Works Published in 2011
Displaying works 61 - 80 of 123 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Suicide and Pesticide Use among Pesticide Applicators and Their Spouses in the Agricultural Health Study
Environmental Health Perspectives, 119(11), 1610–1615.
Contributors: J. Beard *, D. Umbach *, J. Hoppin* , M. Richards*, M. Alavanja*, A. Blair*, D. Sandler *, F. Kamel*
author keywords: farmers; pesticide applicators; pesticides; spouses; suicide
MeSH headings : Adult; Aged; Cause of Death; Cohort Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Health Surveys; Humans; Incidence; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure; Pesticides / toxicity; Proportional Hazards Models; Prospective Studies; Risk Factors; Socioeconomic Factors; Spouses; Suicide / statistics & numerical data; Surveys and Questionnaires; Young Adult
TL;DR:
Findings do not support an association between moderate pesticide use and suicide in applicators and their spouses, and were consistent across several measures of pesticide use.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2011 journal article
Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk
Environmental Health Perspectives, 119(12), 1726–1732.
Contributors: K. Barry *, S. Koutros *, S. Berndt *, G. Andreotti *, J. Hoppin* , D. Sandler *, L. Burdette*, M. Yeager *
author keywords: DNA repair; gene-environment interactions; pesticide; polymorphisms; prostate cancer
MeSH headings : Case-Control Studies; DNA Repair / genetics; Fonofos / adverse effects; Genetic Variation; Genotype; Humans; Likelihood Functions; Logistic Models; Male; N-Glycosyl Hydrolases / genetics; North Carolina / epidemiology; Occupational Exposure / adverse effects; Odds Ratio; Pesticides / adverse effects; Polymorphism, Single Nucleotide / genetics; Prostatic Neoplasms / chemically induced; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / genetics; Risk Assessment
TL;DR:
A role of BER genetic variation in pesticide-associated prostate cancer risk is suggested in a nested case–control study of white Agricultural Health Study pesticide applicators.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 13, 2019
2011 journal article
An Updated Algorithm for Estimation of Pesticide Exposure Intensity in the Agricultural Health Study
International Journal of Environmental Research and Public Health, 8(12), 4608–4622.
Contributors: J. Coble*, K. Thomas *, C. Hines*, J. Hoppin* , M. Dosemeci*, B. Curwin*, J. Lubin*, L. Freeman*
author keywords: pesticides; exposure algorithm; epidemiology; 2,4-D; chlorpyrifos; captan
MeSH headings : Agriculture; Algorithms; Environmental Exposure; Humans; Pesticides / toxicity
TL;DR:
The weighting factors for the revised algorithm now incorporate exposure measurements taken on Agricultural Health Study (AHS) participants for the application methods and personal protective equipment (PPE) commonly reported by study participants.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2011 journal article
Allergy-related outcomes in relation to serum IgE: Results from the National Health and Nutrition Examination Survey 2005-2006
Journal of Allergy and Clinical Immunology, 127(5), 1226–1235.e7.
Contributors: P. Salo*, A. Calatroni*, P. Gergen*, J. Hoppin* , M. Sever*, R. Jaramillo *, S. Arbes Jr., D. Zeldin *
author keywords: Allergen; allergy; allergic sensitization; serum IgE
MeSH headings : Allergens / immunology; Animals; Antibody Specificity; Cats; Cattle; Cross-Sectional Studies; Dogs; Female; Fungi / immunology; Humans; Hypersensitivity, Immediate / epidemiology; Hypersensitivity, Immediate / immunology; Immunoglobulin E / blood; Male; Mice; Nutrition Surveys; Pets / immunology; Plants / immunology; Prevalence; Rats; Rhinitis, Allergic, Seasonal / epidemiology; Rhinitis, Allergic, Seasonal / immunology; Surveys and Questionnaires; United States / epidemiology
TL;DR:
In the US population self-reported allergy symptoms are most consistently associated with increased levels of plant-, pet-, and mold-specific IgE, which contributed independently to allergy-related symptoms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2011 journal article
AGRICOH: A Consortium of Agricultural Cohorts
International Journal of Environmental Research and Public Health, 8(5), 1341–1357.
