Works Published in 2015
Displaying works 81 - 100 of 327 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology, 33(9), 933–940.
MeSH headings : Computer Simulation; Dose-Response Relationship, Drug; Genetic Predisposition to Disease / genetics; Genetics, Population; Hazardous Substances / toxicity; High-Throughput Screening Assays / methods; Humans; Incidence; Lymphocytes / cytology; Lymphocytes / drug effects; Lymphocytes / physiology; Models, Genetic; Risk Assessment / methods; Toxicity Tests / methods
TL;DR:
The results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal.
(via Semantic Scholar)
www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: February 24, 2020
2015 journal article
Erratum: Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology, 33(10), 1109–1109.
TL;DR:
The authors have added 12 additional authors to the list of “Other participants in the NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration,” including Alok Jaiswal, Antti Poso, Himanshu Chheda, Ismeet Kaur, Jing Tang, John-Patrick Mpindi, Krister Wennerberg, Natalio Krasnogor, Samuel Kaski and Tero Aittokallio.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A
Reproductive Toxicology, 58, 119–130.
Contributors: J. Kendziorski* & S. Belcher*
author keywords: BPA; Endocrine disruptor; Uterus; Mouse; Collagen; Dose response; Endometrial periglandular fibrosis; Equine endometrosis; Matrix metalloproteinase; Non-monotonic
MeSH headings : Age Factors; Animals; Benzhydryl Compounds / toxicity; Collagen Type I / metabolism; Collagen Type III / metabolism; Endocrine Disruptors / toxicity; Endometriosis / chemically induced; Endometriosis / genetics; Endometriosis / metabolism; Endometriosis / pathology; Endometrium / drug effects; Endometrium / metabolism; Endometrium / pathology; Female; Fibrosis; Matrix Metalloproteinase 14 / genetics; Matrix Metalloproteinase 14 / metabolism; Matrix Metalloproteinase 2 / genetics; Matrix Metalloproteinase 2 / metabolism; Mice, Inbred C57BL; Phenols / toxicity; Phenotype; Species Specificity
TL;DR:
The association between the pro-collagen shift in increased collagen expression and decreased MMP2 expression and activity implies that strain differences and BPA exposure alter regulation of endometrial remodeling and contribute to increased fibrosis, a component of several human uterine diseases.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2015 journal article
Single-Molecule Imaging Reveals Dynamics of SA1-TRF1 Interactions on Telomeric DNA
Biophysical Journal, 108(2), 206a.
TL;DR:
The cohesin complex plays a crucial role in accurate chromosome segregation, organization of interphase chromatin, DNA replication, and post replicative DNA repair in part by promoting DNA-DNA pairing.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2015 journal article
Determining the DNA Diffusion Behavior of SA2 on Various DNA Substrates
Biophysical Journal, 108(2), 397a.
TL;DR:
It is proposed that 1-D sliding and sequence dependent pausing by SA1 provides binding specificity and stability during the cohesion process at telomeres, while SA2 alone, lacking the AT hook domain, uses different DNA binding mechanisms.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2015 journal article
Revealing Structure and Dynamics of Telomere Maintenance Proteins on DNA: One Molecule at a Time
Biophysical Journal, 108(2), 7a.
TL;DR:
Three complementary single-molecule imaging platforms are established: a newly developed Dual-Resonance-frequency-Enhanced Electrostatic force Microscopy technique capable of revealing DNA paths in protein-DNA complexes, fluorescence imaging of quantum dot-labeled proteins for tracking dynamics of proteins on DNA tightropes, and a nanochannel based imaging platform for studying protein-mediated DNA-DNA pairing/looping in real time.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2015 journal article
Comparison of Ensemble and Single Molecule Methods for Particle Characterization and Binding Analysis of a PEGylated Single-Domain Antibody
Journal of Pharmaceutical Sciences, 104(12), 4015–4024.
author keywords: proteins; PEGylation; microscopy; light scattering (static); calorimetry (ITC)
MeSH headings : Antibodies / chemistry; Biological Assay / methods; Half-Life; Kinetics; Microscopy, Atomic Force / methods; Polyethylene Glycols / chemistry; Protein Binding / drug effects; Proteins / chemistry; Surface Plasmon Resonance / methods
TL;DR:
This study has used AFM single-molecule studies to determine the mechanism of PEG-dependent reductions in the effectiveness of the dAb observed by SPR kinetic studies, and helps explain the disconnect between the SPR, determined kinetically, and the force microscopy and ITC results that demonstrated that PEG does not change the binding energy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2015 conference paper
Results of a National Survey about the Public Acceptability of Reclaimed Water
World Environmental and Water Resources Congress 2015. Presented at the World Environmental and Water Resources Congress 2015.
