Works Published in 2020
Displaying works 1 - 20 of 143 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
Social approach and social vigilance are differentially regulated by oxytocin receptors in the nucleus accumbens
Neuropsychopharmacology, 45(9), 1423–1430.
TL;DR:
It is suggested that OTR in the NAc differentially modulate social approach and social vigilance, primarily through an OTR-Gq mechanism.
(via Semantic Scholar)
www.nature.com (publisher PDF)
Source: ORCID
Added: January 28, 2024
2020 journal article
Histamine-dependent interactions between mast cells, glia, and neurons are altered following early-life adversity in mice and humans
American Journal of Physiology-Gastrointestinal and Liver Physiology, 319(6), G655–G668.
TL;DR:
Early life stress alters interactions between enteric glia and mast cells that are mediated by histamine, and this mechanism could contribute to enteric neuroplasticity driven by early life adversity.
(via Semantic Scholar)
Source: ORCID
Added: January 28, 2024
2020 journal article
Extrahypothalamic oxytocin neurons drive stress-induced social vigilance and avoidance
Proceedings of the National Academy of Sciences, 117(42), 26406–26413.
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: January 28, 2024
2020 journal article
Androgen-Dependent Excitability of Mouse Ventral Hippocampal Afferents to Nucleus Accumbens Underlies Sex-Specific Susceptibility to Stress
Biological Psychiatry, 87(6), 492–501.
TL;DR:
A circuit-specific sex difference in vHPC-NAc neurons that is dependent on testosterone and causes susceptibility to stress in female mice is demonstrated, providing a substantive mechanism linking gonadal hormones to cellular excitability and anhedonia-a key feature in depressive states.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: January 28, 2024
2020 journal article
Rapid Characterization of Per- and Polyfluoroalkyl Substances (PFAS) by Ion Mobility Spectrometry–Mass Spectrometry (IMS-MS)
Analytical Chemistry, 92(6), 4427–4435.
MeSH headings : Hydrocarbons, Fluorinated / analysis; Ion Mobility Spectrometry; Mass Spectrometry; Molecular Structure; Polymers / analysis
TL;DR:
Results from this study show that the IMS separation provides novel information to support traditional LC-MS PFAS analyses and will greatly benefit the evaluation of unknown pollutants in future environmental studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: ORCID
Added: September 9, 2023
2020 article
Vesicular and Extravesicular Protein Signatures From the Airspaces of Ozone-Exposed Mice Reflect Muco-Inflammatory Disturbances.
Choudhary, I., Vo, T., Paudel, K., Gupta, R., Kesimer, M., Patial, S., & Saini, Y. (2020, December).
TL;DR:
This study identified exosomal, secretory, and cell-specific proteins and biological pathways following sub-chronic exposure of mice to ozone, indicating the cellular sources of the proteins that are ferried in the exosomes upon ozone-induced lung injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice.
Frontiers in Immunology.
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / prevention & control; Alveolar Epithelial Cells / metabolism; Animals; Bone Marrow Transplantation; Bronchoalveolar Lavage Fluid / chemistry; Bronchoalveolar Lavage Fluid / cytology; Chemotaxis, Leukocyte; Cytokines / physiology; Endothelial Cells / metabolism; Female; Fibroblasts / metabolism; Lipopolysaccharides / toxicity; Male; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils / immunology; Radiation Chimera; Tristetraprolin / biosynthesis; Tristetraprolin / deficiency; Tristetraprolin / genetics; Tristetraprolin / physiology; Up-Regulation
TL;DR:
It is suggested that non-HPCs-specific overexpression of TTP within the lungs protects against ALI via downregulation of neutrophil chemoattractants and reduction in neutrophilic infiltration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects.
Cancers, 6.
TL;DR:
The various hallmark molecular traits of cancers that are reported to be regulated by the tristetraprolin family of RNA-binding proteins are summarized and the role of the TTP family RBPs in the regulation of trait-associated mRNA targets in relevant cancer types/cell lines is emphasized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice.
Journal of Immunology (Baltimore, Md. : 1950), 9.
MeSH headings : Animals; Cells, Cultured; Cystic Fibrosis / immunology; Disease Models, Animal; Epithelial Cells / metabolism; Epithelial Cells / pathology; Epithelial Sodium Channels / genetics; Homeodomain Proteins / genetics; Humans; Immunity, Innate; Inflammation / immunology; Metaplasia; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mucin-5B / genetics; Mucin-5B / metabolism; Respiratory Tract Diseases / immunology; Up-Regulation
TL;DR:
Collectively, these data indicate that, in the context of airway mucus obstruction, the adaptive immune system suppresses antibacterial macrophage activation, whereas the innate lymphoid system contributes to MCM, mucin production, and mucus obstruct.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 article
Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2
Vo, T., Paudel, K., Choudhary, I., Patial, S., & Saini, Y. (2020, November).
TL;DR:
The data indicate that the unhealthy levels of ozone in the environment may predispose individuals to severe SARS-CoV-2 infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
Lung macrophages: current understanding of their roles in Ozone-induced lung diseases.
Critical Reviews in Toxicology, 4.
MeSH headings : Air Pollutants / toxicity; Air Pollution / statistics & numerical data; Animals; Humans; Lung / physiopathology; Lung Diseases / epidemiology; Lung Diseases / etiology; Macrophages / drug effects; Macrophages / physiology; Ozone / toxicity; United States
TL;DR:
There is a vital need for additional policy-relevant scientific information, including mechanistic studies to further define the role of macrophages in response to O3, and a comprehensive list of currently known macrophage-specific roles in O3-induced lung diseases is included in this review.
