Rodney L. Page

Works (45)

Updated: July 13th, 2023 20:00

2002 journal article

Preoperative radiotherapy for vaccine associated sarcoma in 92 cats

VETERINARY RADIOLOGY & ULTRASOUND, 43(5), 473–479.

By: T. Kobayashi  n, M. Hauck n, R. Dodge*, R. Page*, G. Price, L. Williams n, E. Hardie n, K. Mathews n, D. Thrall n

author keywords: cat; vaccine-associated sarcoma; radiation therapy; preoperative irradiation
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Carboplatin / administration & dosage; Carboplatin / therapeutic use; Cat Diseases / chemically induced; Cat Diseases / drug therapy; Cat Diseases / radiotherapy; Cat Diseases / surgery; Cats; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Female; Male; Neoplasm Recurrence, Local / mortality; Neoplasm Recurrence, Local / prevention & control; Neoplasm Recurrence, Local / veterinary; North Carolina; Preoperative Care / veterinary; Records / veterinary; Retrospective Studies; Sarcoma / chemically induced; Sarcoma / mortality; Sarcoma / radiotherapy; Sarcoma / surgery; Sarcoma / veterinary; Soft Tissue Neoplasms / chemically induced; Soft Tissue Neoplasms / mortality; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / surgery; Soft Tissue Neoplasms / veterinary; Treatment Outcome; Vaccination / adverse effects; Vaccination / veterinary
TL;DR: Preoperative irradiation is an effective treatment for cats with vaccine associated sarcoma, especially if complete excision can be accomplished following irradiation, and outcome in cats receiving carboplatin was better than all other treatment groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 article

Retrospective analysis of axial skeleton osteosarcoma in 22 large-breed dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 15, pp. 120–124.

By: M. Dickerson n, R. Page n, T. LaDue n, M. Hauck n, D. Thrall n, M. Stebbins n, G. Price n

author keywords: canine; metastasis; radiation therapy; retriever
TL;DR: Prevalence of metastasis and median survival for large-breed dogs with axial skeleton OSA seems to be similar to that reported for large and purebred dogs with appendicular skeletons OSA, and definitive radiation therapy may have a role in the treatment of axialkeleton osteosarcoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs

In Vivo (Athens, Greece), 14(6), 709–714.

By: J. Poulson, M. Dewhirst, A. Gaskin, Z. Vujaskovic, T. Samulski, D. Prescott, R. Meyer, R. Page, D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Modulation of P-glycoprotein-mediated doxorubicin resistance in canine cell lines

Anticancer Research, 20(5B), 3533–3538.

By: R. Page, C. Hughes, S. Huyan, J. Sagris & M. Trogdon

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Primary irradiation of canine intracranial masses

VETERINARY RADIOLOGY & ULTRASOUND, 41(4), 377–380.

By: E. Spugnini  n, D. Thrall n, G. Price n, N. Sharp n, K. Munana n  & R. Page n

Contributors: E. Spugnini  n, D. Thrall n, G. Price n, N. Sharp n, K. Munana n  & R. Page n

author keywords: dog; brain tumor; radiation therapy
MeSH headings : Animals; Brain Neoplasms / diagnostic imaging; Brain Neoplasms / mortality; Brain Neoplasms / radiotherapy; Brain Neoplasms / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Glioma / diagnostic imaging; Glioma / mortality; Glioma / radiotherapy; Glioma / veterinary; Male; Meningeal Neoplasms / diagnostic imaging; Meningeal Neoplasms / mortality; Meningeal Neoplasms / radiotherapy; Meningeal Neoplasms / veterinary; Radiography; Radiotherapy / veterinary
TL;DR: Radiation therapy is superior to medical treatment of brain tumors in dogs with steroids, is useful for tumors that are not currently operable and may be preferable to surgical resection in dogs if the mass appears infiltrative, however, 22/29 (76%) dogs died of recurrent progressive neuropathy suggestive of tumor regrowth or progression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2000 journal article

Results of irradiation of infiltrative lipoma in 13 dogs

VETERINARY RADIOLOGY & ULTRASOUND, 41(6), 554–556.

