Works Published in 2009
Displaying works 41 - 60 of 118 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Heterocyclic aromatic amine pesticide use and human cancer risk: Results from the U.S. Agricultural Health Study
International Journal of Cancer, 124(5), 1206–1212.
Contributors: S. Koutras, C. Lynch *, M. Xiaomei *, J. Won *, J. Hoppin* , C. Christensen*, G. Andreotti *, L. Freeman*
author keywords: pesticides; bladder; colon; occupational exposures
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / chemically induced; Colonic Neoplasms / chemically induced; Female; Herbicides / adverse effects; Humans; Male; Middle Aged; Nicotinic Acids / adverse effects; Occupational Exposure / adverse effects; Risk Factors; Urinary Bladder Neoplasms / chemically induced
TL;DR:
Exposure to aromatic amine pesticides may be an overlooked exposure in the etiology of bladder and colon cancer and the use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans.
(via Semantic Scholar)
europepmc.org (repository)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Cancer Incidence among Pesticide Applicators Exposed to Permethrin in the Agricultural Health Study
Environmental Health Perspectives, 117(4), 581–586.
Contributors: J. Rusiecki *, R. Patel*, S. Koutros *, L. Beane-Freeman *, O. Landgren *, M. Bonner *, J. Coble*, J. Lubin*
author keywords: agriculture; cancer; multiple myeloma; occupation; permethrin; pesticide applicator; pesticides; pyrethroid
MeSH headings : Adult; Female; Humans; Incidence; Insecticides; Iowa / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / statistics & numerical data; Permethrin
TL;DR:
This study found no association with most cancers analyzed, but found elevated and statistically significant risks for multiple myeloma in the highest tertiles of both lifetime exposure-days and intensity-weighted lifetime exposure days.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Occupational Exposure to Metribuzin and the Incidence of Cancer in the Agricultural Health Study
Annals of Epidemiology, 19(6), 388–395.
Contributors: J. Delancey *, M. Alavanja*, J. Coble*, A. Blair*, J. Hoppin* , H. Austin*, L. Beane Freeman*
author keywords: Pesticides; Cancer; Occupation; Metribuzin; Agricultural Health Study
MeSH headings : Adult; Aged; Agriculture; Carcinogens / toxicity; Cohort Studies; Female; Hematologic Neoplasms / epidemiology; Herbicides / toxicity; Humans; Iowa / epidemiology; Leukemia / epidemiology; Lymphoma / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / analysis; Risk Factors; Surveys and Questionnaires; Triazines / toxicity
TL;DR:
A potential association between metribuzin use and certain lymphohematopoietic malignancies is suggested, however, having not been observed previously, caution should be used in interpretation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa)
International Journal of Hygiene and Environmental Health, 212(5), 481–491.
Contributors: X. Ye*, F. Pierik*, J. Angerer*, H. Meltzer *, V. Jaddoe*, H. Tiemeier *, J. Hoppin* , M. Longnecker*
author keywords: Organophosphate (OP) pesticides; Bisphenol A (BPA); Phthalates; Biological monitoring; Environmental exposure
MeSH headings : Adolescent; Adult; Benzhydryl Compounds; Cohort Studies; Environmental Exposure / analysis; Female; Humans; Middle Aged; Norway; Organophosphates / urine; Pesticides / urine; Phenols / urine; Phthalic Acids / urine; Pregnancy
TL;DR:
The higher levels of metabolites in the MoBa participants may have been from intake via pesticide residues in food, consumption of canned food, especially fish/seafood (BPA), and use of personal care products (selected phthalates).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Pesticide Exposure and Hypertensive Disorders During Pregnancy
Environmental Health Perspectives, 117(9), 1393–1396.
