Works Published in 2006
Displaying works 1 - 20 of 29 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2006 conference paper
Inflammatory status modifies the actions of n3 fatty acids on vascular function
The FASEB Journal, 20(4), A10.
Event: Federation of American Societies for Experimental Biology Meeting
TL;DR:
The specific effects of n3 fatty acids on vascular function appear to be dependent on background inflammatory status of individuals with type II diabetes.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: March 26, 2021
2006 journal article
The nature-versus-nurture debate on bioactive phytochemicals: the genome versus terroir
Journal of the Science of Food and Agriculture, 86(15), 2510–2515.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2006 journal article
Biosynthesis of14C-Phytoene from Tomato Cell Suspension Cultures (Lycopersicon esculentum) for Utilization in Prostate Cancer Cell Culture Studies
Journal of Agricultural and Food Chemistry, 54(3), 747–755.
author keywords: phytoene; phytofluene; carotenoids; tomato; Lycopersicon esculentum; prostate cancer; norflurazon
MeSH headings : Adenocarcinoma / metabolism; Carbon Radioisotopes; Carotenoids / biosynthesis; Carotenoids / metabolism; Cell Line, Tumor; Cells, Cultured; Humans; Isotope Labeling / methods; Solanum lycopersicum / metabolism; Male; Prostatic Neoplasms / metabolism
TL;DR:
The ability to biosynthesize, radiolabel, and isolate these carotenoids from tomato cell cultures is a novel, valuable methodology for further in vitro and in vivo investigations into the roles of phytoene and phy tofluene in cancer chemoprevention.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2006 journal article
Chemopreventive Activity of Polyphenolics from Black Jamapa Bean (Phaseolus vulgarisL.) on HeLa and HaCaT Cells
Journal of Agricultural and Food Chemistry, 54(6), 2116–2122.
author keywords: Phaseolus vulgaris; polyphenolic compounds; cytotoxicity; HeLa cells; HaCaT cells
MeSH headings : Anticarcinogenic Agents / pharmacology; Apoptosis / drug effects; Cell Adhesion / drug effects; Cell Cycle / drug effects; Cell Division / drug effects; Cell Line, Tumor; Flavonoids / pharmacology; HeLa Cells; Humans; Keratinocytes; Methanol; Phaseolus / chemistry; Phenols / pharmacology; Plant Extracts / pharmacology; Polyphenols; Precancerous Conditions; Seeds / chemistry; Skin Neoplasms
TL;DR:
The results indicated that black Jamapa beans could be a source of polyphenolic compounds, which have an inhibitory effect toward HeLa cancer cells but are less aggressive on HaCaT premalignant cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2006 journal article
Identification of isoflavone glycosides inPueraria lobata cultures by tandem mass spectrometry
Phytochemical Analysis, 18(1), 50–59.
author keywords: HPLC-UV-MS; metabolic profiling; isoflavone profiling; puerarin; in vitro cultures; Pueraria lobata
MeSH headings : Cells, Cultured; Chromatography, High Pressure Liquid; Glycosides / analysis; Isoflavones / analysis; Mass Spectrometry; Plant Roots / chemistry; Pueraria / chemistry; Spectrophotometry, Ultraviolet
TL;DR:
The molecular weights, interpretation of characteristic fragment ions obtained from HPLC-MS/MS and comparison with reported data allowed the putative identification of the isoflavone metabolites.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2006 journal article
Modulation of cutaneous wound healing by ozone: Differences between young and aged mice
Toxicology Letters, 160(2), 127–134.
