Works Published in 2004
Displaying all 13 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2004 thesis
Analysis of the bioactivity, metabolism, and pharmacokinetics of anthocyanins in humans
(Thesis). University of Guelph, Guelph, Ont.
Source: NC State University Libraries
Added: March 29, 2021
2004 journal article
Effective Separation of Potent Antiproliferation and Antiadhesion Components from Wild Blueberry (Vaccinium angustifoliumAit.) Fruits
Journal of Agricultural and Food Chemistry, 52(21), 6433–6442.
author keywords: Vaccinium angustifolium Ait.; blueberry; antiproliferation; antiadhesion; proanthocyanidin; condensed tannins
MeSH headings : Animals; Bacterial Adhesion / drug effects; Cell Division / drug effects; Escherichia coli; Humans; Liver Neoplasms, Experimental / pathology; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Polymers / chemistry; Proanthocyanidins / chemistry; Proanthocyanidins / isolation & purification; Proanthocyanidins / pharmacology; Prostatic Neoplasms / pathology; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Tumor Cells, Cultured; Vaccinium / chemistry
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2004 journal article
Biosynthesis and Characterization of14C-Enriched Flavonoid Fractions from Plant Cell Suspension Cultures
Journal of Agricultural and Food Chemistry, 52(5), 1138–1145.
author keywords: radiolabeling; proanthocyanidins; anthocyanins; flavonoid-rich fractions; ohelo (Vaccinium); grape (Vitis)
MeSH headings : Anthocyanins / analysis; Anthocyanins / biosynthesis; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Flavonoids / analysis; Flavonoids / biosynthesis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Vaccinium / metabolism; Vitis / metabolism
TL;DR:
A range of radiolabeled anthocyanins, proanthocyanidins, and other flavonoids were accumulated by cell suspension cultures of two plant species, ohelo and grape, after providing uniformly labeled sucrose to the medium to gauge their bioavailability and accumulation in target organs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2004 journal article
Enhanced inflammatory responses in α-tocopherol transfer protein null mice
Archives of Biochemistry and Biophysics, 423(1), 162–169.
author keywords: alpha-tocopherol; alpha-TTP; oxidative stress; heme oxygenase-1; immune response
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Female; Gene Deletion; Heme Oxygenase (Decyclizing) / metabolism; Heme Oxygenase-1; Inflammation / genetics; Inflammation / metabolism; Liver / metabolism; Lung / metabolism; Male; Membrane Proteins; Mice; Nitrates / metabolism; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type II; Nitrites / metabolism; RNA, Messenger / metabolism; Vitamin E / metabolism
TL;DR:
It is demonstrated that α-tocopherol is important for proper modulation of inflammatory responses and that sub-optimal α-ocopherol concentrations may derange inflammatory–immune responses.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2004 journal article
An enclosed-chamber labeling system for the safe 14C-enrichment of phytochemicals in plant cell suspension cultures
In Vitro Cellular & Developmental Biology - Plant, 40(1), 80–85.
author keywords: flavonoids; radiolabel; Vaccinium pahalae; ohelo berry; Vitis vinifera; grape
TL;DR:
An enclosed-chamber labeling system in which cell suspension cultures can be safely and efficiently grown when supplied with 14C-enriched precursors and showed that flavonoids were produced with either sucrose or glucose as the carbohydrate source, although flavonoid productivity was higher with sucrose.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2004 journal article
Flesh quality and lycopene stability of fresh-cut watermelon
Postharvest Biology and Technology, 31(2), 159–166.
author keywords: carotenoid composition; color; HPLC; soluble solids; titratable acidity; modified atmosphere
Source: Crossref
Added: August 28, 2020
2004 journal article
Ion channels as important targets for antiepileptic drug design
Current Drug Targets, 5(7), 589–602.
Contributors: P. Yogeeswari *, J. Ragavendran, R. Thirumurugan *, A. Saxena & D. Sriram*
author keywords: epilepsy; voltage-gated ion channels; antiepileptic drugs; sodium ion channel; calcium ion channel; potassium ion channel; H-channels
MeSH headings : Anticonvulsants / chemistry; Anticonvulsants / pharmacology; Anticonvulsants / therapeutic use; Calcium Channels / drug effects; Calcium Channels / physiology; Chemistry, Pharmaceutical; Epilepsy / drug therapy; Epilepsy / metabolism; Humans; Ion Channels / drug effects; Ion Channels / physiology; Potassium Channels / drug effects; Potassium Channels / physiology; Sodium Channels / drug effects; Sodium Channels / physiology
TL;DR:
A review on the antiepileptic drugs, both established and currently under development targeted to the ion channels in order to bring about effective seizure control is covered.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 9, 2019
2004 journal article
Antituberculous activity of some aryl semicarbazone derivatives
Bioorg Med Chem Lett, 14(15), 3923–3924.
