Works Published in 2011

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Displaying works 1 - 20 of 31 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2011 journal article

Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke

Gene, 494(1), 36–43.

MeSH headings : Adult; Birth Weight; DNA Methylation; Female; Fetal Blood / chemistry; Genomic Imprinting; Humans; Insulin-Like Growth Factor II / genetics; Male; Maternal-Fetal Exchange; Pregnancy; RNA, Long Noncoding; RNA, Untranslated; Sex Characteristics; Smoking / genetics
topics (OpenAlex): Birth, Development, and Health; Epigenetics and DNA Methylation; Cancer Risks and Factors
TL;DR: The findings suggest that IGF2 DMR plasticity is an important mechanism by which in utero adjustments to environmental toxicants are conferred. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: December 5, 2024

2011 journal article

Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.

PloS One, 6(4), 18953.

By: M. Chahal*, M. Cowley*, R. McCole*, R. Oakey*, G. Saadat*, R. Schulz*, B. de*

MeSH headings : Alleles; Animals; DNA Methylation; Genomic Imprinting; Humans; Long Interspersed Nucleotide Elements / genetics; Mice; Mice, Inbred C57BL; Short Interspersed Nucleotide Elements / genetics
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Genomic variations and chromosomal abnormalities
TL;DR: The repeat element content of imprinted retrogene loci with non-imprinted controls that have a similar locus organisation is compared, suggesting that the paucity of SINEs and relative abundance of LINEs at imprinted loci reported by others is not a sequence feature universally required for imprinting. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: ORCID
Added: September 28, 2022

2011 journal article

Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.

Nucleic Acids Research, 39(11), 4577–4586.

MeSH headings : Alleles; Animals; Chromatin / metabolism; DNA Methylation; Genomic Imprinting; Histones / metabolism; Humans; Mice; Promoter Regions, Genetic; Retroelements
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Prenatal Screening and Diagnostics
TL;DR: Two human retrogenes showed monoallelic enrichment of active, but not of repressive marks suggesting a partial uncoupling of the relationship between DNA methylation and repressive histone methylation, possibly due to the smaller size and lower CpG density of these DMRs. (via Semantic Scholar)
Source: ORCID
Added: September 28, 2022

2011 journal article

Melanoma and DNA damage from a distance (farstander effect).

Pigment Cell & Melanoma Research.

Contributors: S. Gaddameedhi* & A. Sancar

MeSH headings : Animals; Bystander Effect; Cell Cycle; DNA Damage; Humans; Melanoma / pathology; Mice; Models, Biological; Oxidation-Reduction
topics (OpenAlex): Effects of Radiation Exposure; DNA Repair Mechanisms; Carcinogens and Genotoxicity Assessment
TL;DR: The paper shows that the same or similar mechanisms that are responsible for BE may cause systemic effects as well (farstander effect, FE) and suggests that S-phase cells of the skin and GIT are more sensitive to DSB formation through FE, as seen previously for BE in an IR-induced cell culture system. (via Semantic Scholar)
Source: ORCID
Added: December 24, 2021

2011 journal article

Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies

International Journal of Epidemiology, 40(5), 1314–1328.

author keywords: Data synthesis; data quality; data pooling; harmonization; meta-analysis; DataSHaPER; retrospective harmonization
MeSH headings : Chronic Disease / epidemiology; Cohort Studies; Data Collection / methods; Data Interpretation, Statistical; Databases, Factual; Epidemiologic Methods; Humans; Retrospective Studies; Risk Factors; Surveys and Questionnaires
topics (OpenAlex): Health, Environment, Cognitive Aging; Genetic Associations and Epidemiology; Advanced Causal Inference Techniques
TL;DR: The current article shows that the DataSHaPER provides an effective and flexible approach for the retrospective harmonization of information across studies and offers the promise of enhanced research potential generated through synthesized databases. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 28, 2021

2011 journal article

High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study

International Archives of Occupational and Environmental Health, 85(5), 505–515.

