Bioinformatics Research Center

Recent Works

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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2025 journal article

Experimental Evolution of Phytophthora infestans on Tomato Reveals Rapid Genotypic and Phenotypic Adaptation and Dynamic RXLR Genome Variation

Phytopathology®.

topics (OpenAlex): Plant Pathogens and Resistance; Plant Disease Resistance and Genetics; Plant-Microbe Interactions and Immunity
Source: ORCID
Added: July 31, 2025

2025 article

Genomic Evaluation of Canine Prostatic Carcinomas as a Model for the Human Disease

Thomas, R., Luff, J. A., Dickey, A. N., Dillon, M. N., Livingston, I. G., Schrag, C. A., … Breen, M. (2025, July 23). VETERINARY AND COMPARATIVE ONCOLOGY.

By: R. Thomas n, J. Luff n, A. Dickey n, M. Dillon n, I. Livingston n, C. Schrag n, S. Suter n, M. Breen n

author keywords: adenocarcinoma; DNA copy number variations; dogs; mutation; prostatic neoplasms; urologic neoplasms
topics (OpenAlex): Veterinary Oncology Research; Veterinary Medicine and Surgery; Human-Animal Interaction Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 28, 2025

2025 journal article

Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae

ISCIENCE, 28(7).

By: Y. Cai n, G. Leitz-Najarian*, R. Rosen n, K. Hutson*, A. Moatti n, C. Li n, D. Fitzpatrick*, A. Greenbaum n

topics (OpenAlex): Hearing Loss and Rehabilitation; Hearing, Cochlea, Tinnitus, Genetics; Structural Health Monitoring Techniques
Source: Web Of Science
Added: July 28, 2025

2025 journal article

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits

GENOME RESEARCH, 35(7), 1485–1502.

MeSH headings : Humans; Quantitative Trait Loci; Liver / metabolism; Chromatin / genetics; Chromatin / metabolism; Genome-Wide Association Study; Gene Expression Regulation; Transcription Factors / metabolism; Binding Sites; Polymorphism, Single Nucleotide
topics (OpenAlex): Epigenetics and DNA Methylation; Genomics and Chromatin Dynamics; Genetics and Neurodevelopmental Disorders
Source: Web Of Science
Added: July 21, 2025

2025 journal article

Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice☆

TOXICOLOGY AND APPLIED PHARMACOLOGY, 502.

co-author countries: Canada 🇨🇦
author keywords: Mice; MASH; Liver Pathology; Transcriptomics; Machine Leaning Pathologist Assistance
MeSH headings : Animals; Male; Female; Mice; Disease Models, Animal; Diet, High-Fat / adverse effects; Liver / pathology; Liver / metabolism; Transcriptome; Gene Expression Profiling / methods; Collaborative Cross Mice; Fatty Liver / genetics; Fatty Liver / pathology; Fatty Liver / metabolism; Non-alcoholic Fatty Liver Disease / genetics; Non-alcoholic Fatty Liver Disease / pathology
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Endoplasmic Reticulum Stress and Disease; Hepatocellular Carcinoma Treatment and Prognosis
Source: Web Of Science
Added: July 21, 2025

2025 journal article

Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in<i> Drosophila</i> blastoderm embryos

ISCIENCE, 28(7).

By: A. Schloop n, S. Hiremath n, R. Shaikh*, A. Bhakta*, C. Williams n, G. Reeves*, A. Schloop, S. Hiremath ...

topics (OpenAlex): Botanical Research and Applications; Neurobiology and Insect Physiology Research; Bioactive natural compounds
Sources: Web Of Science, NC State University Libraries
Added: July 21, 2025

2025 journal article

NIAGADS: A data repository for Alzheimer's disease and related dementia genomics

ALZHEIMERS & DEMENTIA, 21(6).

By: A. Kuzma*, O. Valladares*, E. Greenfest-Allen*, H. Nicaretta*, M. Kirsch*, Y. Ren*, Z. Katanic*, H. White* ...

author keywords: Alzheimer's disease; Alzheimer's disease and related dementias; Alzheimer's Disease Sequencing Project; bioinformatics; data repository; dementia; genetics; genomics; National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site; open access; qualified access; sequencing
MeSH headings : Humans; Alzheimer Disease / genetics; Genomics; United States; Databases, Genetic; National Institute on Aging (U.S.); Dementia / genetics; Genome-Wide Association Study; Information Dissemination
topics (OpenAlex): Genomics and Rare Diseases; Bioinformatics and Genomic Networks; Epigenetics and DNA Methylation
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 journal article

Structural variation detection and association analysis of whole-genome-sequence data from 16,543 Alzheimer's disease sequencing project subjects

ALZHEIMERS & DEMENTIA, 21(6).

