Works Published in 2010
Displaying works 1 - 20 of 32 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
P2-317: Resveratrol lowers beta-amyloid accumulation and deposition in vivo by controlling AMPK signaling
Alzheimer's & Dementia, 6, S406–S406.
Source: Crossref
Added: August 16, 2021
2010 journal article
The influence of beverage composition on delivery of phenolic compounds from coffee and tea
Physiology & Behavior, 100(1), 33–41.
author keywords: Tea; Coffee; Bioaccessibility; Bioavailability; Food matrix; Catechins; Phenolics
MeSH headings : Beverages; Biological Availability; Catechin / pharmacokinetics; Chlorogenic Acid / pharmacokinetics; Coffee / chemistry; Flavonoids / chemistry; Flavonoids / metabolism; Flavonoids / pharmacology; Humans; Models, Biological; Phenols / chemistry; Phenols / metabolism; Phenols / pharmacology; Polyphenols; Tea / chemistry
TL;DR:
An overview of the phenolic composition of coffee and tea is discussed in the context of how processing and composition might influence phenolic profiles and bioavailability of individual phenolic components.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 16, 2021
2010 journal article
Screening and Selection of High Carotenoid Producing in Vitro Tomato Cell Culture Lines for [13C]-Carotenoid Production
Journal of Agricultural and Food Chemistry, 58(18), 9979–9987.
author keywords: Solanum lycopersicum; Solanum pimpinellifolium; plant cell culture; lycopene; phytoene; metabolic tracing; isotopic labeling; carotenoids; tomato; nutrition; metabolism
MeSH headings : Carbon Isotopes; Carotenoids / biosynthesis; Cell Line; Isotope Labeling / methods; Solanum lycopersicum / cytology; Solanum lycopersicum / metabolism
TL;DR:
This is the first report of highly enriched 13C-carotenoid production from in vitro plant cell culture and the best producers with or without the bleaching herbicides, norflurazon and 2-(4-chlorophenyl-thio)triethylamine (CPTA).
(via Semantic Scholar)
europepmc.org (repository)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2010 journal article
Novel PKCs activate ERK through PKD1 in MCF-7 cells
In Vitro Cellular & Developmental Biology - Animal, 47(1), 73–81.
author keywords: MCF-7 cells; PKC; Raf-1; RKIP; PKD; RIN1; ERK
TL;DR:
It is found that nPKCs activate ERK through transphosphorylation of PKD1, the blockage of which prevented PMA-stimulated ERK activation in MCF-7 cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2010 journal article
Modified green liquor (MGL) for bioenergy production: a novel and potentially more efficient wood pretreatment methodology relative to existing methods
O Papel, 71(11), 35–43.
Source: NC State University Libraries
Added: December 24, 2020
2010 journal article
Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes
Toxicology and Applied Pharmacology, 248(3), 285–292.
author keywords: Catalase; CYP; Cytokine; Fatty acid; Gene polymorphism; GST
MeSH headings : Adult; Aged; Cytochrome P-450 Enzyme System / blood; Cytochrome P-450 Enzyme System / genetics; Cytokines / blood; Female; Gene Expression Profiling / methods; Gene Frequency / genetics; Humans; Male; Middle Aged; Multiple Chemical Sensitivity / blood; Multiple Chemical Sensitivity / diagnosis; Multiple Chemical Sensitivity / genetics; Oxidation-Reduction / drug effects; Polymorphism, Genetic / genetics; Xenobiotics / adverse effects; Xenobiotics / blood; Young Adult
TL;DR:
Altered redox and cytokine patterns suggest inhibition of expression/activity of metabolizing and antioxidant enzymes in MCS, and metabolic parameters indicating accelerated lipid oxidation, increased nitric oxide production and glutathione depletion in combination with increased plasma inflammatory cytokines should be considered.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2010 journal article
The Physiological Behaviour of IMR-32 Neuroblastoma Cells is Affected by a 12-h Hypoxia/24-h Reoxygenation Period
Neurochemical Research, 35(11), 1691–1699.
author keywords: Hypoxia; Neuroblastoma cells; [Ca2+](i); Desferoxamine-chelatable free iron; F2-isoprostanes; ERK proteins; Oxidative stress
MeSH headings : Adenosine Triphosphate / metabolism; Aldehydes / metabolism; Calcium / metabolism; Cell Hypoxia / physiology; Cell Line, Tumor; Cell Survival; F2-Isoprostanes / metabolism; Humans; Iron / metabolism; Membrane Potential, Mitochondrial / drug effects; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Neuroblastoma / metabolism; Nitric Oxide / metabolism; Oxygen / metabolism; Oxygen / pharmacology; Protein Carbonylation
TL;DR:
The results indicate that 2% O2 hypoxia induces variations of NO and [Ca2+]i with subsequent mitochondrial depolarization, and it is responsible for oxidative stress, represented by increased free iron and F2-isoprostane, protein carbonyls and 4 hydroxynonenal protein adducts levels.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2010 journal article
Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation
Molecular Nutrition & Food Research, 55(3), 378–386.
