Works Published in 2000
Displaying works 281 - 300 of 349 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2000 journal article
Varying migration and deme size and the feasibility of the shifting balance
EVOLUTION, 54(1), 324–327.
author keywords: pesticide resistance; shifting balance theory; stepping stone model; stochastic migration; varying deme size
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 review
The role of liposomes in drug delivery and diagnostic imaging: A review
[Review of ]. VETERINARY RADIOLOGY & ULTRASOUND, 41(2), 100–107.
MeSH headings : Animal Diseases / diagnostic imaging; Animals; Contrast Media / administration & dosage; Diagnostic Imaging / methods; Diagnostic Imaging / veterinary; Drug Carriers; Drug Delivery Systems / veterinary; Liposomes; Radiography; Veterinary Drugs / administration & dosage
TL;DR:
Because of their unique properties liposomes will continue to be investigated in drug delivery and imaging systems, and very likely will be incorporated into the discipline of veterinary medicine as the clinical applications of liposome technology continue to expand.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
The effects of long-term caging and molt of Single Comb White Leghorn hens on herterophil to lymphocyte ratios, corticosterone and thyroid hormones
POULTRY SCIENCE, 79(4), 514–518.
author keywords: egg production; corticosterone; heterophil to lymphocyte ratio; thyroid hormones; molt
MeSH headings : Aging; Animals; Chickens / physiology; Corticosterone / blood; Female; Housing, Animal; Leukocyte Count; Lymphocyte Count; Molting; Oviposition; Thyroid Hormones / blood; Thyroxine / blood; Triiodothyronine / blood
TL;DR:
The physiological and metabolic parameters of the different hen strains and cage densities were similar during egg production, however, CS, T3, T4, and H:L changed with age in relation to the egg production cycle, and these parameters were affected by bird age.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
Synthesis and properties of uniquely modified oligoribonucleotides: Yeast tRNA(Phe) fragments with 6-methyluridine and 5,6-dimethyluridine at site-specific positions
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 19(3), 515–531.
MeSH headings : Anticodon; Magnetic Resonance Spectroscopy; Methylation; Molecular Conformation; Oligoribonucleotides / chemical synthesis; Oligoribonucleotides / chemistry; Organophosphorus Compounds / chemistry; RNA, Transfer, Phe / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Uridine / analogs & derivatives; Uridine / chemistry; Yeasts / chemistry
TL;DR:
Stability when the modified uridine is in a loop is sequence context dependent, and can not, at this time, be predicted from the location in the loop, but decrease in RNA duplex stability is predictable.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Synthesis and excited-state photodynamics of phenylethyne- linked porphyrin-phthalocyanine dyads
Journal of Materials Chemistry, 10(2), 283–296.
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2000 journal article
Rapid identification and differentiation of Bartonella species using a single-step PCR assay
Journal of Clinical Microbiology, 38(5), 1717–1722.
Source: NC State University Libraries
Added: August 6, 2018
2000 article
Molecular cloning of canine bullous pemphigoid antigen 2 cDNA and immunomapping of NC16A domain by canine bullous pemphigoid autoantibodies
Xu, L. T., EA O'Toole, Olivry, T., Hernandez, C., Peng, J., Chen, M., & Chan, L. S. (2000, January 3). BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, Vol. 1500, pp. 97–107.
Contributors: L. Xu, . E.A. O'Toole, T. Olivry* , C. Hernandez, J. Peng, M. Chen, L. Chan
author keywords: autoimmunity; veterinary immunology; ELISA; peptide; cloning; canine
MeSH headings : Animals; Autoantibodies / blood; Autoantibodies / metabolism; Autoantigens / genetics; Autoantigens / immunology; Autoantigens / metabolism; Base Sequence; Basement Membrane / metabolism; Carrier Proteins; Cell Line; Cloning, Molecular; Collagen; Cytoskeletal Proteins; Dog Diseases / genetics; Dog Diseases / immunology; Dogs; Dystonin; Epitopes / immunology; Humans; Keratinocytes / cytology; Microscopy, Immunoelectron; Molecular Sequence Data; Nerve Tissue Proteins; Non-Fibrillar Collagens; Pemphigoid, Bullous / genetics; Pemphigoid, Bullous / immunology; Pemphigoid, Bullous / veterinary; Protein Structure, Tertiary; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Skin / metabolism; Skin / ultrastructure
TL;DR:
The cloning of the cDNA encoding this disease-associated protein may allow us to develop a canine model in dissecting the immunopathologic mechanism underlying bullous pemphigoid.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism
GASTROENTEROLOGY, 118(1), 90–100.
