Works Published in 2011
Displaying works 1 - 20 of 127 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Perfusion method for harvesting bone marrow cells from dogs
American Journal of Veterinary Research, 72(10), 1344–1348. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000295390000007&KeyUID=WOS:000295390000007
Contributors: M. Sato, Y. Goto-Koshino, H. Mochizuki , Y. Fujino, K. Ohno & H. Tsujimoto
Source: ORCID
Added: May 23, 2023
2011 journal article
Multiplex PCR and Genescan analysis to detect immunoglobulin heavy chain gene rearrangement in feline B-cell neoplasms
Veterinary Immunology and Immunopathology, 143(1-2), 38–45.
Contributors: H. Mochizuki* , K. Nakamura *, H. Sato *, Y. Goto-Koshino *, M. Sato*, M. Takahashi*, Y. Fujino*, K. Ohno *
MeSH headings : Animals; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Cloning, Molecular; Complementarity Determining Regions; DNA Primers / genetics; DNA, Complementary / genetics; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Leukemia, B-Cell / genetics; Leukemia, B-Cell / immunology; Leukemia, B-Cell / veterinary; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / veterinary; Multiplex Polymerase Chain Reaction; Polymerase Chain Reaction / methods
TL;DR:
The multiplex PCR-based assay and Genescan analysis developed in the present study would be useful and practical tools to detect clonal IGHV gene rearrangement in feline B-cell neoplasms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2011 journal article
Establishment of a novel feline leukemia virus (FeLV)-negative B-cell cell line from a cat with B-cell lymphoma
Veterinary Immunology and Immunopathology, 140(3-4), 307–311.
Contributors: H. Mochizuki* , M. Takahashi*, K. Nishigaki *, T. Ide*, Y. Goto-Koshino *, S. Watanabe *, H. Sato *, M. Sato*
MeSH headings : Animals; B-Lymphocytes / immunology; B-Lymphocytes / virology; Base Sequence; Cat Diseases / genetics; Cat Diseases / immunology; Cat Diseases / virology; Cats; Cell Line, Tumor; DNA, Viral / genetics; DNA, Viral / isolation & purification; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Immunophenotyping; Leukemia Virus, Feline / genetics; Leukemia Virus, Feline / isolation & purification; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / veterinary; Lymphoma, B-Cell / virology; Male
TL;DR:
The MS4 cell line is the first FeLV-negative feline B-cell lymphoma cell line, and may be used to investigate the pathogenesis of spontaneously occurring feline lymphoma and the development of new therapies.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2011 journal article
Characterization of canine BCL6 cDNA and detection systems for its protein expression
Veterinary Immunology and Immunopathology, 140(1-2), 166–169.
Contributors: M. Sato*, Y. Goto-Koshino *, H. Kanemoto*, H. Mochizuki* , Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal; Cloning, Molecular; DNA, Complementary; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; Dogs / genetics; Dogs / immunology; Germinal Center / immunology; Immunoblotting / veterinary; Molecular Sequence Data
TL;DR:
The deduced amino acid sequence of canine BCL 6 showed close homology to that of human BCL6 (96.3%), especially in the zinc-finger motifs and POZ (poxvirus and zinc finger) domain with complete identity.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2011 journal article
A Rapid and Simple Method to Obtain Canine Peripheral Blood-Derived Macrophages
Journal of Veterinary Medical Science, 73(6), 773–778.
Contributors: Y. Goto-Koshino *, K. Ohno *, M. Nakajima*, H. Mochizuki* , H. Kanemoto* & H. Tsujimoto *
MeSH headings : Animals; Cell Culture Techniques / methods; Cell Culture Techniques / veterinary; Dogs / blood; Dogs / immunology; Flow Cytometry / veterinary; Histocytochemistry; Immunophenotyping / veterinary; Leukocytes, Mononuclear / cytology; Macrophages / cytology; Macrophages / immunology; Phagocytosis / immunology
TL;DR:
This method facilitates a high yield of macrophages in a short cultivation period compared with previous studies, and might be a powerful tool to study macrophage functions in dogs.
(via Semantic Scholar)
www.jstage.jst.go.jp (publisher PDF)
Source: ORCID
Added: May 23, 2023
2011 journal article
The genome of the green anole lizard and a comparative analysis with birds and mammals
Nature, 477(7366), 587–591.
MeSH headings : Animals; Birds / genetics; Chickens / genetics; Evolution, Molecular; GC Rich Sequence / genetics; Genome / genetics; Genomics; Humans; Lizards / genetics; Mammals / genetics; Molecular Sequence Data; Phylogeny; Synteny / genetics; X Chromosome / genetics
TL;DR:
Comparative gene analysis shows that amniote egg proteins have evolved significantly more rapidly than other proteins, and an anole phylogeny resolves basal branches to illuminate the history of their repeated adaptive radiations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Crossref
Added: August 14, 2021
2011 journal article
TRPV1 lineage neurons and their functional role in thermal nociception
Neuroscience Research, 71, e80.
