Works Published in 2016
Displaying works 1 - 20 of 59 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2016 journal article
The de-etiolated 1 homolog of arabidopsis modulates the ABA signaling pathway and ABA biosynthesis in rice
Plant Physiology, 171(2), 1259–1276.
Contributors: G. Zang *, H. Zou*, Y. Zhang *, Z. Xiang *, J. Huang *, L. Luo *, C. Wang *, K. Lei*
TL;DR:
The data suggest that OsDET1 plays an important role in maintaining normal development in rice and mediates the cross talk between ABA biosynthesis and ABA signaling pathways in rice.
(via Semantic Scholar)
www.plantphysiol.org (publisher PDF)
Source: ORCID
Added: August 5, 2023
2016 journal article
Transcriptome Analysis Reveals Candidate Genes involved in Blister Blight defense in Tea (Camellia sinensis (L) Kuntze)
Scientific Reports, 6(1).
Contributors: K. Jayaswall *, P. Mahajan*, G. Singh *, R. Parmar*, R. Seth* , A. Raina*, M. Swarnkar *, A. Singh *, R. Shankar *, R. Sharma *
MeSH headings : Camellia sinensis / genetics; Camellia sinensis / metabolism; Camellia sinensis / microbiology; Computational Biology / methods; Disease Resistance / genetics; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Ontology; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Host-Pathogen Interactions / genetics; Molecular Sequence Annotation; Plant Diseases / genetics; Plant Diseases / microbiology; Transcriptome
TL;DR:
Compendiously, the current study provides a comprehensive gene expression and insights into the molecular mechanism of tea defense against BB to serve as a resource for unravelling the possible regulatory mechanism of immunity against various biotic stresses in tea and other crops.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 8, 2022
2016 journal article
Low bioaccessibility of vitamin D2from yeast-fortified bread compared to crystalline D2bread and D3from fluid milks
Food & Function, 7(11), 4589–4596.
MeSH headings : Animals; Biological Availability; Bread / analysis; Chromatography, High Pressure Liquid; Ergocalciferols / chemistry; Ergocalciferols / pharmacokinetics; Food Analysis; Food, Fortified; Mass Spectrometry; Milk / chemistry; Yeasts
TL;DR:
The results indicate that the low bioavailability of yeast D2 in comparison to other vitamin D2 sources is likely due to entrapment within a less digestible yeast matrix and not only to metabolic differences between vitamins D2 and D3.
(via Semantic Scholar)
Source: Crossref
Added: January 24, 2021
2016 journal article
Influence of Temperature and Humidity on the Stability of Carotenoids in Biofortified Maize (Zea maysL.) Genotypes during Controlled Postharvest Storage
Journal of Agricultural and Food Chemistry, 64(13), 2727–2736.
author keywords: biofortified corn; carotenoid degradation; retention; nutritional impact; postharvest storage
MeSH headings : Algorithms; Carotenoids / analysis; Carotenoids / chemistry; Edible Grain / chemistry; Genotype; Humidity; Models, Chemical; Temperature; Zea mays / chemistry; Zea mays / genetics
TL;DR:
The results of this study support the notion that effective control of moisture content and temperature of the kernels during storage conditions is essential to reduce the speed of degradative reactions.
(via Semantic Scholar)
Source: Crossref
Added: January 24, 2021
2016 journal article
Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress
ACS Chemical Neuroscience, 7(6), 737–748.
author keywords: TRPV1 ligands; capsaicin; antioxidant; oxidative stress; neuroprotective; antinociceptive
MeSH headings : Analgesics / pharmacology; Animals; CHO Cells; Capsaicin / pharmacology; Cricetulus / metabolism; Male; Models, Molecular; Oxidative Stress / drug effects; Rats, Wistar; TRPV Cation Channels / agonists; TRPV Cation Channels / metabolism; Thiophenes / chemical synthesis; Thiophenes / chemistry; Thiophenes / pharmacology
TL;DR:
4-(Thiophen-2-yl)butanoic acid was identified as a cyclic substitute of the unsaturated alkyl chain of the natural ligand, capsaicin and synthesized in good yield and high purity and their molecular recognition against the target was investigated by means of docking experiments followed by molecular dynamics simulations, in order to rationalize their geometrical and thermodynamic profiles.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2016 journal article
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity
European Journal of Medicinal Chemistry, 109, 99–106.