Contributors: T. Saldana*, O. Basso, D. Baírd, J. Hoppin* , C. Weinberg *, A. Blair*, M. Alavanja*, D. Sandler
author keywords: pesticide exposure; preeclampsia; pregnancy-induced hypertension
MeSH headings : Adolescent; Adult; Environmental Exposure; Female; Humans; Hypertension / chemically induced; Hypertension / complications; Middle Aged; Pesticides / toxicity; Pregnancy; Pregnancy Complications, Cardiovascular / chemically induced
TL;DR:
Exposure to pesticides during pregnancy may increase the risk of hypertensive disorders of pregnancy, including pregnancy-induced hypertension (PIH) and preeclampsia (PE).
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Pesticides and Myocardial Infarction Incidence and Mortality Among Male Pesticide Applicators in the Agricultural Health Study
American Journal of Epidemiology, 170(7), 892–900.
Contributors: K. Mills *, A. Blair*, L. Freeman, D. Sandler * & J. Hoppin*
author keywords: agriculture; cardiovascular diseases; myocardial infarction; occupational exposure; pesticides
MeSH headings : Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / mortality; Follow-Up Studies; Humans; Incidence; Iowa / epidemiology; Male; Middle Aged; Myocardial Infarction / chemically induced; Myocardial Infarction / epidemiology; Myocardial Infarction / mortality; North Carolina / epidemiology; Pesticides / adverse effects; Proportional Hazards Models; Risk
TL;DR:
In a population with low risk for myocardial infarction, the authors observed little evidence of increased risk of myocardioinfarction mortality or nonfatal myocardia infarctions associated with the occupational use of pesticides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Rhinitis associated with pesticide exposure among commercial pesticide applicators in the Agricultural Health Study
Occupational and Environmental Medicine, 66(11), 718–724.
Contributors: R. Slager*, J. Poole *, T. LeVan*, D. Sandler *, M. Alavanja* & J. Hoppin*
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Benomyl / toxicity; Diazinon / toxicity; Epidemiologic Methods; Glycine / analogs & derivatives; Glycine / toxicity; Humans; Male; Middle Aged; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Oxygenases / toxicity; Pesticides / toxicity; Petroleum / toxicity; Quebec / epidemiology; Rhinitis / chemically induced; Rhinitis / epidemiology; Young Adult
TL;DR:
Exposure to pesticides may increase the risk of rhinitis, based on both current use and exposure–response models, and both petroleum oil and diazinon showed consistent evidence of an association with rhInitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Pesticide exposure and risk of monoclonal gammopathy of undetermined significance in the Agricultural Health Study
Blood, 113(25), 6386–6391.
Contributors: O. Landgren *, R. Kyle *, J. Hoppin* , L. Beane Freeman*, J. Cerhan *, J. Katzmann*, S. Rajkumar *, M. Alavanja*
MeSH headings : Adult; Age Factors; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Blood Protein Electrophoresis; Carbon Disulfide / adverse effects; Carbon Tetrachloride / adverse effects; Cohort Studies; Dieldrin / adverse effects; Electrophoresis, Agar Gel; Humans; Iowa / epidemiology; Male; Middle Aged; Nitriles / adverse effects; North Carolina / epidemiology; Occupational Exposure; Paraproteinemias / chemically induced; Paraproteinemias / epidemiology; Pesticides / adverse effects; Prevalence; Prospective Studies; Sampling Studies
TL;DR:
The prevalence of MGUS among pesticide applicators was twice that in a population-based sample of men from Minnesota, adding support to the hypothesis that specific pesticides are causatively linked to myelomagenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Pesticide use and adult-onset asthma among male farmers in the Agricultural Health Study
European Respiratory Journal, 34(6), 1296–1303.
