Works Published in 2008
Displaying works 1 - 20 of 25 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
Impact of Deliquescence on the Chemical Stability of Vitamins B1, B6, and C in Powder Blends
Journal of Agricultural and Food Chemistry, 56(15), 6471–6479.
author keywords: deliquescence; thiamin; pyridoxine; ascorbate; stability; humidity
MeSH headings : Adsorption; Ascorbic Acid / chemistry; Chromatography, High Pressure Liquid; Drug Stability; Humidity; Hydrogen-Ion Concentration; Pharmaceutical Preparations / chemistry; Powders / chemistry; Thiamine / chemistry; Vitamin B 6 / chemistry; Water / analysis
TL;DR:
Formulation, storage conditions, and the relation of these to deliquescence points may affect the shelf life, quality, and functionality of vitamin blends and should be considered in product development, processing, storage, and use.
(via Semantic Scholar)
Source: Crossref
Added: January 24, 2021
2008 journal article
Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures
Genes & Nutrition, 4(1).
author keywords: beta-Carotene; Lycopene; Cigarette smoke; Lung inflammation; Oligonucleotide arrays; Granulocytes; C57BL/6 mice
TL;DR:
The data suggest that mice offer a viable in vivo model for studying bioactivities of dietary CARs and their modulatory effects on lung genomic expression in both health and after exposure to CS toxicants.
(via Semantic Scholar)
genesandnutrition.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2008 journal article
Severe Vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model
Free Radical Research, 42(4), 387–396.
author keywords: eosinophils; allergic inflammation; asthma; cytokines; IgE; vitamin E
MeSH headings : Animals; Asthma / genetics; Asthma / metabolism; Asthma / pathology; Bronchial Hyperreactivity / metabolism; Carrier Proteins / genetics; Eosinophils / metabolism; Gene Expression Regulation; Immunoglobulin E / blood; Inflammation; Interleukin-5 / metabolism; Lung / pathology; Mice; Mice, Knockout; Ovalbumin / chemistry; Oxidative Stress; Vitamin E Deficiency / complications
TL;DR:
It was concluded that the initial stimulation of immune responses by the TTP−/− mice were generally blunted compared to the T TP+/+ mice, thus diminishing some aspects of subsequent allergic inflammatory processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2008 journal article
Antiproliferative and Survival Properties of PMA in MCF-7 Breast Cancer Cell
Cancer Investigation, 26(1), 13–21.
MeSH headings : Blotting, Western; Breast Neoplasms / metabolism; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Extracellular Signal-Regulated MAP Kinases / drug effects; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Flavonoids / pharmacology; Fluorescent Antibody Technique; Gene Expression / drug effects; Humans; Immunohistochemistry; Phorbol Esters / pharmacology; Proliferating Cell Nuclear Antigen / drug effects; Proliferating Cell Nuclear Antigen / metabolism; Signal Transduction / drug effects; Tetradecanoylphorbol Acetate / pharmacology; Tumor Suppressor Protein p53 / drug effects; Tumor Suppressor Protein p53 / metabolism; p21-Activated Kinases / drug effects; p21-Activated Kinases / metabolism
TL;DR:
It is concluded that PMA inhibits MCF-7 cell growth and simultaneously stimulates cell survival; both responses are linked to ERK-dependent and p53-independent p21 induction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2008 journal article
Rottlerin inhibits the nuclear factor κB/Cyclin-D1 cascade in MCF-7 breast cancer cells
Life Sciences, 82(11-12), 638–643.
author keywords: Rottlerin; MCF-7 cells; cyclin-D1; NF kappa B; CaMKII
MeSH headings : Acetophenones / metabolism; Acetophenones / pharmacology; Benzopyrans / metabolism; Benzopyrans / pharmacology; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism; Cell Line, Tumor / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin D1 / genetics; Cyclin D1 / metabolism; Enzyme Inhibitors / metabolism; Enzyme Inhibitors / pharmacology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Humans; Indoles / metabolism; Indoles / pharmacology; Maleimides / metabolism; Maleimides / pharmacology; NF-kappa B / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction / physiology
TL;DR:
Preliminary evidence is provided that the interference on the NFkappaB activation process likely occurs at the level of calcium/calmodulin-dependent protein kinase II (CaMKII), a known Rottlerin target, and the drug prevented calcium-induced CaMKII autophosphorylation which, in turn, led to decreased NFkakuB activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 11, 2020
2008 journal article
Isolation of Radiolabeled Isoflavones from Kudzu (Pueraria lobata) Root Cultures
Journal of Agricultural and Food Chemistry, 56(17), 7860–7865.