Contributors: J. Rhoads n, R. Argenzio n, W. Chen n, L. Graves n, L. Licato n, A. Blikslager n , J. Smith n, J. Gatzy n, D. Brenner n
MeSH headings : Cell Division / drug effects; Cell Line; Cyclic AMP / analogs & derivatives; Cyclic AMP / metabolism; Cyclic AMP / pharmacology; DNA / biosynthesis; DNA / drug effects; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Epidermal Growth Factor / metabolism; Epidermal Growth Factor / pharmacology; Flavonoids / pharmacology; Glutamine / metabolism; Glutamine / pharmacology; Intestinal Mucosa / metabolism; Intestines / cytology; MAP Kinase Signaling System / drug effects; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Oxygen Consumption / drug effects; Thionucleotides / pharmacology; Thymidine / metabolism
TL;DR:
In vitro kinase assays showed that glutamine signaling requires an intact ERK (extracellular signal-related kinase) pathway in unstarved cells and increased levels of intracellular cAMP inhibit ERKs but only partially reduce glutamine-stimulated proliferation in enterocytes adapted to low glutamine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
Familial glomerulonephropathy in a litter of Beagles
Journal of the American Veterinary Medical Association, 216(1), 46–50.
MeSH headings : Animals; Blood Chemical Analysis / veterinary; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Fatal Outcome; Female; Glomerulonephritis, Membranoproliferative / diagnosis; Glomerulonephritis, Membranoproliferative / genetics; Glomerulonephritis, Membranoproliferative / veterinary; Kidney / pathology; Kidney / ultrastructure; Male; Microscopy, Electron / veterinary; Proteinuria / veterinary
TL;DR:
Families of Beagles raised in more than 1 area of the United States with similar clinicopathologic abnormalities, common genetic background, and identical histopathologic and electron microscopic findings, familial renal disease was diagnosed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2000 article
Estimating the distribution of quality-adjusted life with censored data
Tsiatis, A. A. (2000, April). AMERICAN HEART JOURNAL, Vol. 139, pp. S177–S181.
MeSH headings : Cardiovascular Agents / adverse effects; Cardiovascular Agents / therapeutic use; Data Interpretation, Statistical; Humans; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic / statistics & numerical data; Survival Analysis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Correlation of transforming growth factor-beta messenger RNA (TGF-beta mRNA) expression with cellular immunoassays in triamcinolone-treated captive hybrid striped bass
JOURNAL OF AQUATIC ANIMAL HEALTH, 12(1), 9–17.
TL;DR:
Since triamcinolone is used therapeutically as a suppressive immunomodulator, the enhanced immune functions indicated by the cellular immunoassays were unexpected; however, the inverse response of TGF-β production and macrophage bactericidal activity was consistent with the known relationship between TGF/macrophage activation in mammals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Cardiovascular evidence for an intermediate or higher metabolic rate in an ornithischian dinosaur
SCIENCE, 288(5465), 503–505.
MeSH headings : Animals; Aorta / anatomy & histology; Basal Metabolism; Birds / anatomy & histology; Birds / metabolism; Body Weight; Fossils; Heart / anatomy & histology; Heart / diagnostic imaging; Image Processing, Computer-Assisted; Iron Compounds / analysis; Minerals; Paleontology; Reptiles / anatomy & histology; Reptiles / metabolism; Tomography Scanners, X-Ray Computed; Tomography, X-Ray Computed; X-Ray Diffraction
TL;DR:
Computerized tomography scans of a ferruginous concretion within the chest region of an ornithischian dinosaur reveal structures that are suggestive of a four-chambered heart and a single systemic aorta, which suggests the existence of intermediate-to-high metabolic rates among dinosaurs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 personal communication
Optical coherence tomography (OCT) abnormalities in rhodopsin mutant transgenic swine with retinal degeneration
Huang, Y. J., Cideciyan, A. V., Aleman, T. S., Banin, E., Huang, J. C., Syed, N. A., … Jacobson, S. G. (2000, February).