By: S. Starks*, F. Gerr*, F. Kamel*, C. Lynch*, M. Alavanja*, D. Sandler*, J. Hoppin*

author keywords: Agricultural workers; Epidemiology; Neurobehavioral testing; Pesticide exposure; High pesticide exposure event
MeSH headings : Aged; Aged, 80 and over; Agriculture; Central Nervous System / drug effects; Humans; Iowa; Linear Models; Male; Middle Aged; North Carolina; Occupational Diseases / chemically induced; Occupational Diseases / diagnosis; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Pesticides / poisoning; Prospective Studies; Surveys and Questionnaires
topics (OpenAlex): Pesticide Exposure and Toxicity; Insect and Pesticide Research; Pesticide and Herbicide Environmental Studies
TL;DR: One or more HPEE may contribute to adverse CNS outcomes independent of diagnosed pesticide poisoning, and no significant associations were observed between participants who ever had an HPEE and the remaining neurobehavioral tests. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020

2011 journal article

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

Nature, 469(7331), 534–538.

By: A. Garfield*, M. Cowley*, F. Smith*, K. Moorwood*, J. Stewart-Cox*, K. Gilroy*, S. Baker*, J. Xia* ...

MeSH headings : Alleles; Animals; Behavior, Animal / physiology; Central Nervous System / embryology; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Social Dominance
topics (OpenAlex): Genetic Syndromes and Imprinting; Epigenetics and DNA Methylation; Prenatal Screening and Diagnostics
TL;DR: It is demonstrated that within the brain Grb10 is expressed from the paternal allele from fetal life into adulthood and that ablation of this expression engenders increased social dominance specifically among other aspects of social behaviour, a finding supported by the observed increase in allogrooming by paternal Grb 10-deficient animals. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2011 journal article

A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer

Nutrition Research, 31(1), 1–8.

By: C. Williams*, B. Whitley*, C. Hoyo*, D. Grant*, J. Iraggi*, K. Newman*, L. Gerber*, L. Taylor*, M. McKeever*, S. Freedland*

author keywords: Dietary fatty acids; Prostate cancer; Veterans; Race; Case control
MeSH headings : Aged; Case-Control Studies; Confidence Intervals; Diet; Dietary Fats, Unsaturated / metabolism; Fatty Acids, Omega-3 / metabolism; Fatty Acids, Omega-6 / metabolism; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Prostatic Neoplasms / metabolism; Risk Factors; Surveys and Questionnaires
topics (OpenAlex): Fatty Acid Research and Health; Cancer, Lipids, and Metabolism; Nutritional Studies and Diet
TL;DR: It is suggested that a high dietary ratio of n-6/n-3 fatty acids may increase the risk of overall prostate cancer among white men and possibly increase therisk of high-grade prostate canceramong all men. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2011 journal article

1613 GENETIC VARIATION IN OBESITY-RELATED GENES ADBR2, ADBR3, GHRL, HSD11B1, AND SHC1 AND RISK OF PROSTATE CANCER: A VA CASE-CONTROL STUDY

Journal of Urology, 185(4S).

By: E. Masko*, D. Moreira*, L. Bañez*, C. Hoyo*, D. Grant*, E. Calloway*, K. Shuler*, K. Newman* ...

topics (OpenAlex): Prostate Cancer Treatment and Research
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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2011 journal article

605 COMBINATION OF ADH GENE POLYMORPHISM AND ALCOHOL CONSUMPTION CONSTITUTES A NOVEL PROSTATE CANCER RISK FACTOR IN AFRICAN-AMERICAN MEN

Journal of Urology, 185(4S).

By: L. Bañez*, C. Hoyo*, E. Masko*, E. Calloway*, K. Shuler*, K. Newman*, A. Gaines*, S. Freedland*, C. Robertson*

topics (OpenAlex): Alcohol Consumption and Health Effects; Cancer, Lipids, and Metabolism; Glutathione Transferases and Polymorphisms
TL;DR: Preliminary findings suggest the ADH1B*3 variant allele and alcohol intake is a novel gene-environment interaction for PC risk, nearly unique to AAM. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2011 journal article

The association of diabetes mellitus and high-grade prostate cancer in a multiethnic biopsy series

Cancer Causes & Control, 22(7), 977–983.