author keywords: kudzu; Pueraria lobata; isoflavones; puerarin; daidzein
MeSH headings : Carbon Radioisotopes; Isoflavones / analysis; Isoflavones / isolation & purification; Isotope Labeling; Plant Roots / chemistry; Pueraria / chemistry; Tissue Culture Techniques
TL;DR:
The isolated isoflavones isolated from kudzu root cultures were sufficiently (14)C-labeled to permit utilization for subsequent in vivo metabolic tracking studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Optimization of Lycopene Extraction from Tomato Cell Suspension Culture by Response Surface Methodology
Journal of Agricultural and Food Chemistry, 56(17), 7710–7714.
author keywords: tomato; cell culture; lycopene; extraction; RSM
MeSH headings : Carotenoids / analysis; Carotenoids / isolation & purification; Cell Culture Techniques; Chromatography, High Pressure Liquid; Ethanol; Fruit / chemistry; Fruit / cytology; Hydroxides; Lycopene; Solanum lycopersicum / chemistry; Organophosphates; Plant Extracts / chemistry; Potassium Compounds; Statistics as Topic
TL;DR:
These optimal conditions predicted by RSM were confirmed to enhance lycopene yield from standardized tomato cell cultures by more than 3-fold.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells
Journal of Agricultural and Food Chemistry, 56(10), 3532–3537.
author keywords: ecdysteroid; ajuga; spinach; protein synthesis; skeletal muscle; myotube; C2C12
MeSH headings : Ajuga / chemistry; Animals; Cell Line; Ecdysteroids / analysis; Ecdysteroids / pharmacology; Ecdysterone / pharmacology; Humans; Male; Mice; Muscle Cells / drug effects; Muscle Cells / metabolism; Muscle Fibers, Skeletal / drug effects; Muscle Fibers, Skeletal / metabolism; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Plants / chemistry; Protein Biosynthesis / drug effects; Rats; Rats, Sprague-Dawley; Spinacia oleracea / chemistry
TL;DR:
An in vitro cellular assay of protein synthesis was developed and found that phytoecdysteroids increased protein synthesis by up to 20% and ecdysteroid-containing plant extracts produced similar results, which suggests a PI3K-mediated mechanism.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Influence of Alternative Liquid Chromatography Techniques on the Chemical Complexity and Bioactivity of Isolated Proanthocyanidin Mixtures
Journal of Agricultural and Food Chemistry, 56(6), 1896–1906.
author keywords: proanthocyanidins; wild blueberry; Vaccinium angustifolium Ait.; Toyopearl HW-40; sephadex; LH-20; silica gel type G; topolsomerase II bioassay
MeSH headings : Chromatography, High Pressure Liquid; Chromatography, Liquid / methods; Enzyme Inhibitors / pharmacology; Humans; Plant Extracts / chemistry; Plant Extracts / pharmacology; Proanthocyanidins / chemistry; Proanthocyanidins / isolation & purification; Spectrometry, Mass, Electrospray Ionization; Topoisomerase II Inhibitors
TL;DR:
A 2(3) factorial analysis revealed that the vacuum and open column strategies for separation did not yield significantly different results in terms of mass recovery, DP, or bioactivity; however, interactions with other factors such as matrix or subfraction series resulted in distinctive shifts in fraction profiles and biological activity.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Phytochemical Composition and Metabolic Performance-Enhancing Activity of Dietary Berries Traditionally Used by Native North Americans
Journal of Agricultural and Food Chemistry, 56(3), 654–660.
author keywords: Amelanchier alnifolia; Viburnum trilobum; Prunus virginiana; Shepherdia argentea; diabetes; inflammation; energy expenditure
MeSH headings : Aldehyde Reductase / antagonists & inhibitors; Anthocyanins / analysis; Diet; Elaeagnaceae / chemistry; Energy Metabolism / drug effects; Flavonoids / analysis; Fruit / chemistry; Humans; Indians, North American; Plant Extracts / chemistry; Prunus / chemistry; Rosaceae / chemistry; Viburnum / chemistry
TL;DR:
Four wild berry species integral to the traditional subsistence diet of Native American tribal communities contain a rich array of phytochemicals that have the capacity to promote health and protect against chronic diseases, such as diabetes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Satiety in rats following blueberry extract consumption induced by appetite-suppressing mechanisms unrelated to in vitro or in vivo antioxidant capacity
Food Chemistry, 107(3), 1039–1044.
author keywords: blueberry; cultivars; satiety; rats; antioxidant; FRAP
TL;DR:
The observed results suggest that the reduction in food intake and decrease in body weight in experimental animals is not merely a consequence of antioxidant mechanisms, and BBE may provide a good satiety inducer and weight management modulator.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Plant extracts from central Asia showing antiinflammatory activities in gene expression assays
Phytotherapy Research, 22(7), 929–934.
