Works Published in 1988

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Displaying all 7 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

1988 thesis

Factors influencing mercury accumulation in yellow perch (Perca flavescens) and aufwuchs in selected north-central Wisconsin lakes

(M.Sc. Thesis). University of Wisconsin-La Crosse, La Crosse, WI.

By: W. Cope

Source: NC State University Libraries
Added: September 23, 2022

1988 journal article

Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes

The Journal of Biological Chemistry, 263(30), 15732–15739.

By: G. Le Blanc* & D. Waxman*

TL;DR: The studies establish that the effects of cisplatin on hepatic P-450 enzyme expression result from its interruption of the hypothalamic-pituitary stimulation of testicular androgen production and that this, in turn, leads to a depletion of circulating androgens required for maintenance of normal P- 450 enzyme expression in adult male rats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: November 24, 2021

1988 journal article

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression

The Journal of Biological Chemistry, 263(23), 11396–11406.

By: D. Waxman*, G. Le Blanc*, J. Morrissey*, J. Staunton* & D. Lapenson*

TL;DR: Rat hepatic cytochrome P-450 form RLM2 is a testosterone 15 alpha-hydroxylase reported to be male-specific on the basis of purification studies and its adult male- specific expression is imprinted (programmed) in response to neonatal testosterone exposure. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: November 24, 2021

1988 journal article

Induction of cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl

Molecular Pharmacology, 33(3), 272–278.

By: H. Yeowell, D. Waxman, G. Le Blanc, P. Linko & J. Goldstein

Source: NC State University Libraries
Added: November 16, 2021

1988 journal article

Relationships between the structures of chlorinated phenols, their toxicity, and their ability to induce glutathione S-transferase activity in Daphnia magna

Aquatic Toxicology, 12(2), 147–155.

By: G. LeBlanc*, B. Hilgenberg* & B. Cochrane*

TL;DR: It is suggested that in fact all of these compounds act in a similar manner internally to modulate enzyme activity, and that apparent differences in activity are a reflection of differences in bioconcentration of the different compounds. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 10, 2020

1988 journal article

Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-o-tetradecanoylphorbol-13-acetate

Cancer Research, 48(21), 5941–5946.

By: M. Huang, R. Smart, C. Wong & A. Conney

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1988 journal article

COMPARISON OF THE EFFECT OF SN-1,2-DIDECANOYLGLYCEROL AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON CUTANEOUS MORPHOLOGY, INFLAMMATION AND TUMOR PROMOTION IN CD-1 MICE

CARCINOGENESIS, 9(12), 2221–2226.

By: R. Smart n, M. Huang*, N. Monteiroriviere, C. Wong*, K. Mills & A. Conney*

MeSH headings : Animals; Carcinogens; Diglycerides / toxicity; Edema / chemically induced; Enzyme Induction; Female; Glycerides / toxicity; Hyperplasia / chemically induced; Mice; Ornithine Decarboxylase / biosynthesis; Skin / drug effects; Skin / enzymology; Skin / pathology; Skin Neoplasms / chemically induced; Tetradecanoylphorbol Acetate / toxicity
TL;DR: It was determined that topical application of 2.5 or 10 mumol of sn-1,2-didecanoylglycerol induced epidermal ornithine decarboxylase activity to about the same extent as the application of 1 or 2 nmol of TPA, but it did not cause morphological changes in the epidermis when applied once or when applied twice a week for 4 weeks and did not function as a complete tumor promoter. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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