By: M. McEntee*, R. Page n, G. Mauldin* & D. Thrall n

author keywords: infiltrating or infiltrative lipoma; radiation therapy; canine
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Female; Lipoma / mortality; Lipoma / radiotherapy; Lipoma / veterinary; Male; North Carolina / epidemiology; Records / veterinary; Retrospective Studies; Survival Analysis; Tomography, X-Ray Computed / veterinary; Treatment Outcome
TL;DR: It appears that dogs with infiltrative lipomas can benefit from external beam irradiation alone or in combination with surgery to effect long-term local tumor control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 46(1), 179–185.

By: Z. Vujaskovic*, J. Poulson*, A. Gaskin*, D. Thrall n, R. Page n, H. Charles *, . MacFall*, D. Brizel * ...

author keywords: tumors; hyperthermia blood how; pO(2); pH; thermal dose
MeSH headings : Animals; Combined Modality Therapy; Dogs; Female; Hydrogen-Ion Concentration; Hyperthermia, Induced / methods; Male; Oxygen / metabolism; Partial Pressure; Sarcoma, Experimental / blood supply; Sarcoma, Experimental / metabolism; Sarcoma, Experimental / radiotherapy; Sarcoma, Experimental / therapy; Soft Tissue Neoplasms / blood supply; Soft Tissue Neoplasms / metabolism; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / therapy
TL;DR: This study suggests that hyperthermia has biphasic effects on tumor physiologic parameters, and suggests that the thermal threshold for vascular damage is higher in spontaneous tumors than in more rapidly growing rodent tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

The pharmacokinetics and pharmacodynamics of GW395058, a peptide agonist of the thrombopoietin receptor, in the dog, a large-animal model of chemotherapy-induced thrombocytopenia

STEM CELLS, 18(5), 360–365.

By: B. Case*, M. Hauck*, R. Yeager*, A. Simkins*, M. Serres*, V. Schmith*, J. Dillberger*, R. Page n

author keywords: thrombocytopenia; thrombopoietin; mimetic peptide; GW395058; canine; pharmacokinetics; pharmacodynamics
MeSH headings : Animals; Carboplatin / toxicity; Dogs; Female; Injections, Intravenous; Injections, Subcutaneous; Leukocyte Count / drug effects; Male; Metabolic Clearance Rate; Molecular Mimicry; Neoplasm Proteins; Neutrophils / drug effects; Peptides / blood; Peptides / pharmacokinetics; Peptides / pharmacology; Platelet Count / drug effects; Proto-Oncogene Proteins / agonists; Proto-Oncogene Proteins / physiology; Receptors, Cytokine; Receptors, Thrombopoietin; Thrombocytopenia / blood; Thrombocytopenia / chemically induced; Thrombocytopenia / therapy; Thrombopoietin / physiology
TL;DR: The pharmacokinetics and pharmacodynamics of GW395058 were characterized using a randomized, crossover study in a large‐animal model (dog) of chemotherapy‐induced thrombocytopenia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

The relationship between intracellular and extracellular pH in spontaneous canine tumors

Clinical Cancer Research, 6(6), 2501–2505.

By: D. Prescott, H. Charles, J. Poulson, R. Page, D. Thrall, Z. Vujaskovic, M. Dewhirst

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Factors influencing survival after radiotherapy of nasal tumors in 130 dogs

VETERINARY RADIOLOGY & ULTRASOUND, 40(3), 312–317.

By: T. LaDue n, R. Dodge n, R. Page n, G. Price n, M. Hauck n & D. Thrall n

author keywords: dog; nasal tumor; radiation therapy; cobalt; predictive factors
MeSH headings : Animals; Dog Diseases / mortality; Dog Diseases / radiotherapy; Dogs; Multivariate Analysis; Nose Neoplasms / mortality; Nose Neoplasms / radiotherapy; Nose Neoplasms / veterinary; Prognosis; Radiotherapy Dosage; Survival Rate
TL;DR: In a subset of dogs that received cobalt radiation, after adjusting for age, dogs treated with a boost technique had decreased survival and in general, local control of canine nasal tumors following aggressive radiation therapy is poor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 article

Palliative radiotherapy of appendicular osteosarcoma in 95 dogs

VETERINARY RADIOLOGY & ULTRASOUND, Vol. 40, pp. 517–522.

