Works Published in 1999

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Displaying all 7 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

1999 article

Methods of treating alopecia

(Vol. 5, 965, 551). Vol. 5, 965, 551. Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: ORCID
Added: May 12, 2022

1999 journal article

C/EBP beta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression

Molecular and Cellular Biology, 19(10), 7181–7190.

MeSH headings : Animals; CCAAT-Enhancer-Binding Proteins; Calcium Signaling; Cell Differentiation; Cell Division; Cells, Cultured; DNA-Binding Proteins / metabolism; Epidermal Cells; Keratin-10; Keratinocytes / cytology; Keratins / biosynthesis; Membrane Proteins / biosynthesis; Mice; Mice, Mutant Strains; Nuclear Proteins / metabolism; Protein Precursors / biosynthesis; Transcriptional Activation
TL;DR: It is demonstrated that C/EBPβ plays an important role in the early events of stratified squamous differentiation in keratinocytes involving growth arrest and K1 and K10 expression and expression of later-stage markers was only minimally altered. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

1999 journal article

A multihit, multistage model of chemical carcinogenesis

CARCINOGENESIS, 20(9), 1837–1844.

By: D. Owens, S. Wei* & R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Acetone / toxicity; Animals; Carcinogens / toxicity; Carcinoma, Squamous Cell / chemically induced; Carcinoma, Squamous Cell / pathology; Cell Transformation, Neoplastic / chemically induced; Cell Transformation, Neoplastic / genetics; Cocarcinogenesis; DNA Mutational Analysis; DNA, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Keratinocytes / drug effects; Keratinocytes / pathology; Keratins / biosynthesis; Keratins / genetics; Mice; Models, Biological; Neoplasm Proteins / biosynthesis; Neoplasm Proteins / genetics; Papilloma / chemically induced; Papilloma / pathology; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; S Phase; Skin Neoplasms / chemically induced; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / toxicity
TL;DR: Promotion between the first and second hits has a profound outcome on carcinogenesis, presumably by increasing the probability that a second hit will occur in a previously initiated cell; continued promotion after the second hit is required for full expression of malignancy; and the classic initiation-promotion protocol can be extended to a multihit, multistage model. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 journal article

Overexpression of protein kinase C-[alpha] in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2, and TNF-[alpha] but not tumor promotion

Journal of Cell Science, 112(20), 3497–3506.

By: H. Wang & R. Smart

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

1999 journal article

Correlation between expression of peroxisome proliferator-activated receptor beta and squamous differentiation in epidermal and tracheobronchial epithelial cells

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 147(1-2), 85–92.

By: H. Matsuura*, H. Adachi*, R. Smart n, X. Xu*, J. Arata* & A. Jetten*

author keywords: peroxisome proliferator-activated receptor; epidermis; keratinocyte; trachea; phorbol ester; retinoic acid; transglutaminase
MeSH headings : Animals; Bronchi / cytology; Cell Differentiation / drug effects; Cell Line; Cornified Envelope Proline-Rich Proteins; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Female; Humans; Interferon-gamma / pharmacology; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Membrane Proteins / genetics; Mice; Mice, Inbred Strains; RNA, Messenger / metabolism; Receptors, Cytoplasmic and Nuclear / genetics; Tetradecanoylphorbol Acetate / pharmacology; Time Factors; Trachea / cytology; Transcription Factors / genetics; Transcriptional Activation / drug effects; Transforming Growth Factor beta / pharmacology; Transglutaminases / genetics; Tretinoin / pharmacology
TL;DR: The results demonstrate that the expression of PPARbeta is associated with squamous differentiation suggesting a regulatory role for this receptor in the control of specific genes during this differentiation process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 article

Effects of 17-beta-estradiol and ICI 182 780 on hair growth in various strains of mice

Smart, R. C., Oh, H. S., Chanda, S., & Robinette, C. L. (1999, December). JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, Vol. 4, pp. 285–289.

By: R. Smart n, H. Oh n, S. Chanda n & C. Robinette n

author keywords: alopecia; dermal papilla; estrogen receptor; hair follicle
MeSH headings : Administration, Topical; Animals; Estradiol / administration & dosage; Estradiol / analogs & derivatives; Estrogen Antagonists / administration & dosage; Female; Fulvestrant; Hair / drug effects; Hair / growth & development; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL
TL;DR: The results demonstrate that (i) the route of administration of 17-beta-estradiol is critical for its ability to block hair growth, and (ii) C57BL/6 and C3H mice, two commonly employed mouse strains for hair growth studies, responded to 17- beta-ESTradiol and ICI 182 780 in a manner similar to that described in CD-1 mice. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 patent

Methods of treating alopecia

Washington, DC: U.S. Patent and Trademark Office.

By: R. Smart & H. Oh

Source: NC State University Libraries
Added: August 6, 2018

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