By: D. Moreira*, T. Anderson*, L. Gerber*, J. Thomas*, L. Bañez*, M. McKeever*, C. Hoyo*, D. Grant*, J. Jayachandran*, S. Freedland*

author keywords: Prostatic neoplasm; Prostate-specific antigen; Diabetes Mellitus; Incidence; Epidemiology; Case-control studies; Obesity; Population groups; Ethnic groups; Continental population groups; Male
MeSH headings : Aged; Biopsy; Body Mass Index; Carcinoma / complications; Carcinoma / epidemiology; Carcinoma / ethnology; Carcinoma / pathology; Diabetes Complications / epidemiology; Diabetes Complications / ethnology; Diabetes Mellitus / epidemiology; Diabetes Mellitus / ethnology; Ethnicity / statistics & numerical data; Humans; Male; Middle Aged; Obesity / complications; Obesity / epidemiology; Obesity / ethnology; Prostatic Neoplasms / complications; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / ethnology; Prostatic Neoplasms / pathology; Retrospective Studies
topics (OpenAlex): Metabolism, Diabetes, and Cancer; Prostate Cancer Treatment and Research; Cancer Risks and Factors
TL;DR: The association of diabetes mellitus with risk of prostate cancer and cancer grade among men undergoing prostate biopsy is analyzed and how obesity and race modify these associations is analyzed to suggest the effect of DM on high-grade prostate cancer is modified by race and obesity. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2011 journal article

Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria

Proceedings of the National Academy of Sciences, 108(45), 18313–18317.

By: S. Pierce*, C. Spurrell*, J. Mandell*, M. Lee*, S. Zeligson*, M. Bereman*, S. Stray*, S. Fokstuen* ...

author keywords: dicarbonyl reductase; exome sequencing; glucuronic acid; history of genetics
MeSH headings : Blotting, Western; Carbohydrate Metabolism, Inborn Errors / ethnology; Carbohydrate Metabolism, Inborn Errors / genetics; DNA / genetics; Female; Humans; Jews; Male; Mutation; Pedigree; RNA, Messenger / genetics; Sugar Alcohol Dehydrogenases / deficiency; Sugar Alcohol Dehydrogenases / genetics; Xylulose / genetics
topics (OpenAlex): Metabolism and Genetic Disorders; Biomedical Research and Pathophysiology; Amino Acid Enzymes and Metabolism
TL;DR: Pentosuria, which affects almost exclusively individuals of Ashkenazi Jewish ancestry, is characterized by high levels of the pentose sugar l-xylulose in blood and urine and deficiency of the enzyme l-Xylulosing reductase, and the relationship between the DCXR genotypes and the pentosuric phenotype was confirmed. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 24, 2020

2011 journal article

Comparison between procedures using SDS for shotgun proteomic analyses of complex samples

PROTEOMICS, 11(14), 2931–2935.

author keywords: Bottom-up proteomics; Protein identifications; Sample preparation protocols; Shotgun proteomics; Sodium dodecyl sulfate; Technology
MeSH headings : Animals; Caenorhabditis elegans Proteins / analysis; HEK293 Cells / chemistry; Humans; Mass Spectrometry / methods; Peptides / analysis; Proteins / analysis; Proteomics / methods; Saccharomyces cerevisiae Proteins / analysis; Sodium Dodecyl Sulfate / chemistry; Surface-Active Agents / chemistry
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Mass Spectrometry Techniques and Applications; Identification and Quantification in Food
TL;DR: Filter‐aided sample preparation (FASP) and a new sample preparation method using a modified commercial SDS removal spin column are quantitatively compared in terms of their performance for shotgun proteomic experiments in three complex proteomic samples. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2011 journal article

Control of skin cancer by the circadian rhythm

Proceedings of the National Academy of Sciences, 108(46), 18790–18795.

By: S. Gaddameedhi*, C. Selby*, W. Kaufmann*, R. Smart n & A. Sancar*

Contributors: S. Gaddameedhi*, C. Selby*, W. Kaufmann*, R. Smart n & A. Sancar*

author keywords: circadian clock; cryptochrome; sunbathing; tanning salons
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / physiopathology; Circadian Rhythm / physiology; DNA Damage; DNA Repair; Disease Models, Animal; Humans; Immunohistochemistry / methods; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / radiation effects; Skin Neoplasms / etiology; Skin Neoplasms / physiopathology; Sunlight; Time Factors; Xeroderma Pigmentosum Group A Protein / biosynthesis; Xeroderma Pigmentosum Group A Protein / genetics
topics (OpenAlex): Circadian rhythm and melatonin; Genetics, Aging, and Longevity in Model Organisms; Light effects on plants
TL;DR: It is concluded that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2011 journal article

Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer

Pharmacogenetics and Genomics, 21(10), 615–623.

