Works Published in 2020
Displaying works 1 - 20 of 131 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs
Science Translational Medicine, 12(538).
MeSH headings : Animals; Cell- and Tissue-Based Therapy; Extracellular Matrix; Heart; Myocardial Infarction / therapy; Myocardium; Rats; Swine
TL;DR:
The artCP is a clinically feasible, easy-to-store, and cell-free alternative to myocardial repair using cell-based cardiac patches and supported cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 22, 2023
2020 journal article
Delivery of mscs with a hybrid β-sheet peptide hydrogel consisting igf-1c domain and d-form peptide for acute kidney injury therapy
International Journal of Nanomedicine, 15, 4311–4324.
Contributors: H. Wang *, Y. Shang *, X. Chen*, Z. Wang*, D. Zhu* , Y. Liu *, C. Zhang *, P. Chen *
MeSH headings : Acute Kidney Injury / drug therapy; Acute Kidney Injury / physiopathology; Animals; Biocompatible Materials / chemistry; Cell Survival; Female; Fibrosis; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Hydrogels / chemical synthesis; Hydrogels / chemistry; Insulin-Like Growth Factor I / chemistry; Kidney / pathology; Kidney / physiopathology; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells / cytology; Mice, Transgenic; Neovascularization, Physiologic; Peptides / chemistry; Placenta / cytology; Pregnancy; Protein Conformation, beta-Strand; Protein Domains
TL;DR:
By covalently linking the desired functional groups to D-form peptides to create functional hydrogels, self-assembling β-sheet peptidehydrogels may serve as a promising platform for tissue-engineering and stem cell therapy.
(via Semantic Scholar)
Source: ORCID
Added: April 19, 2023
2020 journal article
Multifunctional natural polymer nanoparticles as antifibrotic gene carriers for CKD therapy
Journal of the American Society of Nephrology, 31(10), 2292–2311.
Contributors: A. Midgley *, Y. Wei*, D. Zhu* , F. Gao*, H. Yan *, A. Khalique*, W. Luo *, H. Jiang *
MeSH headings : Animals; Antifibrinolytic Agents / administration & dosage; Bone Morphogenetic Protein 7 / genetics; Cell Culture Techniques; Chitosan; Disease Models, Animal; Gene Transfer Techniques; Hepatocyte Growth Factor / genetics; Hyaluronic Acid; Mice; Multifunctional Nanoparticles; Polymers; Renal Insufficiency, Chronic / therapy
TL;DR:
Nanoparticle delivery of HGF/NK1 conveyed potent antifibrotic and proregenerative effects in vivo and provided the proof of concept on which to base future investigations for enhanced targeting and transfection of therapeutic genes to kidney tissues, and an avenue toward treatment of CKD.
(via Semantic Scholar)
Source: ORCID
Added: April 19, 2023
2020 journal article
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice
Behavioural Brain Research, 379.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Antiparkinson Agents / administration & dosage; Antiparkinson Agents / pharmacology; Apoptosis / drug effects; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Inflammation / drug therapy; Levodopa; Male; Mice; Mice, Inbred BALB C; Nerve Degeneration / drug therapy; Parkinson Disease / drug therapy; Parkinsonian Disorders / drug therapy; Sesquiterpenes / administration & dosage; Sesquiterpenes / analysis; Sesquiterpenes / pharmacology
TL;DR:
The effects of the co-administration of ACT001 and l-DOPA were equivalent to those of the administration of 8 mg/kg l-dOPA in MPTP-induced Parkinson's disease in mice, suggesting that l- DOPA + ACT001 may be used for the treatment of PD.
(via Semantic Scholar)
Source: ORCID
Added: April 19, 2023
2020 journal article
Effects of 17β-trenbolone exposure on sex hormone synthesis and social behaviours in adolescent mice
Chemosphere, 245.
MeSH headings : Animals; Anxiety / chemically induced; Avoidance Learning / drug effects; Endocrine Disruptors / pharmacology; Gonadal Steroid Hormones / biosynthesis; Male; Mice; Myelin Sheath / drug effects; Oligodendroglia / drug effects; Social Behavior; Trenbolone Acetate / pharmacology
TL;DR:
Exposure to 17β-TBOH during puberty increased anxiety-like behaviours and affected testicular development and endogenous androgen synthesis in male mice, and the inhibition of the secretion of endogenous hormones and decrease in the formation of the myelin sheath in mPFC may be associated with the 17 β-T BOH-induced behavioural changes in mice.
