Works Published in 2012
Displaying works 21 - 40 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Tu1855 Tritrichomonas Foetus ADHERE to Intestinal Epithelium by Sialic Acid and Cysteine Protease-Dependent Mechanisms
Gastroenterology, 142(5), S-861-S-862.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020
2012 journal article
Mo1784 The In Vivo Transcriptional Response of Intestinal Epithelium to C. Parvum Infection is Dominated by Interferon-Alpha Signaling Pathways
Gastroenterology, 142(5), S-684.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020
2012 journal article
Uropathogenic E. coli Promote a Paracellular Urothelial Barrier Defect Characterized by Altered Tight Junction Integrity, Epithelial Cell Sloughing and Cytokine Release
Journal of Comparative Pathology, 147(1), 11–19.
author keywords: cytokine; tight junction; urinary tract infection; urothelial permeability
MeSH headings : Animals; Cell Membrane Permeability / physiology; Cytokines / metabolism; Diffusion Chambers, Culture; Dogs; Electric Conductivity; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Epithelial Cells / pathology; Tight Junctions / pathology; Tight Junctions / ultrastructure; Tissue Culture Techniques; Urinary Bladder / metabolism; Urinary Bladder / microbiology; Urinary Bladder / pathology; Uropathogenic Escherichia coli / physiology; Urothelium / metabolism; Urothelium / microbiology; Urothelium / pathology
TL;DR:
A potential role for IL-15 is pointed to in UTI-induced urothelial injury after changes in both tissue ultrastructure and TER indicated that uropathogenic E. coli infection promotes a paracellular permeability defect associated with the failure of umbrella cell tight junction formation and umbrella cell sloughing.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2012 journal article
Proteasome Inhibition of Pathologic Shedding of Enterocytes to Defend Barrier Function Requires X-Linked Inhibitor of Apoptosis Protein and Nuclear Factor κB
Gastroenterology, 143(1), 133–144.e4.
author keywords: Protozoan; Intestine; Parasitic Infection; Cell Death
MeSH headings : Animals; Apoptosis; Caspase 3 / metabolism; Cryptosporidiosis / metabolism; Cryptosporidium parvum; Disease Models, Animal; Enterocytes / metabolism; Enterocytes / microbiology; Ileum / microbiology; Ileum / physiopathology; Intestinal Mucosa / metabolism; NF-kappa B / metabolism; Proteasome Endopeptidase Complex / metabolism; Signal Transduction; Swine; X-Linked Inhibitor of Apoptosis Protein / metabolism
TL;DR:
A pathway by which villus epithelial cells are maintained during C parvum infection is identified, which might be used to promote clearance of minimally invasive enteropathogens, such as by increasing the rate of migration of epithelial Cells from the crypt to the villus tip.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
2012 journal article
Anchoring hepatic gene expression with development of fibrosis and neoplasia in a toxicant-induced fish model of liver injury
Toxicologic Pathology, 1–17.
author keywords: dimethylnitrosamine; liver; fibrosis; neoplasia; medaka; Oryzias latipes; gene expression
MeSH headings : Animals; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / genetics; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Dimethylnitrosamine / toxicity; Disease Models, Animal; Female; Fish Proteins / chemistry; Fish Proteins / genetics; Fish Proteins / metabolism; Gene Expression; Immunohistochemistry; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Cirrhosis / chemically induced; Liver Cirrhosis / genetics; Liver Cirrhosis / metabolism; Liver Cirrhosis / pathology; Male; Microscopy, Electron, Transmission; Oryzias; Phenotype
TL;DR:
This study identified a group of candidate genes likely to be involved in the development of hepatic fibrosis and demonstrated that the TGF-β pathway likely plays a major role in the pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 8, 2019
2012 journal article
Safety and Efficacy of Allogeneic Cell Therapy in Infarcted Rats Transplanted With Mismatched Cardiosphere-Derived Cells
Circulation, 125(1), 100–112.