By: O. Ramirez, R. Dodge, R. Page*, G. Price, M. Hauck*, T. LaDue, F. Nutter*, D. Thrall*

author keywords: canine; osteosarcoma; palliative radiotherapy
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / radiotherapy; Bone Neoplasms / veterinary; Dog Diseases / drug therapy; Dog Diseases / radiotherapy; Dogs; Dose-Response Relationship, Radiation; Female; Male; Multivariate Analysis; Osteosarcoma / drug therapy; Osteosarcoma / radiotherapy; Osteosarcoma / veterinary; Palliative Care; Probability
TL;DR: Ninety-five dogs with either a presumptive or biopsy confirmed diagnosis of osteosarcoma received palliative radiotherapy using 60Co photons and seventy-three of the 95 dogs experienced pain relief following treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Phase I and pharmacokinetic analysis of high-dose tamoxifen and chemotherapy in normal and tumor-bearing dogs

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 44(1), 74–80.

By: . Waddle, R. Fine*, B. Case*, M. Trogdon, K. Tyczkowska*, D. Frazier*, R. Page*

author keywords: P-glycoprotein 170; multidrug resistance; tamoxifen; doxorubicin; canine
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects; Animals; Antineoplastic Agents, Hormonal / administration & dosage; Antineoplastic Agents, Hormonal / adverse effects; Antineoplastic Agents, Hormonal / pharmacokinetics; Digestive System / drug effects; Dogs; Dose-Response Relationship, Drug; Doxorubicin / adverse effects; Doxorubicin / pharmacokinetics; Drug Interactions; Drug Resistance, Multiple; Female; Male; Neoplasms, Experimental / metabolism; Tamoxifen / administration & dosage; Tamoxifen / adverse effects; Tamoxifen / pharmacokinetics; Tissue Distribution
TL;DR: Concentrations of tamoxifen/NDMT sufficient to inhibit Pgp may be achieved in dogs receiving full-dose chemotherapy with a moderate but acceptable increase in gastrointestinal toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Tumour cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia

International Journal of Hyperthermia, 15(6), 475–486.

By: S. Larue *, M. Fox, G. Ogilvie, R. Page*, D. Getzy, D. Thrall*, J. Johnson, M. Dewhirst*, E. Gillette

MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Cycle; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Doxorubicin / administration & dosage; Hyperthermia, Induced; Indazoles / administration & dosage; Lymphoma / drug therapy; Lymphoma / therapy; Lymphoma / veterinary; Prognosis
TL;DR: Kinetic parameters including potential doubling time (Tpot), duration of S phase (Ts), labelling index (LI), and DNA index (DI) were obtained from 42 dogs with previously untreated lymphoma and dogs treated only with chemotherapy had significantly longer remission duration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Use of whole body hyperthermia as a method to heat inaccessible tumours uniformly: a phase III trial in canine brain masses

International Journal of Hyperthermia, 15(5), 383–398.

By: D. Thrall, S. Larue, B. Powers, R. Page, J. Johnson, S. George, J. Kornegay, M. McEntee ...

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Vertebral plasma cell tumors in 8 dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 13(2), 126–133.

By: C. Rusbridge *, S. Wheeler*, C. Lamb *, R. Page n, S. Carmichael*, M. Brearley*, A. Bjornson*

author keywords: canine; chemotherapy; multiple myeloma; radiotherapy; solitary plasmacytoma; survival
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

What is your diagnosis? Radiographic Diagnosis - Substantial soft tissue swelling on the dorsal and palmar surfaces of the carpus?

Journal of the American Veterinary Medical Association, 214(1), 29–30.

By: A. Applewhite, R. Page & O. Ramirez

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

What is your diagnosis? Soft tissue neoplasm of the right carpus in a dog

Journal of the American Veterinary Medical Association, 214(1), 29–30.

By: A. Applewhite, R. Page & O. Ramirez

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Characterization of canine MDR1 mRNA: Its abundance in drug resistant cell lines and in vivo

Anticancer Research, 18(1A), 393–400.

By: S. Steingold, N. Sharp, M. McGahan, C. Hughes, S. Dunn & R. Page

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Immunophenotypic Comparison of Blood and Lymph Node from Dogs with Lymphoma

Veterinary Clinical Pathology, 27(1), 16–20.

By: C. Grindem n, R. Page n, B. Ammerman n & E. Breitschwerdt n 

author keywords: immunophenotyping; blood; bone marrow; lymph nodes; lymphoma; dogs
TL;DR: Simultaneous immunophenotyping of lymph node, blood and bone marrow cannot be recommended routinely without further studies to document its value as an independent prognostic indicator, however, it is potentially useful for tumor staging and monitoring remission, especially in lymphoma patients with a leukemic phase. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1998 journal article

Potential complications associated with normothermic lonidamine infusion and with systemic acidosis in dogs receiving lonidamine during whole body hyperthermia (WBH)

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 14(3), 271–283.

