metabolism; Substrate Specificity; Recombinant Proteins / chemistry; Recombinant Proteins / metabolism; Recombinant Proteins / genetics; Firmicutes / enzymology
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Enzyme Structure and Function; Biochemical and Molecular Research
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Sources: Web Of Science, NC State University Libraries
Added: April 14, 2025

2024 article

Beyond low lignin: Identifying the primary barrier to plant biomass conversion by fermentative bacteria

Bing, R. G., Sulis, D. B., Carey, M. J., Manesh, M. J. H., Ford, K. C., Straub, C. T., … Kelly, R. M. (2024, October 18). Science Advances, Vol. 10.

By: R. Bing n , D. Sulis  n, M. Carey n, M. Manesh  n, K. Ford n, C. Straub n, T. Laemthong n, B. Alexander  n ...

Contributors: R. Bing n , M. Carey n, M. Manesh  n, K. Ford n, C. Straub n, T. Laemthong n, B. Alexander  n, D. Willard n ...

MeSH headings : Lignin / metabolism; Biomass; Fermentation; Populus / metabolism; Populus / genetics; Bacteria / metabolism; Bacteria / genetics; Plants / metabolism
topics (OpenAlex): Biofuel production and bioconversion; Lignin and Wood Chemistry; Microbial Metabolic Engineering and Bioproduction
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 1, 2024

2024 article

Engineering ethanologenicity into the extremely thermophilic bacterium Anaerocellum (f. Caldicellulosiriuptor) bescii

Bing, R. G., Ford, K. C., Willard, D. J., Manesh, M. J. H., Straub, C. T., Laemthong, T., … Kelly, R. M. (2024, September 19). Metabolic Engineering, Vol. 86, pp. 99–114.

By: R. Bing n , K. Ford n, D. Willard n, M. Manesh  n, C. Straub n, T. Laemthong n, B. Alexander  n, T. Tanwee * ...

author keywords: Anaerocellum bescii; Ethanol; Extreme thermophile; Cellulose
MeSH headings : Metabolic Engineering; Ethanol / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Firmicutes / genetics; Firmicutes / metabolism; Caldicellulosiruptor
topics (OpenAlex): Biofuel production and bioconversion; Anaerobic Digestion and Biogas Production; Microbial Metabolic Engineering and Bioproduction
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Sources: Web Of Science, NC State University Libraries
Added: October 14, 2024

2022 article

Plant biomass fermentation by the extreme thermophile Caldicellulosiruptor bescii for co-production of green hydrogen and acetone: Technoeconomic analysis

Bing, R. G., Straub, C. T., Sulis, D. B., Wang, J. P., Adams, M. W. W., & Kelly, R. M. (2022, January 29). Bioresource Technology, Vol. 3.

By: R. Bing n , C. Straub n, D. Sulis n, J. Wang n , M. Adams * & R. Kelly n 

Contributors: R. Bing n , C. Straub n, R. Kelly n , D. Sulis n, J. Wang n  & M. Adams *

author keywords: Acetone; Green hydrogen; Caldicellulosiruptor bescii; Extreme thermophiles; Technoeconomic analysis
MeSH headings : Acetone; Biomass; Caldicellulosiruptor; Fermentation; Hydrogen; Lignin / chemistry
topics (OpenAlex): Biofuel production and bioconversion; Microbial Metabolic Engineering and Bioproduction; Anaerobic Digestion and Biogas Production
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 25, 2022

2020 article

Metabolically engineered Caldicellulosiruptor bescii as a platform for producing acetone and hydrogen from lignocellulose

Straub, C. T., Bing, R. G., Otten, J. K., Keller, L. M., Zeldes, B. M., Adams, M. W. W., & Kelly, R. M. (2020, August 8). Biotechnology and Bioengineering, Vol. 117, pp. 3799–3808.

By: C. Straub n, R. Bing n , J. Otten  n, L. Keller  n, B. Zeldes n, M. Adams *, R. Kelly n 

author keywords: acetone; Caldicellulosiruptor bescii; extreme thermophiles; metabolic engineering
MeSH headings : Acetone / metabolism; Biomass; Caldicellulosiruptor / genetics; Caldicellulosiruptor / metabolism; Hydrogen / metabolism; Lignin / metabolism; Metabolic Engineering
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Biofuel production and bioconversion; Catalysis for Biomass Conversion
TL;DR: C. bescii can be engineered with balanced pathways in which renewable carbohydrate sources are converted to useful metabolites, primarily acetone and H2, without net production of its native fermentation products, acetate and lactate. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 7, 2020

2020 article

Modification of the glycolytic pathway in Pyrococcus furiosus and the implications for metabolic engineering

Straub, C. T., Schut, G., Otten, J. K., Keller, L. M., Adams, M. W. W., & Kelly, R. M. (2020, May 15). Extremophiles.

