Works Published in 2015
Displaying works 41 - 60 of 154 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Pharmaceutical occurrence in groundwater and surface waters in forests land-applied with municipal wastewater
Environmental Toxicology and Chemistry, 35(4), 898–905.
author keywords: Pharmaceuticals; Wastewater; Groundwater; Liquid chromatography-tandem mass spectrometry
MeSH headings : Cities; Forests; Geography; Groundwater / chemistry; Household Products / analysis; North Carolina; Pharmaceutical Preparations / analysis; Wastewater / chemistry; Water Pollutants, Chemical / analysis
TL;DR:
Results provide important documentation for pharmaceutical fate and transport in forest systems irrigated with municipal wastewater, a previously undocumented source of environmental entry.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Crossref
Added: January 8, 2020
2015 journal article
Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma
Nature Communications, 6(1).
MeSH headings : Asthma / genetics; Carrier Proteins / genetics; Female; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study / methods; Humans; Linkage Disequilibrium / genetics; Male; Membrane Proteins / genetics; Neoplasm Proteins / genetics
TL;DR:
The results suggest that associations with rare and low-frequency variants are ethnic specific and not likely to explain a significant proportion of the ‘missing heritability’ of asthma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 5, 2020
2015 journal article
Associations of Ozone and PM2.5 Concentrations With Parkinsonʼs Disease Among Participants in the Agricultural Health Study
Journal of Occupational and Environmental Medicine, 57(5), 509–517.
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agriculture; Air Pollutants, Occupational / adverse effects; Air Pollutants, Occupational / analysis; Air Pollution / adverse effects; Air Pollution / analysis; Child; Farmers; Female; Follow-Up Studies; Humans; Iowa; Logistic Models; Male; Middle Aged; North Carolina; Occupational Diseases / etiology; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Ozone / adverse effects; Ozone / analysis; Parkinson Disease / etiology; Particulate Matter / adverse effects; Particulate Matter / analysis; Young Adult
TL;DR:
The plausibility of an effect of ambient concentrations of these pollutants on Parkinson's disease risk is supported by experimental data demonstrating damage to dopaminergic neurons at relevant concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2015 journal article
IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans
Environmental Health Perspectives, 123(6), 507–514.
MeSH headings : Biomedical Research; Carcinogens, Environmental; Humans; International Agencies / organization & administration; Neoplasms; Public Health; Publications
TL;DR:
Criticism of the IARC classification process are unconvincing, the procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 5, 2020
2015 journal article
Short-term fish reproduction assays with methyl tertiary butyl ether with zebrafish and fathead minnow: Implications for evaluation of potential for endocrine activity
Environmental Toxicology and Chemistry, 34(9), 2013–2022.
author keywords: Methy-tert-butyl ether (MTBE); Endocrine disruptor; Fish short-term reproduction assay; Aquatic toxicology
MeSH headings : Animals; Cyprinidae / growth & development; Cyprinidae / physiology; Endocrine System / drug effects; Endocrine System / metabolism; Enzyme-Linked Immunosorbent Assay; Female; Fertility; Male; Methyl Ethers / chemistry; Methyl Ethers / toxicity; Reproduction / drug effects; Vitellogenins / blood; Water Pollutants, Chemical / chemistry; Water Pollutants, Chemical / toxicity; Zebrafish / growth & development; Zebrafish / physiology
TL;DR:
The results of these 2 guideline studies indicate that MTBE does not interact with the hypothalamic–pituitary–gonadal axis of zebrafish or fathead minnow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 17, 2019
2015 journal article
High dimension low sample size asymptotics of robust PCA
Electronic Journal of Statistics, 9(1), 204–218.
Source: ORCID
Added: October 7, 2019
2015 journal article
Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis
Chest, 148(2), 507–515.
Source: ORCID
Added: October 7, 2019
2015 journal article
The projack: a resampling approach to correct for ranking bias in high-throughput studies
Biostatistics, 17(1), 54–64.
Source: ORCID
Added: October 7, 2019
2015 journal article
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Nature Communications, 6, 8382.