(via Semantic Scholar)
Source: ORCID
Added: April 19, 2023
2020 journal article
Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair
ACS Nano, 14(9), 12133–12147.
Contributors: C. Zhang *, Y. Shang *, X. Chen*, A. Midgley *, Z. Wang*, D. Zhu* , J. Wu *, P. Chen *
MeSH headings : Animals; Arginine; Aspartic Acid; Extracellular Vesicles; Glycine; Kidney; Mice; Nanofibers; Oligopeptides
TL;DR:
An RGD-scaffold was developed to increase the EV integrin-mediated loading and in-turn improved therapeutic efficacy in renal repair, therefore this strategy shed light on MSC-EVs application as cell-free treatment for potentiated efficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 19, 2023
2020 journal article
Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice
Behavioural Brain Research, 383.
Contributors: Q. Liu *, X. Guo *, Z. Huang *, Q. He*, D. Zhu* , S. Zhang*, Z. Peng*, Y. Che*, X. Feng
MeSH headings : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal / drug effects; Catalase / drug effects; Catalase / metabolism; Circadian Rhythm / drug effects; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Corpus Striatum / pathology; Cytokines / drug effects; Cytokines / metabolism; Dopaminergic Neurons / drug effects; Dopaminergic Neurons / metabolism; Dopaminergic Neurons / pathology; Inflammasomes / drug effects; Inflammasomes / metabolism; Inflammation / metabolism; Inflammation / physiopathology; Malondialdehyde / metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein / drug effects; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidative Stress / drug effects; Parkinsonian Disorders / metabolism; Parkinsonian Disorders / physiopathology; Sesquiterpenes, Guaiane / pharmacology; Substantia Nigra / drug effects; Substantia Nigra / metabolism; Substantia Nigra / pathology; Superoxide Dismutase / drug effects; Superoxide Dismutase / metabolism; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
The study showed that ACT001 alleviates NLRP3-mediated neuroinflammation in PD mice induced by MPTP, and attenuates microglial activation in the nigrostriatal pathway.
(via Semantic Scholar)
Source: ORCID
Added: April 19, 2023
2020 journal article
Targeted Repair of Vascular Injury by Adipose-Derived Stem Cells Modified with P-Selectin Binding Peptide
Advanced Science, 7(11).
Contributors: H. Yan *, X. Mi*, A. Midgley *, X. Du *, Z. Huang *, T. Wei *, R. Liu *, T. Ma*
TL;DR:
Overall, DPP‐ADSCs promote vascular repair, inhibit neointimal hyperplasia, increase endothelium functionality, and maintain normal VSMCs alignment, supporting preclinical noninvasive utilization of D PP‐AD SCs for vascular injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: April 19, 2023
2020 journal article
Exosome and Biomimetic Nanoparticle Therapies for Cardiac Regenerative Medicine
Current Stem Cell Research & Therapy, 15(8), 674–684.
author keywords: Exosomes; regenerative medicine; biomimetic nanoparticles; drug delivery; extracellular vesicles; mesenchymal stem cells; secretome
MeSH headings : Biomimetics; Exosomes; Heart Diseases / therapy; Nanoparticles; Regenerative Medicine; Reproducibility of Results
TL;DR:
Current research on exosome therapeutics and the application of biomimetic nanoparticles in cardiac regenerative medicine, as well as applications for exosomes expansion and delivery on a larger and more clinical scale are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 8, 2022
2020 journal article
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
ELife, 9.
MeSH headings : Animals; Brain / embryology; Cell Shape; Hedgehog Proteins / metabolism; Hedgehog Proteins / physiology; Mice; Mice, Inbred C57BL; Neural Crest / embryology; Neural Tube / embryology; Neural Tube / growth & development
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 23, 2022
2020 article
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
Brooks, E. R., Islam, M. T., Anderson, K. V., & Zallen, J. A. (2020, October 13). (Vol. 10). Vol. 10.