Contributors: D. Sriram *, P. Yogeeswari * & R. Thirumurugan *
author keywords: antitubercular; aryl semicarbazones
MeSH headings : Antitubercular Agents / chemical synthesis; Antitubercular Agents / pharmacology; Microbial Sensitivity Tests; Molecular Conformation; Molecular Structure; Mycobacterium tuberculosis / drug effects; Semicarbazones / chemical synthesis; Semicarbazones / pharmacology; Structure-Activity Relationship
TL;DR:
This paper is first of its kind in which aryl semicarbazones are reported to possess antimycobacterials potency greater than p-aminosalicylic acid, ethionamide, ethambutol, ciprofloxacin and kanamycin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 9, 2019
2004 journal article
3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity
Eur J Med Chem, 39(8), 729–734.
Contributors: P. Yogeeswari *, R. Thirumurugan *, R. Kavya *, J. Samuel, J. Stables & D. Sriram *
author keywords: aryl semicarbazones; 3-Chloro-2-methyl substituted phenyl semicarbazones; anti convulsants; CNS depressants
MeSH headings : Animals; Anticonvulsants / chemical synthesis; Anticonvulsants / therapeutic use; Male; Mice; Rats; Rats, Sprague-Dawley; Rats, Wistar; Seizures / prevention & control; Semicarbazones / chemical synthesis; Semicarbazones / therapeutic use
TL;DR:
A series of 3-chloro-2-methylphenyl substituted semicarbazones was synthesized and evaluated for anticonvulsant and CNS activities and exhibited lesser CNS depression and neurotoxicity compared to phenytoin or carbamazepine as was evident from the CNS studies.
(via Semantic Scholar)
Source: ORCID
Added: December 9, 2019
2004 journal article
Methods of analysis for anthocyanins in plants and biological fluids
Journal of AOAC International, 87(1), 129–145.
Source: ORCID
Added: November 13, 2019
2004 journal article
Anthocyanin metabolites in human urine and serum
British Journal of Nutrition, 91(6), 933–942.
author keywords: flavonoids; cyanidin 3-glycosides; glucurottide; methylated anthocyanins
MeSH headings : Adult; Anthocyanins / blood; Anthocyanins / metabolism; Anthocyanins / urine; Blueberry Plants; Chromatography, High Pressure Liquid / methods; Fruit / metabolism; Gas Chromatography-Mass Spectrometry / methods; Glucosides / blood; Glucosides / metabolism; Glucosides / urine; Humans; Hydrolysis; Male; Mass Spectrometry / methods; Middle Aged; Plant Extracts / administration & dosage; Plant Extracts / metabolism
TL;DR:
It is confirmed that human subjects have the capacity to metabolise cyanidin 3-glycosides, as at least ten individual anthocyanin metabolites in the urine and serum, and these metabolic products are likely in part responsible for the reported health benefits associated with the consumption of Anthocyanins.
(via Semantic Scholar)
www.cambridge.org (publisher PDF)
Sources: Crossref, Web Of Science, ORCID
Added: November 13, 2019
2004 journal article
Polyphenolics in Rhizophora mangle L. leaves and their changes during leaf development and senescence
Trees - Structure and Function, 18(5), 518–528.
Contributors: F. Kandil*, M. Grace* , D. Seigler * & J. Cheeseman*
author keywords: flavonoids; quercetin glycosides; condensed tannins; proanthocyanidin glycosides; 5,4 '-dimethoxy-7,3 ',5 '-trihydroxyflavone
TL;DR:
The overall pools of plant phenolics in R. mangle leaves are quantified, identify the major constituents of these pools and document their changes during leaf maturation and senescence, where polyphenolic pools become simplified.
(via Semantic Scholar)
Source: ORCID
Added: November 12, 2019
2004 journal article
A quick and efficient system for antibiotic-free expression of heterologous genes in tobacco roots
Plant Cell Reports, 22(10), 765–773.
author keywords: plant genetic engineering; selectable marker; rol genes; hairy roots; recombinant protein production
MeSH headings : Agrobacterium tumefaciens / genetics; Culture Media; Gene Expression; Genetic Markers; Genetic Vectors; Glucuronidase / metabolism; Plant Roots / genetics; Plant Roots / metabolism; Plants, Genetically Modified; Recombinant Proteins / isolation & purification; Recombinant Proteins / metabolism; Tobacco / genetics; Transformation, Genetic
TL;DR:
This work has developed a rapid transformation tool using hairy root formation as a selection marker for transgenic plants and found higher levels of transgene expression in the roots correlated positively with the rates of root elongation on hormone-free medium and thus could be used for positive selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: November 11, 2019
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