Works Published in 2013
Displaying works 1 - 20 of 61 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 chapter
Potential Health Benefits of Blackcurrants
In M. Skinner & D. Hunter (Eds.), Bioactives in fruit: health benefits and functional foods (pp. 215–250).
Ed(s): M. Skinner & D. Hunter
Sources: NC State University Libraries, NC State University Libraries
Added: March 19, 2021
2013 journal article
The metabolic fate of anthocyanins in humans
FASEB Journal, 27(Supplement 1), 125.7.
Event: Experimental Biology 2013 Meeting at Boston, MA
TL;DR:
Results indicate that ACNs are extensively metabolised in vivo, with little suggestion of plasma accumulation following repeated exposure, and most likely relates to the high concentrations of circulating phenolic metabolites.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: March 19, 2021
2013 journal article
Absorption, distribution, metabolism and elimination of a stable isotope-labelled anthocyanin in humans
FASEB Journal, 27(Supplement 1), 125.6.
Event: Experimental Biology 2013 Meeting
Source: NC State University Libraries
Added: March 9, 2021
2013 journal article
Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model
Molecular Nutrition & Food Research, 57(12), 2091–2102.
author keywords: Metabolic syndrome; Polyphenols; Standardized grape polyphenol preparation; Synaptic plasticity
MeSH headings : Animals; Biological Availability; Brain / drug effects; Brain / physiopathology; Dietary Fats / pharmacology; Disease Models, Animal; Female; Grape Seed Extract / pharmacology; Male; Metabolic Syndrome / diet therapy; Metabolic Syndrome / drug therapy; Mice; Mice, Inbred C57BL; Neuronal Plasticity / drug effects; Polyphenols / pharmacokinetics; Polyphenols / pharmacology; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes / pharmacology; Synapses / drug effects; Vitis / chemistry
TL;DR:
This study demonstrated that SGP, comprised of multiple bioavailable and bioactive components targeting a wide range of metabolic syndrome related pathological features, provides greater global protection against peripheral and central nervous system dysfunctions and can be potentially developed as a novel prevention/treatment for improving brain connectivity and synaptic plasticity important for learning and memory.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2013 journal article
Metabolism of dietary flavonoids alters their effect on tumor necrosis factor-α
Cytokine, 63(3), 259.
Event: SI: 2013 ICS at San Francisco, CA on September 29 - October 3, 2013
TL;DR:
Metabolism of parent flavonoids may increase their anti-inflammatory bioactivity, and protein data are not corroborated at the mRNA level, suggesting the treatments are having a post-translational effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: November 6, 2020
2013 journal article
NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells
Toxicology and Applied Pharmacology, 267(1), 30–40.
author keywords: Keap1; Ozone; 4-hydroxynonenal; Hydrogen peroxyde; Heme oxygenase-1
MeSH headings : Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular / cytology; Endothelium, Vascular / drug effects; Endothelium, Vascular / metabolism; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / blood; Homeostasis / drug effects; Humans; NF-E2-Related Factor 2 / blood; NF-E2-Related Factor 2 / physiology; Oxidation-Reduction / drug effects; Ozone / toxicity; Serum / metabolism; Serum / physiology; Up-Regulation / drug effects; Up-Regulation / physiology
TL;DR:
New insight is provided on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonation autohemotherapy, targeted to the restoration of redox homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2013 journal article
Ozonated oils as functional dermatological matrices: Effects on the wound healing process using SKH1 mice
International Journal of Pharmaceutics, 458(1), 65–73.
author keywords: Wound healing; 1,2,4-Trioxolane moiety; Prodrugs; Vegetable matrices
MeSH headings : Animals; Collagen / metabolism; Female; Mice; NF-kappa B / metabolism; Plant Oils / pharmacology; Proliferating Cell Nuclear Antigen / metabolism; Skin / drug effects; Skin / metabolism; Vascular Endothelial Growth Factor A / metabolism; Wound Healing / drug effects
TL;DR:
Only treatment with ozonated sesame oil shows a faster wound closure in the first 7 days, paralleled with the increased VEGF and PCNA levels, NFκB nuclear translocation and 4-HNE formation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2013 journal article
Scavenger receptor B1 post-translational modifications in Rett syndrome
FEBS Letters, 587(14), 2199–2204.
author keywords: Oxidative stress; 4-Hydroxynonenal; Ubiquitination; Protein adducts; HDL; Cholesterol
MeSH headings : Adolescent; Adult; Aldehydes / metabolism; Case-Control Studies; Cells, Cultured; Child; Female; Fibroblasts / metabolism; Humans; Lipid Peroxidation; Lipids / blood; Oxidative Stress; Rett Syndrome / metabolism; Scavenger Receptors, Class B / metabolism; Ubiquitination; Young Adult
TL;DR:
These findings show for the first time a loss of SRB1 in RTT cells and its relationship with a chronic oxidative stress status.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2013 journal article
Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes
European Journal of Pharmaceutical Sciences, 49(2), 133–141.
