Works Published in 2014
Displaying works 41 - 60 of 135 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Annotation of long non-coding RNAs expressed in Collaborative Cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts
RNA Biology, 11(7), 875–890.
author keywords: long non-coding rna; influenza virus; sars-cov; rna-seq; interferon; collaborative cross
MeSH headings : Animals; Antiviral Agents / administration & dosage; Antiviral Agents / pharmacology; Cell Line; Female; Gene Expression Profiling; Gene Expression Regulation / drug effects; Influenza A virus / drug effects; Influenza A virus / physiology; Interferon-alpha / administration & dosage; Interferon-alpha / pharmacology; Lung / metabolism; Lung / virology; Mice; Mice, Inbred C57BL; Molecular Sequence Annotation; RNA Virus Infections / drug therapy; RNA Virus Infections / genetics; RNA Virus Infections / virology; RNA, Long Noncoding / genetics; Severe acute respiratory syndrome-related coronavirus / drug effects; Severe acute respiratory syndrome-related coronavirus / physiology; Sequence Analysis, RNA
TL;DR:
A broad categorization of potential lncRNA functions is provided and subsets of lncRNAs with likely key roles in respiratory virus pathogenesis are identified.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2014 journal article
Deep Transcriptional Sequencing of Mucosal Challenge Compartment from Rhesus Macaques Acutely Infected with Simian Immunodeficiency Virus Implicates Loss of Cell Adhesion Preceding Immune Activation
Journal of Virology, 88(14), 7962–7972.
Ed(s): G. Silvestri
MeSH headings : Animals; B-Lymphocytes / immunology; Cell Adhesion; Claudins / metabolism; Cytoskeleton / metabolism; Gene Expression Profiling; Host-Pathogen Interactions; Intestinal Mucosa / immunology; Intestinal Mucosa / physiology; Intestinal Mucosa / virology; Killer Cells, Natural / immunology; Macaca mulatta; Male; Rectum / immunology; Rectum / virology; Simian Immunodeficiency Virus / immunology; T-Lymphocytes / immunology; Time Factors
TL;DR:
During acute infection, a significant host response was mounted in the mucosa before inflammation was triggered, and the response has a detrimental effect on tissue integrity, causing increased permeability, tissue damage, and recruitment of SIV target cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2014 journal article
Deep Sequencing of HIV-Infected Cells: Insights into Nascent Transcription and Host-Directed Therapy
Journal of Virology, 88(16), 8768–8782.
MeSH headings : CD4-Positive T-Lymphocytes / virology; Cell Line; Gene Expression Profiling / methods; Gene Expression Regulation / genetics; HIV Infections / genetics; HIV Infections / virology; HIV-1 / genetics; High-Throughput Nucleotide Sequencing / methods; Humans; RNA / genetics; RNA, Messenger / genetics; Transcription, Genetic / genetics; Virus Replication / genetics
TL;DR:
Mass sequencing is used to identify genes differentially expressed in CD4+ T cells during HIV-1 infection and shows that it is possible to identify candidate drugs for host-directed therapy against HIV/AIDS using the genomics-based approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2014 journal article
Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset
PLoS Pathogens, 10(8), e1004250.
Ed(s): M. Denison
MeSH headings : Animals; Callithrix; Coronavirus Infections / pathology; Coronavirus Infections / virology; Disease Models, Animal; Immunohistochemistry; Male; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral / pathology; Pneumonia, Viral / virology; Real-Time Polymerase Chain Reaction
TL;DR:
This is the first description of a severe, partially lethal, disease model of MERS-CoV, and as such will have a major impact on the ability to assess the efficacy of vaccines and treatment strategies as well as allowing more detailed pathogenesis studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2014 journal article
Assessment and improvement of Indian-origin rhesus macaque and Mauritian-origin cynomolgus macaque genome annotations using deep transcriptome sequencing data
Journal of Medical Primatology, 43(5), 317–328.