By: G. Price n, J. Cline*, R. Page n, J. Riviere n & D. Thrall n

author keywords: lonidamine; whole body hyperthermia; vascular toxicosis; systemic pH; haemorrhage
MeSH headings : Acidosis; Animals; Dogs; Hyperthermia, Induced; Indazoles / adverse effects; Radiation-Sensitizing Agents / adverse effects; Thrombosis / chemically induced; Vasculitis / chemically induced
TL;DR: The observations confirm the results of in vitro studies which suggest that the combined effect of lonidamine and hyperthermia is enhanced under acidic conditions and indicate that acid-base status of patients receiving l onidamine during WBH must be monitored carefully to avoid serious complications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Radiation therapy and surgery for fibrosarcoma in 33 cats

VETERINARY RADIOLOGY & ULTRASOUND, 39(1), 51–56.

By: K. Cronin n, R. Page n, G. Spodnick n, R. Dodge n, E. Hardie n, G. Price n, D. Ruslander n, D. Thrall n

MeSH headings : Animals; Antibiotics, Antineoplastic / therapeutic use; Cat Diseases / radiotherapy; Cat Diseases / surgery; Cats; Chemotherapy, Adjuvant / veterinary; Cobalt Radioisotopes / therapeutic use; Confidence Intervals; Disease-Free Survival; Doxorubicin / therapeutic use; Female; Fibrosarcoma / pathology; Fibrosarcoma / radiotherapy; Fibrosarcoma / secondary; Fibrosarcoma / surgery; Fibrosarcoma / veterinary; Follow-Up Studies; Lung Neoplasms / secondary; Lung Neoplasms / veterinary; Lymphatic Metastasis; Male; Neoplasm Recurrence, Local / pathology; Neoplasm Recurrence, Local / veterinary; Neoplasm Staging / veterinary; Neoplasm, Residual / veterinary; Radiopharmaceuticals / therapeutic use; Radiotherapy Dosage / veterinary; Reoperation / veterinary; Retrospective Studies; Soft Tissue Neoplasms / pathology; Soft Tissue Neoplasms / radiotherapy; Soft Tissue Neoplasms / surgery; Soft Tissue Neoplasms / veterinary; Survival Rate; Treatment Failure; Treatment Outcome
TL;DR: It is found that the presence of tumor cells at the margin of resected tissue after radiation was the only variable which influenced treatment success and the disease free interval in cats with histologically confirmed fibrosarcomas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Radiation therapy for incompletely resected canine mast cell tumors

VETERINARY RADIOLOGY & ULTRASOUND, 39(1), 57–62.

By: T. LaDue n, G. Price n, R. Dodge n, R. Page n & D. Thrall n

author keywords: canine; mast cell neoplasia; megavoltage radiation
MeSH headings : Adrenal Cortex Hormones / therapeutic use; Age Factors; Animals; Cobalt Radioisotopes / therapeutic use; Disease-Free Survival; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dog Diseases / surgery; Dogs; Dose Fractionation, Radiation; Female; Follow-Up Studies; Lymph Nodes / radiation effects; Lymphatic Metastasis / radiotherapy; Male; Mast-Cell Sarcoma / pathology; Mast-Cell Sarcoma / radiotherapy; Mast-Cell Sarcoma / secondary; Mast-Cell Sarcoma / surgery; Mast-Cell Sarcoma / veterinary; Neoplasm Recurrence, Local / pathology; Neoplasm Recurrence, Local / veterinary; Neoplasm Staging / veterinary; Neoplasm, Residual / radiotherapy; Neoplasm, Residual / veterinary; Neoplasms, Second Primary / pathology; Neoplasms, Second Primary / veterinary; Radiopharmaceuticals / therapeutic use; Radiotherapy Dosage / veterinary; Radiotherapy, High-Energy / veterinary; Retrospective Studies; Sex Factors; Skin Neoplasms / pathology; Skin Neoplasms / radiotherapy; Skin Neoplasms / surgery; Skin Neoplasms / veterinary; Survival Rate; Time Factors
TL;DR: Data presented herein support megavoltage radiation as an effective treatment for canine mast cell neoplasia, and suggest that disease free interval in dogs treated with daily fractions may be longer than that achieved with alternating day fractions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Correlation between thoracic radiographic changes and remission/survival duration in 270 dogs with lymphosarcoma

VETERINARY RADIOLOGY & ULTRASOUND, 38(6), 411–418.

