Works Published in 2012

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Displaying works 1 - 20 of 54 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2012 journal article

P3-342: Intranasal delivery of bioactive polyphenol metabolites to prevent and/or treat Alzheimer's disease and other forms of dementia

Alzheimer's & Dementia, 8(4S_Part_16), P577–P577.

By: L. Knable*, P. Vempati*, D. Freire*, M. Ferruzzi* & G. Pasinetti*

Source: Crossref
Added: August 16, 2021

2012 journal article

Different concentrations of grape seed extract affectin vitrostarch fermentation by porcine small and large intestinal inocula

Journal of the Science of Food and Agriculture, 93(2), 276–283.

author keywords: Grape seed extract; pig; intestinal microbiota; in vitro fermentation; short-chain fatty acids; cumulative gas production; ammonia
MeSH headings : Ammonia / metabolism; Animals; Dietary Supplements; Fatty Acids, Volatile / metabolism; Feces / microbiology; Fermentation; Gastrointestinal Agents / metabolism; Gram-Negative Bacteria / isolation & purification; Gram-Negative Bacteria / metabolism; Gram-Positive Bacteria / isolation & purification; Gram-Positive Bacteria / metabolism; Grape Seed Extract / metabolism; Ileum / microbiology; Intestine, Large / microbiology; Intestine, Small / microbiology; Kinetics; Queensland; Seeds / chemistry; Starch / metabolism; Sus scrofa / microbiology; Vitis / chemistry
TL;DR: It is shown that GSE phenolics at a concentration over 250 µg ml⁻¹ can have measurable effects on microbial activity in an in vitro fermentation system, as evidenced by the changes in kinetics and end-products from starch fermentation. (via Semantic Scholar)
Source: Crossref
Added: January 24, 2021

2012 journal article

Continuous Infusion of 20-Hydroxyecdysone Increased Mass of Triceps Brachii in C57BL/6 Mice

Phytotherapy Research, 27(1), 107–111.

By: D. Cheng*, L. Kutzler*, D. Boler*, J. Drnevich*, J. Killefer* & M. Lila*

author keywords: 20-hydroxyecdysone; infusion; mice; microarray; phytoecdysteroids; skeletal muscle
MeSH headings : Anabolic Agents / pharmacology; Animals; Ecdysterone / pharmacology; Gene Expression; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal / drug effects; Muscle, Skeletal / physiology; Oligonucleotide Array Sequence Analysis; Organ Size; Transcriptome
TL;DR: Overall, the data suggest that 20E does not have potent anabolic properties, however, a muscle‐specific increase was observed and genes were identified to provide an explanation for the muscle accretion. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 21, 2021

2012 journal article

Synthesis of [6, 8, 10, 3’, 5’-C-13 (5)]-cyanidin-3-glucoside, for human in vivo metabolism studies

Journal of Labelled Compounds & Radiopharmaceuticals, 55(3), 131–132.

By: Q. Zhang, N. Botting & C. Kay

Source: NC State University Libraries
Added: November 6, 2020

2012 journal article

Effects of pistachios and walnuts on hemodynamic reactivity to stress: Clinical trials in adults with dyslipidemia

Australasian Medical Journal (Online, 5(12), 676.

By: S. West, S. Gebauer, C. Kay, A. Skulas-Ray & P. Kris-Etherton

Source: NC State University Libraries
Added: November 6, 2020

2012 journal article

The Magic Velvet Bean of Mucuna pruriens

Journal of Traditional and Complementary Medicine, 2(4), 331–339.

By: L. Lampariello*, A. Cortelazzo*, R. Guerranti*, C. Sticozzi* & G. Valacchi*

TL;DR: In this review, M. pruriens has been shown to have anti-parkinson and neuroprotective effects, which may be related to its anti-oxidant activity. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020

2012 journal article

Modulation of skin oxidative stress and inflammatory markers by environmental stressors. Differences between young and old

Journal of Dermatological Science, 65(3), 226–228.

By: C. Sticozzi*, A. Pecorelli*, Y. Lim*, E. Maioli*, E. Pagnin*, P. Davis*, G. Valacchi*

MeSH headings : Aging / metabolism; Aging / pathology; Aldehydes / metabolism; Animals; Biomarkers / metabolism; Heme Oxygenase-1 / metabolism; Inflammation / physiopathology; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Mice; Mice, Inbred Strains; Models, Animal; NADPH Oxidases / metabolism; Oxidative Stress / physiology; Ozone / adverse effects; Skin / metabolism; Skin / pathology; Skin / physiopathology; Smoking / adverse effects
TL;DR: In conclusion, epidermogenesis in a skin wound, in the absence of a well-developed BM, results in altered skin homeostasis with an activated epidermis and myofibroblast differentiation, and this results in hypertrophic scar or keloid formation. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020

2012 journal article

Morphological changes and oxidative damage in Rett Syndrome erythrocytes

Biochimica Et Biophysica Acta (BBA) - General Subjects, 1820(4), 511–520.