author keywords: Anthocyanins; Glucuronide; Metabolism; Phenolic acids
MeSH headings : Analysis of Variance; Anthocyanins / metabolism; Chromatography, High Pressure Liquid; Digestion; Glucosides / metabolism; Glucuronides / chemical synthesis; Glucuronides / metabolism; Humans; Hydroxybenzoates / chemical synthesis; Hydroxybenzoates / metabolism; Intestinal Mucosa / metabolism; Male; Microsomes, Liver / metabolism; Parabens / metabolism
TL;DR:
It is proposed that following ingestion, anthocyanins may be found in the systemic circulation as free or conjugated phenolic acids, which should be a focus of future dietary interventions.
(via Semantic Scholar)
Source: Crossref
Added: September 11, 2020
2010 journal article
Antioxidant Capacity and in Vitro Inhibition of Adipogenesis and Inflammation by Phenolic Extracts of Vaccinium floribundum and Aristotelia chilensis
Journal of Agricultural and Food Chemistry, 58(16), 8966–8976.
author keywords: Aristotelia chilensis; Vaccinium floribundum; adipogenesis; anthocyanins; inflammation; proanthocyanidins; obesity
MeSH headings : 3T3-L1 Cells; Adipogenesis / drug effects; Animals; Antioxidants / analysis; Cell Line; Elaeocarpaceae / chemistry; In Vitro Techniques; Inflammation / prevention & control; Mice; Phenols / chemistry; Plant Extracts / pharmacology; Polyphenols / analysis; Polyphenols / pharmacology; Vaccinium / chemistry
TL;DR:
The anthocyanins and proanthocyanidin-enriched fraction from V. floribundum and A. chilensis phytochemicals limit adipogenesis and inflammatory pathways in vitro, warranting further in vivo studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2010 journal article
Method for evaluating the potential of 14C labeled plant polyphenols to cross the blood–brain barrier using accelerator mass spectrometry
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 268(7-8), 1313–1316.
author keywords: Blood-brain barrier; Grape polyphenols; Pharmacokinetics; Accelerator mass spectrometry; C-14 labeled plant polyphenols
TL;DR:
Using AMS in combination with traditional methods, it is possible to study uptake by blood, distribution to ISF and determine the amount of a dose which can reach the brain and follow the pharmacokinetics in the brain.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2010 journal article
Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells
Journal of Ethnopharmacology, 130(3), 536–544.
author keywords: Tea; Ardisia; Polyphenols; Liver cancer; HepG2; Apoptosis
MeSH headings : Antineoplastic Agents, Phytogenic / administration & dosage; Antineoplastic Agents, Phytogenic / pharmacology; Antioxidants / administration & dosage; Antioxidants / isolation & purification; Antioxidants / pharmacology; Apoptosis / drug effects; Ardisia / chemistry; Flavonoids / administration & dosage; Flavonoids / isolation & purification; Flavonoids / pharmacology; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms / drug therapy; Liver Neoplasms / pathology; Medicine, Traditional; Phenols / administration & dosage; Phenols / isolation & purification; Phenols / pharmacology; Plant Extracts / administration & dosage; Plant Extracts / pharmacology; Polyphenols; Species Specificity; Tea / chemistry; Topoisomerase II Inhibitors
TL;DR:
Although the mechanism is not entirely clear, AC, ACR, and AJ are the Ardisia species with the greatest anticancer potential against liver cancer cells in vitro and deserve further investigation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2010 journal article
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
Journal of Biological Chemistry, 285(12), 9100–9113.
MeSH headings : AMP-Activated Protein Kinases / metabolism; Alzheimer Disease / metabolism; Amyloid beta-Peptides / chemistry; Animals; Autophagy; Calcium / metabolism; Cytosol / metabolism; Enzyme Inhibitors / pharmacology; Humans; Lysosomes / metabolism; Male; Mice; Mice, Transgenic; Neurons / metabolism; Resveratrol; Signal Transduction; Stilbenes / pharmacology
TL;DR:
It is shown that AMPK signaling controls Aβ metabolism and mediates the anti-amyloidogenic effect of resveratrol in non-neuronal and neuronal cells, including in mouse primary neurons, and that resver atrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
Green and Black Tea Inhibit Cytokine-Induced Il-8 Production and Secretion in AGS Gastric Cancer Cells via Inhibition of NF-κB Activity
Planta Medica, 76(15), 1659–1665.