Contributors: J. Hoppin* , D. Umbach, S. London, P. Henneberger, G. Kullman, J. Coble, M. Alavanja, L. Beane Freeman, D. Sandler
author keywords: Allergy; farming; occupational exposure; pesticides; respiratory disease
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / etiology; Agriculture; Asthma / chemically induced; Asthma / etiology; Carbon Disulfide / toxicity; Carbon Tetrachloride / toxicity; DDT / toxicity; Ethylene Dibromide / toxicity; Humans; Iowa; Male; Middle Aged; North Carolina; Occupational Exposure; Parathion / toxicity; Pesticides / toxicity; Prospective Studies; Smoking; Surveys and Questionnaires
TL;DR:
Pesticide use may be an overlooked contributor to asthma risk among farmers and there was little evidence that allergy alone was driving these associations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort
International Journal of Cancer, 124(10), 2495–2500.
Contributors: G. Andreotti *, L. Freeman*, L. Hou *, J. Coble*, J. Rusiecki *, J. Hoppin* , D. Silverman *, M. Alavanja*
author keywords: pancreatic cancer; pesticides; agriculture
MeSH headings : Aged; Agriculture; Carcinogens / toxicity; Case-Control Studies; Female; Humans; Male; Middle Aged; Occupational Exposure; Pancreatic Neoplasms / chemically induced; Pancreatic Neoplasms / epidemiology; Pesticides / toxicity; Prospective Studies; Registries; Surveys and Questionnaires; United States / epidemiology
TL;DR:
It is suggested that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Cancer incidence among pesticide applicators exposed to butylate in the Agricultural Health Study (AHS)
Environmental Research, 109(7), 860–868.
Contributors: S. Lynch *, R. Mahajan*, L. Beane Freeman*, J. Hoppin* & M. Alavanja*
author keywords: Butylate; Pesticide; Cancer; Agricultural Health Study
MeSH headings : Adult; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Cohort Studies; Female; Humans; Iowa / epidemiology; Lymphoma, Non-Hodgkin / chemically induced; Lymphoma, Non-Hodgkin / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / poisoning; Prevalence; Prospective Studies; Prostatic Neoplasms / chemically induced; Prostatic Neoplasms / epidemiology; Surveys and Questionnaires; Thiocarbamates / poisoning
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2009 journal article
Cancer Incidence Among Paraquat Exposed Applicators in the Agricultural Health Study: A Prospective Cohort Study
International Journal of Occupational and Environmental Health, 15(3), 274–281.
MeSH headings : Adult; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Female; Herbicides / toxicity; Humans; Incidence; Iowa / epidemiology; Lymphoma, Non-Hodgkin / chemically induced; Lymphoma, Non-Hodgkin / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Paraquat / toxicity; Prospective Studies; Risk
TL;DR:
There was some suggestion of a possible link between paraquat exposure and NHL risk in humans, but the inconsistency in exposure level trend suggests that this could be a chance finding.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, ORCID
Added: September 13, 2019
2009 journal article
Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions
The American Journal of Pathology, 175(1), 283–293.
MeSH headings : ADAM Proteins / metabolism; ADAM10 Protein; ADAM17 Protein; Adult; Aged; Aged, 80 and over; Amyloid Precursor Protein Secretases / metabolism; Blotting, Western; Brain / metabolism; Female; Furin / metabolism; Gene Expression; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins / metabolism; Male; Membrane Proteins / metabolism; Middle Aged; Multiple Sclerosis / genetics; Multiple Sclerosis / metabolism; Neuroglia / metabolism; Oncogene Proteins / metabolism; Proto-Oncogene Proteins / metabolism; Receptor Protein-Tyrosine Kinases / metabolism; Up-Regulation; c-Mer Tyrosine Kinase; Axl Receptor Tyrosine Kinase
TL;DR:
Levels of membrane-bound Mer, soluble Mer, and soluble Axl were all significantly elevated in homogenates from established multiple sclerosis lesions comprised of both chronic active and chronic silent lesions, and dysregulation of protective Gas6 receptor signaling may prolong lesion activity.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2009 journal article
Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior
Frontiers in Behavioral Neuroscience, 3, 10.
author keywords: bisphenol; genistein; soy; estrogen receptors; development; sexual differentiation
TL;DR:
An overview of how exposure to EDCs, particularly those that interfere with estrogen action, impacts reproductive physiology and behaviors in vertebrates is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 25, 2019
2009 journal article
Text mining and manual curation of chemical-gene-disease networks for the Comparative Toxicogenomics Database (CTD)
BMC Bioinformatics, 10(1).
