Works Published in 2011
Displaying all 14 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.
PloS One, 6(4), 18953.
MeSH headings : Alleles; Animals; DNA Methylation; Genomic Imprinting; Humans; Long Interspersed Nucleotide Elements / genetics; Mice; Mice, Inbred C57BL; Short Interspersed Nucleotide Elements / genetics
TL;DR:
The repeat element content of imprinted retrogene loci with non-imprinted controls that have a similar locus organisation is compared, suggesting that the paucity of SINEs and relative abundance of LINEs at imprinted loci reported by others is not a sequence feature universally required for imprinting.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: September 28, 2022
2011 journal article
Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.
Nucleic Acids Research, 39(11), 4577–4586.
MeSH headings : Alleles; Animals; Chromatin / metabolism; DNA Methylation; Genomic Imprinting; Histones / metabolism; Humans; Mice; Promoter Regions, Genetic; Retroelements
TL;DR:
Two human retrogenes showed monoallelic enrichment of active, but not of repressive marks suggesting a partial uncoupling of the relationship between DNA methylation and repressive histone methylation, possibly due to the smaller size and lower CpG density of these DMRs.
(via Semantic Scholar)
Source: ORCID
Added: September 28, 2022
2011 journal article
Distinct physiological and behavioural functions for parental alleles of imprinted Grb10
Nature, 469(7331), 534–538.
MeSH headings : Alleles; Animals; Behavior, Animal / physiology; Central Nervous System / embryology; Female; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / metabolism; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Social Dominance
TL;DR:
It is demonstrated that within the brain Grb10 is expressed from the paternal allele from fetal life into adulthood and that ablation of this expression engenders increased social dominance specifically among other aspects of social behaviour, a finding supported by the observed increase in allogrooming by paternal Grb 10-deficient animals.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2011 journal article
A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer
Nutrition Research, 31(1), 1–8.
author keywords: Dietary fatty acids; Prostate cancer; Veterans; Race; Case control
MeSH headings : Aged; Case-Control Studies; Confidence Intervals; Diet; Dietary Fats, Unsaturated / metabolism; Fatty Acids, Omega-3 / metabolism; Fatty Acids, Omega-6 / metabolism; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Prostatic Neoplasms / metabolism; Risk Factors; Surveys and Questionnaires
TL;DR:
It is suggested that a high dietary ratio of n-6/n-3 fatty acids may increase the risk of overall prostate cancer among white men and possibly increase therisk of high-grade prostate canceramong all men.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
1613 GENETIC VARIATION IN OBESITY-RELATED GENES ADBR2, ADBR3, GHRL, HSD11B1, AND SHC1 AND RISK OF PROSTATE CANCER: A VA CASE-CONTROL STUDY
Journal of Urology, 185(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
605 COMBINATION OF ADH GENE POLYMORPHISM AND ALCOHOL CONSUMPTION CONSTITUTES A NOVEL PROSTATE CANCER RISK FACTOR IN AFRICAN-AMERICAN MEN
Journal of Urology, 185(4S).
TL;DR:
Preliminary findings suggest the ADH1B*3 variant allele and alcohol intake is a novel gene-environment interaction for PC risk, nearly unique to AAM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
The association of diabetes mellitus and high-grade prostate cancer in a multiethnic biopsy series
Cancer Causes & Control, 22(7), 977–983.
author keywords: Prostatic neoplasm; Prostate-specific antigen; Diabetes Mellitus; Incidence; Epidemiology; Case-control studies; Obesity; Population groups; Ethnic groups; Continental population groups; Male
MeSH headings : Aged; Biopsy; Body Mass Index; Carcinoma / complications; Carcinoma / epidemiology; Carcinoma / ethnology; Carcinoma / pathology; Diabetes Complications / epidemiology; Diabetes Complications / ethnology; Diabetes Mellitus / epidemiology; Diabetes Mellitus / ethnology; Ethnicity / statistics & numerical data; Humans; Male; Middle Aged; Obesity / complications; Obesity / epidemiology; Obesity / ethnology; Prostatic Neoplasms / complications; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / ethnology; Prostatic Neoplasms / pathology; Retrospective Studies
TL;DR:
The association of diabetes mellitus with risk of prostate cancer and cancer grade among men undergoing prostate biopsy is analyzed and how obesity and race modify these associations is analyzed to suggest the effect of DM on high-grade prostate cancer is modified by race and obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Garrod's fourth inborn error of metabolism solved by the identification of mutations causing pentosuria
Proceedings of the National Academy of Sciences, 108(45), 18313–18317.
