Works Published in 2013

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2013 journal article

Antiplasmodial activity of cucurbitacin glycosides from Datisca glomerata (C. Presl) Baill

PHYTOCHEMISTRY, 87, 78–85.

By: R. Graziose, M. Grace*, T. Rathinasabapathy*, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila*, P. Smith, I. Raskin

Contributors: R. Graziose, M. Grace*, T. Rathinasabapathy*, P. Rojas-Silva, C. Dekock, A. Poulev, M. Lila*, P. Smith, I. Raskin

author keywords: Datisca glomerata; Cucurbitales; Datiscaceae; Durango root; Bioassay guided fractionation; Cucurbitacin; Antimalarial; Antileishmanial; Cytotoxicity
MeSH headings : Animals; Antimalarials / chemistry; Antimalarials / pharmacology; CHO Cells; Cell Line; Cricetinae; Glycosides / chemistry; Glycosides / pharmacology; Magnoliopsida / chemistry; Molecular Structure; Plants, Medicinal / chemistry; Plasmodium falciparum / drug effects; Rats; Triterpenes / chemistry; Triterpenes / pharmacology
TL;DR: The traditionally used antimalarial plant, Datisca glomerata (C. Presl) Baill, was subjected to antiplasmodial assay guided fractionation, which led to the isolation of seven cucurbitacin glycosides, datiscosides I-O, along with two known compounds from the aerial parts of D. glomersata, which displayed cytotoxicity against L6 but not CHO mammalian cells. (via Semantic Scholar)
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Added: August 6, 2018

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