author keywords: COX-2 inhibitors; 1,5-diarylpyrrole derivatives; Anti-inflammatory agents; Antinociceptive agents; Antiproliferative activity; Molecular modelling
MeSH headings : Adult; Analgesics / chemical synthesis; Analgesics / chemistry; Analgesics / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / chemistry; Antineoplastic Agents / therapeutic use; Cell Line; Cell Proliferation / drug effects; Cyclooxygenase 2 / metabolism; Cyclooxygenase 2 Inhibitors / chemical synthesis; Cyclooxygenase 2 Inhibitors / chemistry; Cyclooxygenase 2 Inhibitors / therapeutic use; Edema / drug therapy; Halogenation; Humans; Hyperalgesia / drug therapy; Models, Molecular; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / therapeutic use; Rats; Skin / drug effects; Skin / pathology; Skin Neoplasms / drug therapy; Skin Neoplasms / pathology
TL;DR:
A series of substituted 1,5-diarylpyrrole-3-alkoxyethyl ethers synthesized showed antiproliferative activity in the HaCaT (aneuploid immortal keratinocyte from adult human skin) cell models and exhibited a prominent in vivo anti-inflammatory and antinociceptive activities, in addition its antiprolifierative power in an in-vitro model of human skin cancer is herein described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2016 journal article
Association between siesta (daytime sleep), dietary patterns and the presence of metabolic syndrome in elderly living in Mediterranean area (MEDIS study): The moderating effect of gender
The Journal of Nutrition, Health & Aging, 21(10), 1118–1124.
author keywords: Metabolic syndrome; sleep; elderly; diet; lifestyle; MEDIS; siesta; mediterranean-type diet
MeSH headings : Aged; Aged, 80 and over; Cross-Sectional Studies; Energy Intake / physiology; Feeding Behavior / physiology; Female; Gender Identity; Humans; Life Style; Male; Mediterranean Islands; Metabolic Syndrome / epidemiology; Metabolic Syndrome / etiology; Prevalence; Sleep / physiology
TL;DR:
Lifestyle parameters including sleep and diet quality are strongly associated with the presence of MetS in elderly cohort, but different their level of influence appears to be different, depending on gender.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2016 journal article
Ozone mediators effect on “in vitro” scratch wound closure
Free Radical Research, 50(9), 1022–1031.
author keywords: Cutaneous tissues; wound healing; HNE; H2O2; oxidative stress
MeSH headings : Humans; Hydrogen Peroxide / metabolism; Oxidative Stress; Skin / drug effects; Wound Healing / physiology
TL;DR:
The present work suggests that ozonated saline effect on wound closure is the results of the combination of more molecules among which HNE and H2O2 play a key role.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome
Neuroscience Research, 105, 28–34.
author keywords: Protein glycosylation; Neurological disorders; Nucleotide pyrophosphatase; Mecp2
MeSH headings : Animals; Brain / metabolism; Glycosylation; Membrane Glycoproteins / metabolism; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mice, Mutant Strains; Pyrophosphatases / metabolism; Rett Syndrome / metabolism
TL;DR:
The findings indicate that there is a causal link between the amount of Mecp2 and the N-glycosylation of NPP-5, and that this link is likely to be causal for Rett syndrome.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Ozone-induced damage in 3D-Skin Model is prevented by topical vitamin C and vitamin E compound mixtures application
Journal of Dermatological Science, 82(3), 209–212.