By: H. Wang*, B. Dombroski*, P. Cheng*, A. Tucci n, Y. Si n, J. Farrell*, J. Tzeng n, Y. Leung* ...

author keywords: Alzheimer's disease; copy number variation; NCK2; RNA5SP293; structural variation
MeSH headings : Humans; Alzheimer Disease / genetics; Whole Genome Sequencing; Genetic Predisposition to Disease / genetics; LDL-Receptor Related Proteins / genetics; ATP-Binding Cassette Transporters / genetics; Membrane Transport Proteins / genetics; Male; Polymorphism, Single Nucleotide; Female; Linkage Disequilibrium; Amyloid beta-Protein Precursor / genetics; Genome-Wide Association Study
topics (OpenAlex): Genomics and Rare Diseases; RNA Research and Splicing; Genetic Associations and Epidemiology
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Guidelines for preventing and reporting contamination in low-biomass microbiome studies

Fierer, N., Leung, P. M., Lappan, R., Eisenhofer, R., Ricci, F., Holland, S. I., … Greening, C. (2025, June 20). NATURE MICROBIOLOGY, Vol. 6.

co-author countries: Australia 🇦🇺 Canada 🇨🇦 Chile 🇨🇱 China 🇨🇳 Germany 🇩🇪 Denmark 🇩🇰 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Japan 🇯🇵 Singapore 🇸🇬 South Africa 🇿🇦
topics (OpenAlex): Gut microbiota and health; Molecular Biology Techniques and Applications; Microbial Community Ecology and Physiology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 30, 2025

2025 article

Knowledge and Opportunities for Managing Plant-Parasitic Nematodes Using Decision Intelligence

Roberts, D. L., Gorny, A., Jones, D. S., Kudenov, M. W., Pratt, L., Malcolm, N., & Williams, C. (2025, June 18). PHYTOFRONTIERS, Vol. 6.

By: D. Roberts n, A. Gorny n, D. Jones n, M. Kudenov n, L. Pratt, N. Malcolm, C. Williams n

author keywords: data science; decision; decision intelligence; modelling; nematodes
topics (OpenAlex): Statistical Methods and Applications; Technology Adoption and User Behaviour
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 30, 2025

2025 journal article

Optimization of Adventitious Shoot Regeneration Protocols for Six<i> Vaccinium corymbosum </i>Cultivars

HORTSCIENCE, 60(7), 1109–1117.

By: F. Kelso n, K. Da n, R. Dewey n, D. Reiland n, C. Almeyda n, W. Liu n, H. Ashrafi n

author keywords: blueberry; genotype-independent regeneration; tissue culture recalcitrance; 2iP; zeatin
topics (OpenAlex): Plant tissue culture and regeneration; Plant Pathogens and Fungal Diseases; Berry genetics and cultivation research
Sources: Web Of Science, NC State University Libraries
Added: June 30, 2025

2025 journal article

Asian diversity in human immune cells

CELL, 188(8).

By: K. Kock*, L. Tan*, K. Han*, Y. Ando*, D. Jevapatarakul*, A. Chatterjee, Q. Lin*, E. Buyamin* ...

co-author countries: India 🇮🇳 Italy 🇮🇹 Japan 🇯🇵 Korea (Republic of) 🇰🇷 Singapore 🇸🇬 Thailand 🇹🇭
MeSH headings : Humans; Asian People / genetics; Single-Cell Analysis; Female; Male; Genetic Variation; Asia; Adult; Middle Aged
topics (OpenAlex): Immune Cell Function and Interaction; Immune responses and vaccinations; T-cell and B-cell Immunology
Source: Web Of Science
Added: May 27, 2025

2025 journal article

The integration of quantitative trait locus mapping and transcriptome studies reveals candidate genes for water stress response in St. Augustinegrass

BMC PLANT BIOLOGY, 25(1).

author keywords: QTL mapping; Transcriptome; Drought stress; St. Augustinegrass
MeSH headings : Quantitative Trait Loci / genetics; Chromosome Mapping; Transcriptome; Droughts; Genes, Plant; Gene Expression Profiling; Polymorphism, Single Nucleotide; Stress, Physiological / genetics; Genotype
topics (OpenAlex): Turfgrass Adaptation and Management; Plant and Fungal Interactions Research; Plant Disease Resistance and Genetics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 27, 2025

2025 journal article

A Class of Allopolyploidy Showing High Duplicate Retention and Continued Homoeologous Exchanges

GENOME BIOLOGY AND EVOLUTION, 17(4).

By: A. Coppage n, E. Bhatnagar n, M. Joshi n, M. Siddiqui n, L. McRae n & G. Conant n

author keywords: polyploidy; ohnolog retention; evolutionary model
MeSH headings : Polyploidy; Evolution, Molecular; Gene Conversion; Gene Duplication; Genome, Plant; Models, Genetic
topics (OpenAlex): Chromosomal and Genetic Variations; Genomics and Phylogenetic Studies; Evolution and Genetic Dynamics
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 14, 2025

2025 article

A theory of heterosis

Zeng, Z.-B., Gesteira, G. D. S., Mo, L., Xiao, Y., & Yan, J. (2025, April 8). GENETICS.