Contributors: L. Garcia-Cuerva n, M. Schmidt n, E. Berglund n & A. Binder n
Event: World Environmental and Water Resources Congress 2015
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2015 journal article
Phosphoproteome Analysis Links Protein Phosphorylation to Cellular Remodeling and Metabolic Adaptation during Magnaporthe oryzae Appressorium Development
Journal of Proteome Research, 14(6), 2408–2424.
author keywords: Magnaporthe oryzae; quantitative phosphoproteomics; appressorium formation; network analysis; transcription factors
MeSH headings : Adaptation, Physiological; Basic Helix-Loop-Helix Transcription Factors / metabolism; Chromatography, Liquid; Fungal Proteins / metabolism; Magnaporthe / metabolism; Magnaporthe / physiology; Oryza / microbiology; Phosphoproteins / metabolism; Phosphorylation; Proteomics; Signal Transduction; Tandem Mass Spectrometry
TL;DR:
Network analysis incorporating regulation from transcriptomic, proteomic, and phosphoproteomic data revealed new insights into the regulation of the metabolism of conidial storage reserves and phospholipids, autophagy, actin dynamics, and cell wall metabolism during appressorium formation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2015 journal article
Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder
The American Journal of Human Genetics, 96(2), 283–294.
MeSH headings : Bipolar Disorder / genetics; Depressive Disorder, Major / genetics; Genetic Testing / methods; Genetics, Medical / methods; Humans; Linear Models; Mental Disorders / genetics; Multifactorial Inheritance / genetics; Multivariate Analysis; Polymorphism, Single Nucleotide / genetics; Risk Assessment / methods; Schizophrenia / genetics
TL;DR:
The multivariate approach significantly increases the prediction accuracy for schizophrenia, bipolar disorder, and major depressive disorder in the discovery as well as in independent validation datasets and is a flexible and powerful tool to maximize prediction accuracy.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Erratum: Corrigendum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Nature Genetics, 47(6), 690–690.
Source: Crossref
Added: February 24, 2020
2015 journal article
Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance
Nature Genetics, 47(4), 353–360.
MeSH headings : Alleles; Allelic Imbalance / genetics; Animals; Crosses, Genetic; Dosage Compensation, Genetic; Female; Gene Expression; Genetic Speciation; Humans; Male; Mice / genetics; Mice, Knockout; Phylogeny; Polymorphism, Single Nucleotide
TL;DR:
It is concluded that, as with humans, pervasive regulatory variation influences complex genetic traits in mice and provide a new resource toward understanding the genetic control of transcription in mammals.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Vitamin B1 ecophysiology of marine picoeukaryotic algae: Strain-specific differences and a new role for bacteria in vitamin cycling
Limnology and Oceanography, 60(1), 215–228.
TL;DR:
It is confirmed that bacteria influence vitamin B1 availability beyond de novo synthesis and consumption; they can also serve as conduits that chemically alter, but not completely degrade or retain B1 analogs (e.g., TDP) and make them accessible to a broader range of microbes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020
2015 journal article
Suboptimal nutrient balancing despite dietary choice in glucose-averse German cockroaches, Blattella germanica
Journal of Insect Physiology, 81, 42–47.
author keywords: Carbohydrate; Deterrence; Geometric framework; Glucose aversion; Gustatory functioning; Oocyte development; Optimal foraging; Protein; Taste adaptation; Toxin avoidance
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Blattellidae / growth & development; Blattellidae / physiology; Choice Behavior; Dietary Carbohydrates; Dietary Proteins; Feeding Behavior / physiology; Female; Fructose; Glucose; Oocytes / growth & development
TL;DR:
German cockroaches did not compromise on their aversion to glucose in order to balance their protein and carbohydrate intake, and experienced lower sexual maturation rates as a consequence, and nutrient specific hunger via feedback mechanisms, and adjustments to gustatory sensitivity thus do not override the deterrence of glucose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2015 journal article
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Nature Communications, 6(1).