By: S. Koutros*, G. Andreotti*, S. Berndt*, K. Hughes Barry*, J. Lubin*, J. Hoppin*, F. Kamel*, D. Sandler* ...

Contributors: S. Koutros*, G. Andreotti*, S. Berndt*, K. Hughes Barry*, J. Lubin*, J. Hoppin*, F. Kamel*, D. Sandler* ...

author keywords: interaction; pesticides; prostate cancer; single nucleotide polymorphism; xenobiotic-metabolizing enzymes
MeSH headings : Alleles; Epoxide Hydrolases / genetics; Genetic Association Studies; Glutamate-Cysteine Ligase / genetics; Humans; Logistic Models; Male; Occupational Exposure; Oxidative Stress / genetics; Peroxidase / genetics; Pesticides / adverse effects; Polymorphism, Single Nucleotide; Prostatic Neoplasms / genetics; Risk Factors; Thioredoxin Reductase 2 / genetics; Xenobiotics / metabolism
topics (OpenAlex): Glutathione Transferases and Polymorphisms; Pesticide Exposure and Toxicity; Pharmacogenetics and Drug Metabolism
TL;DR: The number of observed interactions in XMEs was comparable with the number expected by chance alone, and several pesticide–SNP interactions in oxidative stress and phase I/II enzyme genes and risk of prostate cancer were observed. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2011 journal article

Mortality in the agricultural health study, 1993-2007

Mortality in the Agricultural Health Study, 1993-2007. American Journal of Epidemiology, 173(1), 71–83.

By: J. Waggoner*, G. Kullman, P. Henneberger, D. Umbach, A. Blair, M. Alavanja, F. Kamel, C. Lynch ...

Contributors: J. Waggoner*, G. Kullman, P. Henneberger, D. Umbach, A. Blair, M. Alavanja, F. Kamel, C. Lynch ...

author keywords: agriculture; healthy worker effect; mortality; neoplasms; pesticides; wounds and injuries
MeSH headings : Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / mortality; Cause of Death / trends; Female; Humans; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Retrospective Studies; Survival Rate / trends
topics (OpenAlex): Agriculture and Farm Safety; Climate Change and Health Impacts; Occupational Health and Safety Research
TL;DR: Using data from the Agricultural Health Study, a cohort of 89,656 pesticide applicators and their spouses in North Carolina and Iowa, standardized mortality ratios (SMRs) were computed comparing deaths from time of the enrollment through 2007 to state-specific rates. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 13, 2019

2011 journal article

Neurologic Symptoms Associated With Raising Poultry and Swine Among Participants in the Agricultural Health Study

Journal of Occupational and Environmental Medicine, 53(2), 190–195.

By: M. Davis*, F. Kamel*, J. Hoppin*, M. Alavanja*, L. Freeman*, G. Gray*, K. Nelson*, E. Silbergeld*

Contributors: M. Davis*, F. Kamel*, J. Hoppin*, M. Alavanja*, L. Freeman*, G. Gray*, K. Nelson*, E. Silbergeld*

MeSH headings : Adult; Agricultural Workers' Diseases / diagnosis; Agricultural Workers' Diseases / epidemiology; Alcohol Drinking / epidemiology; Animals; Female; Guillain-Barre Syndrome / epidemiology; Humans; Hypesthesia / diagnosis; Hypesthesia / epidemiology; Male; Middle Aged; Muscle Weakness / diagnosis; Muscle Weakness / epidemiology; Nervous System Diseases / diagnosis; Nervous System Diseases / epidemiology; Poultry; Prevalence; Smoking / epidemiology; Swine
topics (OpenAlex): Peripheral Neuropathies and Disorders; Viral gastroenteritis research and epidemiology; Clostridium difficile and Clostridium perfringens research
TL;DR: Occupational contact with live poultry or swine, potentially related to C. jejuni exposure, was associated with increased reporting of GBS-like symptoms. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2011 journal article

Questionnaire Predictors of Atopy in a US Population Sample: Findings From the National Health and Nutrition Examination Survey, 2005-2006

American Journal of Epidemiology, 173(5), 544–552.