MeSH headings : Animals; Animals, Genetically Modified; Mutation / genetics; Retinal Degeneration / genetics; Rhodopsin / genetics; Swine; Tomography
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Cost-effectiveness of platelet glycoprotein IIb/IIIa inhibition with eptifibatide in patients with non-ST-elevation acute coronary syndromes
CIRCULATION, 101(4), 366–371.
author keywords: coronary disease; cost-benefit analysis; glycoproteins; eptifibatide
MeSH headings : Angina, Unstable / drug therapy; Angina, Unstable / economics; Cost-Benefit Analysis; Eptifibatide; Female; Follow-Up Studies; Humans; Length of Stay; Male; Middle Aged; Myocardial Infarction / drug therapy; Myocardial Infarction / economics; Peptides / economics; Peptides / therapeutic use; Platelet Aggregation Inhibitors / economics; Platelet Aggregation Inhibitors / therapeutic use; Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors; Prospective Studies; Risk Factors; United States
TL;DR:
Based on the results observed in the US PURSUIT patients, the routine addition of eptifibatide to standard care for non-ST-elevation acute coronary syndrome patients is economically attractive by conventional standards.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Using conditional logistic regression to fit proportional odds models to interval censored data
BIOMETRICS, 56(2), 511–518.
author keywords: AIDS; current status data; nonparametric maximum likelihood; survival analysis
MeSH headings : Acquired Immunodeficiency Syndrome / drug therapy; Acquired Immunodeficiency Syndrome / immunology; Acquired Immunodeficiency Syndrome / mortality; Anti-HIV Agents / therapeutic use; Biometry / methods; CD4 Lymphocyte Count; Drug Therapy, Combination; Humans; Likelihood Functions; Models, Statistical; Regression Analysis; Statistics, Nonparametric; Survival Analysis; Zalcitabine / therapeutic use; Zidovudine / therapeutic use
TL;DR:
An easily implemented approach to fitting the proportional odds regression model to interval‐censored data is presented based on using conditional logistic regression routines in standard statistical packages to sidestep complications that attend estimation of the baseline odds ratio function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Theory and simulation of the swelling of polymer gels
JOURNAL OF CHEMICAL PHYSICS, 113(1), 404–418.
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
The effects of Tempol on ferritin synthesis and Fe metabolism in lens epithelial cells
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1497(1), 51–60.
author keywords: ferritin; Fe metabolism; lens; cataract; lens epithelial cell; tempol; oxidative damage; peroxide; free radical
MeSH headings : Animals; Antioxidants / pharmacology; Cyclic N-Oxides / pharmacology; Dogs; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Female; Ferritins / biosynthesis; Ferritins / drug effects; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Male; Spin Labels; Time Factors; tert-Butylhydroperoxide / pharmacology
TL;DR:
The redistribution of Fe within the cell after 20 h of Tempol treatment appears to render the cells more vulnerable to oxidative stress, likely due to its effects on Fe metabolism, perhaps by reducing the availability of Fe for incorporation into ferritin and Fe-dependent enzymes as well as enlarging a low molecular weight pool of Fe which may be capable of catalyzing damaging free radical reactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses
Nature Medicine, 6(3), 327–331.
MeSH headings : Animals; Cell Transplantation; Disease Models, Animal; Hepatitis B / pathology; Hepatitis B / transmission; Hepatitis B virus / isolation & purification; Hepatitis D / pathology; Hepatitis D / transmission; Hepatitis Delta Virus / isolation & purification; Humans; Liver / cytology; Liver / pathology; Liver / virology; Mice; Mice, Inbred NOD; Mice, SCID; Proto-Oncogene Proteins c-met / immunology; Time Factors; Transplantation, Heterologous
TL;DR:
A new xenotransplant model that allows study of multiple aspects of human hepatitis viral infections, and may enhance studies of human liver diseases, is described.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Serum oxytetracycline concentrations in African elephant (Loxodonta africana) calves after long-acting formulation injection
Journal of Zoo and Wildlife Medicine, 31(1), 41–46.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Laser scanning confocal microscopy study of dye diffusion in fibers
MACROMOLECULES, 33(12), 4478–4485.
Source: Web Of Science
Added: August 6, 2018
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