author keywords: antiinflammatory natural product; gene expression; real-time RT-PCR
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Asia, Central; Cell Survival / drug effects; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dose-Response Relationship, Drug; Gene Expression / drug effects; Gene Expression Profiling; Inhibitory Concentration 50; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Macrophages / drug effects; Macrophages / metabolism; Medicine, East Asian Traditional; Mice; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Phytotherapy; Plant Extracts / pharmacology; Plants, Medicinal / chemistry; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
A mouse macrophage‐based quantitative, reverse transcription polymerase chain reaction (qRT‐PCR) system was optimized to screen plant extracts for antiinflammatory activities using three well known genetic markers of inflammation, and extracts identified were able to reduce inflammatory symptoms in vivo.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 9, 2020
2008 journal article
Interaction of Environmental Moisture with Powdered Green Tea Formulations: Effect on Catechin Chemical Stability
Journal of Agricultural and Food Chemistry, 56(11), 4068–4077.
author keywords: green tea; catechin stability; degradation; powder; humidity
MeSH headings : Adsorption; Ascorbic Acid / chemistry; Catechin / chemistry; Drug Stability; Environment; Food Preservation; Humidity; Sodium Nitrite / pharmacology; Tea / chemistry
TL;DR:
Results are the first to demonstrate that addition of other dry components to tea powders may affect catechin stability in finished dry blends and highlight the importance of considering the complex interplay between a multicomponent system and its environment for developing stable products.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Carotenoid Bioaccessibility from Whole Grain and Degermed Maize Meal Products
Journal of Agricultural and Food Chemistry, 56(21), 9918–9926.
author keywords: Carotenoids; maize; lutein; carotene; bread; porridge; bioaccessibility
MeSH headings : Biological Availability; Carotenoids / analysis; Food-Processing Industry; Lutein / analysis; Xanthophylls / analysis; Zea mays / chemistry; Zeaxanthins
TL;DR:
The results suggest that maize-based food products are good dietary sources of bioaccessible carotenoids and that specific food preparation methods may influence the relative bioaccessibility of individual carotanoid species.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Impact of the Hard-to-Cook Phenomenon on Phenolic Antioxidants in Dry Beans (Phaseolus vulgaris)
Journal of Agricultural and Food Chemistry, 56(9), 3102–3110.
author keywords: common beans; Phaseolus vulgaris; phenolic acids; antioxidant activity; hard-to-cook phenomenon
MeSH headings : Antioxidants / analysis; Food Preservation; Food Technology; Hot Temperature; Hydroxybenzoates / analysis; Phaseolus / chemistry; Phenols / analysis; Seeds / chemistry; Time Factors
TL;DR:
This study showed that the HTC phenomenon affected a potential nutritive characteristic of dry beans, and the contents of free and acid hydrolyzable phenolic acids were reduced and the antioxidant activity was reduced.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2008 journal article
Epigallocatechin-3-gallate (EGCG) inhibits PC-3 prostate cancer cell proliferation via MEK-independent ERK1/2 activation
Chemico-Biological Interactions, 171(1), 89–95.
author keywords: epigallocatechin-3-gallate; extracellular signal-regulated kinase; prostate cancer; green tea
MeSH headings : Anticarcinogenic Agents / pharmacology; Catechin / analogs & derivatives; Catechin / pharmacology; Cell Line; Cell Line, Tumor; Cell Proliferation / drug effects; Chromones / pharmacology; Enzyme Activation / drug effects; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Flavonoids / pharmacology; Humans; Inhibitory Concentration 50; Male; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases / metabolism; Morpholines / pharmacology; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation / drug effects; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Kinase Inhibitors / pharmacology
TL;DR:
Results suggest that ERK1/2 activation via a MEK-independent, PI3-K-dependent signaling pathway is partially responsible for the antiproliferative effects of EGCG in PC-3 cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2008 journal article
Cucurbit Grafting
Critical Reviews in Plant Sciences, 27(1), 50–74.
author keywords: Cucurbitaceae; watermelon; cantaloupe; cucumber; methods; quality; yield
Source: Crossref
Added: August 28, 2020
2008 journal article
Blueberry fruit response to postharvest application of ultraviolet radiation
Postharvest Biology and Technology, 47(3), 280–285.
author keywords: UV-C; phototreatment; ripe rot; anthracnose; antioxidant; V. corymbosum
Source: Crossref
Added: August 28, 2020
2008 journal article
The major intestinal metabolites of anthocyanins are unlikely to be conjugates of their parent compounds but metabolites of their degradation products
Proceedings of the Nutrition Society, 67(OCE8).
TL;DR:
) does not appear achievable inhuman subjects and the in vitro mechanistic bioactivity of anthocyanins has been exclusively explored using aglycones andglycoside conjugates, despite a lack of evidence establishing these compounds as the biologically-available forms.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2008 journal article
Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study--
The American Journal of Clinical Nutrition, 88(3), 651–659.
Source: ORCID
Added: November 13, 2019
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