Works (24)
Updated: April 4th, 2024 10:40
2023 article
A textile-reinforced composite vascular graft that modulates macrophage polarization and enhances endothelial cell migration, adhesion and proliferation in vitro
Zhang, F., Tao, H., Gluck, J. M., Wang, L., Daneshmand, M. A., & King, M. W. (2023, January 20). SOFT MATTER, Vol. 1.
MeSH headings : Endothelial Cells; Macrophage Activation; Textiles; Hydrogels; Cell Proliferation; Macrophages; Tissue Engineering
TL;DR:
The textile-reinforced hydrogel shows it potential to be a promising scaffold material to fabricate a tissue engineered vascular graft and improves the survival, adhesion and proliferation of endothelial cells in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 9, 2023
2023 journal article
Application of Noggin-Coated Electrospun Scaffold in Corneal Wound Healing
Translational Vision Science & Technology, 12(8), 15.
TL;DR:
This Noggin-coated electrospun scaffold represents a step toward, expanding treatment options for patients with indolent corneal ulcers, and provides a better perspective for understanding electroSpun scaffolds as a tunable platform to infuse topical therapeutics and use as aCorneal bandage.
(via Semantic Scholar)
doi.org (publisher)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 4, 2023
2023 journal article
Comparison of NIH 3T3 Cellular Adhesion on Fibrous Scaffolds Constructed from Natural and Synthetic Polymers
BIOMIMETICS, 8(1).
author keywords: collagen; PLA; tissue engineering; cell adhesion; cell proliferation; biomimetic materials
TL;DR:
An evaluation of the cellular response of embryonic mouse fibroblasts (NIH 3T3 line) to the different polymer types was conducted and indicated that NIH3T3 cells prefer collagen-based scaffolds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 1, 2023
2023 journal article
Development of a Pneumatic-Driven Fiber-Shaped Robot Scaffold for Use as a Complex 3D Dynamic Culture System
BIOMIMETICS, 8(2).
author keywords: tissue engineering; fiber actuators; 3D dynamic cell culture; cyclic strain
TL;DR:
A simple and cost-effective 3D dynamic culture system has been proposed, which can be easily implemented to study complex biological phenomena in vitro, and shown to support cell proliferation with minimal cytotoxicity similar to static cultures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 10, 2023
2023 journal article
Effects of sterilization methods on gelatin methacryloyl hydrogel properties and macrophage gene expression in vitro
BIOMEDICAL MATERIALS, 18(1).
author keywords: gelatin methacryloyl; hydrogel; sterilization; macrophage phenotype; gene expression
MeSH headings : Hydrogels; Macrophages
TL;DR:
It was found that the sterilization methods only marginally altered the hydrogel morphology, swelling behavior and elastic modulus, but significantly impacted macrophage gene expression within 48 h and over 7 d in vitro, suggesting that not only the sterility and hydrogels properties, such as material destruction and degradation caused by temperature and moisture, should be taken into consideration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 22, 2022
2023 journal article
Heparin Affinity-Based IL-4 Delivery to Modulate Macrophage Phenotype and Endothelial Cell Activity In Vitro
ACS APPLIED MATERIALS & INTERFACES, 15(23), 27457–27470.
author keywords: gelatin methacryloyl; heparin; interleukin4; hydrogel; macrophage; endothelial cell; immunomodulation
MeSH headings : Interleukin-4 / pharmacology; Heparin / pharmacology; Heparin / metabolism; Macrophages / metabolism; Phenotype; Hydrogels / pharmacology; Hydrogels / metabolism
TL;DR:
A gelatin-heparin-methacrylate hydrogel is engineered that gradually releases interleukin-4 (IL-4), a cytokine that modulates macrophages to adopt the M2 phenotype and synergistically downregulated M1 gene expression and upregulated M2 gene expression within 48 h of in vitro cell culture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 26, 2023
2022 article
A standardized procedure for quantitative evaluation of residual viral activity on antiviral treated textiles
Wang, Z., Amanah, A. Y., Ali, K. M., Payne, L. C., Kisthardt, S., Scholle, F., … Gluck, J. M. (2022, November 2). TEXTILE RESEARCH JOURNAL, Vol. 11.
author keywords: SARS-CoV-2; antiviral textiles; Tissue Culture Infectious Dose 50
TL;DR:
This pilot study aims to develop and refine a standardized protocol to quantitatively evaluate residual viral activity on antiviral textiles and used HCoV-229E and Huh-7 human liver cancer cells for this investigation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 3, 2022
2022 journal article
Electrospun Carbon Nanotube-Based Scaffolds Exhibit High Conductivity and Cytocompatibility for Tissue Engineering Applications
ACS OMEGA, 7(23), 20006–20019.
