Center for Human Health and the Environment

Works Published in 2011

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Displaying works 221 - 225 of 225 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2011 journal article

Top-down control analysis of the cadmium effects on molluscan mitochondria and the mechanisms of cadmium-induced mitochondrial dysfunction

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 300(1), R21–R31.

By: I. Kurochkin*, M. Etzkorn *, D. Buchwalter n, L. Leamy* & I. Sokolova *

author keywords: cadmium; reactive oxygen species; proton leak; substrate oxidation; mitovite
MeSH headings : Adenosine Triphosphate / metabolism; Adenosine Triphosphate / pharmacology; Animals; Antioxidants / pharmacology; Cadmium / pharmacology; Crassostrea / physiology; Mitochondria / drug effects; Mitochondria / physiology; Models, Animal; Organophosphorus Compounds / pharmacology; Phosphorylation / drug effects; Reactive Oxygen Species / metabolism; Ubiquinone / pharmacology
TL;DR: Data suggest that Cd-induced decrease of mitochondrial efficiency and ATP production are predominantly driven by the high sensitivity of substrate oxidation and proton leak subsystems to this metal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Interpersonal Amplification of Risk? Citizen Discussions and Their Impact on Perceptions of Risks and Benefits of a Biological Research Facility

RISK ANALYSIS, 31(2), 324–334.

By: A. Binder n , D. Scheufele *, D. Brossard * & A. Gunther*

Contributors: A. Gunther*, D. Brossard *, D. Scheufele * & A. Binder n 

author keywords: Interpersonal discussion; risk communication; social amplification of risk
MeSH headings : Academies and Institutes; Biomedical Research; Humans; Risk Assessment; United States
TL;DR: The results demonstrate the potential for discussions to operate as amplifiers or attenuators of perceptions of both risks and benefits in the context of a new biological research facility. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR: A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Evidence for viable, non-clonal but fatherless Boa constrictors

BIOLOGY LETTERS, 7(2), 253–256.

By: W. Booth n, D. Johnson, S. Moore, C. Schal n  & E. Vargo n

author keywords: facultative parthenogenesis; asexual reproduction; Boidae; WW female; microsatellite DNA fingerprinting
MeSH headings : Animals; Boidae / genetics; Boidae / physiology; DNA Fingerprinting; Female; Male; Microsatellite Repeats; Parthenogenesis; Sex Determination Processes
TL;DR: Through microsatellite DNA fingerprinting, this work provides the first evidence of facultative parthenogenesis in a Boa constrictor, identifying multiple, viable, non-experimentally induced females for the first time in any vertebrate lineage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Autocrine Effects of Interleukin-6 Mediate Acute-Phase Proinflammatory and Tissue-Reparative Transcriptional Responses of Canine Bladder Mucosa

INFECTION AND IMMUNITY, 79(2), 708–715.

By: M. Wood n, E. Breitschwerdt n  & J. Gookin n 

MeSH headings : Acute-Phase Reaction / metabolism; Animals; Dogs; Humans; Interleukin-6 / metabolism; Mucous Membrane / metabolism; Mucous Membrane / microbiology; Signal Transduction; Tissue Culture Techniques; Urinary Bladder / metabolism; Urinary Bladder / microbiology; Uropathogenic Escherichia coli; Urothelium / metabolism
TL;DR: It is demonstrated that uropathogenic Escherichia coli infection stimulates the synthesis of IL-6 by all urothelial cell layers, with the u rothelial cells alone representing the only site of unequivocal IL- 6 receptor expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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