MeSH headings : Adolescent; Adult; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Child; Cystic Fibrosis / genetics; Cystic Fibrosis / metabolism; Cystic Fibrosis / pathology; Female; Genome-Wide Association Study; Humans; Lung / metabolism; Lung / pathology; Male; Middle Aged; Mucin-4 / genetics; Mucins / genetics; Severity of Illness Index; Transcription Factors / genetics; Young Adult
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 5, 2020
2015 journal article
Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer
Chemical Research in Toxicology, 28(6), 1144–1155.
MeSH headings : Adult; Aged; Arsenic / metabolism; Arsenic / toxicity; Cell Transformation, Neoplastic / chemically induced; DNA Methylation / drug effects; DNA Methylation / genetics; Female; Humans; Middle Aged; Urinary Bladder Neoplasms / chemically induced; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urothelium / cytology; Urothelium / drug effects; Young Adult
TL;DR:
Both the arsenic- and cancer-associated genes are enriched for the binding sites of common transcription factors known to play roles in carcinogenesis, demonstrating a novel potential mechanistic link between iAs exposure and bladder cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Crossref
Added: February 5, 2020
2015 journal article
Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster
ELife, 4.
MeSH headings : Africa; Animals; Caribbean Region; Drosophila melanogaster / chemistry; Drosophila melanogaster / genetics; Female; Gene Knockout Techniques; Hydrocarbons / analysis; Hydrocarbons / metabolism; Integumentary System; Male; Metabolic Networks and Pathways / genetics
TL;DR:
This work quantified variation in CHC profiles in the D. melanogaster Genetic Reference Panel (DGRP) and identified novel CHCs and identified polymorphisms in or near 305 and 173 genes in females and males associated with variation in these PCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Crossref
Added: January 28, 2020
2015 journal article
Effects of recombination on densovirus phylogeny
Archives of Virology, 161(1), 63–75.
MeSH headings : Densovirus / classification; Densovirus / genetics; Densovirus / isolation & purification; Evolution, Molecular; Open Reading Frames; Phylogeny; Recombination, Genetic; Viral Proteins / genetics
TL;DR:
The aim of the present work was to study possible recombination events in the evolutionary history of densoviruses and to assess possible effects of recombination on phylogenies inferred using amino acid sequences of nonstructural (NS) and capsid (viral protein, VP) proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 28, 2020
2015 journal article
Gustatory adaptation affects sexual maturation in male German cockroaches, Blattella germanica
Physiological Entomology, 41(1), 19–23.
author keywords: Adaptive behaviour; Blattodea; carbohydrate; courtship; developmental cost; fructose; glucose aversion; performance; taste evolution; toxin avoidance
TL;DR:
It is demonstrated that an adaptive gustatory mutation conferring protection from a toxin may have comparatively detrimental effects under conditions where the toxin has vanished, both by delaying female sexual maturation and signalling and by delaying male sexual m maturity and courtship under conditionsWhere glucose is a major energy source.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 28, 2020
2015 journal article
Factors Associated with Parent Concern for Child Weight and Parenting Behaviors
Childhood Obesity, 11(3), 269–274.
MeSH headings : Adolescent; Adult; Body Mass Index; Child; Educational Status; Female; Health Behavior; Health Knowledge, Attitudes, Practice; Humans; Male; Obesity / epidemiology; Obesity / prevention & control; Obesity / psychology; Parenting / psychology; Parents / education; Parents / psychology; Pennsylvania / epidemiology; Social Perception; Surveys and Questionnaires
TL;DR:
Results support the hypothesis that normal weight parents are more likely to engage in healthy behaviors and that overweight parents areMore likely to report concern about child weight, however, overweight parents are also morelikely to acknowledge overweight status in their own child.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 14, 2020
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