MeSH headings : Computational Biology / methods; Databases, Factual; Gene Regulatory Networks; Information Storage and Retrieval / methods; Toxicogenetics
TL;DR:
This text-mining project is unique in its integration of existing tools into a single workflow with direct application to CTD, which allowed us to measure the potential of these integrated tools to improve prioritization of journal articles for manual curation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2009 journal article
Perturbation of Defense Pathways by Low-Dose Arsenic Exposure in Zebrafish Embryos
Environmental Health Perspectives, 117(6), 981–987.
Contributors: C. Mattingly* , T. Hampton, K. Brothers, N. Griffin & A. Planchart*
author keywords: arsenic; Comparative Toxicogenomics Database; embryonic development; gene regulatory networks; immunity; microarray; toxicogenomics; transcriptional profiling; zebrafish
MeSH headings : Animals; Arsenic / toxicity; Embryo, Nonmammalian; Gene Expression / drug effects; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Water Pollutants, Chemical / toxicity; Zebrafish / metabolism
TL;DR:
It is demonstrated that arsenic significantly down-regulates expression levels of multiple genes potentially critical for regulating the establishment of an immune response, and provides molecular evidence consistent with phenotypic observations reported in other model systems.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 10, 2019
2009 journal article
Chemical databases for environmental health and clinical research
Toxicology Letters, 186(1), 62–65.
author keywords: Chemical; Drug; Database; Toxicogenomics
MeSH headings : Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Environmental Exposure; Environmental Health; Environmental Medicine; Environmental Pollutants / toxicity; Humans; Toxicogenetics
TL;DR:
These databases and their associated resources are incrementally strengthening the expanding field of toxicogenomics-based research by providing centralized sources of manually and computationally curated datasets and highly sophisticated tools for the meta-analysis of continually increasing environmental chemical, drug and small-molecule datasets.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2009 journal article
Genetic and environmental pathways to complex diseases
BMC Systems Biology, 3(1), 46.
MeSH headings : Databases, Genetic; Disease / genetics; Environment; Evolution, Molecular; Gene Expression Regulation; Genome-Wide Association Study; Genotype; Humans; Mental Disorders / etiology; Mental Disorders / genetics; Mental Disorders / metabolism; Mental Disorders / pathology; Metabolic Diseases / etiology; Metabolic Diseases / genetics; Metabolic Diseases / metabolism; Metabolic Diseases / pathology; Phenotype; Transcription, Genetic
TL;DR:
This analysis identifies natural and synthetic retinoids, antipsychotic medications, Omega 3 fatty acids, and pyrethroid pesticides as potential environmental modulators of metabolic syndrome phenotypes through PPAR and adipocytokine signaling and organophosphate pesticides as potential environmental modulators of neuropsychiatric phenotypes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2009 journal article
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks
Nucleic Acids Research, 37(Database), D786–D792.
MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Genes; Genomics; Hazardous Substances / toxicity; Humans; Models, Biological; Proteins / drug effects; Proteins / genetics; Systems Integration; Toxicogenetics
TL;DR:
The Comparative Toxicogenomics Database is a curated database that promotes understanding about the effects of environmental chemicals on human health by integrating data to be integrated to construct chemical–gene–disease networks.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2009 journal article
GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles
Bioinformation, 4(4), 173–174.
author keywords: gene; chemical; toxicogenomic; database; curation
TL;DR:
GeneComps and ChemComps are now provided for every curated gene and chemical in CTD and provide a novel way to view and classify genes and chemicals and will help advance testable hypotheses about environmental chemical-genedisease networks.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
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