Works Published in 2014
Displaying works 201 - 215 of 215 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma
PIGMENT CELL & MELANOMA RESEARCH, 27(1).
author keywords: melanoma; animal model; comparative study; clinical trial design; image analysis; digital telepathology; signal transduction
MeSH headings : Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Humans; MAP Kinase Signaling System / genetics; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Melanoma / veterinary; Mouth Neoplasms / genetics; Mouth Neoplasms / metabolism; Mouth Neoplasms / pathology; Mouth Neoplasms / veterinary; Neoplasm Metastasis; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / veterinary
TL;DR:
There is significant overlap in the clinical and histopathological features of canine and human mucosal melanomas, which represents opportunity to explore canine oral cavity melanoma as a preclinical model.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 306(3), L269–L276.
author keywords: cigarette smoking; epithelial cells; antiprotease
MeSH headings : Adult; Animals; Epithelial Cells / metabolism; Female; Humans; Leukocyte Elastase / antagonists & inhibitors; Lung / metabolism; Male; Mice; Nasal Lavage Fluid; Nasal Mucosa / metabolism; STAT1 Transcription Factor / biosynthesis; Secretory Leukocyte Peptidase Inhibitor / biosynthesis; Smoking / genetics
TL;DR:
It is demonstrated that smoking enhances expression of SLPI in NECs in vitro and in vivo, and that this response is regulated by STAT1, and antiprotease activity against neutrophil elastase is enhanced in smokers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Novel Avian Coronavirus and Fulminating Disease in Guinea Fowl, France
EMERGING INFECTIOUS DISEASES, 20(1), 105–108.
MeSH headings : Animals; Bird Diseases / epidemiology; Coronavirus / classification; Coronavirus / genetics; Coronavirus Infections / veterinary; France / epidemiology; Galliformes / virology; Genome, Viral; Genotype; Molecular Sequence Data; Molecular Typing; Phylogeny; Spike Glycoprotein, Coronavirus / genetics
TL;DR:
A novel avian gammacoronavirus associated with fulminating enteritis of unclear origin is identified that is distantly related to turkey coronaviruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Effects of pentoxifylline on immediate and late-phase cutaneous reactions in response to anti-immunoglobulin E antibodies in clinically normal dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(2), 152–160.
MeSH headings : Administration, Cutaneous; Animals; Antibodies, Anti-Idiotypic / adverse effects; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dogs; Free Radical Scavengers / therapeutic use; Immunoglobulin E / immunology; Inflammation / drug therapy; Inflammation / veterinary; Injections, Intradermal / veterinary; Intradermal Tests / veterinary; Pentoxifylline / therapeutic use; Skin Diseases / chemically induced; Skin Diseases / drug therapy; Skin Diseases / veterinary; Skin Tests / veterinary
TL;DR:
In clinically normal dogs, pentoxifylline effectively impaired late-phase reactions but not immediate reactions at sites of intradermal injection of IgE-specific antibodies by inhibiting mast cell degranulation and recruitment of cutaneous inflammatory cells, especially eosinophils.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 personal communication
Effects of excess dietary fructose on liver pathology study have significant methodologic limitations: Reply
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(4), 1312–1319.
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / chemistry; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Apoptosis / drug effects; Caspase 3 / metabolism; Cell Proliferation / drug effects; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation / drug effects; HL-60 Cells; Humans; Hydrazones / chemistry; Hydrazones / pharmacology; Lymphoma / drug therapy; Lymphoma / pathology; Mice; Mice, Inbred C57BL; Molecular Structure; Piperazines / chemistry; Piperazines / pharmacology; Structure-Activity Relationship; Tumor Cells, Cultured
TL;DR:
The data suggest the potential of PAC-1/1541B combinations for the treatment of cancer and demonstrate that differentially acting enzyme activators can potently synergize to give a significantly heightened biological effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Comparing Real-Time and Conventional PCR to Culture-Based Methods for Detecting and Quantifying Escherichia coli O157 in Cattle Feces
JOURNAL OF FOOD PROTECTION, 77(2), 314–319.
MeSH headings : Animals; Bacterial Shedding; Cattle; Colony Count, Microbial; DNA, Bacterial / genetics; Escherichia coli O157 / genetics; Escherichia coli O157 / isolation & purification; Escherichia coli Proteins / genetics; Feces / microbiology; Immunomagnetic Separation / methods; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / standards; Real-Time Polymerase Chain Reaction / methods; Real-Time Polymerase Chain Reaction / standards; Sensitivity and Specificity; Shiga Toxin 1 / genetics; Shiga Toxin 2 / genetics
TL;DR:
It is suggested that mqPCR and conventional PCR are most useful in identifying high shedder animals and may not be an appropriate substitute to culture-based methods for detection of E. coli O157 in cattle feces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Tetracycline Residues in Porcine Stomach after Administration via Drinking Water on a Swine Farm
JOURNAL OF FOOD PROTECTION, 77(1), 122–126.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Europe; Meat / analysis; Monte Carlo Method; Russia; Stomach / chemistry; Swine; Tetracycline / blood; Tetracycline / pharmacokinetics; United States; Water / chemistry
TL;DR:
It is demonstrated that tetracycline residues are still detectable in the stomach tissues after the established United States withdrawal time of 4 days, which may explain why stomach tissues tested in Russia and Europe show positive residues for tetrACYcline, even though the meat may pass inspection here in the United States prior to export.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Plasma and pulmonary pharmacokinetics of desfuroylceftiofur acetamide after weekly administration of ceftiofur crystalline free acid to adult horses
EQUINE VETERINARY JOURNAL, 46(2), 252–255.
