Works Published in 2014
Displaying works 1 - 20 of 135 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells
Research in Veterinary Science, 97(1), 60–63.
Contributors: A. Fujiwara-Igarashi *, Y. Goto-Koshino *, H. Mochizuki* , M. Sato*, Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Animals; Azacitidine / pharmacology; Base Sequence; Cell Line, Tumor; CpG Islands / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Methylation; DNA Primers / genetics; Dog Diseases / genetics; Dogs; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Genes, Tumor Suppressor; Lymphoma / genetics; Lymphoma / veterinary; Molecular Sequence Data; Promoter Regions, Genetic / genetics
TL;DR:
This study revealed the inactivation of p16 gene through hypermethylation of its CpG island in a fraction of canine lymphoid tumor cells.
(via Semantic Scholar)
Source: ORCID
Added: May 23, 2023
2014 journal article
Chronic myelogenous leukaemia with persistent neutrophilia, eosinophilia and basophilia in a cat
Journal of Feline Medicine and Surgery, 16(6), 517–521.
Contributors: H. Mochizuki* , T. Seki *, Y. Nakahara*, A. Tomita*, M. Takahashi*, Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Animals; Basophils; Cat Diseases / pathology; Cat Diseases / therapy; Cats; Eosinophilia / complications; Eosinophilia / pathology; Eosinophilia / veterinary; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / veterinary; Leukocyte Count / veterinary; Male; Remission Induction; Treatment Outcome
TL;DR:
The cat was still in good physical condition 63 months after diagnosis, despite the persistence of marked neutrophilia, eosinophilia and basophilia, and the severe leukocytosis did not respond to antibiotic therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2014 journal article
Hypermethylation of the death-associated protein kinase CpG island in canine B-cell lymphoid tumors
Veterinary Immunology and Immunopathology, 161(3-4), 222–231.
Contributors: M. Sato*, H. Mochizuki* , Y. Goto-Koshino *, A. Fujiwara-Igarashi *, M. Takahashi*, Y. Fujino*, K. Ohno *, H. Tsujimoto *
MeSH headings : Alkynes; Amino Acid Sequence; Animals; Cloning, Molecular; CpG Islands / physiology; Death-Associated Protein Kinases / genetics; Death-Associated Protein Kinases / metabolism; Dog Diseases / metabolism; Dogs; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / veterinary; Molecular Sequence Data
TL;DR:
DAPK was inactivated through hypermethylation of its CpG island in canine B-cell lymphoid tumor cells and this study will lead to the use of dogs with various lymphoid tumors as an animal model to evaluate the efficacy of demethylating agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: May 23, 2023
2014 journal article
Coordinated genomic control of ciliogenesis and cell movement by RFX2.
ELife.
MeSH headings : Animals; Cell Movement / genetics; Cilia / metabolism; Computational Biology; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Databases, Genetic; Embryo, Nonmammalian / metabolism; Epithelial Cells / metabolism; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Morphogenesis; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors / genetics; Transcription Factors / metabolism; Xenopus Proteins / genetics; Xenopus Proteins / metabolism; Xenopus laevis / embryology
TL;DR:
Rfx2 coordinates multiple, distinct gene expression programs in MCCs, regulating genes that control cell movement, ciliogenesis, and cilia function, and serves as a paradigm for understanding genomic control of cell biological processes that span from early cell morphogenetic events to terminally differentiated cellular functions.
(via Semantic Scholar)
doi.org (publisher)
Source: ORCID
Added: March 23, 2022
2014 journal article
Multiciliated cells.
Current Biology : CB.
MeSH headings : Biological Evolution; Cell Polarity; Cilia / metabolism; Eukaryota / cytology; Eukaryota / physiology; Humans; Microtubules / metabolism; Phylogeny
TL;DR:
The general phylogeny and physiology of multiciliation is reviewed and the current understanding of the developmental and cellular events underlying the specification, differentiation and function of multiciliated cells in vertebrates is detailed.
