Works Published in 2012
Displaying works 21 - 40 of 260 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Inhibition of stathmin1 accelerates the metastatic process
Cancer Research, 72(20), 5407–5417.
Contributors: K. Williams *, R. Ghosh *, P. Giridhar*, G. Gu*, T. Case *, S. Belcher* , S. Kasper*
MeSH headings : Base Sequence; Cells, Cultured; DNA Primers; Down-Regulation; Humans; Male; Neoplasm Metastasis; Signal Transduction; Stathmin / antagonists & inhibitors
TL;DR:
It is reported for the first time that STMN1 strongly inhibits metastatic behavior in both normal epithelial and cancerous epithelial cells, suggesting that there may be a tumor stage-specific window-of-opportunity in which conserving ST MN1 expression is required to inhibit emergence of metastatic disease.
(via Semantic Scholar)
cancerres.aacrjournals.org (publisher PDF)
Source: ORCID
Added: March 5, 2021
2012 journal article
N-(pyridin-4-yl)benzo[d]thiazole-6-carboxamide inhibits E. coli UT189 bacterial capsule biogenesis
Probe Reports from the NIH Molecular Libraries Program. https://www.ncbi.nlm.nih.gov/books/NBK148500/
Source: NC State University Libraries
Added: January 30, 2021
2012 report
3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl) thiophene-2-carboxylic acid inhibits E.coli UT189 bacterial capsule biogenesis
In Probe Reports from the NIH Molecular Libraries Program. https://www.ncbi.nlm.nih.gov/books/NBK143534/
Source: NC State University Libraries
Added: January 28, 2021
2012 journal article
Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico
Journal of Exposure Science & Environmental Epidemiology, 23(2), 151–155.
author keywords: biomonitoring; disease; emerging contaminants; metals
MeSH headings : Adolescent; Adult; Arsenic / metabolism; Arsenic / toxicity; Diabetes Mellitus / epidemiology; Environmental Exposure; Female; Humans; Male; Methyltransferases / genetics; Mexico / epidemiology; Middle Aged; Polymorphism, Single Nucleotide; Prevalence; Young Adult
TL;DR:
Carriers of 287T and 4965C may produce more DMAsIII and be more likely to develop diabetes when exposed to arsenic, and individuals with M287T and G4965C polymorphisms had higher levels of urinary DMAs III and were more frequently diabetic than the respective wild-type carriers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2012 journal article
The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic
Toxicology and Applied Pharmacology, 264(3), 439–450.
author keywords: Arsenic; Folate; Epigenetics; DNA methylation; Transplacental exposure; CD1 mice
MeSH headings : Animals; Arsenites / administration & dosage; Arsenites / toxicity; Epigenomics; Female; Fetal Weight / drug effects; Fetus / drug effects; Folic Acid / administration & dosage; Folic Acid / blood; Folic Acid / pharmacology; Gene Expression Regulation, Developmental / drug effects; Liver / drug effects; Liver / embryology; Liver / metabolism; Male; Mice; Pregnancy; S-Adenosylhomocysteine / metabolism; S-Adenosylmethionine / metabolism; Sodium Compounds / administration & dosage; Sodium Compounds / toxicity
TL;DR:
A combined in utero exposure to iAs and a high folate intake may adversely influence DNA methylation profiles and weight of fetuses, compromising fetal development and possibly increasing the risk for early-onset of disease in offspring.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2012 journal article
Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione
Toxicology and Applied Pharmacology, 264(1), 121–130.
author keywords: Arsenic methylation; AS3MT polymorphism; Thioredoxin reductase; Glutathione
MeSH headings : Animals; Arsenicals / metabolism; Arsenites / metabolism; Glutathione / metabolism; Humans; Methylation / drug effects; Methyltransferases / genetics; Methyltransferases / metabolism; Phosphines / metabolism; Polymorphism, Genetic; Rats; S-Adenosylmethionine / metabolism; Thioredoxin-Disulfide Reductase / metabolism
TL;DR:
1mM GSH modulates AS3MT activity, increasing both methylation rates and yield of DMAs(III) and, ultimately, to differences in the disease susceptibility in individuals chronically exposed to inorganic arsenic.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2012 journal article
Disease dynamics in wild populations: modeling and estimation: a review
Journal of Ornithology, 152(S2), 485–509.
author keywords: Detection probability; Disease models; Mark-recapture; Multi-state models; Parameterization; Time series; Uncertain state
TL;DR:
The need to account for detectability in modeling disease dynamics is demonstrated, and a number of mark–recapture and occupancy study designs for estimating disease parameters while simultaneously accounting for variation in detectability are explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science)
15. Life on Land
(Web of Science)
Source: Crossref
Added: January 14, 2021
2012 journal article
Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior
Proceedings of the National Academy of Sciences, 110(3), 1017–1022.