By: Z. Zeng n, G. Gesteira n, L. Mo n, Y. Xiao* & J. Yan*

co-author countries: China 🇨🇳
author keywords: heterosis; quantitative genetic model; dominance; epistasis; model selection; hybrid breeding; Plant Genetics and Genomics
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Genetic and phenotypic traits in livestock; Genetics and Plant Breeding
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: April 14, 2025

2025 article

A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets

Tsai, H.-H. D., Oware, K. D., Wright, F. A., Chiu, W. A., & Rusyn, I. (2025, April 3). TOXICOLOGICAL SCIENCES.

author keywords: transcriptomics; key characteristics; gene set enrichment; gene expression
topics (OpenAlex): Computational Drug Discovery Methods; Carcinogens and Genotoxicity Assessment; Gene expression and cancer classification
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 14, 2025

2025 journal article

Identification of late blight resistance QTLs <i>in an interspecific RIL population of tomato </i>via genotyping-by-sequencing

MOLECULAR BREEDING, 45(4).

author keywords: Disease resistance; Genotyping-by-sequencing; <italic>Phytophthora infestans</italic>; QTL mapping; Recombinant inbred line; SNP; <italic>Solanum lycopersicum</italic>; <italic>Solanum pimpinellifolium</italic>
topics (OpenAlex): Plant Pathogens and Resistance; Plant Disease Resistance and Genetics; Plant Pathogens and Fungal Diseases
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 8, 2025

2025 article

Co-occurrence drives horizontal gene transfer among marine prokaryotes

Douglas, G. M., Tromas, N., Gaudin, M., Lypaczewksi, P., Bobay, L.-M., Shapiro, B. J., & Chaffron, S. (2025, March 28).

By: G. Douglas, N. Tromas, M. Gaudin, P. Lypaczewksi, L. Bobay*, B. Shapiro, S. Chaffron

topics (OpenAlex): Microbial Community Ecology and Physiology; Bacteriophages and microbial interactions; Polar Research and Ecology
Source: ORCID
Added: April 1, 2025

2025 article

Development of ferret immune repertoire reference resources and single-cell-based high-throughput profiling assays

Walsh, E. S., Yang, K., Tollison, T. S., Seenu, S., Adams, N., Zeitoun, G., … Peng, X. (2025, March 21). JOURNAL OF VIROLOGY, Vol. 3.

By: E. Walsh n, K. Yang*, T. Tollison n, S. Seenu*, N. Adams n, G. Zeitoun*, I. Sideri*, G. Folch* ...

co-author countries: France 🇫🇷
author keywords: ferret; immune repertoire; reference resource development; VDJ annotation; single-cell sequencing; repertoire profiling
MeSH headings : Animals; Ferrets / immunology; Ferrets / genetics; Single-Cell Analysis / methods; Receptors, Antigen, T-Cell / genetics; Receptors, Antigen, T-Cell / immunology; High-Throughput Nucleotide Sequencing; Transcriptome; Lymph Nodes / immunology; Gene Expression Profiling; Spleen / immunology; Spleen / cytology
topics (OpenAlex): Single-cell and spatial transcriptomics; T-cell and B-cell Immunology; Immune Cell Function and Interaction
Sources: Web Of Science, NC State University Libraries
Added: March 31, 2025

2025 article

Human long noncoding RNA <i>VILMIR</i> is induced by major respiratory viral infections and modulates the host interferon response

John, K., Huntress, I., Smith, E., Chou, H., Tollison, T. S., Covarrubias, S., … Peng, X. (2025, March 25). (T. Gallagher, Ed.). JOURNAL OF VIROLOGY, Vol. 3.

Ed(s): T. Gallagher

author keywords: interferon; lncRNA; influenza; SARS-CoV-2; RSV; ISG; RNA-seq
MeSH headings : Humans; RNA, Long Noncoding / genetics; RNA, Long Noncoding / metabolism; A549 Cells; Interferon-beta / pharmacology; SARS-CoV-2 / immunology; COVID-19 / genetics; COVID-19 / immunology; COVID-19 / virology; Influenza, Human / genetics; Influenza, Human / immunology; Influenza, Human / virology; Influenza A virus / immunology; Respiratory Syncytial Virus Infections / genetics; Respiratory Syncytial Virus Infections / immunology; Respiratory Syncytial Virus Infections / virology; Epithelial Cells / virology; Interferons; Host-Pathogen Interactions; Cell Line
topics (OpenAlex): Cancer-related molecular mechanisms research; RNA modifications and cancer; interferon and immune responses
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 25, 2025

2025 journal article

Diagnostic-avoiding <i>Chlamydia trachomatis</i> variants detected in cervical and endometrial specimens from women during 16S microbiome profiling

BMC INFECTIOUS DISEASES, 25(1).

