Works Published in 2008
Displaying works 41 - 60 of 213 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach
The American Journal of Human Genetics, 82(5), 1224.
doi.org (publisher)
Source: Crossref
Added: August 28, 2020
2008 journal article
Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach
The American Journal of Human Genetics, 82(5), 1064–1074.
MeSH headings : Genome, Human; Haplotypes; Humans; Likelihood Functions; Models, Genetic; Odds Ratio; Software
TL;DR:
This work introduces a method, based on the estimate of genetic effect and its standard error as reported by standard statistical software, to correct for this bias in case-control association studies and develops a principled method to construct confidence intervals for the genetic effect that acknowledges the conditioning on statistical significance.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Comment on a Simple and Improved Correction for Population Stratification
The American Journal of Human Genetics, 82(2), 524–526.
MeSH headings : Case-Control Studies; Genetic Markers; Genetics, Population; Genotype; Humans; Polymorphism, Single Nucleotide; Regression Analysis; Research Design
TL;DR:
To the Editor: In the May 2007 issue of the American Journal of Human Genetics, Epstein, Allen, and Satten1 (hereafter referred to as EAS) introduced a new method for controlling population stratification in case-control association studies.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons
Toxicology Letters, 176(2), 149–156.
Contributors: H. Le*, E. Carlson*, J. Chua* & S. Belcher*
author keywords: BPA endocrine disruption; estrogen; neurotoxicity; non-genomic
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Cell Survival / drug effects; Cells, Cultured; Cerebellum / cytology; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endocrine Disruptors / chemistry; Endocrine Disruptors / metabolism; Endocrine Disruptors / toxicity; Enzyme-Linked Immunosorbent Assay; Estradiol / pharmacology; Estrogens / toxicity; Female; Humans; Immunochemistry; L-Lactate Dehydrogenase / metabolism; Neurons / cytology; Neurons / drug effects; Neurons / metabolism; Phenols / chemistry; Phenols / metabolism; Phenols / toxicity; Polycarboxylate Cement / chemistry; Product Packaging; Rats; Rats, Sprague-Dawley; Temperature; Time Factors; Water / analysis; Water / chemistry
TL;DR:
The estrogenic bioactivity of the BPA-like immunoreactivity released into the water samples was confirmed using an in vitro assay of rapid estrogen signaling and neurotoxicity in developing cerebellar neurons and should be considered as a contributing source to the total "EDC-burden" to which some individuals are exposed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2008 journal article
Non invasive high resolution in vivo imaging of α-naphthylisothiocyanate (ANIT) induced hepatobiliary toxicity in STII medaka
Aquatic Toxicology, 86(1), 20–37.
author keywords: fish; toxicology; hepatobiliary; liver; toxicity; medaka; ANIT; biliary; biliary toxicity; alpha-naphthylisothiocyanate; hepatotoxicity; piscine liver
MeSH headings : 1-Naphthylisothiocyanate / toxicity; Animals; Antibodies / metabolism; Apoptosis; Bile Ducts, Intrahepatic / drug effects; Bile Ducts, Intrahepatic / pathology; Bile Ducts, Intrahepatic / ultrastructure; Blood Vessels / drug effects; Epithelial Cells / cytology; Epithelial Cells / drug effects; Fluorescent Dyes / analysis; Image Processing, Computer-Assisted; Imaging, Three-Dimensional / veterinary; Liver / blood supply; Liver / drug effects; Liver / pathology; Liver / ultrastructure; Microscopy, Confocal / veterinary; Models, Animal; Oryzias / genetics; Oryzias / physiology; Phenotype
TL;DR:
The findings presented show for the first time in vivo evaluation of toxicity in the STII medaka hepatobiliary system, and, in conjunction with prior in vivo work characterizing normalcy, advance the comparative understanding of this lower vertebrate hepatOBiliary system and its response to toxic insult.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2008 journal article
Basolumenal endoderm intercalation: A geometrically unique execution of convergent extension during gut tube elongation
Developmental Biology, 319(2), 513.
