Works Published in 2012
Displaying all 8 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
The interface of protein structure, protein biophysics, and molecular evolution
Protein Science, 21(6), 769–785.
author keywords: evolutionary modeling; domain evolution; sequence-structure-function relationships; protein dynamics; protein thermodynamics; gene duplication; protein expression; ancestral sequence reconstruction
MeSH headings : Amino Acid Sequence; Animals; Evolution, Molecular; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Folding; Proteins / chemistry; Proteins / genetics; RNA, Messenger / genetics; Sequence Alignment
TL;DR:
The relationship between modeling and needed high‐throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 chapter
Composite Interval Mapping and Multiple Interval Mapping: Procedures and Guidelines for Using Windows QTL Cartographer
In Methods in Molecular Biology (pp. 75–119).
MeSH headings : Animals; Drosophila melanogaster / genetics; Inbreeding; Models, Statistical; Quantitative Trait Loci / genetics; Software
TL;DR:
This chapter provides an introduction of composite interval mapping and multiple interval mapping methods for mapping QTL from inbred line crosses and also detailed instructions to perform the analyses in Windows QTL Cartographer.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2012 journal article
Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment
PLoS ONE, 7(7), e38386.
Ed(s): M. Oresic
MeSH headings : Adult; Amino Acids, Essential / blood; Biomarkers, Pharmacological / blood; Cholesterol, LDL / blood; Citrulline / blood; Cystine / blood; Female; Fructose / blood; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Lauric Acids / blood; Male; Metabolomics; Nitric Oxide Synthase / blood; Ornithine / blood; Simvastatin / pharmacology; Simvastatin / therapeutic use; Stearic Acids / blood; Succinic Acid / blood; Xanthine / blood; alpha-Tocopherol / blood
TL;DR:
The findings from this study indicate that clusters of metabolites involved in multiple pathways not directly connected with cholesterol metabolism may play a role in modulating the response to simvastatin treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2012 journal article
Multiple trait multiple interval mapping of quantitative trait loci from inbred line crosses
BMC Genetics, 13.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Cerebrospinal Fluid Metabolome in Mood Disorders-Remission State has a Unique Metabolic Profile
Scientific Reports, 2(1).
MeSH headings : Adult; Biogenic Monoamines / cerebrospinal fluid; Biosynthetic Pathways; Case-Control Studies; Depressive Disorder, Major / cerebrospinal fluid; Female; Humans; Male; Metabolome; Middle Aged; Multivariate Analysis; Remission, Spontaneous; Severity of Illness Index
TL;DR:
The reductions in metabolites associated with tryptophan and tyrosine pathways in rMDD may relate to the vulnerability this population shows for developing depressive symptoms under tryPTophan or catecholamine depletion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018
2012 review
The interface of protein structure, protein biophysics, and molecular evolution
[Review of ]. Protein Science, 21(6), 769–785.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Merging pharmacometabolomics with pharmacogenomics using ‘1000 Genomes’ single-nucleotide polymorphism imputation
Pharmacogenetics and Genomics, 22(4), 247–253.
author keywords: 1000 Genomes; HapMap; imputation; major depressive disorder; pharmacometabolomics; pharmacogenomics; selective serotonin reuptake inhibitors; tag single-nucleotide polymorphisms
MeSH headings : Citalopram / adverse effects; Citalopram / therapeutic use; Depressive Disorder / drug therapy; Depressive Disorder / genetics; Genome-Wide Association Study / methods; Glycine / biosynthesis; Glycine / genetics; Glycine / metabolism; Glycine Dehydrogenase / genetics; HapMap Project; Haplotypes; Humans; Metabolic Networks and Pathways / genetics; Metabolomics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Selective Serotonin Reuptake Inhibitors / metabolism
TL;DR:
The results indicate that the use of GWAS data to impute SNPs for genes in pathways identified by other ‘omics’ approaches makes it possible to rapidly and cost efficiently identify SNP markers to ‘broaden’ and accelerate pharmacogenomic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 journal article
A predictive model for Efavirenz dosing
Pharmacogenomics, 13(2), 137–138.
Source: NC State University Libraries
Added: August 6, 2018
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