author keywords: allogeneic transplantation; paracrine communication; regeneration; stem cells
MeSH headings : Animals; Cell Survival / physiology; Cells, Cultured; Female; Graft Survival / genetics; Graft Survival / physiology; Humans; Male; Myocardial Infarction / pathology; Myocardial Infarction / surgery; Myocytes, Cardiac / pathology; Myocytes, Cardiac / physiology; Myocytes, Cardiac / transplantation; Rats; Rats, Inbred BN; Rats, Inbred WKY; Spheroids, Cellular / pathology; Spheroids, Cellular / physiology; Spheroids, Cellular / transplantation; Transplantation, Homologous; Treatment Outcome
TL;DR:
Allogeneic CDC transplantation without immunosuppression is safe, promotes cardiac regeneration, and improves heart function in a rat myocardial infarction model, mainly through stimulation of endogenous repair mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial
The Lancet, 379(9819), 895–904.
MeSH headings : Cicatrix / etiology; Cicatrix / pathology; Coronary Vessels; Female; Heart / physiopathology; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / cytology; Myocardium / pathology; Regeneration; Stem Cell Transplantation; Stroke Volume; Transplantation, Autologous; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel
Biomaterials, 33(21), 5317–5324.
author keywords: Acute myocardial infarction; Biodegradable polymers; Hyaluronan; Cardiac stem cells
MeSH headings : Animals; Apoptosis / drug effects; Cell Differentiation / drug effects; Cell Movement / drug effects; Cell Survival / drug effects; Gelatin / pharmacology; Humans; Hyaluronic Acid / pharmacology; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Male; Mice; Microscopy, Fluorescence; Myocardium / cytology; Neovascularization, Physiologic / drug effects; Polymerization / drug effects; Spheroids, Cellular / cytology; Spheroids, Cellular / drug effects; Spheroids, Cellular / transplantation; Tissue Preservation
TL;DR:
A CDC/hydrogel formulation suitable for catheter-based intramyocardial injection exhibits superior engraftment and functional benefits relative to naked CDCs.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2012 journal article
Intramyocardial Injection of Platelet Gel Promotes Endogenous Repair and Augments Cardiac Function in Rats With Myocardial Infarction
Journal of the American College of Cardiology, 59(3), 256–264.
author keywords: biomaterials; endogenous recruitment; myocardial infarction
MeSH headings : Animals; Blood Platelets; Female; Gels; Heart Function Tests / methods; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Random Allocation; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Regeneration / physiology
TL;DR:
Intramyocardial injection of autologous platelet gel ameliorated cardiac dysfunction after myocardial infarction and provided striking functional benefits, the simplicity of manufacturing, and the potentially autologueous nature of this biomaterial provide impetus for further translation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction
Biomaterials, 33(10), 2872–2879.
author keywords: Cardiac stem cells; Platelet gel; Myocardial infarction; Cardiac regeneration
MeSH headings : Animals; Blood Platelets / cytology; Blood Platelets / ultrastructure; Cell Shape; Cells, Cultured; Endothelial Cells / cytology; Gels / pharmacology; Heart Function Tests; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Regeneration; Stem Cell Transplantation
TL;DR:
Histological analysis revealed that, though some transplanted CDCs differentiated into cardiomyocytes and endothelial cells in the recipients' hearts, most of the incremental benefit arose from CDC-mediated endogenous repair, and hypothesize that pre-seeding platelet gel with CDCs can enhance therapeutic efficacy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction
Journal of Cellular and Molecular Medicine, 16(9), 2112–2116.