Contributors: M. Leon*, L. Beane Freeman*, J. Douwes *, J. Hoppin* , H. Kromhout *, P. Lebailly*, K. Nordby*, M. Schenker *
author keywords: agriculture; cohort studies; consortium, pesticides; occupational exposures
MeSH headings : Agricultural Workers' Diseases; Agriculture; Cohort Studies; Humans; International Cooperation; Occupational Exposure
TL;DR:
Altogether, AGRICOH provides excellent opportunities for studying cancer, respiratory, neurologic, and auto-immune diseases as well as reproductive and allergic disorders, injuries and overall mortality in association with a wide array of exposures, prominent among these the application of pesticides.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2011 journal article
mGluR and NMDAR activation internalize distinct populations of AMPARs
Molecular and Cellular Neuroscience, 48(2), 161–170.
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cells, Cultured; Endocytosis / physiology; Hippocampus / cytology; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Long-Term Synaptic Depression / physiology; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Neurons / cytology; Neurons / physiology; Patch-Clamp Techniques; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Rats; Rats, Sprague-Dawley; Receptors, AMPA / metabolism; Receptors, Metabotropic Glutamate / metabolism; Receptors, N-Methyl-D-Aspartate / metabolism; Signal Transduction / physiology
TL;DR:
Evidence is reported that these two receptor pathways couple to the endocytosis of distinct populations of AMPARs defined by their mobility in the membrane surface, which suggests that the convergence of the mGluR and NMDAR signaling pathways on AMPAR endocyTosis renders these two forms of plasticity functionally equivalent.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2011 journal article
The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database
Database, 2011(0), bar034–bar034.
MeSH headings : Database Management Systems; Databases, Factual; Disease; Humans; Internet; Pharmaceutical Preparations; Toxicogenetics; User-Computer Interface; Vocabulary, Controlled
TL;DR:
This approach to manual curation that uses a powerful and efficient paradigm involving mnemonic codes is incorporated into a web-based curation tool to further increase efficiency and productivity, implement quality control in real-time and accommodate biocurators working remotely.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2011 journal article
DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD
Bioinformation, 7(4), 154–156.
TL;DR:
This work leveraged curated datasets to compute similarity indices that can be used to produce lists of comparable diseases (“DiseaseComps”) based upon shared toxicogenomic profiles, which now classifies diseases with common molecular characteristics, instead of the traditional approach of using histology or tissue of origin to define the disorder.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2011 journal article
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos
Development, 139(2), 437–442.
author keywords: Small-molecule inhibitor; Rho kinase; Photocaging; Xenopus
MeSH headings : Animals; Body Patterning / drug effects; Dioxoles / metabolism; Dioxoles / pharmacology; Embryo, Nonmammalian / metabolism; Immunohistochemistry; Indoles / metabolism; Indoles / pharmacology; Mice; NIH 3T3 Cells; Pyridines / metabolism; Pyridines / pharmacology; Ultraviolet Rays; Xenopus laevis / embryology; Xenopus laevis / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
TL;DR:
A novel pharmacological agent that can be light activated to achieve spatiotemporally limited inhibition of Rho kinase activity in vivo is developed and application to the spatially heterogeneous problem of embryonic left-right asymmetry revealed a differential requirement for Rho signaling on the left and right sides of the primitive gut tube.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, Crossref
Added: May 17, 2019
2011 journal article
Using Nuclear Receptor Activity to Stratify Hepatocarcinogens
PLoS ONE, 6(2).
Contributors: I. Shah *, K. Houck *, R. Judson *, R. Kavlock*, M. Martin*, D. Reif* , J. Wambaugh *, D. Dix*
Ed(s): S. Wölfl
MeSH headings : Animals; Carcinogens / classification; Carcinogens / toxicity; Carcinoma, Hepatocellular / chemically induced; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cells, Cultured; Constitutive Androstane Receptor; Disease Progression; Drug Evaluation, Preclinical / methods; Gene Expression / drug effects; Gene Expression Profiling; Gene Regulatory Networks / drug effects; High-Throughput Screening Assays / methods; Humans; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Neoplasms / chemically induced; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; Mice; Microarray Analysis; Rats; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Cytoplasmic and Nuclear / physiology
TL;DR:
These results do not prove the role of NR activation in human liver cancer, but they do have implications for nuclear receptor chemical biology and provide insights into putative toxicity pathways and suggest the utility of in vitro assays for stratifying environmental contaminants based on a combination of human bioactivity and rodent toxicity.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.