By: C. Straub n, G. Schut *, J. Otten  n, L. Keller  n, M. Adams * & R. Kelly n 

author keywords: Pyrococcus; Thermophile; Central metabolism; Glycolysis
MeSH headings : Fermentation; Glyceraldehyde 3-Phosphate; Glycolysis; Metabolic Engineering; Pyrococcus furiosus
topics (OpenAlex): Enzyme Structure and Function; Genomics and Phylogenetic Studies; Biochemical and Molecular Research
TL;DR: Insertion of a single gene encoding the thermostable NADPH-dependent primary alcohol dehydrogenase (adhA) from Caldanaerobacter subterraneus resulted in a strain producing ethanol via the previously established aldehyde oxidoreductase (AOR) pathway, and demonstrated a high ratio of ethanol over acetate at 80 °C and enabled ethanol production up to 85 °C, the highest temperature for bio-ethanol production reported to date. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020

2020 article

Use of the lignocellulose-degrading bacterium Caldicellulosiruptor bescii to assess recalcitrance and conversion of wild-type and transgenic poplar

Straub, C. T., Bing, R. G., Wang, J. P., Chiang, V. L., Adams, M. W. W., & Kelly, R. M. (2020, March 11). Biotechnology for Biofuels, Vol. 13.

By: C. Straub n, R. Bing n , J. Wang n , V. Chiang n, M. Adams * & R. Kelly n 

Contributors: C. Straub n, R. Bing n , R. Kelly n , J. Wang n , V. Chiang n & M. Adams *

author keywords: Caldicellulosiruptor; Extreme thermophiles; Lignocellulose; Biofuel; Poplar
topics (OpenAlex): Biofuel production and bioconversion; Microbial Metabolic Engineering and Bioproduction; Enzyme Production and Characterization; Bioenergy crop production and management; Bioeconomy and Sustainability Development
TL;DR: Utilizing C. bescii as a screening assay for recalcitrance, poplar lines with down-regulation of coumarate 3-hydroxylase 3 (C3H3) resulted in the highest degrees of solubilization and conversion by C. Bescii, suggesting that excellent digestibility can be achieved without compromising fitness of the tree. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 6, 2020

2019 journal article

Extreme thermophiles as emerging metabolic engineering platforms

Current Opinion in Biotechnology, 59, 55–64.

By: J. Crosby n, T. Laemthong n, A. Lewis n, C. Straub n, M. Adams * & R. Kelly n 

MeSH headings : Archaea; Biotechnology; Genetic Engineering; Metabolic Engineering; Waste Products
topics (OpenAlex): Enzyme Catalysis and Immobilization; Microbial Metabolic Engineering and Bioproduction; Biofuel production and bioconversion
TL;DR: If non-model platforms are successfully deployed, new avenues for production of fuels and chemicals from renewable feedstocks or waste materials will emerge. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: November 25, 2019

2019 article

Lignocellulose solubilization and conversion by extremely thermophilic Caldicellulosiruptor bescii improves by maintaining metabolic activity

Straub, C. T., Khatibi, P. A., Otten, J. K., Adams, M. W. W., & Kelly, R. M. (2019, April 14). Biotechnology and Bioengineering, Vol. 116, pp. 1901–1908.

By: C. Straub n, P. Khatibi n, J. Otten  n, M. Adams * & R. Kelly n 

author keywords: biofuels; bioreactor; Caldicellulosiruptor bescii; lignocellulose; switchgrass
MeSH headings : Biofuels / microbiology; Bioreactors; Caldicellulosiruptor; Fermentation; Firmicutes / growth & development; Firmicutes / metabolism; Lignin / metabolism; Panicum / metabolism; Solubility
topics (OpenAlex): Biofuel production and bioconversion; Advanced Cellulose Research Studies; Microbial Metabolic Engineering and Bioproduction
TL;DR: The extreme thermophile Caldicellulosiruptor bescii solubilized carbohydrate conversion to fermentation products increased from 40% in batch to over 80% in the purged system, an improvement attributed to maintaining the bioreactor culture in a metabolically active state. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 19, 2019

2019 article

Quantitative fermentation of unpretreated transgenic poplar by Caldicellulosiruptor bescii

Straub, C. T., Khatibi, P. A., Wang, J. P., Conway, J. M., Williams-Rhaesa, A. M., Peszlen, I. M., … Kelly, R. M. (2019, August 7). Nature Communications, Vol. 10.

