Works Published in 2014
Displaying all 12 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.
PLoS Biology, 12(2), 1001799,
MeSH headings : Animals; Body Size / genetics; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting; Karyopherins / physiology; Lactation / genetics; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear / physiology; STAT5 Transcription Factor / physiology
TL;DR:
A mouse genetic study reveals that a single gene acting in both mother and offspring has a central role in the uniquely mammalian phenomenon of nutrient provisioning through the placenta and the mammary gland.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
Source: ORCID
Added: September 28, 2022
2014 journal article
Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes.
BMC Biology, 12, 771,
author keywords: Adiposity; Body proportions; Genomic imprinting; Glucose-regulated metabolism; Growth; Mouse genetics
MeSH headings : Absorptiometry, Photon; Adipose Tissue / metabolism; Animals; Calcium-Binding Proteins; Cell Proliferation; Female; Fetal Development / genetics; Fibroblasts / metabolism; G2 Phase; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Genomic Imprinting; Glucose Tolerance Test; History, Ancient; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Intercellular Signaling Peptides and Proteins / genetics; Intercellular Signaling Peptides and Proteins / metabolism; Liver / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; S Phase; Triglycerides / blood
TL;DR:
Genetic and physiological evidence is presented that Dlk1 and Grb10 define a mammalian growth axis that is separate from the IGF pathway, yet also features an antagonistic imprinted gene pair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 28, 2022
2014 journal article
Carbohydrate intake, glycemic index and prostate cancer risk
The Prostate, 75(4), 430–439.
author keywords: carbohydrates; glycemic index; prostate cancer
MeSH headings : Aged; Black People; Case-Control Studies; Diet; Dietary Carbohydrates / administration & dosage; Dietary Carbohydrates / adverse effects; Glycemic Index; Humans; Male; Middle Aged; Prostatic Neoplasms / etiology; Risk; Surveys and Questionnaires; White People
TL;DR:
Reported associations between dietary carbohydrate and prostate cancer risk are poorly characterized by race and may be driven by different underlying mechanisms, including diet and age.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2014 journal article
Do early paternal exposures to lifestyle factors such as smoking increase the risk of chronic diseases in the offspring?
European Journal of Human Genetics, 22(12), 1341–1342.
MeSH headings : Adiposity; Female; Humans; Male; Paternal Exposure; Puberty; Smoking / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
PD31-11 CARBOHYDRATE INTAKE, GLYCEMIC INDEX AND PROSTATE CANCER RISK
Journal of Urology, 191(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort
Cancer Causes & Control, 25(8), 1029–1035.
author keywords: Prostate cancer; Risk; Initial biopsy; Race; Equal access
MeSH headings : Aged; Biopsy, Needle; Black People / statistics & numerical data; Cohort Studies; Health Services Accessibility; Humans; Male; Middle Aged; North Carolina; Prostatic Neoplasms / ethnology; Prostatic Neoplasms / pathology; Retrospective Studies; Veterans / statistics & numerical data; White People / statistics & numerical data
TL;DR:
In an equal access healthcare facility, black race was associated with greater risk of PC detection on initial biopsy and of high-grade PC after adjusting for clinical characteristics and mechanisms linking black race and PC risk and PC aggressiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
BioEssays, 36(4), 359–371.
author keywords: developmental origins of health and disease (DOHaD); environment; epigenetics; imprinted genes; offspring; paternal exposures; spermatogenesis; transgenerational effects
MeSH headings : Animals; DNA Methylation; Diet; Epigenesis, Genetic; Gene-Environment Interaction; Genomic Imprinting; Histones / metabolism; Humans; Life Style; Male; Obesity / genetics; Paternal Exposure; RNA, Untranslated; Radiation, Ionizing; Spermatogenesis / physiology; Spermatozoa / physiology; Zygote
TL;DR:
This essay suggests the existence of epigenetic windows of susceptibility to environmental insults during sperm development and suggests changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Evidence of the Biochemical Basis of Host Virulence in the Greenbug Aphid,Schizaphis graminum(Homoptera: Aphididae)
Journal of Proteome Research, 13(4), 2094–2108.