(via Semantic Scholar)
Source: ORCID
Added: March 23, 2022
2014 journal article
Two-Faced Cyclins with Eyes on the Targets
Cell Cycle.
author keywords: Clb5; hydrophobic patch; B-type cyclin; RXL; DNA replication
MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Cell Cycle / genetics; Cell Cycle / physiology; Cyclin B / chemistry; Cyclin B / genetics; Cyclin B / physiology; Cyclin-Dependent Kinases / genetics; Cyclin-Dependent Kinases / physiology; Cyclins / genetics; Cyclins / physiology; DNA Replication; Gene Expression Regulation, Fungal; Hydrophobic and Hydrophilic Interactions; Molecular Sequence Data; Origin Recognition Complex / chemistry; Origin Recognition Complex / genetics; Origin Recognition Complex / physiology; Protein Structure, Tertiary; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / physiology; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR:
The observations as well as work from other groups suggest that HP-RXL interactions are functionally important for cyclin-Cdk signaling to other targets, and the evolutionary conservation of the HP motif suggests that it allows cyclins to carry out important and specialized functions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: ORCID
Added: February 16, 2022
2014 journal article
Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.
Antioxidants & Redox Signaling.
MeSH headings : Animals; Bystander Effect / drug effects; Female; Humans; Mice; Mice, Nude; NAD(P)H Dehydrogenase (Quinone) / deficiency; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism; Naphthoquinones / pharmacology; Oxidation-Reduction / drug effects; Quinones / pharmacology; Radiation-Sensitizing Agents / pharmacology; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / metabolism; Triple Negative Breast Neoplasms / pathology; Tumor Cells, Cultured; Xenograft Model Antitumor Assays
TL;DR:
Bystander effects elicited by NQO1 bioactivatable drugs (β-lap or deoxynyboquinone [DNQ]) likely contribute to their efficacies, killing NQo1(+) solid cancer cells and eliminating surrounding heterogeneous N QO1(low) cancer cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: June 25, 2021
2014 journal article
Making heads or tails: planarian stem cells in the classroom.
Journal of Microbiology & Biology Education.
TL;DR:
A hands-on introductory laboratory module that introduces students to stem cell biology and can be easily incorporated into existing curricula is developed and implemented and piloted at the high school, community college, and university levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
14. Life Below Water
(Web of Science)
Source: ORCID
Added: June 25, 2021
2014 journal article
CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction
Journal of the American Heart Association, 3(5), 001260.
Source: NC State University Libraries
Added: April 24, 2021
2014 chapter
Hooking up with some helminths
In E. A. Stone & C. Dewey (Eds.), Sick! Curious tales of pests and parasites we share with animals (pp. 162–166). Guelph, Ontario: Ontario Veterinary College, University of Guelph.
Ed(s): E. Stone & C. Dewey
Source: NC State University Libraries
Added: October 21, 2020
2014 chapter
Update on treatment of T. foetus and Giardia infections
In J. D. Bonagura & D. C. Twedt (Eds.), Kirk's Current Veterinary Therapy XV (15th ed., p. 528). St. Louis, MO: Elsevier/Saunders.
Ed(s): J. Bonagura & D. Twedt
Source: NC State University Libraries
Added: October 21, 2020
2014 journal article
Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions
The Journal of Cell Biology, 205(2), 251–263.
MeSH headings : Cadherins / genetics; Cadherins / metabolism; Cell Adhesion / physiology; Cell Communication / physiology; Cell Line, Tumor; Extracellular Matrix / genetics; Extracellular Matrix / metabolism; Humans; Mechanotransduction, Cellular / physiology; Phosphorylation / physiology; Proto-Oncogene Proteins c-abl / genetics; Proto-Oncogene Proteins c-abl / metabolism; Vinculin / genetics; Vinculin / metabolism
TL;DR:
Vinculin phosphorylation on residue Y822 is necessary for cell stiffening in response to tension on cadherins but not integrins.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells
Nature Communications, 5(1).
MeSH headings : Animals; Aorta / cytology; Aorta / enzymology; Aorta / metabolism; Aorta / physiology; Cyclic AMP-Dependent Protein Kinases / metabolism; Endothelium, Vascular / cytology; Endothelium, Vascular / enzymology; Endothelium, Vascular / metabolism; Endothelium, Vascular / physiology; Extracellular Matrix / enzymology; Extracellular Matrix / metabolism; Extracellular Matrix / physiology; Focal Adhesions; Hemodynamics; Male; Mice; Mice, Inbred C57BL; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; rhoA GTP-Binding Protein / metabolism
TL;DR:
It is shown that the interaction of extracellular matrix proteins with adhesion molecules on the endothelial cell surface determines cellular stiffness and sensitivity to mechanical forces.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
In-vitro bipolar nano- and microsecond electro-pulse bursts for irreversible electroporation therapies
Bioelectrochemistry, 100, 69–79.