By: C. Straub n, P. Khatibi n, J. Wang n , J. Conway n, A. Williams-Rhaesa *, I. Peszlen n , V. Chiang n, M. Adams *, R. Kelly n 

Contributors: C. Straub n, P. Khatibi n, J. Wang n , J. Conway n, A. Williams-Rhaesa *, I. Peszlen n , V. Chiang n, M. Adams *, R. Kelly n 

MeSH headings : Biomass; Cellulose / metabolism; Clostridiales / genetics; Clostridiales / metabolism; Ethanol / metabolism; Fermentation; Industrial Microbiology; Lignin / metabolism; Metabolic Engineering; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Polysaccharides / metabolism; Populus / chemistry; Populus / genetics; Populus / metabolism
topics (OpenAlex): Biofuel production and bioconversion; Microbial Metabolic Engineering and Bioproduction; Catalysis for Biomass Conversion
TL;DR: The authors pair transgenic lignin modified poplar lines with engineered Caldicellusiruptor bescii to achieve biomass solubilization and ethanol conversion without pretreatment and the nearly quantitative microbial conversion of the carbohydrate content of unpretreated transgen lignocellulosic biomass bodes well for full utilization of renewable biomass feedstocks. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 26, 2019

2019 article

The biology and biotechnology of the genus Caldicellulosiruptor: recent developments in ‘Caldi World’

Lee, L. L., Crosby, J. R., Rubinstein, G. M., Laemthong, T., Bing, R. G., Straub, C. T., … Kelly, R. M. (2019, July 29). The biology and biotechnology of the genus Caldicellulosiruptor: recent developments in ‘Caldi World.’ Extremophiles, Vol. 24, pp. 1–15.

By: L. Lee n, J. Crosby n, G. Rubinstein *, T. Laemthong n, R. Bing n , C. Straub n, M. Adams *, R. Kelly n 

author keywords: Caldicellulosiruptor; Extreme thermophiles; Lignocellulose
MeSH headings : Biomass; Biotechnology; Clostridiales; Glycoside Hydrolases; Hot Springs
topics (OpenAlex): Biofuel production and bioconversion; Enzyme Production and Characterization; Microbial Metabolic Engineering and Bioproduction
TL;DR: Improvements in the amount of carbohydrate released and in the production of bio-based chemicals are required to successfully realize the biotechnological potential of Caldicellulosiruptor organisms. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 27, 2020

2018 article

A synthetic enzymatic pathway for extremely thermophilic acetone production based on the unexpectedly thermostable acetoacetate decarboxylase from Clostridium acetobutylicum

Zeldes, B. M., Straub, C. T., Otten, J. K., Adams, M. W. W., & Kelly, R. M. (2018, September 10). Biotechnology and Bioengineering, Vol. 115, pp. 2951–2961.

By: B. Zeldes n, C. Straub n, J. Otten  n, M. Adams* & R. Kelly n 

author keywords: acetone; biotransformations; extreme thermophiles
MeSH headings : Acetone / metabolism; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Carboxy-Lyases / genetics; Carboxy-Lyases / metabolism; Clostridium acetobutylicum / enzymology; Clostridium acetobutylicum / genetics; Clostridium acetobutylicum / metabolism; Enzyme Stability; Hot Temperature; Metabolic Engineering; Metabolic Networks and Pathways / genetics; Synthetic Biology / methods
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Enzyme Catalysis and Immobilization; Biofuel production and bioconversion
TL;DR: A synthetic enzymatic pathway for acetone production that functions up to at least 70°C in vitro, made possible by the unusual thermostability of Adc from the mesophile C. acetobutylicum, paving the way for bio‐reactive distillation of acetone using a metabolically engineered extreme thermophile as a production host. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 3, 2018

2018 article

Biotechnology of extremely thermophilic archaea

Straub, C. T., Counts, J. A., Nguyen, D. M. N., Wu, C.-H., Zeldes, B. M., Crosby, J. R., … Kelly, R. M. (2018, June 23). FEMS Microbiology Reviews, Vol. 42, pp. 543–578.

