Works Published in 2012
Displaying works 1 - 20 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
X-Chromosome Inactivation Pattern Analysis for the Assessment of Cell Clonality in Cats
Veterinary Pathology, 49(6), 963–970.
Contributors: H. Mochizuki* , Y. Goto-Koshino *, M. Takahashi*, Y. Fujino*, K. Ohno * & H. Tsujimoto *
MeSH headings : Animals; Biopsy, Needle / veterinary; Bone Marrow / pathology; Cat Diseases / genetics; Cat Diseases / pathology; Cats; Cell Line, Tumor; DNA / genetics; Exons / genetics; Female; Heterozygote; Male; Myelodysplastic Syndromes / genetics; Myelodysplastic Syndromes / pathology; Myelodysplastic Syndromes / veterinary; Neoplasms / genetics; Neoplasms / veterinary; Polymerase Chain Reaction / veterinary; Polymorphism, Genetic / genetics; Receptors, Androgen / genetics; Reproducibility of Results; Sensitivity and Specificity; Sequence Analysis, DNA / veterinary; Tandem Repeat Sequences / genetics; X Chromosome Inactivation / genetics
TL;DR:
The polymerase chain reaction–based feline XCIP analysis developed in this study can provide information on cell clonality in female cats, potentially facilitating the differential diagnosis of various disorders in cats.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2012 journal article
GeneScan analysis to detect clonality of T-cell receptor gamma gene rearrangement in feline lymphoid neoplasms
Veterinary Immunology and Immunopathology, 145(1-2), 402–409.
Contributors: H. Mochizuki* , K. Nakamura *, H. Sato *, Y. Goto-Koshino *, M. Sato*, M. Takahashi*, K. Fukushima*, K. Nakashima *
MeSH headings : Animals; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel / veterinary; Female; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / genetics; Heteroduplex Analysis / veterinary; Lymphocytes / immunology; Lymphocytes / metabolism; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / genetics; Lymphoma, T-Cell / immunology; Lymphoma, T-Cell / veterinary; Male; Polymerase Chain Reaction / veterinary
TL;DR:
The PCR assay system to detect clonal TCRγ gene rearrangement in feline lymphoid cells, using GeneScan analysis, would be a useful molecular diagnostic tool for feline T-cell neoplasms, with high fidelity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2012 journal article
Comparison of the antitumor effects of an MDM2 inhibitor, nutlin-3, in feline lymphoma cell lines with or without p53 mutation
Veterinary Immunology and Immunopathology, 147(3-4), 187–194.
Contributors: H. Mochizuki* , Y. Goto-Koshino *, M. Sato*, Y. Fujino*, K. Ohno * & H. Tsujimoto *
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Base Sequence; Cat Diseases / drug therapy; Cat Diseases / genetics; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; Cell Cycle Checkpoints / drug effects; Cell Line, Tumor; DNA, Neoplasm / genetics; Genes, p53; Humans; Imidazoles / pharmacology; Lymphoma / drug therapy; Lymphoma / genetics; Lymphoma / metabolism; Lymphoma / veterinary; Mutation; Piperazines / pharmacology; Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors; Tumor Suppressor Protein p53 / metabolism
TL;DR:
It is concluded that nutlin-3 has an antitumor effect on feline lymphoma cell lines harboring the wt-p53 gene through accumulation and activation of P53 leading to cell cycle arrest and apoptosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2012 journal article
Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma
Veterinary Journal, 191(1), 108–114.
Contributors: M. Sato, H. Kanemoto, Y. Kagawa, T. Kobayashi, Y. Goto-Koshino, H. Mochizuki* , M. Takahashi, Y. Fujino, K. Ohno, H. Tsujimoto
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / genetics; Dog Diseases / mortality; Dog Diseases / pathology; Dogs; Female; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / mortality; Lymphoma, B-Cell / veterinary; Male; Neoplasm Recurrence, Local / genetics; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / veterinary; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins c-bcl-6 / genetics; RNA, Messenger / analysis
TL;DR:
Most canine high-grade B-cell lymphomas correspond to human diffuse large B- cell lymphoma with no immunohistochemical expression of BCL6, according to the updated Kiel classification.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2012 journal article
Control of vertebrate intraflagellar transport by the planar cell polarity effector Fuz.
The Journal of Cell Biology.