Source: Crossref
Added: August 28, 2020
2008 journal article
Heterotaxin: A novel pyridine compound that perturbs left–right asymmetric organ morphogenesis
Developmental Biology, 319(2), 513.
Source: Crossref
Added: August 28, 2020
2008 journal article
Small molecule-mediated “phenotypic engineering” reveals a role for retinoic acid in anuran gut evolution
Developmental Biology, 319(2), 497–498.
Source: Crossref
Added: August 28, 2020
2008 journal article
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
Molecular Psychiatry, 14(4), 359–375.
author keywords: major depressive disorder; genome-wide association; Netherlands study of depression and anxiety; Netherlands twin registry
MeSH headings : Adult; Case-Control Studies; Cohort Studies; Cytoskeletal Proteins / genetics; Depressive Disorder, Major / genetics; Female; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study / methods; Humans; Male; Middle Aged; Neuropeptides / genetics; Polymorphism, Single Nucleotide / genetics
TL;DR:
A genome-wide association study of single nucleotide polymorphisms genotyped in 1738 MDD cases and 1802 controls selected to be at low liability for MDD found 11 signals localized to a 167 kb region overlapping the gene piccolo, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2008 journal article
203 TAK1 Is Essential for Intestinal Epithelial Cell Survival and Regulates Intestinal Integrity
Gastroenterology, 134(4), A-35-A-36.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2008 journal article
Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest
Journal of Biological Chemistry, 283(49), 33911–33918.
MeSH headings : Antigens, CD / chemistry; Apoferritins / chemistry; Cation Transport Proteins / biosynthesis; Cation Transport Proteins / chemistry; Cell Cycle; Cell Line, Tumor; Ferritins / chemistry; Homeostasis; Humans; Iron / chemistry; Models, Biological; Protein Binding; Protein Structure, Tertiary; RNA Processing, Post-Transcriptional; Receptors, Transferrin / chemistry; Transcription, Genetic; Tumor Suppressor Protein p53 / metabolism
TL;DR:
The results suggest that p53 may induce cell cycle arrest not only by well described mechanisms involving the induction of cyclin-dependent kinase inhibitors but also by the recruitment of pathways that reduce the availability of intracellular iron.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Intrauterine Growth Restriction Affects the Proteomes of the Small Intestine, Liver, and Skeletal Muscle in Newborn Pigs
The Journal of Nutrition, 138(1), 60–66.
MeSH headings : Animals; Animals, Newborn; Birth Weight; Female; Fetal Growth Retardation / metabolism; Gene Expression Profiling; Intestine, Small / growth & development; Intestine, Small / metabolism; Liver / growth & development; Liver / metabolism; Muscle Proteins / metabolism; Muscle, Skeletal / growth & development; Muscle, Skeletal / metabolism; Pregnancy; Proteome / metabolism; Swine / growth & development
TL;DR:
The novel findings suggest that cellular signaling defects, redox imbalance, reduced protein synthesis, and enhanced proteolysis may be the major mechanisms responsible for abnormal absorption and metabolism of nutrients, as well as reduced growth and impaired development of the small intestine, liver, and muscle in IUGR neonates.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020
2008 conference paper
NIR responsive core/shell nanohybrids for smart drug delivery
8th World Biomaterials Congress 2008, 1, 297. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869034553&partnerID=MN8TOARS
Contributors: Q. Wei , J. Ji & J. Shen
Source: ORCID
Added: April 10, 2020
2008 journal article
Using Biodynamic Models to Reconcile Differences between Laboratory Toxicity Tests and Field Biomonitoring with Aquatic Insects
Environmental Science & Technology, 42(8), 3117–3117.
Source: Crossref
Added: February 24, 2020
2008 journal article
Human Proteinpedia enables sharing of human protein data
Nature Biotechnology, 26(2), 164–167.