author keywords: COX-2 inhibitor; 1,5-Diarylpyrrole-3-alkopyrrole-3-alkoxyethyl ethers; Cyclin D1; p21
MeSH headings : Cell Line; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / genetics; Cyclin D1 / metabolism; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 Inhibitors / pharmacology; Gene Expression / drug effects; Humans; Keratinocytes; NF-kappa B / metabolism; Pyrroles / pharmacology; RNA, Messenger / metabolism; Sulfones / pharmacology
TL;DR:
Compounds VA441 and VA428, along with their role in inhibiting COX-2 and inflammation, could have a possible therapeutic (topical and systemic) use against skin proliferative disorders, such as psoriasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2013 journal article
Incorporation of quercetin in respirable lipid microparticles: Effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells
Colloids and Surfaces B: Biointerfaces, 112, 322–329.
author keywords: Quercetin; Pulmonary delivery; Lipid microparticles; Alveolar epithelial cells; Stability; Cellular uptake
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / cytology; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / administration & dosage; Antioxidants / pharmacokinetics; Biological Transport, Active; Cell Line; Cell Survival / drug effects; Drug Carriers / chemistry; Drug Compounding; Drug Stability; Humans; Lipids / chemistry; Particle Size; Quercetin / administration & dosage; Quercetin / pharmacokinetics
TL;DR:
Viability studies performed by lactate dehydrogenase assay demonstrated that quercetin LMs showed no significant cytotoxicity on the A549 cells, over the concentration 0.1-5μM, and the enhanced intracellular delivery of quercets achieved by the LMs is likely due to the flavonoid stabilization after encapsulation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2013 journal article
Non-protein-bound iron and 4-hydroxynonenal protein adducts in classic autism
Brain and Development, 35(2), 146–154.
author keywords: Neurodevelopment disorders; Oxidative stress; Free iron; Lipid peroxidation; 4-hydroxynonenal protein adducts
MeSH headings : Adolescent; Adult; Aldehydes / blood; Autistic Disorder / blood; Blotting, Western; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diagnostic and Statistical Manual of Mental Disorders; Erythrocyte Membrane / chemistry; Erythrocytes / chemistry; Female; Glutathione / blood; Humans; Intelligence Tests; Male; Neuropsychological Tests; Nonheme Iron Proteins / blood; Oxidative Stress / physiology; Plasma / chemistry; Young Adult
TL;DR:
An impairment of the redox status in classic autism patients is indicated, with a consequent imbalance between oxidative stress and antioxidant defences, potentially contributing to the autistic phenotype.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2013 journal article
F2-Dihomo-isoprostanes and brain white matter damage in stage 1 Rett syndrome
Biochimie, 95(1), 86–90.
author keywords: MeCP2; Oxidative damage; Adrenic acid; F-2-Dihomo-isoprostanes; Total synthesis; Myelin damage; Autism spectrum disorders; Biomarkers
MeSH headings : Biomarkers / blood; Brain / drug effects; Brain / metabolism; Brain / pathology; Erucic Acids / chemistry; Erucic Acids / metabolism; F2-Isoprostanes / administration & dosage; F2-Isoprostanes / blood; F2-Isoprostanes / chemical synthesis; F2-Isoprostanes / pharmacokinetics; Fatty Acids, Unsaturated; Humans; Leukoencephalopathies / drug therapy; Leukoencephalopathies / metabolism; Leukoencephalopathies / pathology; Lipid Peroxidation / drug effects; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Myelin Sheath / chemistry; Myelin Sheath / pathology; Oxidative Stress; Rett Syndrome / blood; Rett Syndrome / diagnosis; Rett Syndrome / pathology
TL;DR:
Data indicate for the first time that quantification of F(2)-Dihomo-IsoPs in plasma represents an early marker of the disease and may provide a better understanding of the pathogenic mechanisms behind the neurological regression in patients with RTT.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2013 journal article
Bioaccessibility of Carotenoids from Transgenic Provitamin A Biofortified Sorghum
Journal of Agricultural and Food Chemistry, 61(24), 5764–5771.
author keywords: provitamin A; carotenoids; beta-carotene; biofortification; bioaccessibility; sorghum; in vitro digestion; micellarization
MeSH headings : Carotenoids / analysis; Carotenoids / metabolism; Cooking; Dietary Fats / metabolism; Digestion; Fatty Acids, Monounsaturated / metabolism; Food Handling; Humans; Micelles; Models, Biological; Nutritive Value; Plants, Genetically Modified / chemistry; Rapeseed Oil; Seeds / chemistry; Seeds / genetics; Seeds / metabolism; Sorghum / chemistry; Sorghum / genetics; Sorghum / metabolism; Vitamin A / analysis; Vitamin A / biosynthesis; Vitamin A / metabolism
TL;DR:
The notion that biofortification of sorghum can enhance total and bioaccessible provitamin A carotenoid levels is supported, using an in vitro digestion model to screen vectors and independent transgenic events for the bioaccessibility of prov vitamin ACarotenoids.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Photo- and Thermodegradation of Anthocyanins from Grape and Purple Sweet Potato in Model Beverage Systems
Journal of Agricultural and Food Chemistry, 61(6), 1364–1372.
