Environmental Health Science

Works Published in 2002

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2002 journal article

17 beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice

TOXICOLOGICAL SCIENCES, 69(1), 42–48.

By: K. Porter*, S. Chanda, H. Wang, K. Gaido, R. Smart  & C. Robinette

author keywords: mirex; skin; 17 beta-estradiol; tumor promotion; endocrine
MeSH headings : Animals; Carcinogens / toxicity; Cell Line; Chlordecone / toxicity; Drug Implants; Estradiol / administration & dosage; Estradiol / pharmacology; Female; Genes, Reporter / drug effects; Insecticides / toxicity; Luciferases / biosynthesis; Male; Mice; Mirex / toxicity; Orchiectomy; Ovariectomy; Radioimmunoassay; Sex Characteristics
TL;DR: Collectively, these studies indicate that E2 is a major ovarian hormone responsible for mirex tumor promotion sensitivity in female mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(1), 207–212.

By: S. Zhu n, K. Yoon n, E. Sterneck  n, P. Johnson  n & R. Smart n 

MeSH headings : 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Blotting, Western; Bromodeoxyuridine / pharmacology; CCAAT-Enhancer-Binding Protein-beta / genetics; CCAAT-Enhancer-Binding Protein-beta / metabolism; CCAAT-Enhancer-Binding Protein-beta / physiology; Carcinogens; Cell Division; Cell Survival; Genes, Reporter; Keratinocytes / cytology; Keratinocytes / metabolism; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Mutagens; Mutation; Oncogene Protein p21(ras) / genetics; Oncogene Protein p21(ras) / physiology; Phosphorylation; Signal Transduction; Skin Neoplasms / metabolism; Tetradecanoylphorbol Acetate; Time Factors; Transcriptional Activation
TL;DR: It is reported here that C/EBPβ-nullizygous mice are completely refractory to skin tumor development induced by a variety of carcinogens and carcinogenesis protocols, including 7,12-dimethylbenz[a]anthracene-initiation/12-O-tetradecanoylphorbol 13-acetate promotion, that produce tumors containing oncogenic Ras mutations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis

Cancer Research, 62(12), 3395–3401.

By: H. Tiano, C. Loftin, J. Akunda, C. Lee, J. Spalding, A. Sessoms, D. Dunson, E. Rogan ...

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

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