By: S. Jeong n, T. Tollison n, H. Brochu n, H. Chou n, T. Yu*, P. Baghaie*, K. Yount*, T. Darville* ...

author keywords: NAAT; Chlamydia; Gonorrhea; Microbiome; 16S rRNA; False negative; 23S
MeSH headings : Humans; Female; Chlamydia trachomatis / genetics; Chlamydia trachomatis / isolation & purification; Chlamydia Infections / diagnosis; Chlamydia Infections / microbiology; RNA, Ribosomal, 16S / genetics; Cervix Uteri / microbiology; Microbiota / genetics; Adult; DNA, Bacterial / genetics; Endometrium / microbiology; Gonorrhea / diagnosis; Gonorrhea / microbiology; RNA, Ribosomal, 23S / genetics; Neisseria gonorrhoeae / genetics; Neisseria gonorrhoeae / isolation & purification; Young Adult; Pennsylvania
topics (OpenAlex): Reproductive tract infections research; Syphilis Diagnosis and Treatment; Cervical Cancer and HPV Research
Sources: Web Of Science, NC State University Libraries
Added: March 24, 2025

2025 article

Genetic control of prickles in tetraploid blackberry

Johns, C. A., Silva, A., Chizk, T. M., Nelson, L., Clark, J. R., Aryal, R., … Worthington, M. L. (2025, April 23). (E. Akhunov, Ed.). G3-GENES GENOMES GENETICS, Vol. 3.

By: C. Johns*, A. Silva*, T. Chizk*, L. Nelson*, J. Clark*, R. Aryal n, H. Ashrafi n, E. Thompson*, M. Hardigan*, M. Worthington*

Ed(s): E. Akhunov

author keywords: Rubus subgenus Rubus; thorns; GWAS; KASP; marker-assisted selection; autopolyploid; bramble; caneberry
topics (OpenAlex): Berry genetics and cultivation research; Plant Disease Management Techniques; Fungal Plant Pathogen Control
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 20, 2025

2025 article

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells

Wang, H., Chang, T. S., Dombroski, B. A., Cheng, P.-L., Si, Y.-Q., Tucci, A., … Grp, P. S. P. G. S. (2025, March 8). MOVEMENT DISORDERS, Vol. 3.

co-author countries: Australia 🇦🇺 Belgium 🇧🇪 Canada 🇨🇦 Cyprus 🇨🇾 Germany 🇩🇪 Spain 🇪🇸 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Greece 🇬🇷 Netherlands 🇳🇱
author keywords: progressive supranuclear palsy; H1 and H2 haplotypes; 17q21.31; copy number variations; single-cell gene expression
topics (OpenAlex): Genomic variations and chromosomal abnormalities; Genetics and Neurodevelopmental Disorders; RNA regulation and disease
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 12, 2025

2025 journal article

A high sensitivity assay of UBE3A ubiquitin ligase activity

METHODS, 235, 92–99.

By: L. Han n, Z. Yagci n & A. Keung n

author keywords: Biochemical assay; Neurodevelopmental disorder; Therapeutic endpoint; Biomarker; Angelman Syndrome; Autism Spectrum Disorder; Dup15q Syndrome
MeSH headings : Ubiquitin-Protein Ligases / metabolism; Ubiquitin-Protein Ligases / genetics; Humans; Tumor Suppressor Protein p53 / metabolism; Tumor Suppressor Protein p53 / genetics; Ubiquitination; Animals; Mice; Substrate Specificity; Enzyme Assays / methods
topics (OpenAlex): Ubiquitin and proteasome pathways; Protein Degradation and Inhibitors; Genetics and Neurodevelopmental Disorders
Sources: Web Of Science, NC State University Libraries
Added: March 3, 2025

2025 article

Connected Chromatin Amplifies Acetylation-Modulated Nucleosome Interactions

Li, R., & Lin, X. (2025, March 3). BIOCHEMISTRY, Vol. 3.

By: R. Li n & X. Lin n

co-author countries: Japan 🇯🇵
MeSH headings : Nucleosomes / metabolism; Nucleosomes / chemistry; Acetylation; Histones / metabolism; Histones / chemistry; Chromatin / metabolism; Chromatin / chemistry; Protein Processing, Post-Translational; DNA / metabolism; DNA / chemistry; Molecular Dynamics Simulation; Humans; Chromatin Assembly and Disassembly
topics (OpenAlex): Genomics and Chromatin Dynamics; RNA Research and Splicing; DNA and Nucleic Acid Chemistry
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 3, 2025

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