TL;DR:
Results reveal a morphogenetic program of patterned apical constriction governed by Shh signaling that generates structural changes in the developing mammalian brain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 23, 2022
2020 article
Using Metacognitive Strategies to Improve Academic Performance in Biochemistry
Miller, H. B., & Srougi, M. C. (2020, July 9). (Vol. 7). Vol. 7.
TL;DR:
Although students’ mindsets did not change as a result of metacognitive interventions, their positive perceptions about learning vs performance did increase and students receiving growth mindset interventions significantly outperformed students who did not receive interventions on the final cumulative exam that assessed critical thinking skills.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: ORCID
Added: June 25, 2021
2020 article
Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma
Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.
TL;DR:
The data suggests that genomic instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 8, 2021
2020 article
A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans
LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.
TL;DR:
This work exemplifies the type of approach meant to further establish the comparative relevance of canine to human cancer and provide opportunities to explore hypotheses related to detection and treatment in both species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: March 8, 2021
2020 journal article
Extrahepatic biliary tract obstruction secondary to a diaphragmatic rent in a dog
VETERINARY RECORD CASE REPORTS, 8(2).
TL;DR:
A 13-month-old intact female Akita was referred to a specialty hospital with suspected pancreatitis and exploratory coeliotomy identified a right dorsolateral diaphragmatic rent with pyloric, proximal duodenal, right pancreatic and associated omental entrapment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021
2020 article
Emergent functions of cyclin-dependent kinase 4 regulating aurora b and cenpp transcription
Lee, S. H., Rodriguez, L. R., Marval, P. L. M., & Rodriguez-Puebla, M. L. (2020, August). CANCER RESEARCH, Vol. 80.
Source: Web Of Science
Added: March 8, 2021
2020 journal article
Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases
Science Advances, 6(19).
Contributors: R. Zhang *, W. Luo *, Y. Zhang *, D. Zhu* , A. Midgley *, H. Song *, A. Khalique*, H. Zhang *
TL;DR:
A particle-based artificial stem cell spheroid (ASSP) technology is introduced that recapitulates paracrine functions of three-dimensional (3D) SSPs for vasculature regeneration and addresses issues faced by the bottlenecked development in the delivery of stem cell therapies.
(via Semantic Scholar)
Source: ORCID
Added: March 6, 2021
2020 journal article
Evaluation of repeated dosing of a dexmedetomidine oromucosal gel for treatment of noise aversion in dogs over a series of noise events
VETERINARY RECORD, 187(12).
MeSH headings : Animals; Anti-Anxiety Agents / administration & dosage; Anti-Anxiety Agents / therapeutic use; Anxiety / drug therapy; Behavior, Animal / drug effects; Cost of Illness; Dexmedetomidine / administration & dosage; Dexmedetomidine / therapeutic use; Dogs / psychology; Fear / drug effects; Female; Gels; Humans; Male; Noise / adverse effects; Surveys and Questionnaires
TL;DR:
Repeated use of dexmedetomidine gel for noise events resulted in decreased need for administration and overall burden of care was manageable, yet many owners agreed with statements regarding frustration, stress, guilt, guilt and sadness about their dog’s condition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 1, 2021
2020 journal article
PREVALENCE OF THE ABCB1-1 Delta GENE IN NONDOMESTIC SPECIES OF THE CANIDAE FAMILY
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 51(4), 1007–1011.
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics; Animals; Animals, Zoo; Canidae / genetics; Mutation
TL;DR:
Evaluating Canidae species ABCB1-1Δ gene mutation status allows for safe and effective therapeutic treatment of nondomestic animals, ensuring any anticipated adverse drug events are prevented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 8, 2021
2020 journal article
PHARMACOKINETICS OF A SINGLE DOSE OF FLURALANER ADMINISTERED ORALLY TO AMERICAN BLACK BEARS (URSUS AMERICANUS)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 51(3), 691–695.
MeSH headings : Acaricides / pharmacokinetics; Administration, Oral; Animals; Half-Life; Isoxazoles / pharmacokinetics; Plasma / chemistry; Ursidae / blood
TL;DR:
Administration of a single oral dose of fluralaner may be a viable treatment option for captive and free-ranging black bears affected by mange and it was estimated that the average drug withdrawal time is approximately 64–72 days in this species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021
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