Jessica Gluck

Works (27)

Updated: May 13th, 2025 05:01

2025 journal article

Comparison of Collagen and Polylactic Acid Multifilament Yarns for Developing Textile Scaffolds for Tendon Tissue Engineering Applications

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 113(5).

By: Y. Huang , R. Tonndorf, J. Gluck , E. Cadet, M. King  & J. Cole 

author keywords: collagen; genipin; polylactic acid; tendon repair; tissue engineering; yarn
MeSH headings : Polyesters / chemistry; Tissue Engineering / methods; Tissue Scaffolds / chemistry; Tendons / cytology; Collagen / chemistry; Animals; Materials Testing; Polymers / chemistry; Lactic Acid / chemistry; Iridoids / chemistry; Tensile Strength; Textiles
topics (OpenAlex):
Sources: ORCID, Web Of Science
Added: May 5, 2025

2024 article

Development of Optical Nanosensors for Detection of Potassium Ions and Assessment of Their Biocompatibility with Corneal Epithelial Cells

Dewey, H. M., Mahmood, N., Abello, S. M., Sultana, N., Jones, J., Gluck, J. M., & Budhathoki-Uprety, J. (2024, June 11). ACS OMEGA, Vol. 6.

By: H. Dewey n, N. Mahmood n, S. Abello n, N. Sultana n , J. Jones n, J. Gluck n , J. Budhathoki-Uprety  n

topics (OpenAlex): Analytical Chemistry and Sensors; Electrochemical Analysis and Applications; Electrochemical sensors and biosensors
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 15, 2024

2024 article

Preparation and Characterization of Hydrogels Fabricated From Chitosan and Poly(vinyl alcohol) for Tissue Engineering Applications

Wang, Z., Mahmood, N., Budhathoki-Uprety, J., Brown, A. C., King, M. W., & Gluck, J. M. (2024, July 22). ACS APPLIED BIO MATERIALS, Vol. 7.

By: Z. Wang n , N. Mahmood n, J. Budhathoki-Uprety  n, A. Brown* , M. King n  & J. Gluck n 

author keywords: chitosan; molecular weight; poly(viny alcohol); hydrogel; tissue engineering
MeSH headings : Chitosan / chemistry; Polyvinyl Alcohol / chemistry; Hydrogels / chemistry; Hydrogels / pharmacology; Tissue Engineering; Humans; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Biocompatible Materials / chemical synthesis; Materials Testing; Cell Survival / drug effects; Fibroblasts / drug effects; Fibroblasts / cytology; Particle Size
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Nanocomposite Films for Food Packaging; Hydrogels: synthesis, properties, applications
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 1, 2024

2023 article

A textile-reinforced composite vascular graft that modulates macrophage polarization and enhances endothelial cell migration, adhesion and proliferation in vitro

Zhang, F., Tao, H., Gluck, J. M., Wang, L., Daneshmand, M. A., & King, M. W. (2023, January 20). SOFT MATTER, Vol. 1.

By: F. Zhang n , H. Tao *, J. Gluck n , L. Wang *, M. Daneshmand * & M. King n 

MeSH headings : Endothelial Cells; Macrophage Activation; Textiles; Hydrogels; Cell Proliferation; Macrophages; Tissue Engineering
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; 3D Printing in Biomedical Research; Graphene and Nanomaterials Applications
TL;DR: The textile-reinforced hydrogel shows it potential to be a promising scaffold material to fabricate a tissue engineered vascular graft and improves the survival, adhesion and proliferation of endothelial cells in vitro. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 9, 2023

2023 journal article

Application of Noggin-Coated Electrospun Scaffold in Corneal Wound Healing

Translational Vision Science & Technology, 12(8), 15.