By: L. Ciccoli*, C. De Felice*, E. Paccagnini*, S. Leoncini*, A. Pecorelli*, C. Signorini*, G. Belmonte*, G. Valacchi*, M. Rossi*, J. Hayek*

author keywords: Rett syndrome; Erythrocytes; Oxidative stress; Hypoxemia; F-2-Isoprostanes; Non protein-bound iron
MeSH headings : Adolescent; Adult; Biomarkers / blood; Cell Hypoxia; Cell Shape; Child; Child, Preschool; Erythrocytes / cytology; Erythrocytes / metabolism; F2-Isoprostanes / blood; Fatty Acids, Omega-3 / administration & dosage; Female; Glutathione / blood; Humans; Hypoxia; Oxidation-Reduction; Oxidative Stress; Oxygen; Pulmonary Gas Exchange; Rett Syndrome / blood; Rett Syndrome / genetics; Young Adult
TL;DR: Findings indicate that in RTT RBCs shape is altered, the OS-hypoxia diad is critical in generating altered R BCs shape and membrane damage, and ω-3 PUFAs are able to partially rescue RBC’s morphology and theOS-derived damage. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020

2012 journal article

Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil

Genes & Nutrition, 7(3), 447–458.

By: C. De Felice*, C. Signorini*, T. Durand*, L. Ciccoli*, S. Leoncini*, M. D’Esposito*, S. Filosa*, C. Oger* ...

author keywords: Rett syndrome; MeCP2; Oxidative Stress; omega-3 polyunsaturated fatty acids; Isoprostanes; Nonprotein bound iron; Antioxidants
TL;DR: For the first time, these findings strongly suggest that a dietary intervention in this genetic disease at an early stage of its natural history can lead to a partial clinical and biochemical rescue. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020

2012 journal article

Cucurbitacin glycosides from Datisca glomerata with antiplasmodial activity

Planta Medica, 78(11).

By: R. Graziose*, M. Grace n, T. Rathinasabapathy*, P. Rojas-Silva*, C. Dekock*, A. Poulev*, M. Lila n, P. Smith*, I. Raskin*

Source: Crossref
Added: September 9, 2020

2012 journal article

Seeking novel Leishmanicidal natural products from common medicinal plants, the example of Eryngium foetidum L

Planta Medica, 78(11).

By: P. Rojas-Silva*, R. Graziose*, A. Poulev*, F. Mbeunkui n, M. Grace n, M. Lila n, I. Raskin*

Source: Crossref
Added: September 9, 2020

2012 journal article

Kinetic Study of Catechin Stability: Effects of pH, Concentration, and Temperature

Journal of Agricultural and Food Chemistry, 60(51), 12531–12539.

author keywords: EGCG; stability; pH; kinetic model; shelf life; tea
MeSH headings : Catechin / analogs & derivatives; Catechin / chemistry; Drug Stability; Food Preservation; Hydrogen-Ion Concentration; Kinetics; Solutions / chemistry; Tea / chemistry; Temperature
TL;DR: An empirical model for catechin content was established as a function of pH and temperature and showed good correlation between green tea concentrated solutions and previous reports of catechine stability in powder systems, providing useful approaches for shelf life calculations and catechchin loss predictions at given temperature and pH conditions in green tea concentrates. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Does flavor impact function? Potential consequences of polyphenol–protein interactions in delivery and bioactivity of flavan-3-ols from foods

Physiology & Behavior, 107(4), 591–597.

author keywords: Polyphenols; Proteins; Astringency; Binding; Flavan-3-ols; Bioaccessibility; Bioavailability
MeSH headings : Astringents / metabolism; Biological Availability; Digestive System / drug effects; Digestive System / enzymology; Enzyme Inhibitors / pharmacokinetics; Enzyme Inhibitors / pharmacology; Flavonoids / chemistry; Flavonoids / pharmacokinetics; Flavonoids / pharmacology; Humans; Molecular Structure; Polyphenols / chemistry; Polyphenols / pharmacokinetics; Polyphenols / pharmacology; Protein Binding; Proteins / metabolism; Taste
TL;DR: The physiological implications of these interactions in food and through the gut will be discussed in relation to manipulation of flavan-3-ol bioavailability, metabolism and biological activities including inhibition of digestive enzymes in the gut. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: August 28, 2020

2012 journal article

Effect of a flash vacuum expansion process on grape juice yield and quality

LWT - Food Science and Technology, 48(2), 147–155.