author keywords: dicarbonyl reductase; exome sequencing; glucuronic acid; history of genetics
MeSH headings : Blotting, Western; Carbohydrate Metabolism, Inborn Errors / ethnology; Carbohydrate Metabolism, Inborn Errors / genetics; DNA / genetics; Female; Humans; Jews; Male; Mutation; Pedigree; RNA, Messenger / genetics; Sugar Alcohol Dehydrogenases / deficiency; Sugar Alcohol Dehydrogenases / genetics; Xylulose / genetics
TL;DR:
Pentosuria, which affects almost exclusively individuals of Ashkenazi Jewish ancestry, is characterized by high levels of the pentose sugar l-xylulose in blood and urine and deficiency of the enzyme l-Xylulosing reductase, and the relationship between the DCXR genotypes and the pentosuric phenotype was confirmed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2011 journal article
Comparison between procedures using SDS for shotgun proteomic analyses of complex samples
PROTEOMICS, 11(14), 2931–2935.
author keywords: Bottom-up proteomics; Protein identifications; Sample preparation protocols; Shotgun proteomics; Sodium dodecyl sulfate; Technology
MeSH headings : Animals; Caenorhabditis elegans Proteins / analysis; HEK293 Cells / chemistry; Humans; Mass Spectrometry / methods; Peptides / analysis; Proteins / analysis; Proteomics / methods; Saccharomyces cerevisiae Proteins / analysis; Sodium Dodecyl Sulfate / chemistry; Surface-Active Agents / chemistry
TL;DR:
Filter‐aided sample preparation (FASP) and a new sample preparation method using a modified commercial SDS removal spin column are quantitatively compared in terms of their performance for shotgun proteomic experiments in three complex proteomic samples.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2011 journal article
Control of skin cancer by the circadian rhythm
Proceedings of the National Academy of Sciences, 108(46), 18790–18795.
author keywords: circadian clock; cryptochrome; sunbathing; tanning salons
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / physiopathology; Circadian Rhythm / physiology; DNA Damage; DNA Repair; Disease Models, Animal; Humans; Immunohistochemistry / methods; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / radiation effects; Skin Neoplasms / etiology; Skin Neoplasms / physiopathology; Sunlight; Time Factors; Xeroderma Pigmentosum Group A Protein / biosynthesis; Xeroderma Pigmentosum Group A Protein / genetics
TL;DR:
It is concluded that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2011 journal article
One-year plasma N-linked glycome intra-individual and inter-individual variability in the chicken model of spontaneous ovarian adenocarcinoma
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 305(2-3), 79–86.
author keywords: N-linked glycans; HILIC; FTMS; Longitudinal sampling
TL;DR:
The initial interrogation of longitudinally-procured samples provides evidence that supports the value of this strategy in the search for glycomic biomarkers, and identifies 35 N-linked glycans identified in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
CD34 antigen: Determination of specific sites of phosphorylation in vitro and in vivo
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 301(1-3), 12–21.
author keywords: CD34; Phosphorylation; PKC kinase; AKT2 kinase; LC/MS/MS
TL;DR:
The identification of the in vitro sites of phosphorylation on the intracellular domain of mouse CD34 following PKC treatment suggests that other kinases, as well as PKC, may have important signaling functions in CD34.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
PTEN Positively Regulates UVB-Induced DNA Damage Repair
CANCER RESEARCH, 71(15), 5287–5295.
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / genetics; Carcinoma, Squamous Cell / pathology; Cell Line / metabolism; Cell Line / pathology; Cell Line / radiation effects; Checkpoint Kinase 1; Checkpoint Kinase 2; DNA Damage; DNA Repair / genetics; DNA Repair / physiology; DNA-Binding Proteins / physiology; Down-Regulation; Humans; Keratinocytes / metabolism; Keratinocytes / pathology; Keratinocytes / radiation effects; Keratosis, Actinic / genetics; Keratosis, Actinic / pathology; Mice; Neoplasms, Radiation-Induced / genetics; Neoplasms, Radiation-Induced / pathology; PTEN Phosphohydrolase / antagonists & inhibitors; PTEN Phosphohydrolase / deficiency; PTEN Phosphohydrolase / genetics; PTEN Phosphohydrolase / physiology; Papilloma / etiology; Papilloma / genetics; Papilloma / pathology; Precancerous Conditions / etiology; Precancerous Conditions / genetics; Protein Kinases / physiology; Protein Serine-Threonine Kinases / physiology; Proto-Oncogene Proteins c-akt / physiology; RNA, Small Interfering / pharmacology; Skin Neoplasms / etiology; Skin Neoplasms / genetics; Skin Neoplasms / pathology; Ultraviolet Rays / adverse effects; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors
TL;DR:
This work shows that attenuating PTEN in epidermal keratinocytes is a predisposing factor for UVB-induced skin carcinogenesis in mice, and defines PTEN as an essential genomic gatekeeper in the skin through its ability to positively regulate XPC-dependent GG-NER following DNA damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1339–1346.
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
TL;DR:
It is observed that C/EBPα is induced in normal human epidermal keratinocytes and in the epidermis of human subjects exposed to UVB radiation, and loss of C/ EBPα confers susceptibility toUVB-induced skin SCCs involving defective cell cycle arrest in response to UVBs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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