author keywords: intergenic transcripts; non-coding RNA; non-polyadenylated RNA; RNAseq
MeSH headings : Animals; Ebolavirus / physiology; Hemorrhagic Fever, Ebola / genetics; Hemorrhagic Fever, Ebola / virology; High-Throughput Nucleotide Sequencing; India; Macaca fascicularis; Macaca mulatta; Mauritius; Molecular Sequence Data; Monkey Diseases / genetics; Monkey Diseases / virology; RNA, Untranslated / genetics; RNA, Untranslated / metabolism; Sequence Analysis, RNA; Simian Acquired Immunodeficiency Syndrome / genetics; Simian Acquired Immunodeficiency Syndrome / virology; Simian Immunodeficiency Virus / physiology; Transcriptome
TL;DR:
The genome annotations of rhesus ( Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques, two of the most common non‐human primate animal models, are limited.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2014 journal article
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease
Nature Biotechnology, 32(12), 1250–1255.
MeSH headings : Animals; Base Sequence; Chromosome Mapping; Disease Models, Animal; Ferrets / genetics; Genome; High-Throughput Nucleotide Sequencing; Humans; Influenza, Human / genetics; Influenza, Human / transmission; Influenza, Human / virology; Molecular Sequence Annotation; Molecular Sequence Data; Orthomyxoviridae / genetics; Orthomyxoviridae / pathogenicity; Sequence Analysis, DNA
TL;DR:
It is shown that transcriptional changes in the CFTR-knockout ferret lung reflect pathways of early disease that cannot be readily studied in human infants with cystic fibrosis disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019
2014 journal article
Tissue-specific transcriptome sequencing analysis expands the non-human primate reference transcriptome resource (NHPRTR)
Nucleic Acids Research, 43(D1), D737–D742.
MeSH headings : Animals; Databases, Genetic; Gene Expression Profiling; Internet; Macaca; Molecular Sequence Annotation; Organ Specificity; Primates / genetics; Reference Standards; Sequence Alignment / standards; Sequence Analysis, RNA
TL;DR:
A major expansion of NHPRTR is described by adding 10.1 billion fragments of tissue-specific RNA-seq data, such that 88% of the reads align to human reference sequences, allowing the full list of expression abundance across all tissues for each species to be computed.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2014 journal article
Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion.
Journal of Controlled Release : Official Journal of the Controlled Release Society.
author keywords: Lipid emulsion; Local anesthetic; Bupivacaine; Triglyceride; Antidote; Biodetoxification
MeSH headings : Animals; Bupivacaine / pharmacokinetics; Bupivacaine / toxicity; Cardiac Output / drug effects; Cardiotonic Agents / administration & dosage; Cardiotonic Agents / pharmacology; Cardiotonic Agents / therapeutic use; Cardiotoxicity / drug therapy; Cardiotoxicity / metabolism; Cardiotoxicity / physiopathology; Cardiotoxins / pharmacokinetics; Cardiotoxins / toxicity; Emulsions / administration & dosage; Emulsions / pharmacology; Emulsions / therapeutic use; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Myocardium / metabolism; Phospholipids / administration & dosage; Phospholipids / pharmacology; Phospholipids / therapeutic use; Rats; Soybean Oil / administration & dosage; Soybean Oil / pharmacology; Soybean Oil / therapeutic use; Triglycerides / administration & dosage; Triglycerides / pharmacology; Triglycerides / therapeutic use
TL;DR:
An integrated mechanism of reversal of bupivacaine toxicity that includes both transient drug scavenging and a cardiotonic effect that couple to accelerate movement of the toxin away from sites of toxicity is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 18, 2019
2014 journal article
Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect.
Anesthesiology, 120(4), 915–925.
Contributors: M. Fettiplace *, B. Akpa* , R. Ripper*, B. Zider*, J. Lang*, I. Rubinstein *, G. Weinberg*
MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotonic Agents / therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Fat Emulsions, Intravenous / therapeutic use; Heart / drug effects; Heart / physiopathology; Heart Arrest / chemically induced; Heart Arrest / therapy; Heart Rate / drug effects; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Resuscitation / methods; Sodium Chloride / administration & dosage; Time Factors; Treatment Outcome
TL;DR:
Intravenous lipid emulsion accelerates cardiovascular recovery from bupivacaine toxicity in a dose-dependent manner, which is driven by a cardiotonic response that complements the previously reported sequestration effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 18, 2019
2014 journal article
Neutralization of Mitochondrial Superoxide by Superoxide Dismutase 2 Promotes Bacterial Clearance and Regulates Phagocyte Numbers in Zebrafish
Infection and Immunity, 83(1), 430–440.