TL;DR:
Findings indicate that the suppression of synaptic transmission in the reciprocal synapses in the goldfish olfactory bulb has an important role in the negative regulation of olfaction responsiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: July 30, 2021
2011 journal article
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.
PloS One.
MeSH headings : Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cells, Cultured; DNA Damage / physiology; Guanine Nucleotide Exchange Factors / metabolism; HeLa Cells; Humans; Monomeric GTP-Binding Proteins / metabolism; Oncogene Proteins / antagonists & inhibitors; Oncogene Proteins / genetics; Oncogene Proteins / metabolism; Oncogene Proteins / physiology; Protein Transport / drug effects; RNA, Small Interfering / pharmacology; Signal Transduction / drug effects; Signal Transduction / physiology; Tissue Distribution / drug effects; rhoA GTP-Binding Protein / metabolism
TL;DR:
These results demonstrate the existence of a functional Net1/RhoA signaling pathway within the nucleus of the cell and implicate them in the DNA damage response.
(via Semantic Scholar)
Source: ORCID
Added: June 25, 2021
2011 journal article
The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.
PloS One.
MeSH headings : Breast Neoplasms / genetics; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Carcinoma / genetics; Carcinoma / metabolism; Carcinoma / pathology; Cell Death / drug effects; Cell Death / genetics; Cell Line, Transformed; DNA Damage / drug effects; DNA Damage / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; Guanine Nucleotide Exchange Factors / antagonists & inhibitors; Guanine Nucleotide Exchange Factors / genetics; Guanine Nucleotide Exchange Factors / metabolism; Guanine Nucleotide Exchange Factors / physiology; HeLa Cells; Humans; Oncogene Proteins / antagonists & inhibitors; Oncogene Proteins / genetics; Oncogene Proteins / metabolism; Oncogene Proteins / physiology; Proto-Oncogene Proteins / antagonists & inhibitors; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins / physiology; RNA, Small Interfering / pharmacology; Tumor Cells, Cultured; rhoB GTP-Binding Protein / antagonists & inhibitors; rhoB GTP-Binding Protein / genetics; rhoB GTP-Binding Protein / metabolism; rhoB GTP-Binding Protein / physiology
TL;DR:
A mechanism involving the nuclear GEFs Ect2 and Net1 for activating RhoB after genotoxic stress is suggested, thereby facilitating cell death after treatment with DNA damaging agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 25, 2021
2011 journal article
The CADUCEUS (CArdiosphere-Derived aUtologous Stem CElls to Reverse ventricUlar dySfunction) Trial
Circulation, 124, 2365–2374.
Source: NC State University Libraries
Added: April 24, 2021
2011 journal article
Oxidative stress in neurodegeneration
Advances in Pharmacological Sciences, 2011, 1–13.
TL;DR:
The role of oxidative stress in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's diseases and amyotrophic lateral sclerosis is highlighted, and the role of oxidants and antioxidants causing deregulation of cyclin-dependent kinase 5 (Cdk5) hyperactivity associated with Neurodegeneration is described.
(via Semantic Scholar)
Source: Web Of Science
Added: December 28, 2020
2011 journal article
The Vinculin C-terminal Hairpin Mediates F-actin Bundle Formation, Focal Adhesion, and Cell Mechanical Properties
Journal of Biological Chemistry, 286(52), 45103–45115.
MeSH headings : Actins / genetics; Actins / metabolism; Animals; Avian Proteins / genetics; Avian Proteins / metabolism; Cells, Cultured; Chickens; Fibroblasts / cytology; Fibroblasts / metabolism; Focal Adhesions / genetics; Focal Adhesions / metabolism; Mice; Mice, Knockout; Protein Binding; Protein Multimerization / physiology; Protein Structure, Tertiary; Vinculin / genetics; Vinculin / metabolism
TL;DR:
Results from this study provide additional support for actin-induced Vt self-association and appear distinct from the dimer formed in the absence of actin, which has been proposed to induce formation of a Vt dimer that is necessary for cross-linking actin filaments.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus
Nature Protocols, 6(12), 2050–2060.
MeSH headings : Cell Fractionation / methods; Cell Nucleus / metabolism; Guanine Nucleotide Exchange Factors / analysis; Guanine Nucleotide Exchange Factors / metabolism; HEK293 Cells; Humans; Rho Guanine Nucleotide Exchange Factors; Subcellular Fractions / metabolism; rhoA GTP-Binding Protein / analysis; rhoA GTP-Binding Protein / metabolism
TL;DR:
This protocol can be also used for other Rho GTPases and Rho GEFs, which have also been found in the nucleus, and has been shown that the nuclear guanine nucleotide exchange factor (GEF) Net1 has a role in the regulation of its activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins
Nature Cell Biology, 13(6), 722–727.