By: G. Starrak, C. Berry*, R. Page n, J. Johnson* & D. Thrall*

author keywords: lymphosarcoma; dog; thoracic radiography; phenotype; cranial mediastinal lymphadenomegaly
MeSH headings : Animals; Disease-Free Survival; Dog Diseases / diagnostic imaging; Dogs; Female; Lung Neoplasms / diagnostic imaging; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Lymphocyte Subsets; Lymphoma, Non-Hodgkin / diagnostic imaging; Lymphoma, Non-Hodgkin / mortality; Lymphoma, Non-Hodgkin / pathology; Lymphoma, Non-Hodgkin / veterinary; Male; Multivariate Analysis; Neoplasm Metastasis / diagnostic imaging; Phenotype; Prognosis; Radiography, Thoracic / veterinary; Remission Induction; Retrospective Studies; Sex Factors; Survival Rate
TL;DR: A retrospective study was undertaken wherein the medical records and thoracic radiographs of 270 dogs with lymphosarcoma were reviewed and only T-cell phenotype and the presence of cranial mediastinal lymphadenomegaly were identified as having a significant negative correlation to both primary remission and survival duration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Immunophenotypic characterization of canine lymphoproliferative disorders

In Vivo (Athens, Greece), 11(2), 169–172.

By: D. Ruslander, D. Gebhard, M. Tompkins, C. Grindem & R. Page

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

An in vitro-in vivo validation of the isolated perfused tumor and skin flap preparation as a model of cisplatin delivery to tumors

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 35(3), 173–177.

By: S. Vaden n, R. Page n & J. Riviere n

author keywords: cisplatin; isolated perfused tumor and skin flap; isolated perfusion
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Chemotherapy, Cancer, Regional Perfusion / methods; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Drug Screening Assays, Antitumor; In Vitro Techniques; Injections, Intralesional; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Reproducibility of Results; Surgical Flaps; Swine
TL;DR: Tissue Pt concentrations obtained following systemic administration of cisplatin (CDDP) to whole pigs bearing tumored skin flaps with data obtained from IPTSF treated similarly are compared to that obtained in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Cisplatin-derived Pt [platinum] distribution in canine normal and tumor tissue

Veterinary Cancer Society Newsletter, 20(3), 1.

By: R. Page, J. Lee, J. Riviere, R. Dodge, D. Thrall & M. Dewhirst

Source: NC State University Libraries
Added: August 6, 2018

1996 journal article

Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 38(2), 129–135.

By: G. Price n, R. Page n, J. Riviere n, J. Cline n & D. Thrall n

author keywords: lonidamine; pharmacokinetics; dog
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Dogs; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Injections, Intravenous; Kinetics; Liver / drug effects; Liver / pathology; Male; Testis / drug effects; Testis / pathology; Vomiting / chemically induced
TL;DR: The findings suggest that lonidamine is hepatotoxic in dogs, and the dose and route appears to be a viable and controllable method for prospective quantification of l onidamine interaction with systemic chemotherapy and/or hyperthermia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Phase I evaluation of mitoxantrone alone and combined with whole body hyperthermia in dogs with lymphoma

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 12(3), 309–320.

By: M. Hauck*, G. Price n, G. Ogilvie*, J. Johnson*, E. Gillette*, D. Thrall n, M. Dewhirst*, R. Page*

author keywords: hyperthermia; mitoxanthrone; lymphoma; canine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Antineoplastic Agents / toxicity; Blood Cell Count / veterinary; Dogs; Female; Fever / veterinary; Lymphoma / metabolism; Lymphoma / therapy; Lymphoma / veterinary; Male; Mitoxantrone / therapeutic use; Mitoxantrone / toxicity; Neutropenia / complications; Neutropenia / veterinary; Neutrophils / metabolism; Regression Analysis; Thrombocytopenia / complications; Thrombocytopenia / veterinary
TL;DR: It is concluded that MX may be administered without dose reduction to dogs undergoing WBH and that MX should be evaluated more thoroughly in future thermochemotherapy studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1995 journal article

Absence of whole body hyperthermia effect on cisplatin distribution in spontaneous canine tumors

International Journal of Radiation Oncology*Biology*Physics, 32(4), 1097–1102.