MeSH headings : Animals; Cell Polarity / physiology; Cilia / physiology; Flagella / physiology; Humans; Protein Transport; Xenopus; Xenopus Proteins / genetics; Xenopus Proteins / physiology
TL;DR:
The planar cell polarity effector Fuz is required for normal particle dynamics of the intraflagellar transport system, specifically in the retrograde transport of proteins.
(via Semantic Scholar)
jcb.rupress.org (publisher PDF)
Source: ORCID
Added: March 23, 2022
2012 journal article
A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations
Cancer Genetics, 205(11), 572–587.
author keywords: Osteosarcoma; oligo-aCGH; canine; comparative oncology
MeSH headings : Adolescent; Adult; Algorithms; Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Child; Chromosome Aberrations; Comparative Genomic Hybridization / methods; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Genome, Human; Genomics / methods; Humans; Male; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR:
These findings support and build upon the high level of cytogenetic complexity, through the identification of shared regions of microaberration and functional analysis of possible orthologous OS-associated genes to pinpoint the cellular processes most commonly affected by aberration in human and canine OS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 14, 2021
2012 journal article
Development of a Minimum-Anesthetic-Concentration Depression Model To Study The Effects Of Various Analgesics In Goldfish (Carassius Auratus)
Journal of Zoo and Wildlife Medicine, 43(2), 214–222.
author keywords: Analgesia; Carassius auratus; goldfish; ketoprofen; morphine; tricaine methanesulfonate
MeSH headings : Aminobenzoates / administration & dosage; Aminobenzoates / pharmacology; Analgesia / veterinary; Analgesics / administration & dosage; Analgesics / pharmacology; Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Goldfish; Pain / drug therapy; Pain / veterinary
TL;DR:
Morphine and ketoprofen decrease anesthetic needs in goldfish and may provide analgesia and the fact that MAC increased over time and/or exposure may limit the usefulness of MS-222 in MAC depression studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Crossref
Added: February 12, 2021
2012 journal article
Ileocecal resection (ICR)-driven crypt fission requires intestinal epithelial IGF-1 receptor, is increased with delayed IGF-1 therapy, and results in sustained adaptive increases in body weight and intestinal length
Journal of the American College of Surgeons, 215(3), S77.
TL;DR:
Obese patients were more likely older, black or Hispanic, living in lower income neighborhoods, and using Medicaid, and more likely to undergo laparoscopic appendectomy than non-obese patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2012 chapter
Trichomoniasis
In C. E. Green (Ed.), Infectious Diseases of the Dog and Cat (4th ed., pp. 797–801). St. Louis, MO: Elsevier Saunder.
Ed(s): C. Green
Source: NC State University Libraries
Added: October 21, 2020
2012 journal article
From Mechanical Force to RhoA Activation
Biochemistry, 51(38), 7420–7432.
MeSH headings : Cell Adhesion Molecules / chemistry; Extracellular Matrix / chemistry; Focal Adhesions; Gene Expression; Humans; Neoplasms / pathology; rhoA GTP-Binding Protein / chemistry
TL;DR:
This review focuses on the pathways by which mechanical force leads to RhoA regulation, especially when force is transmitted via cell adhesion molecules that mediate either cell-matrix or cell-cell interactions.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Localized Tensional Forces on PECAM-1 Elicit a Global Mechanotransduction Response via the Integrin-RhoA Pathway
Current Biology, 22(22), 2087–2094.
MeSH headings : Animals; Biomechanical Phenomena; Cattle; Cell Adhesion / physiology; Cells, Cultured; Endothelial Cells / physiology; Gene Expression Regulation / physiology; Integrins / genetics; Integrins / metabolism; Magnetics; Mechanotransduction, Cellular / physiology; Platelet Endothelial Cell Adhesion Molecule-1 / physiology; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism
TL;DR:
This work provides the first evidence of a global signaling event in response to a localized mechanical stress, and provides a possible mechanism for the differential stiffness of vessels exposed to distinct hemodynamic force patterns in vivo.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Dielectrophoretic differentiation of mouse ovarian surface epithelial cells, macrophages, and fibroblasts using contactless dielectrophoresis
Biomicrofluidics, 6(2), 024104.