author keywords: aphid; biotype; vector biology; insect-plant interactions; host virulence; Schizaphis graminum; greenbug; DIGE; LC-MS/MS
MeSH headings : Animals; Aphids / genetics; Aphids / microbiology; Aphids / pathogenicity; Aphids / physiology; Buchnera; Host-Parasite Interactions; Insect Proteins / analysis; Insect Proteins / classification; Insect Proteins / genetics; Insect Proteins / metabolism; Poaceae / parasitology; Proteome / analysis; Proteome / genetics; Proteome / metabolism; Proteome / physiology; Symbiosis
Source: Crossref
Added: August 28, 2020
2014 journal article
C/EBP alpha regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G(1)/S checkpoint
CELL CYCLE, 13(22), 3602–3610.
author keywords: C/EBP alpha; CRL4(Cdt2); G(1)/S DNA damage checkpoint; keratinocytes; p21
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; DNA Damage / genetics; DNA Damage / radiation effects; G1 Phase Cell Cycle Checkpoints / genetics; Keratinocytes / metabolism; Keratinocytes / radiation effects; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Proteolysis; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ultraviolet Rays; p21-Activated Kinases / genetics; p21-Activated Kinases / metabolism
TL;DR:
Findings reveal C/EBPα regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4Cdt2 mediated degradation of p21.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort
EPIGENETICS, 9(8), 1120–1130.
author keywords: birth weight; DNA methylation; imprinted genes; folate; epidemiology; epigenetics
MeSH headings : Adolescent; Adult; Birth Weight / genetics; Cohort Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Erythrocytes / metabolism; Ethnicity; Female; Folic Acid / blood; Genomic Imprinting; Humans; Infant, Newborn; Male; Pregnancy; Racial Groups; Young Adult
TL;DR:
The data suggest that, with respect to birth weight, no additional benefits may be derived from increased maternal folate concentrations, especially in non-obese women, and support epigenetic plasticity as a key mechanistic response to folate availability during early fetal development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA
CANCER CAUSES & CONTROL, 25(8), 1055–1062.
author keywords: Human papillomavirus; Cervical intraepithelial neoplasia; Invasive cervical cancer; Race/ethnicity; Southeastern USA
MeSH headings : Adolescent; Adult; Black People / statistics & numerical data; Female; Humans; Logistic Models; Papillomaviridae / genetics; Papillomavirus Infections / epidemiology; Papillomavirus Infections / virology; Southeastern United States / epidemiology; Uterine Cervical Neoplasms / epidemiology; Uterine Cervical Neoplasms / ethnology; Uterine Cervical Neoplasms / virology; White People / statistics & numerical data; Young Adult; Uterine Cervical Dysplasia / epidemiology; Uterine Cervical Dysplasia / ethnology; Uterine Cervical Dysplasia / virology
TL;DR:
The data suggest that while HPV 16/18 are the most common genotypes among EA women with CIN, AAs may harbor different genotypes, and after adjusting for race, age, parity, income, oral contraception use, and current smoking, aAs were two times less likely to harbor HPV16/18.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Implementation of Statistical Process Control for Proteomic Experiments Via LC MS/MS
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 25(4), 581–587.
author keywords: Quality control; Statistical process control; Proteomics; Mass spectrometry; Shewhart control charts
MeSH headings : Chromatography, Liquid / methods; Models, Statistical; Peptides / analysis; Peptides / chemistry; Proteomics / methods; Tandem Mass Spectrometry / methods
TL;DR:
A tool has been developed termed Statistical Process Control in Proteomics (SProCoP) which implements aspects of SPC (e.g., control charts and Pareto analysis) into the Skyline proteomics software, which monitors five quality control metrics in a shotgun or targeted proteomic workflow.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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