Works Published in 1994
Displaying all 10 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
1994 journal article
Hepatic cadmium, metal-binding proteins and bioaccumulation in bluegills exposed to aqueous cadmium
Environmental Toxicology and Chemistry, 13(4), 553–562.
author keywords: BIOACCUMULATION; CADMIUM; LEPOMIS-MACROCHIRUS; METAL-BINDING PROTEIN; METALLOTHIONEIN
TL;DR:
Nonthionein cytosolic Cd, hepatic MBP, and whole-body Cd in bluegills were linearly related to exposure concentrations within the range 0 to 20 μg Cd per liter, which was the most sensitive indicator of Cd exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 16, 2022
1994 journal article
Effect of the plant compound indole-3-carbinol on hepatic cholesterol homoeostasis
Food and Chemical Toxicology, 32(7), 633–639.
MeSH headings : Animals; Cholesterol / blood; Cholesterol / chemistry; Cholesterol 7-alpha-Hydroxylase / metabolism; Homeostasis / drug effects; Indoles / pharmacology; Liver / chemistry; Liver / drug effects; Male; Mice; Microsomes, Liver / chemistry; Microsomes, Liver / drug effects; Sterol Esterase / metabolism; Sterol O-Acyltransferase / metabolism
TL;DR:
I3C lowers serum cholesterol levels at concentrations that have no discernible effect on hepatic cholesterol homoeostasis, and at higher doses of I3C, hepatic microsomal cholesterol levels are significantly lowered and ACAT activity is significantly elevated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2021
1994 journal article
Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: Initial definition of the maturase domain of the group II intron AI2
Nucleic Acids Research, 22(11), 2057–2064.
Contributors: J. Moran *, K. Mecklenburg*, P. Sass*, S. Belcher* , D. Mahnke*, A. Lewin *, P. Perlman*
MeSH headings : Base Sequence; DNA, Fungal; DNA, Mitochondrial / genetics; Electron Transport Complex IV / genetics; Endoribonucleases / metabolism; Genes, Fungal; Genetic Complementation Test; Introns; Molecular Sequence Data; Mutation; Nucleotidyltransferases / metabolism; Open Reading Frames; RNA Splicing / genetics; RNA, Fungal; Restriction Mapping; Saccharomyces cerevisiae / genetics
TL;DR:
Six mutations blocking the function of a seven intron form of the mitochondrial gene encoding subunit I of cytochrome c oxidase (COXI) and mapping upstream of exon 3 were isolated and characterized and a trans-recessive mutant confirms that the intron 1 reading frame encodes a maturase function.
(via Semantic Scholar)
europepmc.org (repository)
Source: ORCID
Added: March 5, 2021
1994 journal article
In vivo biotransformation of testosterone by phase I and II detoxication enzymes and their modulation by 20-hydroxyecdysone in Daphnia magna
Aquatic Toxicology, 29(1-2), 103–117.
author keywords: TESTOSTERONE; DAPHNIA-MAGNA; OXIDATION; CONJUGATION; 20-HYDROXYECDYSONE
TL;DR:
It is demonstrated that daphnids can convert polycyclic compounds to multiple polar and nonpolar metabolites resulting from both phase I and phase II biotransformations, and that some phase II activities are under the regulatory control of 20-hydroxyecdysone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020
1994 journal article
IDENTIFICATION OF MULTIPLE STEROID HYDROXYLASES IN DAPHNIA MAGNA AND THEIR MODULATION BY XENOBIOTICS
Environmental Toxicology and Chemistry, 13(7), 1013.
author keywords: DAPHNIA; BIOMARKER; P450; TESTOSTERONE; METABOLISM
Sources: Crossref, NC State University Libraries
Added: February 10, 2020
1994 journal article
Assessing deleterious ecosystem-level effects of environmental pollutants as a means of avoiding evolutionary consequences.