By: R. Page n, J. Lee n, J. Riviere n, R. Dodge*, D. Thrall n & M. Dewhirst *

author keywords: HYPERTHERMIA; CISPLATIN; PHARMACOKINETICS; DOGS
MeSH headings : Animals; Cisplatin / pharmacokinetics; Cisplatin / therapeutic use; Combined Modality Therapy / veterinary; Dogs; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Neoplasms / drug therapy; Neoplasms / metabolism; Neoplasms / veterinary; Platinum / metabolism
TL;DR: Pt disposition was unaffected by WBH under conditions reported in this study, and a forced diuresis is necessary to clinically administer CDDP at maximally tolerable doses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

1995 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON LONIDAMINE AND DOXORUBICIN PHARMACOKINETICS AND TOXICITY IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 545–559.

By: G. Price n, R. Page n, J. Riviere n, J. Cline n, D. Frazier* & D. Thrall n

author keywords: LONIDAMINE; DOXORUBICIN; WHOLE BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY
MeSH headings : Animals; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bile Acids and Salts / blood; Blood Chemical Analysis; Dogs; Doxorubicin / blood; Doxorubicin / pharmacokinetics; Doxorubicin / toxicity; Hyperthermia, Induced; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / ultrastructure; Metabolic Clearance Rate; Microscopy, Electron; Myocardial Contraction / drug effects; Myocardium / ultrastructure; Vacuoles / drug effects; Vacuoles / ultrastructure
TL;DR: WBH did not decrease the maximum tolerable dose of doxorubicin when given with lonidamine, and that the antitumour activity of this combination should be assessed, but the biochemical and haematologic toxicities observed did not appear to differ in character or severity from that reported in dogs receiving lonIDamine +/- WBH or doxorbicin +/-WBH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1995 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON THE PHARMACOKINETICS AND TOXICITY OF LONIDAMINE IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 531–544.

By: G. Price n, R. Page n, J. Riviere n, J. Cline n & D. Thrall n

author keywords: LONIDAMINE; WHOLE-BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY; DOG
MeSH headings : Alanine Transaminase / blood; Alkaline Phosphatase / blood; Amylases / blood; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bilirubin / blood; Blood Glucose / metabolism; Carbon Dioxide / blood; Creatine Kinase / blood; Dogs; Hyperthermia, Induced; Hypokalemia / etiology; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / pathology; Sialorrhea / etiology; Urea / blood
TL;DR: The pharmacokinetics and toxicity of intravenous lonidamine were investigated in dogs receiving four cycles of lonidsamine and 400 mg/m2 was identified as the maximum tolerable dose to be administered intravenously to dogs during whole-body hyperthermia (WBH). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1994 journal article

EFFECT OF HYPERTHERMIA ON CISPLATIN AND CARBOPLATIN DISPOSITION IN THE ISOLATED, PERFUSED TUMOR AND SKIN FLAP

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(4), 563–572.

By: S. Vaden n, R. Page n, P. Williams  n & J. Riviere n

author keywords: CISPLATIN; CARBOPLATIN; HYPERTHERMIA; ISOLATED TUMOR PERFUSION
MeSH headings : Animals; Body Temperature Regulation; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Combined Modality Therapy; Hyperthermia, Induced; In Vitro Techniques; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / physiopathology; Neoplasms, Experimental / therapy; Perfusion; Platinum / pharmacokinetics; Surgical Flaps; Swine
TL;DR: Hyperthermia (HT) alters the disposition of Pt from CDDP and CBDCA under conditions of constant rate infusion, and significantly increased Pt mass in the fixed, non-tumour tissue compartment of CBDCA-treated flaps. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1994 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.

By: R. Page n, M. Mcentee n, P. Williams  n, S. George *, G. Price n, C. Novotney n, M. Hauck n, J. Riviere n, M. Dewhirst*, D. Thrall n

MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
TL;DR: A randomized phase II evaluation should be initiated to determine if a therapeutic gain can be achieved using combined CBDCA and WBH and further refinement of the CBDCA dose in such a trial should be based on both pharmacokinetic parameters and normal tissue response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1994 journal article

PRECLINICAL EVALUATION AND PET IMAGING OF F-18 LABELED MEL-14 F(AB')(2) FRAGMENT IN NORMAL DOGS

NUCLEAR MEDICINE AND BIOLOGY, 21(7), 911–919.