(via Semantic Scholar)
Source: ORCID
Added: August 2, 2023
2020 journal article
Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex- and cell type-associated perturbations relevant to mucoinflammatory lung diseases.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 1.
Source: ORCID
Added: August 2, 2023
2020 journal article
Ablation of IL-33 Suppresses <i>Th2</i> Responses but Is Accompanied by Sustained Mucus Obstruction in the <i>Scnn1b</i> Transgenic Mouse Model.
Journal of Immunology (Baltimore, Md. : 1950), 3.
MeSH headings : Animals; Bronchoalveolar Lavage Fluid / cytology; Bronchoalveolar Lavage Fluid / immunology; Cystic Fibrosis / diagnosis; Cystic Fibrosis / genetics; Cystic Fibrosis / immunology; Cystic Fibrosis / pathology; Disease Models, Animal; Eosinophils / immunology; Eosinophils / metabolism; Epithelial Sodium Channels / genetics; Humans; Interleukin-33 / genetics; Interleukin-33 / metabolism; Lung / cytology; Lung / immunology; Lung / pathology; Mice; Mice, Knockout; Mice, Transgenic; Mucin 5AC / metabolism; Mucus / immunology; Mucus / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / immunology; Respiratory Mucosa / metabolism; Th2 Cells / immunology; Th2 Cells / metabolism
TL;DR:
Although IL- 33 modulates Th2 inflammatory responses and MUC5AC protein production, mucus obstruction is not dependent on IL-33, and histological features, including subepithelial airway inflammation and alveolar space enlargement, were somewhat exaggerated inIL-33KO/Tg+ mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 2, 2023
2020 journal article
Fibrate pharmacogenomics: Expanding past the genome
Pharmacogenomics, 21(4), 293–306.
Contributors: J. House* & A. Motsinger-Reif *
MeSH headings : Cardiovascular Diseases / blood; Cardiovascular Diseases / drug therapy; Cardiovascular Diseases / genetics; Fibric Acids / therapeutic use; Genome / genetics; Genome-Wide Association Study / methods; Humans; Hypolipidemic Agents / therapeutic use; Pharmacogenetics / methods; Polymorphism, Single Nucleotide / genetics; Risk Factors; Triglycerides / blood
TL;DR:
Heterogeneity in response to fibrate treatment is well established, and this variation is heritable, but recent innovations in technological platforms and advances in statistical methodologies are revolutionizing the use and integration of other 'omes' in pharmacogenomics studies.
(via Semantic Scholar)
Source: ORCID
Added: April 11, 2023
2020 journal article
Publisher Correction: Exposure to Oil and Hypoxia Results in Alterations of Immune Transcriptional Patterns in Developing Sheepshead Minnows (Cyprinodon variegatus) (Scientific Reports, (2020), 10, 1, (1684), 10.1038/s41598-020-58171-8)
Scientific Reports, 10(1).
Contributors: M. Rodgers* , D. Simning*, M. Sepúlveda *, S. De Guise*, T. Bosker * & R. Griffitt*
TL;DR:
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: April 6, 2023
2020 journal article
Exposure to Oil and Hypoxia Results in Alterations of Immune Transcriptional Patterns in Developing Sheepshead Minnows (Cyprinodon variegatus)
Scientific Reports, 10(1).
Contributors: M. Rodgers* , D. Simning*, M. Sepúlveda *, S. De Guise*, T. Bosker * & R. Griffitt*
TL;DR:
It is suggested that timing of exposure to oil and/or hypoxia matters, and the need to further investigate the impacts of multiple stressors on immune system development in early life stage fishes is underscored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: April 6, 2023
2020 report
Pesticides and your respiratory system: what we know about a lifetime of farm exposures and lung and airway health
Raleigh, NC: North Carolina State University Cooperative Extension Service and North Carolina Department of Agriculture & Consumer Services.
Source: NC State University Libraries
Added: September 15, 2022
2020 journal article
Trophodynamics of Per- and Polyfluoroalkyl Substances in the Food Web of a Large Atlantic Slope River
Environmental Science & Technology, 54(11), 6800–6811.
MeSH headings : Alkanesulfonic Acids / analysis; Animals; Environmental Monitoring; Fluorocarbons / analysis; Food Chain; Humans; North Carolina; Rivers; South Carolina; Water Pollutants, Chemical / analysis
TL;DR:
The prevalence of PFASs in a freshwater food web with potential implications for ecological and human health is demonstrated, with most detections and greatest concentrations in aquatic insects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: September 13, 2022
2020 journal article
Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish
Journal of the American Society for Mass Spectrometry, 31(4), 768–772.
author keywords: zebrafish; mass spectrometry imaging; cryosectioning; IR-MALDESI; lipids
MeSH headings : Animals; Cryoultramicrotomy / methods; Lipids / analysis; Male; Molecular Imaging; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Zebrafish / metabolism
TL;DR:
The zebrafish (Danio rerio) is an ideal model for whole animal studies of lipid metabolism and lipid-related disease, and infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging (MSI) was applied for direct visualization of lipid and metabolite distributions across various organs in whole-body zebra fish tissue sections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 13, 2022
2020 journal article
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
ELife, 9.
MeSH headings : Animals; Brain / embryology; Cell Shape; Hedgehog Proteins / metabolism; Hedgehog Proteins / physiology; Mice; Mice, Inbred C57BL; Neural Crest / embryology; Neural Tube / embryology; Neural Tube / growth & development
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 23, 2022
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