author keywords: aging; ozone; wound healing; TGF beta; NF kappa B; lipid peroxidation
MeSH headings : Aging / physiology; Aldehydes / analysis; Aldehydes / chemistry; Animals; Cross-Linking Reagents / analysis; Cross-Linking Reagents / chemistry; Female; I-kappa B Proteins / biosynthesis; Lipid Peroxidation / drug effects; Mice; Mice, Hairless; Models, Animal; NF-KappaB Inhibitor alpha; Ozone / toxicity; Protein Binding; Proteins / analysis; Proteins / chemistry; Skin / drug effects; Skin / injuries; Skin / metabolism; Transforming Growth Factor beta / biosynthesis; Wound Healing / drug effects
TL;DR:
The hypothesis that oxidant pollutant exposure and age interact so as to disrupt normal wound healing processes is supported.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2006 journal article
Catalytic Inhibition of Human DNA Topoisomerase II by Interactions of Grape Cell Culture Polyphenols
Journal of Agricultural and Food Chemistry, 54(6), 2083–2087.
author keywords: chemopreventive agents; grape cell culture; isobolographic analysis; resveratrol; synergistic interactions; topoisomerase II catalytic inhibition; Vitis
MeSH headings : Catalysis; DNA Topoisomerases, Type II / metabolism; Drug Interactions; Drug Synergism; Enzyme Inhibitors / pharmacology; Flavonoids / pharmacology; Fruit / chemistry; Humans; Phenols / pharmacology; Polyphenols; Topoisomerase II Inhibitors; Vitis / chemistry
TL;DR:
Evaluated the potency of, and potential interactions between, individual fractions and some of the purified bioactive polyphenols that comprise these fractions on human DNA topoisomerase II catalytic activity and demonstrated potentiating interactions between the PB2 and the other polyphenolic constituents mentioned above and between myricetin and resveratrol.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2006 journal article
Cytotoxicity of bioactive polymeric fractions from grape cell culture on human hepatocellular carcinoma, murine leukemia and non-cancerous PK15 kidney cells
Food and Chemical Toxicology, 44(10), 1758–1767.
author keywords: human hepatocellular carcinoma cells; mouse leukemia cells; grape cell culture; proanthocyanidin oligomers
MeSH headings : Animals; Carcinoma, Hepatocellular / drug therapy; Cell Line; Cell Line, Tumor; Flavonoids / pharmacology; Humans; Kidney / drug effects; Leukemia L1210 / drug therapy; Liver Neoplasms / drug therapy; Mice; Plant Extracts / pharmacology; Vitis / chemistry; Vitis / cytology
TL;DR:
Because TP-6 and its subfractions were selectively cytotoxic to cancerous cell lines tested, they warrant further investigation as potential natural anticancer agents.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2006 journal article
Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines
Cancer Letters, 231(2), 240–246.
author keywords: vaccinium; blueberry; prostate cancer; antiproliferation; proanthocyanidin
MeSH headings : Androgens / metabolism; Blueberry Plants / chemistry; Cell Proliferation / drug effects; Humans; Magnetic Resonance Spectroscopy; Male; Neoplasms, Hormone-Dependent / drug therapy; Proanthocyanidins / therapeutic use; Prostatic Neoplasms / drug therapy; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured
TL;DR:
Differences in cell growth inhibition of LNCaP and DU145 cell lines by blueberry fractions rich in proanthocyanidins indicate that blueberry proantho-phenolic compounds have an effect primarily on androgen-dependant growth of prostate cancer cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2006 journal article
Digestive Stability, Micellarization, and Uptake of β-Carotene Isomers by Caco-2 Human Intestinal Cells
Journal of Agricultural and Food Chemistry, 54(7), 2780–2785.
author keywords: beta-carotene; carotenoids; cis isomers; in vitro digestion; Caco-2 intestinal cells; HPLC; electrochemical detection
MeSH headings : Caco-2 Cells; Chromatography, High Pressure Liquid; Dietary Supplements; Digestion; Humans; In Vitro Techniques; Intestinal Mucosa / metabolism; Isomerism; Micelles; beta Carotene / metabolism
TL;DR:
It is suggested that cis isomers of BC are preferentially micellarized during digestion and transferred across the brush-border surface of the enterocyte from mixed micelles with similar efficiency as all-trans-BC at the concentrations of the carotenoids utilized in this study.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Analysis of catechins from milk–tea beverages by enzyme assisted extraction followed by high performance liquid chromatography
Food Chemistry, 99(3), 484–491.