TL;DR:
The increased conductivity and high cytocompatibility of the CNT-incorporated scaffolds make them appropriate candidates for future use in cardiac and neural tissue engineering.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 4, 2022
2022 journal article
In Vitro Biocompatibility and Degradation Analysis of Mass-Produced Collagen Fibers
POLYMERS, 14(10).
author keywords: collagen; tissue engineering; biomaterials; biocompatibility; scaffolds
TL;DR:
This study uses bovine-derived collagen fibers to create yarns using the traditional ring spinning method, and these yarns are proven to be biocompatible and enzymatic biodegradability was confirmed for its potential use in vivo.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 22, 2022
2022 article
Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application
Mahmood, N., Suh, T. C., Ali, K. M., Sefat, E., Jahan, U. M., Huang, Y., … Gluck, J. M. (2022, August 1). STEM CELL REVIEWS AND REPORTS, Vol. 8.
author keywords: Cornea; Corneal tissue engineering; Induced pluripotent stem cells; Differentiation; Limbal stem cell deficiency
MeSH headings : Humans; Induced Pluripotent Stem Cells; Cell Differentiation / genetics; Cornea; Cell Line; Corneal Diseases / therapy
TL;DR:
The early development of the cornea is discussed because protocols differentiating iPSCs toward corneal lineages rely heavily upon recapitulating this development, and differentiated iPSC phenotypes have been analyzed with an emphasis on feeder- free, xeno-free, and well-defined protocols, which have clinical relevance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 1, 2022
2022 article
Plasma-Induced Diallyldimethylammonium Chloride Antibacterial Hernia Mesh
Wang, Z., Hamedi, H., Zhang, F., El-Shafei, A., Brown, A. C., Gluck, J. M., & King, M. W. (2022, November 29). ACS APPLIED BIO MATERIALS, Vol. 11.
author keywords: hernia mesh; polypropylene; plasma; surface grafting; antibacterial; fibroblast
MeSH headings : Humans; Surgical Mesh / adverse effects; Polypropylenes; Hernia, Ventral / drug therapy; Anti-Bacterial Agents / pharmacology
TL;DR:
A polypropylene mesh with antibacterial properties was developed and grafted onto the mesh surface using pentaerythritol tetraacrylate as the cross-linker since it is able to engage all four functional groups to form a high-density cross-linked network.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 30, 2022
2021 journal article
Cleaner production of mulberry spun silk yarns via a shortened and gassing-free production route
Journal of Cleaner Production, 278, 123690.
author keywords: Mulberry spun silk; Yarn properties; Gassing process; Modified ring spinning; 3D structural configuration
Source: ORCID
Added: September 8, 2020
2020 journal article
Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications
Bioengineering, 7(3), 105.
author keywords: tissue engineering; cardiac tissue engineering; engineered heart tissue; electrospinning; scaffolds; cardiomyocytes; induced pluripotent stem cells
TL;DR:
The requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts are presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 14, 2020
2017 journal article
Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix.
PloS One, 12(9).
Contributors: * , A. Herren *, S. Yechikov*, H. Kao *, A. Khan *, B. Phinney *, N. Chiamvimonvat *, J. Chan*, D. Lieu *
MeSH headings : Animals; Basement Membrane / chemistry; Basement Membrane / metabolism; Basement Membrane / ultrastructure; Biological Clocks / physiology; Biomechanical Phenomena; Collagen / metabolism; Collagen / ultrastructure; Elasticity; Elastin / metabolism; Elastin / ultrastructure; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Fibronectins / metabolism; Fibronectins / ultrastructure; Fluorescent Antibody Technique; Heart Ventricles / chemistry; Heart Ventricles / metabolism; Heart Ventricles / ultrastructure; Mass Spectrometry; Microscopy, Atomic Force; Microscopy, Electrochemical, Scanning; Myocytes, Cardiac / chemistry; Myocytes, Cardiac / metabolism; Proteome; Proteomics; Sinoatrial Node / chemistry; Sinoatrial Node / metabolism; Sinoatrial Node / ultrastructure; Swine; Tensile Strength
TL;DR:
Findings provide the criteria for a suitable matrix scaffold for engineering biopacemakers and suggest that resident pacemaking cardiomyocytes are enclosed in fibrillar collagens that can withstand greater tensile strength while the surrounding elastin-rich regions may undergo deformation to reduce the mechanical strain in these cells.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2017 journal article
Dedifferentiated Adipocytes Improve Heart Function Post-Myocardial Infarction
Journal of Regenerative Medicine.