By: R. Page n, P. Garg *, G. Vaidyanathan * & M. Zalutsky  n

MeSH headings : Animals; Antibodies, Monoclonal / pharmacokinetics; Dogs; Fluorine Radioisotopes; Fluorobenzenes / pharmacokinetics; Half-Life; Kidney / diagnostic imaging; Kidney / metabolism; Liver / diagnostic imaging; Liver / metabolism; Lung / diagnostic imaging; Lung / metabolism; Radiation Dosage; Radiopharmaceuticals / pharmacokinetics; Tissue Distribution; Tomography, Emission-Computed
TL;DR: The F(ab')2 fragment of monoclonal antibody Mel-14, reactive with human melanomas and gliomas, was labeled with 18F using two acylation agents, N-succinimidyl 8-[(4'-[18F]fluorobenzyl)amino]suberate (SFBS) and N-SuccinIMidyl 4-[18F]. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1993 journal article

Development and characterization of an isolated and perfused tumor and skin preparation for evaluation of drug disposition

Cancer Research, 53, 101–105.

By: S. Vaden, R. Page, B. Peters, J. Cline & J. Riviere

Source: NC State University Libraries
Added: August 6, 2018

1993 journal article

EFFECT OF TUMOR PRESENCE ON CISPLATIN AND CARBOPLATIN - DISPOSITION IN THE ISOLATED, PERFUSED TUMOR AND SKIN FLAP

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 32(1), 31–38.

By: S. Vaden n, P. Williams  n, R. Page n & J. Riviere n

author keywords: CISPLATIN; CARBOPLATIN; ISOLATED TUMOR PERFUSION
MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Chemotherapy, Cancer, Regional Perfusion / instrumentation; Choriocarcinoma; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Humans; Models, Biological; Platinum / analysis; Skin / metabolism; Swine; Tumor Cells, Cultured / metabolism; Vascular Resistance
TL;DR: It is concluded that the IPTSF is a useful model for evaluating the disposition of Pt drugs in tumor and non-tumor tissue and that tumor presence alters the disposing of CDDP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1993 journal article

KIDNEY TRACE-METAL RESPONSE TO COMBINED CISPLATIN (CDDP) AND HYPERTHERMIA

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 9(4), 529–537.

By: R. Dewoskin n, R. Page n & J. Riviere n

author keywords: HYPERTHERMIA; CISPLATIN; KIDNEYS; COPPER
MeSH headings : Animals; Blood Urea Nitrogen; Copper / metabolism; Creatinine / blood; Female; Hot Temperature / adverse effects; Kidney / drug effects; Kidney / metabolism; Organoplatinum Compounds / toxicity; Platinum / metabolism; Rats; Rats, Inbred F344; Trace Elements / metabolism; Zinc / metabolism
TL;DR: It is demonstrated that systemic hyperthermia significantly increases CDDP nephrotoxicity in F344 rats and that kidney copper loss from CDDP exposure athyperthermia is similar to the loss observed from CD DP at normothermia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1993 journal article

Pharmacokinetic and Phase I Evaluation of Carboplatin in Dogs

Journal of Veterinary Internal Medicine, 7(4), 235–240.

By: R. Page n, M. McEntee n, S. George*, P. Williams  n, G. Heidner n, C. Novotney n, J. Riviere n, M. Dewhirst *, D. Thrall n

MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / therapeutic use; Carboplatin / toxicity; Dog Diseases / drug therapy; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Infusions, Intravenous / veterinary; Leukocyte Count / veterinary; Male; Neoplasms / drug therapy; Neoplasms / veterinary; Neutrophils / drug effects; Platelet Count / veterinary; Regression Analysis
TL;DR: Dose-independent serum CBDCA pharmacokinetic disposition indicates that detailed investigation of tissue CBDCA distribution would be warranted and may identify novel dosing strategies that could improve the therapeutic index of CBDCA by minimizing toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

1993 journal article

Recent advances in hyperthermia [therapeutic]

Compendium on Continuing Education for the Practicing Veterinarian, 15(6), 781.