By: N. Mahmood  n, E. Sefat  n, D. Roberts  n, B. Gilger n  & J. Gluck n 

MeSH headings : Humans; Contact Lenses; Cornea; Corneal Injuries / therapy; Epithelial Cells; Tissue Scaffolds
topics (OpenAlex): Corneal Surgery and Treatments; Electrospun Nanofibers in Biomedical Applications; Ocular Surface and Contact Lens
TL;DR: This Noggin-coated electrospun scaffold represents a step toward, expanding treatment options for patients with indolent corneal ulcers, and provides a better perspective for understanding electroSpun scaffolds as a tunable platform to infuse topical therapeutics and use as aCorneal bandage. (via Semantic Scholar)
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Sources: ORCID, Crossref, NC State University Libraries
Added: October 4, 2023

2023 journal article

Comparison of NIH 3T3 Cellular Adhesion on Fibrous Scaffolds Constructed from Natural and Synthetic Polymers

BIOMIMETICS, 8(1).

By: K. McGarry n, E. Sefat n, T. Suh  n, K. Ali n & J. Gluck n 

author keywords: collagen; PLA; tissue engineering; cell adhesion; cell proliferation; biomimetic materials
topics (OpenAlex): Bone Tissue Engineering Materials; Electrospun Nanofibers in Biomedical Applications; Collagen: Extraction and Characterization
TL;DR: An evaluation of the cellular response of embryonic mouse fibroblasts (NIH 3T3 line) to the different polymer types was conducted and indicated that NIH3T3 cells prefer collagen-based scaffolds. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 1, 2023

2023 journal article

Development of a Pneumatic-Driven Fiber-Shaped Robot Scaffold for Use as a Complex 3D Dynamic Culture System

BIOMIMETICS, 8(2).

By: M. Hoque n, N. Mahmood n, K. Ali n, E. Sefat n, Y. Huang n , E. Petersen n, S. Harrington n, X. Fang n , J. Gluck n 

author keywords: tissue engineering; fiber actuators; 3D dynamic cell culture; cyclic strain
topics (OpenAlex): 3D Printing in Biomedical Research; Cellular Mechanics and Interactions; Spaceflight effects on biology
TL;DR: A simple and cost-effective 3D dynamic culture system has been proposed, which can be easily implemented to study complex biological phenomena in vitro, and shown to support cell proliferation with minimal cytotoxicity similar to static cultures. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 10, 2023

2023 journal article

Heparin Affinity-Based IL-4 Delivery to Modulate Macrophage Phenotype and Endothelial Cell Activity In Vitro

ACS Applied Materials & Interfaces, 15(23), 27457–27470.

By: F. Zhang n , J. Gluck n , A. Brown n , D. Zaharoff n & M. King n 

author keywords: gelatin methacryloyl; heparin; interleukin4; hydrogel; macrophage; endothelial cell; immunomodulation
MeSH headings : Interleukin-4 / pharmacology; Heparin / pharmacology; Heparin / metabolism; Macrophages / metabolism; Phenotype; Hydrogels / pharmacology; Hydrogels / metabolism
topics (OpenAlex): Wound Healing and Treatments; Immune cells in cancer; Nerve injury and regeneration
TL;DR: A gelatin-heparin-methacrylate hydrogel is engineered that gradually releases interleukin-4 (IL-4), a cytokine that modulates macrophages to adopt the M2 phenotype and synergistically downregulated M1 gene expression and upregulated M2 gene expression within 48 h of in vitro cell culture. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 26, 2023

2022 article

A standardized procedure for quantitative evaluation of residual viral activity on antiviral treated textiles

Wang, Z., Amanah, A. Y., Ali, K. M., Payne, L. C., Kisthardt, S., Scholle, F., … Gluck, J. M. (2022, November 2). TEXTILE RESEARCH JOURNAL, Vol. 11.