Source: ORCID
Added: October 7, 2019
2015 journal article
Population-based in vitro hazard and concentration--response assessment of chemicals: the 1000 genomes high-throughput screening study
Environmental Health Perspectives, 123(5), 458.
Source: ORCID
Added: October 7, 2019
2015 journal article
PathwaySeq: Pathway analysis for RNA-Seq data using a score-based approach
Dim (Data. Test), 1(1000), 448.
Source: ORCID
Added: October 7, 2019
2015 journal article
Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer
Chemical Research in Toxicology, 28(6), 1144–1155.
Source: ORCID
Added: October 7, 2019
2015 journal article
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
Human Molecular Genetics, 24(15), 4464–4479.
Source: ORCID
Added: October 7, 2019
2015 journal article
Effect of predicted protein-truncating genetic variants on the human transcriptome
Science, 348(6235), 666–669.
Source: ORCID
Added: October 7, 2019
2015 journal article
Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes
The American Journal of Human Genetics, 96(2), 318–328.
Source: ORCID
Added: October 7, 2019
2015 journal article
Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study
Occupational and Environmental Medicine, 73(1), 3–12.
MeSH headings : Agriculture; Herbicides / adverse effects; Humans; Incidence; Iowa; Kidney Failure, Chronic / etiology; Male; North Carolina; Occupational Diseases / etiology; Occupational Exposure / adverse effects; Occupations; Pesticides / adverse effects; Proportional Hazards Models; Prospective Studies; Risk Factors
TL;DR:
The findings support an association between ESRD and chronic exposure to specific pesticides, and suggest pesticide exposures resulting in medical visits may increase the risk of E SRD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, Crossref
Added: September 13, 2019
2015 journal article
In Vivo Ca2+ Imaging Reveals that Decreased Dendritic Excitability Drives Startle Habituation
Cell Reports, 13(9), 1733–1740.
MeSH headings : Animals; Calcium / metabolism; Calcium Signaling / drug effects; Dendrites / metabolism; Dizocilpine Maleate / pharmacology; Larva / metabolism; Neuronal Calcium-Sensor Proteins / metabolism; Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate / metabolism; Reflex, Startle / drug effects; Strychnine / pharmacology; Zebrafish / growth & development; Zebrafish / metabolism
TL;DR:
It is found that the amplitude of Ca(2+) signals in the lateral dendrite of the Mauthner neuron determines startle probability and that depression of this dendritic activity rather than downstream inhibition mediates glycine and N-methyl-D-aspartate (NMDA)-receptor-dependent short-term habituation.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2015 journal article
A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning
Neuron, 87(4), 906–907.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2015 journal article
A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning
Neuron, 85(6), 1200–1211.
MeSH headings : Animals; Behavior, Animal; Female; Genetic Testing / methods; Genome, Archaeal; Learning / physiology; Mutation / genetics; Neurons / metabolism; Pregnancy; Pregnancy-Associated Plasma Protein-A / genetics; Pregnancy-Associated Plasma Protein-A / metabolism; Receptor, IGF Type 1 / genetics; Receptor, IGF Type 1 / metabolism; Signal Transduction / genetics; Zebrafish / metabolism
TL;DR:
This work reports on a genome-wide genetic screen that identified 14 zebrafish startle habituation mutants including mutants of the vertebrate-specific gene pregnancy-associated plasma protein-aa (pappaa), and defines the first functional gene set for habituation learning in a vertebrate.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2015 journal article
SNPfisher: tools for probing genetic variation in laboratory-reared zebrafish
Development, 142(8), 1542–1552.
author keywords: Danio rerio; Zebrafish; Genome; SNP; Variation; Next-generation sequencing; Whole-genome sequencing
MeSH headings : Animals; Genetic Variation / genetics; Genome / genetics; High-Throughput Nucleotide Sequencing / methods; Molecular Sequence Annotation / methods; Polymorphism, Single Nucleotide / genetics; Zebrafish
TL;DR:
This survey identified an average of 5.04 million SNPs per strain compared with the Zv9 reference genome sequence, and made all of the identified SNPs accessible through ‘SNPfisher’, a searchable online database (snpfisher.nichd.nih.gov).
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
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