author keywords: genetic architecture; chemosensation; behavioral genetics
MeSH headings : Animals; Behavior, Animal / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Regulatory Networks; Genes, Insect; Genetic Association Studies; Genetic Variation; Genetics, Behavioral; Genome-Wide Association Study; Humans; Male; Models, Genetic; Models, Neurological; Neurogenesis / genetics; Neurogenesis / physiology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Smell / genetics; Smell / physiology
TL;DR:
The results suggest that fully understanding the genotype–phenotype relationship requires a paradigm shift from a focus on single SNPs to pathway associations, and the lack of replication between the GWA analyses, small marginal SNP effects, and convergence on common cellular networks were likely attributable to epistasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 5, 2021
2012 journal article
Effects of Column and Gradient Lengths on Peak Capacity and Peptide Identification in Nanoflow LC-MS/MS of Complex Proteomic Samples
Journal of The American Society for Mass Spectrometry, 24(1), 148–153.
author keywords: Shotgun proteomics; Nanoflow liquid chromatography; Peak capacity
MeSH headings : Caenorhabditis elegans Proteins / analysis; Caenorhabditis elegans Proteins / chemistry; Chromatography, Liquid / instrumentation; Chromatography, Liquid / methods; Nanotechnology / instrumentation; Peptide Mapping / instrumentation; Peptide Mapping / methods; Proteome / analysis; Proteome / chemistry; Proteomics / instrumentation; Proteomics / methods; Tandem Mass Spectrometry / methods
TL;DR:
It is found that while longer column and gradient lengths generally increase peptide identifications, the degree of improvement is dependent on both parameters and is diminished at longer column, gradient, and gradients.
(via Semantic Scholar)
Source: Crossref
Added: January 5, 2021
2012 journal article
Coming of AGE
Virulence, 3(1), 12–14.
author keywords: Salmonella; gene expression; vaccine; AGE; attenuated
MeSH headings : Animals; Escherichia coli Proteins / genetics; Female; Gene Expression; Humans; Molecular Chaperones / genetics; Salmonella Infections / microbiology; Salmonella typhimurium / genetics; Salmonella typhimurium / immunology; Virulence Factors / genetics
TL;DR:
The generation of live attenuated vaccines would be greatly facilitated by novel, portable approaches for attenuating Gram-negative pathogens.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 30, 2020
2012 chapter
Claws, scales, beaks and feathers: Molecular traces in the fossil record
In M. K. Brett-Surman, T. R. Holtz, & J. O. Farlow (Eds.), The Complete Dinosaur (2nd ed., pp. 273–284). Bloomington, IN: Indiana University Press.
Ed(s): M. Brett-Surman, T. Holtz & J. Farlow
Source: NC State University Libraries
Added: October 30, 2020
2012 journal article
Location, location, location: Genetic regulation of neural sex differences
Reviews in Endocrine and Metabolic Disorders, 13(3), 151–161.
author keywords: Sex chromosomes; Estrogen receptors; Calbindin-D28k; Tyrosine hydroxylase; Dopamine; Vasopressin; Sexually dimorphic; Cerebellum; Frontal cortex; Epigenetic
MeSH headings : Animals; Arginine Vasopressin / physiology; Calbindin 1; Calbindins; Epigenesis, Genetic; Estrogen Receptor alpha / physiology; Female; Humans; Male; Mice; Midline Thalamic Nuclei / physiology; Preoptic Area / physiology; Rats; Receptors, Steroid / genetics; S100 Calcium Binding Protein G / genetics; Septal Nuclei / physiology; Sex Characteristics; Sex Chromosomes / physiology; Sexual Behavior, Animal / physiology; Tyrosine 3-Monooxygenase / genetics; Vasopressins / genetics
TL;DR:
The thrust is to examine genetic bases of sex differences and how the use of genetically modified models has advanced understanding of this topic, focusing on three proteins that have well described sexual dimorphisms; calbindin-D28k, a calcium binding protein, tyrosine hydroxylase, the rate limiting enzyme involved in dopamine synthesis and vasopressin, a neuropeptide with central and peripheral sites of action.
(via Semantic Scholar)
Source: Crossref
Added: October 29, 2020
2012 journal article
Cryptic recombination in the ever-young sex chromosomes of Hylid frogs.
Journal of Evolutionary Biology, 10.
author keywords: approximate Bayesian computation; homomorphic sex chromosomes; Hyla; recombination suppression
MeSH headings : Alleles; Animals; Anura / genetics; Anura / physiology; Biological Evolution; Female; Genes, X-Linked; Genes, Y-Linked; Genetic Linkage; Genetic Markers; Genetic Speciation; Male; Recombination, Genetic / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR:
The notion that very low recombination rate may be sufficient to maintain homomorphism in sex chromosomes is supported.