author keywords: cell transplantation; stem cells; cardiospheres; myocardial infarction; dose effects
MeSH headings : Acute Disease; Animals; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / pathology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Spheroids, Cellular; Stem Cell Transplantation / methods; Stem Cells / cytology; Stem Cells / metabolism; Ventricular Remodeling
TL;DR:
Functional assessment and quantitative heart morphometry indicated benefit from higher cell doses in terms of ejection fraction, infarct size and capillary density, and Histological analysis indicated that the dose‐dependent benefit was primarily because of indirect effects of transplanted cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2012 journal article
Disruption of Purkinje cell function prior to huntingtin accumulation and cell loss in an animal model of Huntington Disease
Experimental Neurology, 236(1), 171–178.
author keywords: Cerebellum; Gene expression; Motor impairment; Stereology; Glutamic acid decarboxylase 67; Calbindin; Parvalbumin; Loose patch electrophysiology
MeSH headings : Age Factors; Animals; Disease Models, Animal; Huntingtin Protein; Huntington Disease / genetics; Huntington Disease / metabolism; Huntington Disease / pathology; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phenotype; Purkinje Cells / pathology
TL;DR:
Qualitative real time PCR, Western blot analysis, and immunohistochemistry experiments suggest that early PC dysfunction potentially contributes to motor impairment in this model of HD.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2012 journal article
Developmental Alterations in Motor Coordination and Medium Spiny Neuron Markers in Mice Lacking PGC-1α
PLoS ONE, 7(8), e42878.
Ed(s): M. Coleman
MeSH headings : Animals; Biomarkers / metabolism; Chromatography, High Pressure Liquid; Corpus Striatum / metabolism; Dopamine / metabolism; Gene Expression Profiling; Huntington Disease / metabolism; Huntington Disease / physiopathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons / metabolism; Neurons / physiology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Psychomotor Performance; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Rotarod Performance Test; Trans-Activators / genetics; Trans-Activators / physiology; Transcription Factors; Transcription, Genetic
TL;DR:
It is shown that young P GC-1α −/− mice exhibit severe rotarod deficits, decreased rearing behavior, and increased occurrence of tremor in addition to the previously described hindlimb clasping, and that developmental disruption of PGC-1 α leads to long-term alterations in motor functioning.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2012 journal article
Behavioral effects of auditory stimulation on kenneled dogs
Journal of Veterinary Behavior, 7(5), 268–275.
author keywords: dog; auditory; music; kennel; welfare
Source: Crossref
Added: July 21, 2019
2012 journal article
Psychological Services for US and International Veterinary Students
Journal of Veterinary Medical Education, 39(1), 83–92.
author keywords: psychological services; counseling; student affairs; retention; mental health
MeSH headings : Australia; Canada; Caribbean Region; Counseling / methods; Counseling / statistics & numerical data; Education, Veterinary; Health Surveys; Humans; Mental Health Services / statistics & numerical data; New Zealand; Schools, Veterinary / statistics & numerical data; Student Health Services / methods; Student Health Services / statistics & numerical data; Students, Health Occupations / psychology; United Kingdom; United States; Suicide Prevention
TL;DR:
One objective of the current study was to initiate an avenue for ongoing communication between individuals involved in student counseling within each school, and suggest suggestions for increasing the accessibility of counseling services.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2012 journal article
The Internet and health information: differences in pet owners based on age, gender, and education
Journal of the Medical Library Association : JMLA, 100(3), 197–204.
MeSH headings : Age Distribution; Animal Welfare / statistics & numerical data; Animals; Community Participation / statistics & numerical data; Health Knowledge, Attitudes, Practice; Humans; Information Seeking Behavior; Information Storage and Retrieval / methods; Internet / statistics & numerical data; Sex Distribution; Social Marketing; Socioeconomic Factors; Surveys and Questionnaires; United States
TL;DR:
Results of the study suggest that closer examination of the common perception that gender, age, or education level has an effect on Internet behavior as it relates to veterinary medicine is required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2012 journal article
Three Dimensional Neuronal Cell Cultures More Accurately Model Voltage Gated Calcium Channel Functionality in Freshly Dissected Nerve Tissue
PLoS ONE, 7(9), e45074.