Environmental Health Perspectives, 102(3), 266–267.
author keywords: ECOTOXICOLOGY; EVOLUTION; MESOCOSMS; MICROCOSMS; MODEL ECOSYSTEMS; POLLUTION
MeSH headings : Animals; Biological Evolution; Ecosystem; Environmental Pollutants / pharmacology; Humans
TL;DR:
Emphasis needs to be placed on assessing the adverse effects of environmental pollutants on ecosystem structure and function in order to avoid subsequent evolutionary consequences.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 28, 2020
1994 journal article
Hepatic vectorial transport of xenobiotics
Chemico-Biological Interactions, 90(2), 101–120.
author keywords: TRANSPORT; TRANSFER; XENOBIOTICS; INFLUX; EFFLUX; LIVER
MeSH headings : 3-Hydroxysteroid Dehydrogenases / metabolism; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); ATP Binding Cassette Transporter, Subfamily B, Member 1; Animals; Biological Transport, Active; Carrier Proteins / metabolism; Cell Membrane / metabolism; Cell Nucleus / metabolism; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Glutathione Transferase / metabolism; Humans; Liver / drug effects; Liver / metabolism; Membrane Glycoproteins / metabolism; Neoplasm Proteins; Tumor Suppressor Proteins; Xenobiotics / pharmacokinetics; Xenobiotics / toxicity
TL;DR:
The vectorial transport of xenobiotics across the hepatocyte is mediated by various transport and transfer proteins that differ in ligand specificity and function, which will significantly advance the understanding of processes involved in xenobiotic toxicity and acquired resistance to chemical toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 28, 2020
1994 journal article
Hypocholesterolemic properties of plant indoles
Biochemical Pharmacology, 47(2), 359–364.
author keywords: INDOLE-3-CARBINOL; CHOLESTEROL; ACYL-COA-CHOLESTEROL ACYLTRANSFERASE
MeSH headings : Animals; Anticholesteremic Agents / pharmacology; Cholesterol, LDL / blood; Cholesterol, VLDL / blood; Down-Regulation; Glucosinolates / pharmacology; Indoles / chemical synthesis; Indoles / isolation & purification; Indoles / pharmacology; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Plants / chemistry; Sterol O-Acyltransferase / antagonists & inhibitors; Sterol O-Acyltransferase / metabolism
TL;DR:
I3C lowered serum LDL/VLDL cholesterol levels in mice, and this effect was likely mediated by the inhibition of ACAT by some of the acid condensation products of I3C, which provide a possible mechanism by which I 3C-rich vegetables lower serum cholesterol levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 28, 2020
1994 journal article
Cadmium, Metal-binding Proteins, and Growth in Bluegill (Lepomis macrochirus) Exposed to Contaminated Sediments from the Upper Mississippi River Basin
Canadian Journal of Fisheries and Aquatic Sciences, 51(6), 1356–1367.
TL;DR:
The concentration of hepatic nonthionein cytosolic cadmium (cadmium not bound by metal-binding proteins, MBP) in fish exposed to the two most contaminated sediments exceeded that in controls.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1994 journal article
SYNERGISTIC INTERACTION BETWEEN THE NONPHORBOL ESTER-TYPE PROMOTER MIREX AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN MOUSE SKIN TUMOR PROMOTION
CARCINOGENESIS, 15(1), 47–52.
MeSH headings : Adenine / physiology; Animals; Base Sequence; Carcinogens / toxicity; Dose-Response Relationship, Drug; Drug Synergism; Female; Genes, ras / drug effects; Genes, ras / genetics; Mice; Mice, Inbred Strains; Mirex / toxicity; Molecular Sequence Data; Mutation / drug effects; Mutation / genetics; Papilloma / chemically induced; Papilloma / genetics; Skin / drug effects; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Tetradecanoylphorbol Acetate / toxicity; Thymidine / genetics
TL;DR:
Epidermal DNA synthesis induced by 2 nmol TPA was potentiated by mirex, further supporting a role for mireX in potentiation of epidermal TPA activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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