author keywords: Excede; cephalosporin; horse; ceftiofur
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cephalosporins / administration & dosage; Cephalosporins / blood; Cephalosporins / metabolism; Cephalosporins / pharmacokinetics; Drug Administration Schedule; Female; Half-Life; Horses / blood; Horses / metabolism; Lung / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 article
Pathology in Practice Diagnosis and case summary: LGL lymphoma in a cat
Meichner, K., Palerme, J.-S., & Neel, J. A. (2014, January 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 244, pp. 167–169.
Contributors: K. Meichner n, J. Palerme* & J. Neel*
MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / pathology; Cats; Female; Lymphoma / classification; Lymphoma / pathology; Lymphoma / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Lentivirus-Activated T Regulatory Cells Suppress T Helper Cell Interleukin-2 Production by Inhibiting Nuclear Factor of Activated T Cells 2 Binding to the Interleukin-2 Promoter
AIDS RESEARCH AND HUMAN RETROVIRUSES, 30(1), 58–66.
MeSH headings : Amino Acid Sequence; Animals; Cats; Cell Proliferation; Cells, Cultured; Coculture Techniques; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / biosynthesis; Interleukin-2 / genetics; Lentivirus Infections / immunology; Lentivirus Infections / pathology; Lentivirus Infections / virology; Lymph Nodes / cytology; Lymph Nodes / virology; Lymphocyte Activation / immunology; Molecular Sequence Data; NFATC Transcription Factors / antagonists & inhibitors; NFATC Transcription Factors / genetics; Promoter Regions, Genetic / immunology; Protein Binding / immunology; RNA, Messenger / biosynthesis; Receptors, Transforming Growth Factor beta / biosynthesis; Sequence Alignment; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / virology; Transforming Growth Factor beta / biosynthesis; Transforming Growth Factor beta / pharmacology; Up-Regulation
TL;DR:
Data suggest that TGF-β-mediated Treg cell suppression of IL-2 transcription is modulated through alterations in NFAT2 binding to the IL-1 promoter in suppressed Th cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Development and evaluation of aptamer magnetic capture assay in conjunction with real-time PCR for detection of Campylobacter jejuni
LWT-FOOD SCIENCE AND TECHNOLOGY, 56(2), 256–260.
author keywords: Aptamer; Aptamer magnetic capture; Campylobacter jejuni; Real-time PCR; Pathogen detection
TL;DR:
A prototype method for the concentration and detection of Campylobacter jejuni was developed using a previously reported biotinylated DNA aptamer in conjunction with qPCR, and nucleic acid aptamers are promising alternatives to antibodies for magnetic bead-based capture followed byqPCR detection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Submicrometre particle filtration with a dc activated plasma textile
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 47(2).
author keywords: non-thermal plasmas; filtration; corona discharge; plasma textile
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
NFIL3-Deficient Mice Develop Microbiota-Dependent, IL-12/23-Driven Spontaneous Colitis
JOURNAL OF IMMUNOLOGY, 192(4), 1918–1927.
MeSH headings : Adoptive Transfer; Animals; Arabidopsis Proteins / biosynthesis; Basic-Leucine Zipper Transcription Factors / genetics; Basic-Leucine Zipper Transcription Factors / metabolism; Cells, Cultured; Colon / immunology; Colon / pathology; Genetic Predisposition to Disease; Inflammatory Bowel Diseases / genetics; Inflammatory Bowel Diseases / microbiology; Interleukin-10 / genetics; Interleukin-12 Subunit p40 / genetics; Interleukin-12 Subunit p40 / metabolism; Interleukin-23 Subunit p19 / genetics; Interleukin-23 Subunit p19 / metabolism; Membrane Proteins / biosynthesis; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota / immunology; Th1 Cells / immunology; Th17 Cells / immunology; Tumor Necrosis Factor-alpha / genetics
TL;DR:
NFIL3 is a microbiota-dependent, IL-10–independent regulator of mucosal homeostasis via IL-12p40 via NFIL3, and was abrogated in Nfil3/Il12b double-deficient mice, identifying Il12b dysregulation as a central pathogenic event.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Evaluation of fluorescence in situ hybridization for the detection of bacteria in feline inflammatory liver disease
JOURNAL OF FELINE MEDICINE AND SURGERY, 16(2), 109–117.
MeSH headings : Animals; Bacteria / isolation & purification; Case-Control Studies; Cat Diseases / diagnosis; Cat Diseases / microbiology; Cats; Female; In Situ Hybridization, Fluorescence / methods; In Situ Hybridization, Fluorescence / veterinary; Inflammation / microbiology; Inflammation / veterinary; Liver / microbiology; Liver / pathology; Liver Diseases / microbiology; Liver Diseases / veterinary; Male; Retrospective Studies
TL;DR:
The distribution of bacteria within the liver supports the possibility of colonization via either enteric translocation or hematogenous seeding and suggests a role in etiopathogenesis of feline inflammatory liver disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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