By: S. Paranjpe*, M. Ferruzzi* & M. Morgan*

author keywords: Flash vacuum expansion; Pectinase; Grape juice quality; Juice yield; Polyphenols
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Crossref
Added: August 28, 2020

2012 journal article

Quantification of anthocyanidins in the grapes and grape juice products with acid assisted hydrolysis using LC/MS

Journal of Functional Foods, 4(4), 710–717.

author keywords: Grape; LC-MS; Polyphenols; Anthocyanins; Anthocyanidins; Acidic hydrolysis
Source: Crossref
Added: August 28, 2020

2012 journal article

Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders

Biochemical and Biophysical Research Communications, 417(1), 457–461.

By: J. Blount*, M. Ferruzzi*, D. Raftery*, G. Pasinetti* & R. Dixon*

author keywords: Alzheimer's disease; Grape seed extract; Polyphenols; Glucuronosyl transferase; Epicatechin glucuronides
MeSH headings : Alzheimer Disease / blood; Alzheimer Disease / metabolism; Animals; Catechin / analogs & derivatives; Catechin / biosynthesis; Catechin / chemistry; Catechin / isolation & purification; Chromatography, High Pressure Liquid; Glucuronates / biosynthesis; Glucuronates / chemistry; Glucuronates / isolation & purification; Glucuronosyltransferase / chemistry; Humans; Mice; Proanthocyanidins / biosynthesis; Proanthocyanidins / blood; Proanthocyanidins / chemistry; Recombinant Proteins / chemistry; UDP-Glucuronosyltransferase 1A9
TL;DR: These studies form a basis for generation of mg quantities of pure epicatechin (methyl) glucuronides of biological significance, and provide clarification of structure of previously identified epicateschin metabolites. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Meal triacylglycerol profile modulates postprandial absorption of carotenoids in humans

Molecular Nutrition & Food Research, 56(6), 866–877.

By: S. Goltz*, W. Campbell*, C. Chitchumroonchokchai*, M. Failla* & M. Ferruzzi*

author keywords: Bioavailability; Carotenoids; Clinical trial; Dietary triacylglycerol; Postprandial absorption
MeSH headings : Adolescent; Adult; Butter; Carotenoids / administration & dosage; Carotenoids / blood; Carotenoids / metabolism; Cross-Over Studies; Diet, High-Fat; Fatty Acids, Monounsaturated / administration & dosage; Female; Humans; Intestinal Absorption; Lutein / administration & dosage; Lutein / blood; Lutein / metabolism; Male; Middle Aged; Nutritive Value; Postprandial Period; Rapeseed Oil; Soybean Oil / administration & dosage; Triglycerides / administration & dosage; Triglycerides / blood; Vegetables / chemistry; Young Adult
TL;DR: While both amount and source of co-consumed lipid affect carotenoid bioavailability from vegetables, amount appears to exert a stronger effect. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2012 journal article

Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food products

Molecular Nutrition & Food Research, 56(11), 1605–1616.

author keywords: Blood pressure; Cardiovascular disease; Dose response; Flavonoids; Flow-mediated dilation
MeSH headings : Biomarkers / metabolism; Blood Pressure / drug effects; Cardiovascular Diseases / diet therapy; Cardiovascular Diseases / drug therapy; Cardiovascular Diseases / metabolism; Catechin / pharmacology; Dose-Response Relationship, Drug; Endothelium, Vascular / drug effects; Endothelium, Vascular / physiology; Flavonoids / chemistry; Flavonoids / pharmacology; Flavonoids / therapeutic use; Humans; Proanthocyanidins / pharmacology; Randomized Controlled Trials as Topic; Regression Analysis; Structure-Activity Relationship; United States
TL;DR: The present analysis suggests that flavonoid bioactivity does not follow a classical linear dose-response association and this may have important biological implications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: March 8, 2020

2012 journal article

Promoting wellness in Alaskan villages: Integrating traditional knowledge and science of wild berries

Ecohealth, 8(2), 199–209.

By: C. Flint*, E. Robinson*, J. Kellogg n, G. Ferguson*, L. BouFajreldin*, M. Dolan*, I. Raskin*, M. Lila n

author keywords: traditional ecological knowledge; wild berries; environmental change; participatory research; youth; health; community wellness
MeSH headings : Alaska; Alcoholism / ethnology; Analysis of Variance; Climate Change; Community-Based Participatory Research; Environmental Pollution / adverse effects; Ethnobotany / methods; Feeding Behavior / ethnology; Focus Groups; Fruit / chemistry; Fruit / physiology; Health Knowledge, Attitudes, Practice / ethnology; Health Promotion / methods; Humans; Indians, North American; Interviews as Topic; Inuit; Social Behavior
TL;DR: Multiple berry species were found to have powerful bioactive health properties for ameliorating metabolic syndrome as well as importance for community wellness and suggest the importance of incorporating locally available foods and socio-cultural traditions into community wellness programming. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Source: NC State University Libraries
Added: February 17, 2020

2012 journal article

Modulation of muscle mass and myogenic stem cells with natural products

Planta Medica, 78(11).

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 5, 2020

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