By: R. Page

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

QUANTITATIVE ESTIMATION OF THE THERMAL DOSE-MODIFYING FACTOR FOR CIS-DIAMMINEDICHLOROPLATINUM (CDDP) IN TUMOR-BEARING DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 8(6), 761–769.

By: R. Page n, D. Thrall n, S. George *, G. Price n, G. Heidner n, M. Mcentee n, C. Novotney n, M. Hauck n, M. Dewhirst n

MeSH headings : Animals; Bone Marrow / drug effects; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Drug Tolerance; Female; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Kidney / drug effects; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / adverse effects
TL;DR: A statistical method for estimating clinical toxicity was used to determine a theoretical isoeffect dose-modifying factor for dogs with disseminated or refractory neoplasia treated with cis-diammine dichloroplatinum (II) plus whole-body hyperthermia or CDDP alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1991 journal article

EFFECT OF HYPERTHERMIA ON THE INVITRO HYDROLYSIS OF MELPHALAN

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 7(3), 527–529.

By: J. Riviere n, R. Page n, D. Aucoin n, R. Rogers  n & P. Williams  n

author keywords: NORMOTHERMIC; HYPERTHERMIC; HYDROLYSIS; MELPHALAN
MeSH headings : Animals; Dogs; Hot Temperature; Hydrolysis; In Vitro Techniques; Melphalan / blood; Melphalan / pharmacokinetics; Swine
TL;DR: The pharmacokinetics of melphalan was investigated at 37 degrees C and 42 degrees C in vitro in canine and porcine plasma to assess heat-induced changes in the in vivo rate ofmelphalan hydrolysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1991 journal article

Efficacy and Toxicity of Doxorubicin/Cyclophosphamide Maintenance Therapy in Dogs with Multicentric Lymphosarcoma

Journal of Veterinary Internal Medicine, 5(5), 259–262.

By: G. Price, R. Page*, B. Fischer*, J. Levine*  & T. Gerig n

MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cyclophosphamide / administration & dosage; Diarrhea / chemically induced; Diarrhea / veterinary; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dogs; Doxorubicin / administration & dosage; Female; Heart Diseases / chemically induced; Heart Diseases / veterinary; Lymphoma, Non-Hodgkin / drug therapy; Lymphoma, Non-Hodgkin / veterinary; Male; Neutropenia / chemically induced; Neutropenia / veterinary; Remission Induction; Vomiting / chemically induced; Vomiting / veterinary
TL;DR: The doxorubicin/cyclophosphamide protocol is safe and effective in treating canine multicentric lymphosarcoma and clinical stage, pretreatment steroid therapy, and hypoalbuminemia are prognostic factors for response to this protocol. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

1990 article

DETERMINATION OF CARBOPLATIN IN CANINE PLASMA BY LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET VISIBLE DETECTION AND CONFIRMATION BY ATOMIC-ABSORPTION SPECTROSCOPY

TYCZKOWSKA, K., PAGE, R. L., & RIVIERE, J. E. (1990, May 18). JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, Vol. 527, pp. 447–453.

By: K. Tyczkowska n, R. Page n & J. Riviere n

MeSH headings : Animals; Antineoplastic Agents / blood; Carboplatin; Chromatography, High Pressure Liquid / methods; Dogs; Molecular Structure; Organoplatinum Compounds / blood; Protein Binding; Spectrophotometry, Atomic
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1989 conference paper

Effect of temperature on cisplatin (CDDP) and carboplatin (CBDCA) pharmacokinetic disposition in dogs

Conference Proceedings, 2, 499–501.

By: R. Page, J. Riviere, G. Heidner, M. McEntee & D. Thrall

Source: NC State University Libraries
Added: August 6, 2018

1986 journal article

Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs

International Journal of Hyperthermia, 2, 351–358.

By: J. Riviere n, R. Page n, M. Dewhirst*, K. Tyczkowska n & D. Thrall n

MeSH headings : Animals; Biotransformation; Cisplatin / blood; Cisplatin / metabolism; Dogs; Half-Life; Hyperthermia, Induced / methods; Kinetics; Platinum / blood; Spectrophotometry, Atomic; Ultrafiltration
TL;DR: Data from in vitro and in vivo cisplatin pharmacokinetic studies in dogs would indicate that at the elevated temperatures encountered in whole body hyperthermia, the rate of formation of reactive metabolites from parent cisPlatin is increased. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

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