MeSH headings : Administration, Cutaneous; Antioxidants / administration & dosage; Antioxidants / pharmacology; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Drug Combinations; Environmental Exposure / adverse effects; Epidermis / drug effects; Epidermis / pathology; Humans; Models, Anatomic; Oxidants, Photochemical / toxicity; Ozone / toxicity; Sebum / drug effects; Vitamin E / administration & dosage; Vitamin E / pharmacology
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients
Cytokine, 77, 180–188.
author keywords: Rett syndrome; Autism spectrum disorders; Cytokine; Chemokine; Immune system; Peripheral blood mononuclear cells; Mitochondria
MeSH headings : Adolescent; Adult; Autistic Disorder / blood; Autistic Disorder / genetics; Child; Child, Preschool; Cytokines / blood; Cytokines / genetics; Gene Expression Profiling; Humans; Immunoenzyme Techniques / methods; Interleukin-13 / blood; Interleukin-13 / genetics; Interleukin-15 / blood; Interleukin-15 / genetics; Interleukin-1beta / blood; Interleukin-1beta / genetics; Interleukin-8 / blood; Interleukin-8 / genetics; Interleukin-9 / blood; Interleukin-9 / genetics; Leukocytes, Mononuclear / metabolism; Leukocytes, Mononuclear / ultrastructure; Microscopy, Electron, Transmission; Rett Syndrome / blood; Rett Syndrome / genetics; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A / blood; Vascular Endothelial Growth Factor A / genetics; Young Adult
TL;DR:
A possible role of immune dysfunction in RTT is indicated making the clinical features of this pathology related also to the immunology aspects, suggesting, therefore, novel possible therapeutic interventions for this disorder.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing
Cancer Letters, 380(1), 106–113.
author keywords: Rottlerin; AMPK; mTOR; 4EBP-1; Autophagy; Protein synthesis
MeSH headings : Acetophenones / pharmacology; Adaptor Proteins, Signal Transducing / antagonists & inhibitors; Adaptor Proteins, Signal Transducing / metabolism; Antineoplastic Agents / pharmacology; Antineoplastic Agents / toxicity; Autophagy / drug effects; Benzopyrans / pharmacology; Cell Cycle Proteins; Cell Line; Dose-Response Relationship, Drug; Humans; Mechanistic Target of Rapamycin Complex 1; Melanoma / drug therapy; Melanoma / enzymology; Melanoma / pathology; Multiprotein Complexes / antagonists & inhibitors; Multiprotein Complexes / metabolism; Phosphoproteins / antagonists & inhibitors; Phosphoproteins / metabolism; Protein Biosynthesis / drug effects; Protein Kinase Inhibitors / pharmacology; Protein Kinase Inhibitors / toxicity; Protein Synthesis Inhibitors / pharmacology; Protein Synthesis Inhibitors / toxicity; Signal Transduction / drug effects; Skin Neoplasms / drug therapy; Skin Neoplasms / enzymology; Skin Neoplasms / pathology; TOR Serine-Threonine Kinases / antagonists & inhibitors; TOR Serine-Threonine Kinases / metabolism; Time Factors
TL;DR:
Western blotting analysis, caspase activity assay, nuclear imaging and the effects of autophagy, apoptosis and necroptosis inhibitors indicated that Rottlerin cytotoxicity was due to none of the aforementioned death mechanisms, but in growth arrested cells, the death did occur after a prolonged treatment and most likely ensued from the observed blockage of protein synthesis that reached levels expected to be incompatible with cell survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Redox regulation of inflammatory processes
The International Journal of Biochemistry & Cell Biology, 81, 234–235.