By: C. Straub n, J. Counts n, D. Nguyen*, C. Wu*, B. Zeldes n, J. Crosby n, J. Conway  n, J. Otten  n ...

author keywords: extremely thermophilic archaea; biotechnology; biocatalysis; biooxidation
MeSH headings : Archaea / genetics; Archaea / physiology; Biotechnology / trends; Hot Temperature; Industrial Microbiology / trends; Metabolic Engineering / trends
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Anaerobic Digestion and Biogas Production; Biofuel production and bioconversion
TL;DR: There are barriers and challenges to these organisms reaching their full potential as industrial microorganisms but, if these can be overcome, a new dimension for biotechnology will be forthcoming that strategically exploits biology at high temperatures. (via Semantic Scholar)
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15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018

2017 article

Bioavailability of Carbohydrate Content in Natural and Transgenic Switchgrasses for the Extreme Thermophile Caldicellulosiruptor bescii

Zurawski, J. V., Khatibi, P. A., Akinosho, H. O., Straub, C. T., Compton, S. H., Conway, J. M., … Kelly, R. M. (2017, June 17). Applied and Environmental Microbiology, Vol. 83.

By: J. Zurawski n, P. Khatibi n, H. Akinosho *, C. Straub n, S. Compton n, J. Conway n, L. Lee n, A. Ragauskas * ...

author keywords: Caldicellulosiruptor; switchgrass; lignocellulose deconstruction and conversion; extreme thermophiles; lignocellulose
MeSH headings : Biomass; Fermentation; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / metabolism; Hot Temperature; Lignin / chemistry; Lignin / metabolism; Panicum / chemistry; Panicum / genetics; Panicum / metabolism; Panicum / microbiology; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / genetics; Plants, Genetically Modified / metabolism; Plants, Genetically Modified / microbiology; Polysaccharides / chemistry; Polysaccharides / metabolism
topics (OpenAlex): Biofuel production and bioconversion; Catalysis for Biomass Conversion; Lignin and Wood Chemistry; Advanced Cellulose Research Studies
TL;DR: While C. bescii could significantly solubilize the transgenic switchgrass lines and natural variant tested here, additional or alternative strategies (physical, chemical, enzymatic, and/or genetic) are needed to eliminate recalcitrance. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Extremely thermophilic energy metabolisms: biotechnological prospects

Straub, C. T., Zeldes, B. M., Schut, G. J., Adams, M. W. W., & Kelly, R. M. (2017, March 16). Current Opinion in Biotechnology, Vol. 45, pp. 104–112.

By: C. Straub n, B. Zeldes n, G. Schut *, M. Adams * & R. Kelly n 

MeSH headings : Archaea / classification; Archaea / genetics; Archaea / metabolism; Biotechnology / methods; Carbon Dioxide / metabolism; Chemoautotrophic Growth; Energy Metabolism; Hot Temperature; Lignin / metabolism; Metabolic Engineering
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Biofuel production and bioconversion; Enzyme Catalysis and Immobilization
TL;DR: This review considers recent developments in extreme thermophile biology as they relate to new horizons for energy biotechnology. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Physiological, metabolic and biotechnological features of extremely thermophilic microorganisms

Counts, J. A., Zeldes, B. M., Lee, L. L., Straub, C. T., Adams, M. W. W., & Kelly, R. M. (2017, February 16). WIREs Systems Biology and Medicine, Vol. 9.

By: J. Counts n, B. Zeldes n, L. Lee n, C. Straub n, M. Adams * & R. Kelly n 

MeSH headings : Biocatalysis; Carbohydrate Metabolism; Carbon Dioxide / metabolism; Glycolysis; Metabolic Engineering; Metals / chemistry; Metals / metabolism; Sulfolobales / metabolism; Sulfur / metabolism; Thermoanaerobacter / metabolism; Thermococcales / metabolism; Thermus / metabolism
topics (OpenAlex): Microbial Metabolic Engineering and Bioproduction; Genomics and Phylogenetic Studies; Enzyme Structure and Function
TL;DR: The bacterial genera Caldicellulosiruptor, Thermotoga and Thermus, and the archaea belonging to the orders Thermococcales and Sulfolobales, are among the most studied extreme thermophiles to date. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Extremely thermophilic microorganisms as metabolic engineering platforms for production of fuels and industrial chemicals

Zeldes, B. M., Keller, M. W., Loder, A. J., Straub, C. T., Adams, M. W. W., & Kelly, R. M. (2015, November 5). Frontiers in Microbiology, Vol. 6.

By: B. Zeldes n, M. Keller *, A. Loder n, C. Straub n, M. Adams * & R. Kelly n 

author keywords: extreme thermophiles; metabolic engineering; bio-based chemicals; genetics; biotechnology
topics (OpenAlex): Biofuel production and bioconversion; Enzyme Production and Characterization; Microbial Metabolic Engineering and Bioproduction
TL;DR: The issues and opportunities for extremely thermophilic metabolic engineering platforms are considered with an eye toward potential technological advantages for high temperature industrial biotechnology. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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