Ed(s): G. Cymbalyuk
MeSH headings : Animals; Calcium / metabolism; Calcium Channels / metabolism; Caveolae / physiology; Caveolin 1 / genetics; Caveolin 1 / metabolism; Cell Culture Techniques; Coated Materials, Biocompatible / chemistry; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Gene Expression; Ion Channel Gating / physiology; Lactic Acid / chemistry; Mice; Molecular Imaging; Polyesters; Polymers / chemistry; Polystyrenes / chemistry; Superior Cervical Ganglion / cytology; Superior Cervical Ganglion / metabolism; Tissue Scaffolds
TL;DR:
The results support the view that exaggerated VGCC functionality from 2D cultured SCG cells is possibly due to differences in membrane architecture, characterized by uniquely organized caveolar lipid rafts, and the practical implication of use of 3D-cultured cells in preclinical drug discovery studies would be more effective in eliminating false positive hits and as such improve the overall yield from screening campaigns.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2012 journal article
Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells
Journal of the American College of Cardiology, 59(10), 942–953.
author keywords: cardiac stem cells; mesenchymal stem cells; myocardial regeneration; paracrine effects
MeSH headings : Albumins / pharmacology; Animals; Apoptosis; Bone Marrow Cells / cytology; Cell Differentiation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; In Situ Nick-End Labeling; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mice; Mice, SCID; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Paracrine Communication / physiology; Polyesters / pharmacology; Rats; Rats, Inbred WKY; Stem Cell Transplantation; Wound Healing
TL;DR:
CDCs exhibited a balanced profile of paracrine factor production and, among various comparator cell types/subpopulations, provided the greatest functional benefit in experimental myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2012 journal article
Brief Report: Mechanism of Extravasation of Infused Stem Cells
STEM CELLS, 30(12), 2835–2842.
author keywords: Cell migration; Extravasation; Vasculature; Cell adhesion molecules; Metalloproteinases
MeSH headings : Animals; Cell Movement / physiology; Endothelium, Vascular / cytology; Endothelium, Vascular / metabolism; Female; Humans; Integrins / metabolism; MCF-7 Cells; Matrix Metalloproteinases / metabolism; Myocardium / cytology; Myocardium / metabolism; Peripheral Blood Stem Cell Transplantation / methods; Rats; Rats, Inbred WKY; Spheroids, Cellular; Stem Cells / cytology; Stem Cells / metabolism; Transplantation, Autologous
TL;DR:
In vitro models revealed that active vascular expulsion is generalizable to other stem cell types and to breast cancer cells, and Integrins and matrix metalloproteinases play critical roles in active vascular expelled.
(via Semantic Scholar)
Source: Crossref
Added: July 21, 2019
2012 journal article
A Nociceptive Signaling Role for Neuromedin B
Journal of Neuroscience, 32(25), 8686–8695.
MeSH headings : Animals; Behavior, Animal / physiology; Calcitonin Gene-Related Peptide / metabolism; Ganglia, Spinal / metabolism; Hot Temperature; Immunohistochemistry; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Microarray Analysis; Neuritis / pathology; Neurokinin B / analogs & derivatives; Neurokinin B / antagonists & inhibitors; Neurokinin B / pharmacology; Neurokinin B / physiology; Neuropeptides / biosynthesis; Nociception / physiology; Pain Measurement / drug effects; Posterior Horn Cells / physiology; Receptors, Bombesin / biosynthesis; Receptors, Bombesin / genetics; Sensory Receptor Cells / metabolism; Signal Transduction / physiology; Spinal Cord / physiology; Substance P / metabolism
TL;DR:
An array-based differential screen to uncover the expression of the neuropeptide neuromedin B (NMB) in the trigeminal ganglia of mice reveals a subset of sensory neurons that colabel with calcitonin gene-related peptide and TRPV1 suggestive of a role for NMB in nociception.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
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