TL;DR:
This poster presents a probabilistic model of the response of the immune system to the presence of foreign substances, using a model derived from the model developed at the University of Ferrara in Italy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Proteomic analysis of 4-hydroxynonenal and nitrotyrosine modified proteins in RTT fibroblasts
The International Journal of Biochemistry & Cell Biology, 81, 236–245.
author keywords: Oxidative stress; 4-hydroxynonenal; Nitric monoxide; Nitrotyrosine; Inducible nitric oxide synthase; Post-translational modification
MeSH headings : Aldehydes / chemistry; Aldehydes / metabolism; Blotting, Western; Case-Control Studies; Cells, Cultured; Female; Fibroblasts / chemistry; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Proteins / chemistry; Proteins / genetics; Proteome; Proteomics; Real-Time Polymerase Chain Reaction; Rett Syndrome / genetics; Rett Syndrome / physiopathology; Tyrosine / analogs & derivatives; Tyrosine / chemistry; Tyrosine / metabolism
TL;DR:
The evidence of a wide range of proteins able to forms adducts with 4-HNE, Nitrotyrosine or with both confirms the possible alteration of several aspects of cellular functions that well correlates to the complex clinical features of RTT patients.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
OxInflammation in Rett syndrome
The International Journal of Biochemistry & Cell Biology, 81, 246–253.
author keywords: Rett syndrome; MECP2; Oxidative stress; Inflammation; Cytokines
MeSH headings : Humans; Inflammation / physiopathology; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Oxidative Stress; Rett Syndrome / physiopathology
TL;DR:
It is described and stimulated a new discussion on the idea that systemic subclinical inflammation and oxidative stress are crucial players of a detrimental vicious circle, driving the pathogenesis and clinical course of RTT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases
The International Journal of Biochemistry & Cell Biology, 81, 356–363.
author keywords: Paraoxonase-1; Arylesterase activity; Multiple sclerosis; Alzheimer's disease; Vascular dementia
MeSH headings : Aged; Aryldialkylphosphatase / blood; Aryldialkylphosphatase / metabolism; Biomarkers / blood; Biomarkers / metabolism; Carboxylic Ester Hydrolases / blood; Carboxylic Ester Hydrolases / metabolism; Dementia / blood; Dementia / diagnosis; Dementia / enzymology; Female; Humans; Male; Multiple Sclerosis / blood; Multiple Sclerosis / diagnosis; Multiple Sclerosis / enzymology; Multiple Sclerosis / physiopathology; Neurodegenerative Diseases / blood; Neurodegenerative Diseases / diagnosis; Neurodegenerative Diseases / enzymology; Neurodegenerative Diseases / metabolism; Risk Factors
TL;DR:
The data suggest that a depressed arylesterase activity could be a common denominator of different neurological diseases which, independently of their peculiar ethiopathogenesis and pathophysiology, appear to be all characterized by an altered systemic redox balance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Targeted lipidomics distinguishes patient subgroups in mild cognitive impairment (MCI) and late onset Alzheimer's disease (LOAD)
BBA Clinical, 5, 25–28.
author keywords: MCI; AD; Plasmalogens; DAG; Patient stratification
TL;DR:
These are the first serum biochemical data to stratify MCI and LOAD patients into 3 different patient cohorts within each clinical diagnosis, advancing efforts to biochemically define patient heterogeneity in cognitive disorders.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Skeletal muscle mass and body fat in relation to successful ageing of older adults: The multi-national MEDIS study
Archives of Gerontology and Geriatrics, 66, 95–101.
author keywords: Successful ageing; Appendicular skeletal muscle mass; Body fat; Energy balance; Older adults
MeSH headings : Adipose Tissue; Aged; Aged, 80 and over; Aging; Body Composition; Body Mass Index; Cross-Sectional Studies; Energy Intake; Energy Metabolism; Feeding Behavior; Female; Greece / epidemiology; Humans; Male; Mediterranean Region / epidemiology; Muscle, Skeletal; Quality of Life; Sarcopenia / epidemiology
TL;DR:
Body composition changes seem to be associated with lower quality of life in the older adults, as measured through successful ageing, and results from sensitivity analysis showed that the effects of variations on body composition were consistent, less pronounced in the positive energy balance group and more pronounced among the oldest old.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 4, 2020
2016 journal article
Physicochemical Characterization and Bioactive Value of Tropical Berry Pomaces after Spouted Bed Drying
Journal of Food Quality.
Source: ORCID
Added: March 6, 2020
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