author keywords: black tea; inflammation; gastric cancer; epigallocatechin gallate; green tea
MeSH headings : Camellia sinensis / chemistry; Catechin / analogs & derivatives; Catechin / chemistry; Catechin / pharmacology; Cell Line, Tumor; Chromatography, Liquid; Humans; Interleukin-1beta / pharmacology; Interleukin-8 / metabolism; MAP Kinase Signaling System / drug effects; Mass Spectrometry; NF-kappa B / metabolism; Plant Extracts / chemistry; Plant Extracts / pharmacology; Stomach Neoplasms / metabolism; Tea / chemistry
Source: Crossref
Added: August 28, 2020
2010 journal article
Chocolate Matrix Factors Modulate the Pharmacokinetic Behavior of Cocoa Flavan-3-ol Phase II Metabolites Following Oral Consumption by Sprague−Dawley Rats
Journal of Agricultural and Food Chemistry, 58(11), 6685–6691.
author keywords: Bioavailability; chocolate; flavan-3-ols; epicatechin; phase II metabolism; Sprague-Dawley rat
MeSH headings : Administration, Oral; Animals; Cocos / chemistry; Flavonoids / administration & dosage; Flavonoids / metabolism; Flavonoids / pharmacokinetics; Male; Plant Extracts / administration & dosage; Plant Extracts / metabolism; Plant Extracts / pharmacokinetics; Rats; Rats, Sprague-Dawley
TL;DR:
Milk and sucrose appear to modulate both metabolism and plasma pharmacokinetics and, to a lesser extent, the overall bioavailability of catechins from chocolate confections.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Tea catechin auto-oxidation dimers are accumulated and retained by Caco-2 human intestinal cells
Nutrition Research, 30(5), 327–340.
author keywords: Catechins; Epicatechins; Auto-oxidation; Tea; Dimers; Theasinensin; P-2; Caco-2
MeSH headings : Benzopyrans / chemistry; Benzopyrans / metabolism; Caco-2 Cells; Camellia sinensis / chemistry; Catechin / analogs & derivatives; Catechin / chemistry; Catechin / metabolism; Chromatography, Liquid; Dimerization; Epithelial Cells / metabolism; Humans; Intestinal Absorption; Intestinal Mucosa / metabolism; Mass Spectrometry; Oxidation-Reduction; Phenols / chemistry; Phenols / metabolism; Polymers / chemistry; Polymers / metabolism; Tea / chemistry
TL;DR:
Data suggest that catechin dimers present in the gut lumen may be readily absorbed by intestinal epithelium, suggesting intracellular oxidative conversion of THSNs to P-2.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea
Food Research International, 43(1), 95–102.
author keywords: Bioavailability; Caco-2; Catechin; In vitro digestion; Green tea; Sprague Dawley
TL;DR:
It is suggested that formulation with sucrose and ascorbic acid may improve catechin bioavailability by enhancing bioaccessibility and intestinal uptake from tea.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Development and optimization of an LC-MS/MS-based method for simultaneous quantification of vitamin D2, vitamin D3, 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3
Journal of Separation Science, 34(1), 11–20.
author keywords: Cholecalciferol; Ergocalciferol; LC-MS/MS; Vitamin D
MeSH headings : 25-Hydroxyvitamin D 2 / analysis; Calcifediol / analysis; Cholecalciferol / analysis; Chromatography, Liquid / instrumentation; Chromatography, Liquid / methods; Chromatography, Liquid / standards; Ergocalciferols / analysis; Humans; Molecular Structure; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry / instrumentation; Tandem Mass Spectrometry / methods; Tandem Mass Spectrometry / standards
TL;DR:
A sensitive and reproducible method is reported for simultaneous quantification of vitamin D (2) , vitamin D(3) , 25-hydroxyvitamin D(2) and 25- Hydroxylated molecules in biological samples.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
CVD risk biomarkers and liver and kidney function are not modified following 12-week ingestion of an elderberry extract rich in anthocyanins
Proceedings of the Nutrition Society, 69(OCE1).
TL;DR:
The intake of anthocyanins, a subclass of flavonoids that confers the red, blue and purple colours to plant-based foods such as berries, apples and blackcurrants, has been shown in epidemiological studies to be negatively correlated with CVD risk.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2010 journal article
Anthocyanins form potentially-bioactive phenolic degradation products under simulated physiological conditions
Proceedings of the Nutrition Society, 69(OCE1).
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2010 journal article
The future of flavonoid research
British Journal of Nutrition, 104(S3), S91–S95.
author keywords: Flavonoid; Bioactivity; Bioavailability; Metabolism
MeSH headings : Biological Availability; Biomedical Research; Diet; Flavonoids / metabolism; Flavonoids / pharmacology; Phenols / metabolism; Phenols / pharmacology; Polyphenols
TL;DR:
The following summarises the limitations of polyphenol research as described across various reviews throughout the literature and presents the key requirements for future research.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: November 13, 2019
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