author keywords: High frequency; Cancer; Non-thermal; Ablation
MeSH headings : Animals; Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Electric Stimulation Therapy / adverse effects; Electric Stimulation Therapy / methods; Electroporation / methods; Mice; Models, Biological; Nuclear Envelope; Time Factors
TL;DR:
It is shown that these bursts result in instantaneous and delayed cell death mechanisms and that there exists an inverse relationship between pulse-width and toxicity despite the delivery of equal quantities of energy.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Mechanism of Cytokinetic Contractile Ring Constriction in Fission Yeast
Developmental Cell, 29(5), 547–561.
MeSH headings : Actin Cytoskeleton / metabolism; Actomyosin / metabolism; Computer Simulation; Cytokinesis / physiology; Myosin Type II / metabolism; Polymerization; Schizosaccharomyces / cytology; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
TL;DR:
Computer simulations based on the amounts and biochemical properties of the key proteins showed that they spontaneously self-organize into a tension-generating bundle, revealing that the ring operates close to conditions of isometric tension.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Experimental Measurement and Simulations of the Cytokinetic Ring Tension in Fission Yeast
Biophysical Journal, 106(2), 177a.
TL;DR:
The first measurements of contractile ring tension in fission yeast are reported, using micropipette aspiration of protoplast cell membranes and optical microscopy analysis of membrane deformation by the tense ring as it constricts.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Enteric Glial Cells: Recent Developments and Future Directions
Gastroenterology, 147(6), 1230–1237.
author keywords: Enteric Nervous System; Intestinal Epithelial Barrier; Enteric Neuron
MeSH headings : Enteric Nervous System / cytology; Homeostasis; Humans; Intestinal Diseases / pathology; Intestinal Mucosa / cytology; Intestinal Mucosa / innervation; Neuroglia / cytology
TL;DR:
Emerging concepts as to how EGCs regulate neuromediator expression, exert neuroprotective roles, and even act as neuronal as well as glial progenitors in the enteric nervous system are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus
Nature Cell Biology, 16(4), 376–381.
MeSH headings : Cell Line; Cell Nucleus / genetics; Cell Nucleus / physiology; Chromatin / metabolism; Cytoskeletal Proteins; Cytoskeleton / metabolism; DNA / metabolism; Focal Adhesion Kinase 1 / antagonists & inhibitors; HeLa Cells; Histone Deacetylase Inhibitors / pharmacology; Humans; Hydroxamic Acids / pharmacology; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Mechanotransduction, Cellular / physiology; Membrane Proteins / genetics; Membrane Proteins / metabolism; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / metabolism; Nerve Tissue Proteins / metabolism; Nuclear Lamina / physiology; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phosphorylation; Proto-Oncogene Proteins c-abl / antagonists & inhibitors; RNA Interference; RNA, Small Interfering; Stress, Mechanical
TL;DR:
The results demonstrate that mechanotransduction is not restricted to cell surface receptors and adhesions but can occur in the nucleus, and applying force on nesprin-1 triggers nuclear stiffening that does not involve chromatin or nuclear actin, but requires an intact nuclear lamina and emerin, a protein of the inner nuclear membrane.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells
STEM CELLS, 32(9), 2397–2406.
author keywords: Cardiosphere-derived cells; Cardiomyocyte; Proliferation; Paracrine factors; Cell-cell communication; beta 1 integrin
MeSH headings : Animals; Cell Communication / physiology; Cell Differentiation / physiology; Cells, Cultured; Humans; Integrin beta1 / metabolism; Male; Mice; Mice, SCID; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats
TL;DR:
The hypothesis that cell‐cell contact plays a role in mediating the observed therapeutic benefits of CDCs, above and beyond conventional paracrine effects, is tested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
5 DISRUPTION OF THE HIGH MOBILITY GROUP AT-HOOK 2 (HMGA2) GENE IN SWINE REDUCES POSTNATAL GROWTH
Reproduction, Fertility and Development, 26(1), 117.
TL;DR:
The approach described here will result in a valuable large-animal model of dwarfism, but also in a tool to reduce the size of existing transgenic and nontransgenic swine lines, which will increase the receptivity of valuable transgenic lines by the biomedical community.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
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