(via Semantic Scholar)
Source: ORCID
Added: September 15, 2020
2012 journal article
Coalescent patterns for chromosomal inversions in divergent populations.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2.
author keywords: chromosomal inversions; coalescent models; local adaptation; recombination; genetic variation
MeSH headings : Adaptation, Biological; Alleles; Animals; Chromosome Inversion / genetics; Chromosomes / genetics; Computer Simulation; Evolution, Molecular; Genetic Drift; Genetic Speciation; Genetic Variation; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
TL;DR:
It is found that ancient inversion polymorphisms cause genetic diversity to depart dramatically from neutral expectations, and coalescent models of neutral sites linked to an inversions polymorphism in two locally adapted populations provide the foundation for quantitative analyses of the roles that inversions have played in speciation.
(via Semantic Scholar)
Source: ORCID
Added: September 15, 2020
2012 journal article
REPRODUCTIVE ISOLATION AND LOCAL ADAPTATION QUANTIFIED FOR A CHROMOSOME INVERSION IN A MALARIA MOSQUITO
Evolution, 67(4), 946–958.
author keywords: Anopheles; assortative mating; selection; postzygotic; prezygotic; speciation
MeSH headings : Adaptation, Biological / genetics; Animal Migration; Animals; Anopheles / genetics; Cameroon; Chromosome Inversion; Chromosomes, Insect / genetics; Ecosystem; Evolution, Molecular; Genetic Speciation; Heterozygote; Homozygote; Models, Genetic; Population / genetics; Reproductive Isolation; Selection, Genetic
TL;DR:
The first estimates from any organism for the total amount of reproductive isolation associated with an inversion segregating in natural populations are provided, suggesting that this one inversion can generate most of the genetic barriers needed for speciation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: September 15, 2020
2012 journal article
P60—Preliminary results on subfecundity and plasma concentrations of perfluorinated compounds during pregnancy in the Norwegian Mother and Child Cohort Study, 2002–2004
Reproductive Toxicology, 33(4), 620–621.
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2012 journal article
Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect
Hormones and Behavior, 62(2), 128–135.
author keywords: Maternal experience; Epigenetics; Sodium butyrate; HDAC inhibition; Oxytocin; CBP
MeSH headings : Animals; Animals, Newborn; Behavior, Animal / drug effects; Behavior, Animal / physiology; Butyrates / pharmacology; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / physiology; Exploratory Behavior / drug effects; Exploratory Behavior / physiology; Female; Gene Expression Regulation / drug effects; Gene Expression Regulation / physiology; Histone Deacetylase Inhibitors / pharmacology; Learning / drug effects; Learning / physiology; Maternal Behavior / drug effects; Maternal Behavior / physiology; Mice; Mice, Inbred C57BL; Pregnancy
TL;DR:
Experiences with infants suggest that experience induces high levels of maternal care via epigenetic modifications, which in turn change expression of genes that promote maternal care.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
X-chromosome dosage affects male sexual behavior
Hormones and Behavior, 61(4), 565–572.
author keywords: Klinefelter's Syndrome; Sex Chromosomes; Sexual differentiation; Masculine behavior; Aneuploid
MeSH headings : Aggression / physiology; Animals; Aromatase / biosynthesis; Copulation / physiology; Ejaculation / physiology; Estrogen Receptor alpha / biosynthesis; Female; Gene Dosage; Genitalia, Male / anatomy & histology; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Receptors, Androgen / biosynthesis; Septum of Brain / metabolism; Sex Characteristics; Sexual Behavior, Animal / physiology; Vasopressins / blood; X Chromosome / physiology
TL;DR:
It is speculated that expression levels of a yet to be discovered gene(s) on the X-chromosome may affect sexual behavior in mice and perhaps in other mammals.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Running-induced epigenetic and gene expression changes in the adolescent brain
International Journal of Developmental Neuroscience, 31(6), 382–390.
author keywords: Epigenetic; Exercise; Puberty; Adolescent; Cerebellum; BDNF
MeSH headings : Animals; Animals, Newborn; Brain / physiology; Epigenesis, Genetic / physiology; Epigenomics; Gene Expression / physiology; Histones; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / metabolism; Neuronal Plasticity / physiology; Physical Conditioning, Animal; Signal Transduction / physiology
TL;DR:
After 1 week of exercise, global acetylation of histone 3 was increased in both brain regions, Interestingly this was correlated with increased brain derived neural growth factor in the hippocampus, as noted in many other studies, but only a trend was found in cerebellum.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Resetting for the Next Generation
Molecular Cell, 48(6), 819–821.
TL;DR:
In this issue of Molecular Cell, Seisenberger et al. (2012) refine DNA methylation mapping to interrogate the epigenetic reprogramming of primordial germ cells, defining the timings of methylation loss, linking to pluripotency, and identifying potential routes to transgenerational epigenetic inheritance.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
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