MeSH headings : Database Management Systems; Databases, Protein; Gene Expression Profiling / methods; Information Storage and Retrieval / methods; Internationality; Internet; Magnetic Resonance Spectroscopy / methods; Peptide Mapping / methods; Proteome / chemistry; Proteome / classification; Proteome / metabolism; Proteomics / methods; Software; User-Computer Interface
TL;DR:
MMCD is a practical tool for expediting the time-consuming steps of identifying and researching small molecules and is compatible with both NMR and MS data and facilitates high-throughput metabolomics investigations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2008 journal article
Synthesis, Characterization, and Application of Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy
Journal of the American Chemical Society, 130(7), 2122–2123.
MeSH headings : Alkylation; Amino Acid Sequence; Cysteine / chemistry; Factor VIIIa / antagonists & inhibitors; Hydrophobic and Hydrophilic Interactions; Iodoacetamide / analogs & derivatives; Iodoacetamide / chemical synthesis; Iodoacetamide / chemistry; Molecular Sequence Data; Peptides / analysis; Peptides / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
Hydrophobic tags, derived from iodoacetamide, were synthesized, characterized, and utilized to alkylate peptide E-76, a known inhibitor of coagulation factor VIIIa, and two other cysteine containing peptides to demonstrate an increase in electrospray response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2008 journal article
Pharmacokinetic Modeling of Manganese in the Rat IV: Assessing Factors that Contribute to Brain Accumulation During Inhalation Exposure
Journal of Toxicology and Environmental Health, Part A, 71(7), 413–426.
MeSH headings : Administration, Oral; Air Pollutants / pharmacokinetics; Animals; Brain / drug effects; Brain Chemistry; Disease Models, Animal; Dust; Environmental Exposure / adverse effects; Inhalation Exposure / adverse effects; Liver / drug effects; Manganese / administration & dosage; Manganese / pharmacokinetics; Models, Biological; Rats; Risk Assessment
TL;DR:
Multi-dose-route PBPK models for Mn based on this alternative model structure can be readily scaled to evaluate tissue Mn kinetics in other species and for human populations, and will be useful in tissue-dose based risk assessment with manganese.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein
Inhalation Toxicology, 20(3), 227–243.
MeSH headings : Acrolein / pharmacokinetics; Acrolein / toxicity; Air Pollutants / pharmacokinetics; Air Pollutants / toxicity; Animals; Computer Simulation; Dose-Response Relationship, Drug; Humans; Inhalation Exposure; Models, Biological; Nasal Cavity / drug effects; Nasal Cavity / metabolism; Nasal Cavity / pathology; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Rats
TL;DR:
In this study, anatomically accurate three-dimensional computational fluid dynamics (CFD) models were used to simulate steady-state inspiratory airflow and to quantitatively predict acrolein tissue dose in rat and human nasal passages to estimate a tissue dose-based no-observed-adverse-effect level (NOAEL) for inhaled ac rolein.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity
NeuroToxicology, 29(3), 377–385.
author keywords: brain; monkey; air borne; manganese; glutathione; glutamate
MeSH headings : Amino Acid Transport System X-AG / metabolism; Animals; Biomarkers; Blotting, Northern; Blotting, Western; Brain / metabolism; Excitatory Amino Acid Transporter 2 / metabolism; Glutamate-Ammonia Ligase / metabolism; Glutathione / metabolism; Inhalation Exposure / adverse effects; Macaca mulatta; Male; Manganese / analysis; Manganese / pharmacokinetics; Manganese Poisoning / metabolism; Manganese Poisoning / pathology; Metallothionein / metabolism; Nerve Tissue Proteins / biosynthesis; Nerve Tissue Proteins / genetics; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
The nonhuman primate brain responds to airborne Mn in a heterogeneous manner and most alterations in these biomarkers of neurotoxicity are reversible upon cessation of Mn exposure.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2008 journal article
T1250 Luminal Uptake of L-Arginine By C. Parvum Infected Porcine Ileum Is Promoted By Epithelial Induction of Arginase II and Stimulates Prostaglandin-Dependent Secretory Diarrhea
Gastroenterology, 134(4), A-515-A-516.
Sources: Crossref, NC State University Libraries
Added: February 12, 2020
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