Contributors: J. Hoppin*, R. Jaramillo*, P. Salo*, D. Sandler*, S. London* & D. Zeldin*

author keywords: hypersensitivity; immunoglobulin E; questionnaires; sensitivity and specificity
MeSH headings : Adolescent; Adult; Biomarkers / blood; Child; Child, Preschool; Eczema / epidemiology; Eczema / immunology; Female; Health Surveys / statistics & numerical data; Humans; Hypersensitivity / epidemiology; Hypersensitivity / immunology; Hypersensitivity, Immediate / epidemiology; Immunoglobulin E / blood; Immunologic Factors / blood; Infant; Male; Middle Aged; Nutrition Surveys / statistics & numerical data; Predictive Value of Tests; Rhinitis, Allergic, Seasonal / epidemiology; Sampling Studies; Sensitivity and Specificity; Surveys and Questionnaires; United States / epidemiology
topics (OpenAlex): Allergic Rhinitis and Sensitization; Asthma and respiratory diseases; Food Allergy and Anaphylaxis Research
TL;DR: To assess questionnaires' ability to predict biochemical measures of atopy, the authors used data on 5 allergic conditions and serum-specific immunoglobulin E (IgE) levels from the 2005-2006 National Health and Nutrition Examination Survey to identify participants found to be atopic by biochemical measures. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2011 journal article

Rotenone, Paraquat, and Parkinson’s Disease

Environmental Health Perspectives, 119(6), 866–872.

By: C. Tanner*, F. Kamel*, G. Ross*, J. Hoppin*, S. Goldman*, M. Korell*, C. Marras*, G. Bhudhikanok* ...

Contributors: C. Tanner*, F. Kame*, G. Ross*, J. Hoppin*, S. Goldman*, M. Korell*, C. Marras*, G. Bhudhikanok* ...

author keywords: aging; agricultural epidemiology; environmental epidemiology; epidemiology; fungicides; herbicides; insecticides; persistent organic pollutants; pesticides
MeSH headings : Aged; Case-Control Studies; Female; Herbicides / toxicity; Humans; Insecticides / toxicity; Iowa / epidemiology; Male; Middle Aged; Mitochondria / metabolism; North Carolina / epidemiology; Occupational Exposure; Oxidative Stress; Paraquat / toxicity; Parkinson Disease / epidemiology; Parkinson Disease / etiology; Parkinsonian Disorders / epidemiology; Parkinsonian Disorders / etiology; Rotenone / toxicity
topics (OpenAlex): Parkinson's Disease Mechanisms and Treatments; Biochemical and biochemical processes; Paraquat toxicity studies and treatments
TL;DR: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally—those that impair mitochondrial function and those that increase oxidative stress—supporting a role for these mechanisms in PD pathophysiology. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

2011 journal article

Job Activities and Respiratory Symptoms Among Farmworkers in North Carolina

Archives of Environmental & Occupational Health, 66(3), 178–182.

author keywords: agriculture; asthma; epidemiology; occupational lung disease; respiratory diseases
MeSH headings : Age Factors; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Agriculture / statistics & numerical data; Female; Humans; Logistic Models; Male; North Carolina / epidemiology; Occupational Exposure / adverse effects; Occupational Exposure / statistics & numerical data; Prevalence; Respiratory Sounds; Respiratory Tract Diseases / epidemiology; Respiratory Tract Diseases / etiology; Smoking / adverse effects; Smoking / epidemiology; Surveys and Questionnaires
topics (OpenAlex): Indoor Air Quality and Microbial Exposure; Air Quality and Health Impacts; Occupational exposure and asthma
TL;DR: Though not statistically significant, the odds of wheezing were elevated for individuals who reported performing tobacco-related work in the last 3 days and the odds were decreased among individuals who report harvesting activities. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019

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