author keywords: tea; catechins; flavonoids; milk; extraction; enzyme treatment; pepsin; HPLC
Source: Crossref
Added: August 28, 2020
2006 journal article
High-throughput analysis of catechins and theaflavins by high performance liquid chromatography with diode array detection
Journal of Chromatography A, 1132(1-2), 132–140.
author keywords: catechins; theaflavins; flavonoids; tea; HPLC-DAD; LC-ESI-MS
MeSH headings : Biflavonoids / analysis; Biflavonoids / chemistry; Catechin / analysis; Catechin / chemistry; Chromatography, High Pressure Liquid / instrumentation; Chromatography, High Pressure Liquid / methods; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / methods; Tea / chemistry
TL;DR:
Two new RP-C18 methods for HPLC-DAD analysis of tea flavonoids were developed to facilitate separation of catechins within 5 min and separation ofcatechins and theaflavins within 10 min total analysis time, representing a 2-4-fold reduction in HPLC analysis time from existing analytical methods.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Consumer acceptability of low-sugar watermelon sweetened with non-calorie sweetener by a Native American community
International Journal of Food Sciences and Nutrition, 57(5-6), 363–368.
author keywords: low sugar; glycemic index; lycopene; watermelon
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Caloric Restriction; Carotenoids / analysis; Child; Citrullus / chemistry; Consumer Behavior; Diabetes Mellitus, Type 2 / diet therapy; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / psychology; Dietary Carbohydrates / analysis; Female; Humans; Indians, North American / psychology; Male; Middle Aged; Sucrose / administration & dosage; Sucrose / analogs & derivatives; Sweetening Agents / administration & dosage; Taste / physiology; United States / epidemiology
TL;DR:
The artificially sweetened low-sugar watermelons were lower in sugar composition but were comparable with conventional melons in all other quality factors and were found acceptable in taste by a broad age group of Native American consumers.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Carotenoid Changes of Intact Watermelons after Storage
Journal of Agricultural and Food Chemistry, 54(16), 5868–5874.
author keywords: lycopene; beta-carotene; chilling injury; triploid watemelon; Citrullus lanatus (Thunb Matsum & Nakai)
MeSH headings : Antioxidants / analysis; Carotenoids / analysis; Citrullus / chemistry; Food Preservation / methods; Hydrogen-Ion Concentration; Seeds; Temperature; Time Factors
TL;DR:
It is shown that carotenoid biosynthesis in watermelons can be affected by temperature and storage, and three types of watermelon, open-pollinated seeded, hybrid seeded, and seedless types, were stored at 5, 13, and 21 degrees C for 14 days and flesh color, composition, and carotinoid content were compared to those of fruit not stored.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Carotenoid Content of 50 Watermelon Cultivars
Journal of Agricultural and Food Chemistry, 54(7), 2593–2597.
author keywords: lycopene; free radical scavenger; antioxidant; Citrullus lanatus
MeSH headings : Carotenoids / analysis; Chromatography, High Pressure Liquid; Citrullus / chemistry; Citrullus / genetics; Colorimetry; Fruit / chemistry; Genotype; Lycopene; Species Specificity; Spectrophotometry
TL;DR:
All-trans-lycopene was the predominant carotenoid in all watermelon cultivars measured by high-performance liquid chromatography, but the germplasm differed in the relative amounts of cis-lyCopene, beta-carotene, and phytofluene.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Patenting Applied to Genetic Sequence Information
Biotechnology and Genetic Engineering Reviews, 23(1), 317–330.
MeSH headings : Databases, Genetic / legislation & jurisprudence; Genetic Engineering / legislation & jurisprudence; Humans; Ownership / legislation & jurisprudence; Patents as Topic / legislation & jurisprudence; United States
Sources: Crossref, NC State University Libraries
Added: January 4, 2020
2006 journal article
Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors
Acta Pharm, 56(3), 259–272. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748855540&partnerID=MN8TOARS
Contributors: P. Yogeeswari, D. Sriram, R. Thirumurugan, L. Jeewanlal, S. Jit, J. Ragavendran, R. Kavya, K. Rakhra, V. Saraswat
Source: ORCID
Added: December 9, 2019
2006 journal article
Synthesis and structure-activity relationship on anticonvulsant aryl semicarbazones
Medicinal Chemistry, 2(1), 55–62.