TL;DR:
This study is the first to report that the transplantation of mDFAT cells into a murine model of MI can preserve cardiac function up to eight weeks after the onset of infarction, suggesting a potential role for DFAT cells as a therapeutic pluripotent cell source in cardiovascular tissue repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 20, 2019
2016 journal article
Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology.
Stem Cells (Dayton, Ohio), 11(11), 2670–2680.
Contributors: S. Yechikov*, R. Copaciu*, * , W. Deng *, N. Chiamvimonvat *, J. Chan*, D. Lieu *
author keywords: Human induced pluripotent stem cells; Cardiomyocyte subtype; Electrophysiology; Pacemaker
MeSH headings : Action Potentials / physiology; Biomarkers / metabolism; Cell Differentiation; Cell Line; Cell Lineage / genetics; Electrophysiology; Gene Expression; Heart Atria / cytology; Heart Atria / metabolism; Heart Conduction System / cytology; Heart Conduction System / metabolism; Heart Ventricles / cytology; Heart Ventricles / metabolism; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / genetics; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism; Immunohistochemistry; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; LIM-Homeodomain Proteins / genetics; LIM-Homeodomain Proteins / metabolism; Muscle Proteins / genetics; Muscle Proteins / metabolism; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Organ Specificity; Potassium Channels / genetics; Potassium Channels / metabolism; Single-Cell Analysis / methods; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
expression of proposed pacemaker‐specific markers—hyperpolarization‐activated cyclic nucleotide‐modulated (HCN)4 channel and Islet (Isl)1)—at the protein level in all three hiPSC‐derived cardiomyocyte subtypes are revealed.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2015 journal article
Effect of fiber orientation of collagen-based electrospun meshes on human fibroblasts for ligament tissue engineering applications
Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(1), 39–46.
author keywords: electrospinning; polylactic-co-glycolic acid; polyurethane; collagen I; ligament tissue engineering
MeSH headings : Collagen Type I / chemistry; Elastic Modulus; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Lactic Acid / chemistry; Ligaments; Materials Testing; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Polyurethanes / chemistry; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR:
The effectiveness of electrospun PLGA scaffolds as a suitable candidate for regenerative medicine, capable of being manipulated and combined with other polymers to create three-dimensional microenvironments with adjustable tensile properties to mimic native tissues is demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2014 journal article
Microenvironment influences vascular differentiation of murine cardiovascular progenitor cells.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 11(8), 1730–1739.
Contributors: * , C. Delman*, J. Chyu*, W. MacLellan *, R. Shemin* & S. Heydarkhan-Hagvall*
author keywords: cell differentiation; vascular; progenitor cells; stem cells; scaffolds; extracellular matrix
MeSH headings : Animals; Blood Vessel Prosthesis; Cell Differentiation; Cells, Cultured; Cellular Microenvironment; Endothelial Cells / cytology; Endothelial Cells / metabolism; Extracellular Matrix / chemistry; Mice; Myocardium / cytology; Myocardium / metabolism; Myocytes, Smooth Muscle / cytology; Myocytes, Smooth Muscle / metabolism; Stem Cells / cytology; Stem Cells / metabolism; Tissue Scaffolds / chemistry
TL;DR:
The study characterized the contributions of both ECM proteins and the addition of a 3D culture system to continued vascular differentiation and demonstrated the capability bioengineer a CPC-derived vascular graft.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2013 journal article
Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations
ISRN Tissue Engineering.
TL;DR:
It is shown here that the three-dimensionality of a hyaluronan-based hydrogel greatly induces a CPC population, as marked by Flk-1, and that the 3D microenvironment potently induces a progenitor cell state.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2012 journal article
Stem Cell Extracellular Matrix Interactions in Three- Dimensional System via Integrins
Journal of Regenerative Medicine.
TL;DR:
This work has characterized integrin expression of undifferentiated mES cells and established a system of evaluating the ECM-integrin interactions in three-dimension (3D) using electrospun scaffolds.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2012 journal article
The effect of vitronectin on the differentiation of embryonic stem cells in a 3D culture system
Biomaterials, 33(7), 2032–2040.
author keywords: Extracellular matrix; Niche; Cardiovascular tissue engineering; Stem cell; Scaffold
MeSH headings : Animals; Biocompatible Materials / metabolism; Cell Culture Techniques / methods; Cell Differentiation / physiology; Cell Proliferation; Cells, Cultured; Collagen Type IV / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / physiology; Extracellular Matrix / metabolism; Fibronectins / metabolism; Heart / embryology; Humans; Laminin / metabolism; Mice; Myocardium / cytology; Tissue Engineering / methods; Vascular Endothelial Growth Factor Receptor-2 / genetics; Vascular Endothelial Growth Factor Receptor-2 / metabolism; Vitronectin / metabolism
TL;DR:
The results show the importance of defined culture systems in vitro for studying the guided differentiation of pluripotent embryonic stem cells in the field of cardiovascular tissue engineering and regenerative medicine.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2011 journal article
Hybrid coaxial electrospun nanofibrous scaffolds with limited immunological response created for tissue engineering.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 10(1), 180–190.