author keywords: acylated anthocyanin; light; heat; kinetics; ascorbic acid
MeSH headings : Anthocyanins / chemistry; Beverages / analysis; Beverages / radiation effects; Hot Temperature; Ipomoea batatas / chemistry; Kinetics; Models, Chemical; Vitis / chemistry
TL;DR:
Anthocyanin-rich grape and purple sweet potato extracts to photo- and thermostresses in ready-to-drink (RTD) beverage models including hot fill beverages with various concentrations of ascorbic acid, a preserved beverage, and a vitamin-enriched water beverage found PSP was significantly less stable than grape extract in the vitamin- enriched water model beverage through photostress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Carotenoid bioavailability from raw vegetables and a moderate amount of oil in human subjects is greatest when the majority of daily vegetables are consumed at one meal
Nutrition Research, 33(5), 358–366.
author keywords: Carotenoid; Bioavailability; Postprandial absorption; Meal patterns; Clinical trial; Human
MeSH headings : Adult; Antioxidants / administration & dosage; Antioxidants / pharmacokinetics; Area Under Curve; Biological Availability; Carotenoids / blood; Carotenoids / pharmacokinetics; Chromatography, Liquid; Fatty Acids, Monounsaturated; Feeding Behavior; Humans; Male; Meals; Pilot Projects; Postprandial Period / drug effects; Rapeseed Oil; Triglycerides / blood; Vegetables / chemistry; Young Adult
TL;DR:
Data suggest that carotenoid absorption may be the greatest when daily recommended vegetables are consumed in one meal compared to smaller doses over multiple meals.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Assessment of phytochemical content in human milk during different stages of lactation
Nutrition, 29(1), 195–202.
author keywords: Flavonoid; Carotenoid; Flavan-3-ols; Flavanones; Flavonols
MeSH headings : Adult; Carotenoids / analysis; Catechin / analogs & derivatives; Catechin / analysis; Cryptoxanthins; Female; Flavanones / analysis; Flavonoids / analysis; Hesperidin / analysis; Humans; Kaempferols / analysis; Lactation / metabolism; Lutein / analysis; Lycopene; Milk, Human / chemistry; Postpartum Period / metabolism; Pregnancy; Quercetin / analysis; Time Factors; Xanthophylls / analysis; Zeaxanthins
TL;DR:
The notion that flavonoids, as with carotenoids, are dietary phytochemicals present in human milk and potentially available to breast-fed infants is supported.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Quantification of vitamin D and 25-hydroxyvitamin D in soft tissues by liquid chromatography–tandem mass spectrometry
Journal of Chromatography B, 932, 6–11.
author keywords: 25-Hydroxyvitamin D analysis; Vitamin D analysis; Ergocalciferol; Cholecalciferol; Tissue distribution; LC-MS/MS
MeSH headings : Adipose Tissue / chemistry; Animals; Chromatography, Liquid / methods; Epididymis / chemistry; Liquid-Liquid Extraction; Liver / chemistry; Male; Muscles / chemistry; Rats; Rats, Sprague-Dawley; Solid Phase Extraction; Tandem Mass Spectrometry / methods; Vitamin D / analogs & derivatives; Vitamin D / analysis; Vitamin D / blood
TL;DR:
Soft tissues of rats feeding crystalline vitamin D3 had higher concentrations of total vitamin D than those of rats fed yeast-derived vitamin D2, while total 25(OH)D concentrations were similar between vitamin D sources.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Assessment of verbascoside absorption in human colonic tissues using the Ussing chamber model
Food Research International, 54(1), 132–138.
author keywords: Bioavailability; Human tissues; Permeability coefficient; Ussing chamber; Verbascoside
TL;DR:
The permeability coefficient calculation has contributed in a deeper understanding of VB absorption and transport across the human intestinal barrier and could be utilized for other polyphenols present in food and in dietary supplements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
Color and chemical stability of tea polyphenol (−)-epigallocatechin-3-gallate in solution and solid states
Food Research International, 53(2), 909–921.
author keywords: Stability; EGCG; Theasinensin; GCG; Epimerization; Oxidation; Solid state; Color
Source: Crossref
Added: August 28, 2020
2013 journal article
Assessment of probiotic strains ability to reduce the bioaccessibility of aflatoxin M1 in artificially contaminated milk using an in vitro digestive model
Food Control, 31(1), 202–207.
author keywords: Aflatoxin M-1; Probiotic bacteria; Binding; Bioaccessibility
TL;DR:
The results of this work suggest that the probiotic strains tested could help to reduce harmful effects of AFM 1 to humans exposed to the aflatoxin through consumption of contaminated milk and/or dairy products.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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