Modeling the Living Embryo

Works Published in 2016

search works

Displaying all 5 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2016 journal article

TransOmic analysis of forebrain sections in Sp2 conditional knockout embryonic mice using IR-MALDESI imaging of lipids and LC-MS/MS label-free proteomics

Analytical and Bioanalytical Chemistry, 408(13), 3453–3474.

By: P. Loziuk n, F. Meier  n, C. Johnson  n, H. Ghashghaei  n & D. Muddiman  n

author keywords: IR-MALDESI; Proteomics; Lipidomics; Mass spectrometry imaging; Embryonic brain
MeSH headings : Animals; Chromatography, Liquid / methods; Lipids / analysis; Mass Spectrometry / methods; Mice; Mice, Knockout; Prosencephalon / embryology; Prosencephalon / metabolism; Sp2 Transcription Factor / genetics; Spectrophotometry, Infrared / methods; Transcriptome
TL;DR: An integrated approach for systematic analysis of the “lipidome” in tissue revealed many specific changes to fundamental cellular processes and biosynthetic pathways in the cerebral cortices of Sp2-cKO embryos. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: July 20, 2019

2016 journal article

Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms Regulating Progenitor Behavior and Productivity

JOURNAL OF NEUROSCIENCE, 36(45), 11394–11401.

By: N. Dwyer*, B. Chen *, S. Chou *, S. Hippenmeyer *, L. Nguyen * & H. Ghashghaei  n

author keywords: cortical development; Cux2; cytokinesis; Fezf2; Kif20b; Lhx2; lineage; MADM; microcephaly; mouse; neurogenesis; Sp2; UPR
MeSH headings : Animals; Cell Differentiation / physiology; Cell Proliferation / physiology; Cerebral Cortex / cytology; Cerebral Cortex / physiology; Cytokinesis / physiology; Humans; Neurogenesis / physiology; Neuronal Plasticity / physiology; Neurons / cytology; Neurons / physiology
TL;DR: Four aspects of corticogenesis are focused on: cytokinesis events that follow apical mitoses of NSCs; coordinating abscission with delamination from the apical membrane; timing of neurogenesis and its indirect regulation through emergence of intermediate progenitors; and capacity of single N SCs to generate the correct number and laminar fate of cortical neurons. (via Semantic Scholar)
UN Sustainable Development Goal Categories
8. Decent Work and Economic Growth (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

Journal of Cell Science, 129(9), 1855–1865.

By: K. Sai  n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei  n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n

author keywords: TAK1; Endoplasmic reticulum stress; Leptin; Hypothalamus; Obesity
MeSH headings : Animals; Dietary Fats / adverse effects; Dietary Fats / pharmacology; Endoplasmic Reticulum Stress; Hyperphagia / chemically induced; Hyperphagia / genetics; Hyperphagia / metabolism; Hyperphagia / pathology; Hypothalamus / metabolism; Hypothalamus / pathology; Leptin / genetics; Leptin / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Obesity / chemically induced; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
TL;DR: It is found that deletion of Tak1 increased ER volume and facilitated ER-stress tolerance in cultured cells, which was mediated by upregulation of sterol-regulatory-element-binding protein (SREBP)-dependent lipogenesis and central nervous system (CNS) deletion upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2016 review

Frogs as integrative models for understanding digestive organ development and evolution

[Review of ]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 51, 92–105.

By: M. Womble n, M. Pickett n & N. Nascone-Yoder n

author keywords: Embryo; Xenopus; Lepidobatrachus; Eleutherodactylous coqui; Gut; Specification; Morphogenesis; Evolution
MeSH headings : Animals; Biological Evolution; Calcium Signaling; Cell Communication; Digestive System / cytology; Digestive System / embryology; Endoderm / cytology; Endoderm / embryology; Gene Expression; Gene Expression Regulation, Developmental; Humans; Morphogenesis; Xenopus Proteins / genetics; Xenopus Proteins / metabolism; Xenopus laevis / embryology
TL;DR: The unparalleled experimental versatility of frog embryos make them excellent, integrative models for studying digestive organ development across multiple disciplines, including the regeneration or replacement of diseased organs, the etiology of digestive organ birth defects, and the evolution of specialized features of digestive anatomy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Neurotypic cell attachment and growth on III-nitride lateral polarity structures

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 58, 1194–1198.

By: L. Bain n, R. Kirste n, C. Johnson  n, H. Ghashghaei  n, R. Collazo n  & A. Ivanisevic n

author keywords: Gallium nitride; Cell adhesion; Neurons; Semiconductor; Polarity
MeSH headings : Aluminum Compounds / chemistry; Aluminum Compounds / pharmacology; Animals; Cell Adhesion / drug effects; Cell Differentiation / drug effects; Gallium / chemistry; Gallium / pharmacology; Neurons / cytology; Neurons / drug effects; PC12 Cells; Rats; Semiconductors
TL;DR: The designed material configuration is further explored for biochemical sensing, and the lateral polarity scheme may provide a route in assessing the non-specific protein adsorption to this varying nano-topography that drives the subsequent cell response. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.