Contributors: * , P. Rahgozar*, N. Ingle n, F. Rofail*, A. Petrosian*, M. Cline*, M. Jordan *, K. Roos*
author keywords: coaxial; electrospinning; polycaprolactone; polyurethane; gelatin; tissue engineering
MeSH headings : Animals; Biocompatible Materials / chemistry; Biocompatible Materials / metabolism; Electrochemical Techniques / methods; Foreign-Body Reaction / immunology; Gelatin / chemistry; Implants, Experimental; Materials Testing; Mice; NIH 3T3 Cells; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters / chemistry; Polymers / chemical synthesis; Polymers / chemistry; Polymers / metabolism; Polyurethanes / chemistry; Porosity; Stress, Mechanical; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The results show the advantages of combining both natural and synethic polymers to create a coaxial scaffold capable of withstanding dynamic culture conditions and encourage cellular migration to the interior of the scaffold for tissue-engineering applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 20, 2019
2011 journal article
Recapitulation of the embryonic cardiovascular progenitor cell niche.
Biomaterials, 4(11), 2748–2756.
Contributors: K. Schenke-Layland *, A. Nsair*, B. Van Handel*, E. Angelis*, * , M. Votteler*, J. Goldhaber *, H. Mikkola *, M. Kahn *, W. MacLellan *
author keywords: Extracellular matrix; Cardiac tissue engineering; Stem cell; Scaffold; Heart
MeSH headings : Animals; Cardiovascular System / embryology; Cell Differentiation / physiology; Cell Line; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Extracellular Matrix / metabolism; Female; Flow Cytometry; Fluorescent Antibody Technique; Heart / embryology; Humans; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Confocal; Pregnancy; beta Catenin / metabolism
TL;DR:
This study characterized the cardiovascular progenitor cell (CPC) niche in developing human and mouse hearts, identifying signaling pathways and extracellular matrix (ECM) proteins that are crucial for CPC maintenance and expansion and demonstrates that collagen IV (ColIV) and β-catenin-dependent signaling are essential for maintaining and expanding undifferentiated CPCs.
(via Semantic Scholar)
Source: ORCID
Added: August 20, 2019
2009 journal article
The use of three-dimensional nanostructures to instruct cells to produce extracellular matrix for regenerative medicine strategies.
Biomaterials, 9(27), 4665–4675.
MeSH headings : Adipose Tissue / cytology; Biological Assay; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Extracellular Matrix Proteins / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Fluorescence; Humans; Nanostructures / chemistry; Photons; Polyesters / pharmacology; Porosity / drug effects; Regenerative Medicine / methods; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / ultrastructure; Tissue Scaffolds
TL;DR:
This study developed novel hybrid constructs composed of both strong biosynthetic materials and natural human ECM proteins that exhibited excellent biomechanical properties with fiber and pore sizes that allowed attachment and migration of adipose tissue-derived stem cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, NC State University Libraries
Added: August 6, 2018
Employment
Updated: August 20th, 2019 13:41
2019 - present
NC State University Raleigh , NC, US
Assistant Professor
Textile Engineering, Chemistry & Science
2017 - 2019
Precise Bio Winston Salem, NC, US
Research Scientist
2016 - 2017
Discovery Place Science Charlotte, NC, US
Manager
2013 - 2016
UC Davis Health System Sacramento, CA, US
Postdoctoral Fellow
Internal Medicine: Cardiovascular
Education
Updated: April 3rd, 2014 15:18
2008 - 2013
University of California Los Angeles Los Angeles, CA, US
PhD
Molecular, Cellular & Integrative Physiology
2007 - 2008
University of California Los Angeles Los Angeles, CA, US
MS
Biomedical Engineering
2005 - 2007
North Carolina State University Raleigh, NC, US
MS
Textile Apparel, Technology & Management
2002 - 2005
North Carolina State University Raleigh, NC, US
BS
Textile Technology
Funding History
Funding history based on the linked ORCID record. Updated: July 6th, 2023 11:42
grant
July 1, 2022 - June 30, 2025
Biologically-derived tissue engineered cardiac patch
American Heart Association
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