TL;DR:
It is predicted that cDEP can be utilized for isolation of ovarian cancer cells from peritoneal fluid as an early cancer detection tool.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Multilayer contactless dielectrophoresis: Theoretical considerations
ELECTROPHORESIS, 33(13), 1938–1946.
author keywords: Cancer detection; High throughput; Microfluidics; Numerical model; Rare cell isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Computer Simulation; Electric Conductivity; Electrophoresis / instrumentation; Electrophoresis / methods; Humans; Models, Theoretical; Reproducibility of Results
TL;DR:
This work investigates, for the first time, the properties of multilayer devices in which the sample and electrode channels occupy distinct layers, and concludes that the ultimate limiting factors in device performance resides in breakdown voltage of the barrier material and the ability to generate high‐voltage, high‐frequency signals.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
The Role of the Contractile Ring during Cytokinesis
Biophysical Journal, 102(3), 219a.
Source: Crossref
Added: August 28, 2020
2012 journal article
The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease
Nature Reviews Gastroenterology & Hepatology, 10(2), 90–100.
MeSH headings : Animals; Cell Membrane Permeability / physiology; Cell Proliferation; Enteric Nervous System / cytology; Enteric Nervous System / physiology; Gastrointestinal Diseases / pathology; Gastrointestinal Diseases / physiopathology; Gastrointestinal Tract / cytology; Gastrointestinal Tract / physiology; Homeostasis / physiology; Humans; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Neuroglia / cytology; Neuroglia / physiology; Neurons / cytology; Neurons / physiology; Wound Healing / physiology
TL;DR:
Findings demonstrating that the ENS is a key regulator of IEB function and is actively involved in pathologies associated with altered barrier function are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
GENERATION AND CHARACTERISATION OF INDUCED PLURIPOTENT STEM CELLS (iPSCs) FROM ADULT CANINE FIBROBLASTS
Reproduction, Fertility and Development, 24(1), 285.
TL;DR:
The isolated canine iPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF and LIF is still unknown.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Neurological impacts from inhalation of pollutants and the nose–brain connection
NeuroToxicology, 33(4), 838–841.
author keywords: Air pollution; Neurotoxicity; Olfactory tract
MeSH headings : Air Pollutants / adverse effects; Animals; Body Burden; Environmental Monitoring; Humans; Inhalation Exposure / adverse effects; Nervous System / drug effects; Nervous System / physiopathology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / physiopathology; Nose / drug effects; Nose / physiopathology; Olfactory Pathways / drug effects; Olfactory Pathways / physiopathology; Risk Assessment; Risk Factors
TL;DR:
The key available literature on nanoparticle uptake and transport through the olfactory pathway, the experimental data from animal and in vitro studies, and human epidemiological observations are reviewed to provide an increased understanding of the neurotoxicity associated with air pollution exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas
Cancer, 118(23), 5878–5887.
author keywords: angiosarcoma; p53; phosphoinositide-3-kinase; catalytic; alpha polypeptide; phosphatase and tensin homolog; complex karyotype
MeSH headings : Adult; Aged; Aged, 80 and over; Class I Phosphatidylinositol 3-Kinases; Female; Genes, p53; Genomics; Hemangiosarcoma / etiology; Hemangiosarcoma / genetics; Humans; Male; Middle Aged; Mutation; PTEN Phosphohydrolase / genetics; Phosphatidylinositol 3-Kinases / physiology; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins c-akt / physiology; Proto-Oncogene Proteins c-mdm2 / analysis; Signal Transduction / physiology; TOR Serine-Threonine Kinases / physiology
TL;DR:
The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcomA (UPS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: June 6, 2020
2012 journal article
The outdoor air pollution and brain health workshop
NeuroToxicology, 33(5), 972–984.
author keywords: Air pollution; Brain; Particulate matter; Ozone; Central nervous system; Susceptibility; Epidemiology; Neuroinflammation; Neurotoxicity; Behavior
MeSH headings : Air Pollutants / poisoning; Air Pollution / adverse effects; Brain / pathology; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / pathology; Disease Susceptibility; Encephalitis / etiology; Encephalitis / pathology; Humans; Lung Diseases / chemically induced; Lung Diseases / pathology; Neurotoxicity Syndromes / epidemiology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / pathology
TL;DR:
Recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: February 24, 2020
2012 journal article
IL-17A-mediated STAT6 Independent Mucus Production in Mice
Journal of Allergy and Clinical Immunology, 129(2), AB199.
Source: Crossref
Added: February 21, 2020
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