Ed(s): B. McCormick
MeSH headings : Animals; Immunity, Innate; Leukocyte Count; Macrophages / enzymology; Macrophages / immunology; Mitochondria / enzymology; Mitochondria / metabolism; Pseudomonas aeruginosa / immunology; Superoxide Dismutase / metabolism; Superoxides / metabolism; Zebrafish
TL;DR:
The roles of SOD2 and mitochondrial ROS regulation in the zebrafish innate immune response to P. aeruginosa infection are described and the use of mitochondrion-targeted ROS scavengers as potential adjuvant therapies during severe infections is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref
Added: May 17, 2019
2014 journal article
Pharmacokinetic-pharmacodynamic values for amoxicillin in pigs
American Journal of Veterinary Research, 75(4), 316.
MeSH headings : Amoxicillin / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Bacterial Infections / veterinary; Monte Carlo Method; Swine / blood; Swine Diseases / drug therapy
Sources: NC State University Libraries, NC State University Libraries
Added: April 14, 2019
2014 journal article
Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases)
Veterinary Dermatology, 25(3), 163–175.
Source: NC State University Libraries
Added: April 13, 2019
2014 chapter
Respiratory drug therapy
In J. D. Bonagura & D. C. Twedt (Eds.), Kirk’s Current Veterinary Therapy XV (pp. 622–628). Saunders-Elsevier.
Ed(s): J. Bonagura & D. Twedt
Source: NC State University Libraries
Added: April 5, 2019
2014 chapter
Consulting Editor, Appendix I, Table of Common Drugs: Approximate Dosages
In J. D. Bonagura & D. C. Twedt (Eds.), Kirk’s Current Veterinary Therapy XV (pp. 1307–1335). Saunders- Elsevier.
Ed(s): J. Bonagura & D. Twedt
Source: NC State University Libraries
Added: April 5, 2019
2014 journal article
Response to letter from J Mottet “Comments on the ISCAID Guidelines on the use of antimicrobial therapies in canine superficial bacterial folliculitis”
Response to letter from J Mottet “Comments on the ISCAID Guidelines on the use of antimicrobial therapies in canine superficial bacterial folliculitis.” Veterinary Dermatology, 25(6), 567–568.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Dog Diseases / diagnosis; Folliculitis / veterinary; Skin Diseases, Bacterial / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: March 2, 2019
2014 journal article
Implantation of an ultrafiltration device in the ileum and spiral colon of steers to continuously collect intestinal fluid
Research in Veterinary Science, 97(3), 611–615.
author keywords: Bovine; Gastrointestinal fluid; Surgery; Ultrafiltration
MeSH headings : Animals; Body Fluids; Cattle; Colon / surgery; Ileum / surgery; Intestinal Secretions; Specimen Handling / methods; Specimen Handling / veterinary; Ultrafiltration / instrumentation
TL;DR:
Use of ultrafiltration probes is a novel, consistent and humane method to repeatedly sample the gastrointestinal contents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: March 2, 2019
2014 chapter
Antiprotozoal Drugs
In Canine and Feline Infectious Diseases (pp. 97–104).
Sources: Crossref, NC State University Libraries
Added: February 27, 2019
2014 chapter
Antifungal Drugs
In Canine and Feline Infectious Diseases (pp. 87–96).
Sources: Crossref, NC State University Libraries
Added: February 27, 2019
2014 chapter
Antibacterial Drugs
In Canine and Feline Infectious Diseases (pp. 66–86).
Sources: Crossref, NC State University Libraries
Added: February 27, 2019
2014 chapter
Antiviral and Immunomodulatory Drugs
In Canine and Feline Infectious Diseases (pp. 54–65).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 27, 2019
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