Contributors: P. Yogeeswari *, J. Ragavendran*, R. Thirumurugan, S. Induja*, D. Sriram * & J. Stables*
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / chemical synthesis; Anticonvulsants / therapeutic use; Binding Sites; Electroshock; Injections, Subcutaneous; Mice; Pentylenetetrazole / administration & dosage; Rats; Seizures / chemically induced; Seizures / drug therapy; Semicarbazones / administration & dosage; Semicarbazones / chemical synthesis; Semicarbazones / therapeutic use; Structure-Activity Relationship
TL;DR:
The 4-fluorophenyl substituted semicarbazones (5a-5y) emerged as the most potent compounds exhibiting anticonvulsant activity in mouse intraperitoneal (i.p.) and rat per oral (p.o.) MES, scPTZ and psychomotor seizure screens.
(via Semantic Scholar)
Source: ORCID
Added: December 9, 2019
2006 journal article
Epibatidine and its analogues as nicotinic acetylcholine receptor agonist: an update
Nat Prod Res, 20(5), 497–505.
Contributors: P. Yogeeswari *, D. Sriram *, T. Ratan Bal* & R. Thirumurugan *
author keywords: epibatidine; nicotinic acetylcholine receptor; analgesics; alkaloid
MeSH headings : Analgesics, Non-Narcotic / chemistry; Analgesics, Non-Narcotic / pharmacology; Analgesics, Non-Narcotic / therapeutic use; Analgesics, Non-Narcotic / toxicity; Animals; Anura; Bridged Bicyclo Compounds, Heterocyclic / chemistry; Bridged Bicyclo Compounds, Heterocyclic / pharmacology; Bridged Bicyclo Compounds, Heterocyclic / therapeutic use; Bridged Bicyclo Compounds, Heterocyclic / toxicity; Nicotinic Agonists / chemistry; Nicotinic Agonists / pharmacology; Nicotinic Agonists / therapeutic use; Nicotinic Agonists / toxicity; Pain / drug therapy; Phytotherapy; Pyridines / chemistry; Pyridines / pharmacology; Pyridines / therapeutic use; Pyridines / toxicity; Receptors, Nicotinic / drug effects; Skin / metabolism; Structure-Activity Relationship
TL;DR:
An alkaloid isolated from the skin of the Ecuadorian poison frog, Epipedobates tricolor, has attracted attention because of its exceptionally powerful analgesic properties, and the fact that it acts at nicotine rather than opiate receptors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 9, 2019
2006 journal article
Discovery of new antitubercular oxazolyl thiosemicarbazones
J Med Chem, 49(12), 3448–3450.
Contributors: D. Sriram *, P. Yogeeswari *, R. Thirumurugan * & R. Pavana *
MeSH headings : Antibiotics, Antitubercular / chemical synthesis; Antibiotics, Antitubercular / chemistry; Antibiotics, Antitubercular / pharmacology; Drug Resistance, Multiple, Bacterial; Microbial Sensitivity Tests; Mycobacterium tuberculosis / drug effects; Structure-Activity Relationship; Thiosemicarbazones / chemical synthesis; Thiosemicarbazones / chemistry; Thiosemicarbazones / pharmacology
TL;DR:
N-(5-cyclobutyl-1,3-oxazol-2-yl)thiosemicarbazone 6q was found to be the most active compound in vitro with minimum inhibitory concentration of 0.05 microg/mL against MTB and MDR-TB and in the in vivo animal model 6q decreased the bacterial load in lung and spleen tissues with 2.1 log 10 protections.
(via Semantic Scholar)
Source: ORCID
Added: December 9, 2019
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