Toxicological Sciences, 124(1), 109–127.
Contributors: N. Sipes *, M. Martin*, D. Reif* , N. Kleinstreuer *, R. Judson *, A. Singh*, K. Chandler*, D. Dix*, R. Kavlock*, T. Knudsen *
author keywords: developmental toxicity; ToxCast; ToxRefDB; high-throughput screening; predictive models; computational models predictive toxicology
MeSH headings : Animals; Congenital Abnormalities / etiology; Databases, Factual; Embryonic Development / drug effects; Endpoint Determination; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Fetal Development / drug effects; High-Throughput Screening Assays; Models, Biological; Rabbits; Rats; Species Specificity; Teratogens / classification; Teratogens / toxicity; United States; United States Environmental Protection Agency
TL;DR:
This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity, and builds statistical associations based on HTS and in vivo developmental toxicity data from ToxRefDB.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Predictive model of rat reproductive toxicity from ToxCast high throughput screening.
Biology of Reproduction, 85(2), 327–339.
Contributors: M. Martin*, T. Knudsen *, D. Reif* , K. Houck *, R. Judson *, R. Kavlock*, D. Dix*
author keywords: female reproductive tract; fertility; male reproductive tract; predictive toxicology; reproductive toxicity; toxicology
MeSH headings : Animals; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Male; Predictive Value of Tests; Rats; Reproduction / drug effects; Risk Assessment; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
A robust and stable predictive model was produced capable of identifying rodent reproductive toxicants with 77% ± 2% and 74% ± 5% training and test cross-validation balanced accuracies, further indicating the model's potential for prioritizing the many thousands of environmental chemicals with little to no hazard information.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 conference paper
Optimization of grammatical evolution decision trees
Proceedings of the 13th annual conference companion on Genetic and evolutionary computation - GECCO '11, 35–36.
Contributors: K. Hoover n, R. Marceau n, T. Harris n, N. Hardison n, D. Reif n & A. Motsinger-Reif n
TL;DR:
The results of a parameter sweep evaluating the power of GEDT are presented and it is shown that improved parameter choices improves the performance of the method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Mechanistic indicators of childhood asthma (MICA) study: piloting an integrative design for evaluating environmental health.
BMC Public Health, 11, 344.
Contributors: J. Gallagher*, E. Hudgens*, A. Williams *, J. Inmon*, S. Rhoney*, G. Andrews*, D. Reif* , B. Heidenfelder*
MeSH headings : Adolescent; Asthma / diagnosis; Asthma / etiology; Biomarkers / blood; Child; Disease Susceptibility; Environmental Health; Environmental Monitoring / methods; Female; Genetic Predisposition to Disease / genetics; Humans; Male; Michigan; Risk Factors
TL;DR:
The MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes and incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
BMC Medical Genetics, 12, 25.
Contributors: B. Joubert *, D. Reif* , S. Edwards*, K. Leiner*, E. Hudgens*, P. Egeghy *, J. Gallagher*, E. Hubal
MeSH headings : Adolescent; Black or African American / genetics; Asthma / genetics; Child; Chromosomes, Human, Pair 11 / genetics; Cross-Sectional Studies; Female; Food Hypersensitivity / genetics; Genetic Predisposition to Disease; Glutathione S-Transferase pi / genetics; Glutathione Transferase / genetics; Haplotypes; Humans; Hypersensitivity / genetics; Hypersensitivity, Immediate / genetics; Linkage Disequilibrium; Male; Michigan; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, IgE / genetics; Risk Factors; Sequence Deletion; Urban Population
TL;DR:
Variation in genes associated with asthma in predominantly non-African ethnic groups contributed to increased odds of asthma in this African American study population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay
PLoS ONE, 6(6), e18540.