MeSH headings : Animals; Cell Line; Fibroblasts / cytology; Fibroblasts / metabolism; Guanine Nucleotide Exchange Factors / genetics; Guanine Nucleotide Exchange Factors / metabolism; Integrins / metabolism; Mechanical Phenomena; Mice; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Rho Guanine Nucleotide Exchange Factors
TL;DR:
Two guanine nucleotide exchange factors, LARG and GEF-H1, are identified as key molecules that regulate the cellular adaptation to force and stimulation of integrins with tensional force triggers activation of these two GEFs and their recruitment to adhesion complexes.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Rho protein crosstalk: another social network?
Trends in Cell Biology, 21(12), 718–726.
MeSH headings : Animals; Cell Movement; Feedback, Physiological; GTPase-Activating Proteins / metabolism; Guanine Nucleotide Dissociation Inhibitors / metabolism; Guanine Nucleotide Exchange Factors / metabolism; Humans; rho GTP-Binding Proteins / metabolism; rho-Associated Kinases / metabolism
TL;DR:
The main mechanisms of Rho protein crosstalk are described, which can occur at three different levels of the pathway: (i) throughregulation of activity, (ii) through regulation of protein expression and stability, and (iii)through regulation of downstream signaling pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells
STEM CELLS, 29(11), 1829–1836.
author keywords: Akt; Adipocyte; Focal adhesion; Mechanical force
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Animals; Cells, Cultured; Focal Adhesions / metabolism; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mice; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; Stress, Mechanical
TL;DR:
It is demonstrated that reapplication of cyclic strain within a 24‐hour period leads to amplification of both Akt activation and its subsequent inhibition of GSK3β, such that total cycle number can be reduced while still inhibiting adipogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Modeling and development of a low frequency contactless dielectrophoresis (cDEP) platform to sort cancer cells from dilute whole blood samples
Biosensors and Bioelectronics, 30(1), 13–20.
author keywords: Electrokinetics; Enrichment; Selective isolation; Cancer detection; Lab on a chip
MeSH headings : Biosensing Techniques / instrumentation; Blood Component Removal / instrumentation; Cell Separation / instrumentation; Computer Simulation; Computer-Aided Design; Conductometry / instrumentation; Electrophoresis / instrumentation; Equipment Design; Equipment Failure Analysis; Microfluidic Analytical Techniques / instrumentation; Models, Theoretical; Neoplasms / pathology
TL;DR:
This work presents a continuous sorting device which is the first cDEP design capable of exploiting the Clausius-Mossotti factor at frequencies where it is both positive and negative for mammalian cells.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Contactless dielectrophoretic spectroscopy: Examination of the dielectric properties of cells found in blood
ELECTROPHORESIS, 32(22), 3164–3171.
author keywords: Cancer detection; Clausius-Mossotti factor; Dielectrophoresis; Microfluidics; Sample isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Computer Simulation; Electrophoresis / instrumentation; Humans; Neoplastic Cells, Circulating / chemistry; Spectrum Analysis / instrumentation
TL;DR:
By first establishing the dielectrophoretic responses of cancerous cells within this cDEP device, conditions to detect and enrich tumor cells from mixtures with non‐transformed cells can be determined providing further information to develop methods to isolate these rare cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Selective concentration of human cancer cells using contactless dielectrophoresis
ELECTROPHORESIS, 32(18), 2523–2529.
author keywords: Clausius-Mossotti factor; Dielectrophoresis; Enrichment; Microfluidics; Sample isolation
MeSH headings : Cell Line, Tumor; Cell Separation / instrumentation; Cell Separation / methods; Electrodes; Electrophoresis / instrumentation; Electrophoresis / methods; Humans; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Neoplasms / chemistry; Neoplasms / pathology
TL;DR:
This work is the first to demonstrate the ability of contactless dielectrophoresis (cDEP) to isolate target cell species from a heterogeneous sample of live cells and could provide a workbench for clinicians to detect transformed cells at their earliest stage, screen drug therapies prior to patient treatment, increasing the probability of success, and eliminate unsuccessful treatment options.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure
The Journal of Cell Biology, 192(2), 335–348.
MeSH headings : Actins / metabolism; Actomyosin / metabolism; Amino Acid Motifs; Animals; Cell Adhesion; Cell Adhesion Molecules / chemistry; Cell Adhesion Molecules / metabolism; Cell Movement; Cell Polarity; Drosophila Proteins / chemistry; Drosophila Proteins / metabolism; Drosophila melanogaster / embryology; Drosophila melanogaster / metabolism; Epidermal Cells; Epidermis / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Protein Structure, Tertiary; Repressor Proteins / chemistry; Repressor Proteins / metabolism
TL;DR:
Upon loss of a binding partner in apposed tissue, the homophilic cell adhesion protein Echinoid adopts a planar polarization localization, which promotes the planar polarized localization of thePlanar cell polarity protein Bazooka/Par-3 and targets actomyosin cable assembly to the epidermal leading edge, thus establishing the migration direction of the developing epidermis.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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