Contributors: K. Chandler*, M. Barrier*, S. Jeffay*, H. Nichols*, N. Kleinstreuer *, A. Singh*, D. Reif* , N. Sipes *
Ed(s): A. Cooney
MeSH headings : Animals; Biological Assay; Cell Adhesion / drug effects; Cell Death / drug effects; Cell Differentiation / drug effects; Cell Line; Embryonic Stem Cells / cytology; Embryonic Stem Cells / drug effects; Endpoint Determination; Environmental Pollutants / toxicity; Male; Mice; Models, Biological; Multivariate Analysis; Toxicity Tests / methods
TL;DR:
An initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Environmental Impact on Vascular Development Predicted by High-Throughput Screening
Environ Health Perspect, 119(11), 1596â1603.
Contributors: N. Kleinstreuer *, R. Judson *, D. Reif* , N. Sipes *, A. Singh*, K. Chandler*, R. DeWoskin*, D. Dix*, R. Kavlock*, T. Knudsen *
author keywords: angiogenesis; developmental toxicity; high-throughput screening (HTS); thalidomide; vascular development
MeSH headings : Animals; Cardiovascular System / drug effects; Cardiovascular System / embryology; Computational Biology; Databases, Factual; Environmental Pollutants / analysis; Environmental Pollutants / classification; Environmental Pollutants / immunology; Environmental Pollutants / toxicity; Female; High-Throughput Screening Assays; Humans; Male; Maternal Exposure; Mice; Models, Animal; Multivariate Analysis; Pregnancy; Rabbits; Rats; Risk Assessment; Small Molecule Libraries / analysis; Small Molecule Libraries / classification; Small Molecule Libraries / toxicity; Species Specificity; Toxicology / methods; United States; United States Environmental Protection Agency
TL;DR:
It is predicted that blood vessel development is a target for environmental chemicals acting as putative vascular disruptor compounds (pVDCs) and identified potential species differences in sensitive vascular developmental pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
Toxicology, 282(1-2), 1â15.
Contributors: T. Knudsen *, K. Houck *, N. Sipes *, A. Singh*, R. Judson *, M. Martin*, A. Weissman, N. Kleinstreuer *
author keywords: High-throughput screening; Computational toxicology; ToxCast; Environmental chemicals
MeSH headings : Animal Use Alternatives; Animals; Automation, Laboratory; Cell-Free System; Data Interpretation, Statistical; Databases, Factual; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Enzyme Inhibitors / toxicity; High-Throughput Screening Assays; Humans; Ligands; Models, Biological; Osmolar Concentration; Pesticide Residues / toxicity; Rats; Reproducibility of Results; Toxicity Tests; United States; United States Environmental Protection Agency
TL;DR:
Mapping relationships across 93,440 chemical-assay pairs based on half-maximal activity concentration (AC50) revealed both known and novel targets in signaling and metabolic pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
First Transcriptome of the Testis-Vas Deferens-Male Accessory Gland and Proteome of the Spermatophore from Dermacentor variabilis (Acari: Ixodidae)
PLOS ONE, 6(9).
MeSH headings : Amino Acid Sequence; Animal Structures / metabolism; Animals; Contig Mapping; Dermacentor / genetics; Dermacentor / metabolism; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Heat-Shock Proteins / chemistry; Heat-Shock Proteins / genetics; Heat-Shock Proteins / metabolism; Male; Molecular Sequence Annotation; Molecular Sequence Data; Proteome / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Spermatogonia / metabolism; Testis / metabolism; Transcriptome; Vas Deferens / metabolism
TL;DR:
This first transcriptome to the reproductive biology of fed male ticks, Dermacentor variabilis, was obtained by 454 pyrosequencing and revealed differences in protein distribution in the reproductive system versus the spermatophore.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Food rationing affects dietary selenium bioaccumulation and life cycle performance in the mayfly Centroptilum triangulifer
ECOTOXICOLOGY, 20(8), 1840–1851.
author keywords: Selenium; Mayfly; Periphyton; Toxicity; Maternal transfer; Fecundity; Trophic transfer; Chronic; Bioconcentration
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Body Weight; Female; Fertility; Food Chain; Insecta / growth & development; Insecta / metabolism; Insecta / physiology; Life Cycle Stages; Ovum; Selenium / pharmacokinetics
TL;DR:
The results suggest that the influence of Se on mayfly performance in nature may be tied to food resource availability and quality and nutritional status is an important consideration when applying laboratory derived estimates of toxicity to risk assessments for wild populations.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.