By: Z. Wang n , A. Amanah  n, K. Ali n, L. Payne n, S. Kisthardt n, F. Scholle n , R. Ormond n , K. Mathur n , J. Gluck n 

author keywords: SARS-CoV-2; antiviral textiles; Tissue Culture Infectious Dose 50
topics (OpenAlex): Infection Control and Ventilation; Infection Control in Healthcare; COVID-19 and healthcare impacts
TL;DR: This pilot study aims to develop and refine a standardized protocol to quantitatively evaluate residual viral activity on antiviral textiles and used HCoV-229E and Huh-7 human liver cancer cells for this investigation. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 3, 2022

2022 journal article

Effects of sterilization methods on gelatin methacryloyl hydrogel properties and macrophage gene expression in vitro

Biomedical Materials, 18(1), 015015.

By: F. Zhang n , G. Scull n, J. Gluck n , A. Brown n  & M. King n 

author keywords: gelatin methacryloyl; hydrogel; sterilization; macrophage phenotype; gene expression
MeSH headings : Hydrogels; Macrophages
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; 3D Printing in Biomedical Research; Wound Healing and Treatments
TL;DR: It was found that the sterilization methods only marginally altered the hydrogel morphology, swelling behavior and elastic modulus, but significantly impacted macrophage gene expression within 48 h and over 7 d in vitro, suggesting that not only the sterility and hydrogels properties, such as material destruction and degradation caused by temperature and moisture, should be taken into consideration. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: November 22, 2022

2022 journal article

Electrospun Carbon Nanotube-Based Scaffolds Exhibit High Conductivity and Cytocompatibility for Tissue Engineering Applications

ACS OMEGA, 7(23), 20006–20019.

By: T. Suh  n, J. Twiddy n, N. Mahmood n, K. Ali n, M. Lubna n, P. Bradford n, M. Daniele n , J. Gluck n 

topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Neuroscience and Neural Engineering
TL;DR: The increased conductivity and high cytocompatibility of the CNT-incorporated scaffolds make them appropriate candidates for future use in cardiac and neural tissue engineering. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 4, 2022

2022 journal article

In Vitro Biocompatibility and Degradation Analysis of Mass-Produced Collagen Fibers

POLYMERS, 14(10).

By: K. Ali* , Y. Huang* , A. Amanah *, N. Mahmood*, T. Suh * & J. Gluck* 

author keywords: collagen; tissue engineering; biomaterials; biocompatibility; scaffolds
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials; Collagen: Extraction and Characterization
TL;DR: This study uses bovine-derived collagen fibers to create yarns using the traditional ring spinning method, and these yarns are proven to be biocompatible and enzymatic biodegradability was confirmed for its potential use in vivo. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 22, 2022

2022 article

Induced Pluripotent Stem Cell-Derived Corneal Cells: Current Status and Application

Mahmood, N., Suh, T. C., Ali, K. M., Sefat, E., Jahan, U. M., Huang, Y., … Gluck, J. M. (2022, August 1). STEM CELL REVIEWS AND REPORTS, Vol. 8.

By: N. Mahmood n, T. Suh  n, K. Ali n, E. Sefat n, U. Jahan n , Y. Huang n , B. Gilger n , J. Gluck n 

author keywords: Cornea; Corneal tissue engineering; Induced pluripotent stem cells; Differentiation; Limbal stem cell deficiency
MeSH headings : Humans; Induced Pluripotent Stem Cells; Cell Differentiation / genetics; Cornea; Cell Line; Corneal Diseases / therapy
topics (OpenAlex): Corneal Surgery and Treatments; Pluripotent Stem Cells Research; Developmental Biology and Gene Regulation
TL;DR: The early development of the cornea is discussed because protocols differentiating iPSCs toward corneal lineages rely heavily upon recapitulating this development, and differentiated iPSC phenotypes have been analyzed with an emphasis on feeder- free, xeno-free, and well-defined protocols, which have clinical relevance. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 1, 2022

2022 journal article

Plasma-Induced Diallyldimethylammonium Chloride Antibacterial Hernia Mesh

ACS Applied Bio Materials, 5(12), 5645–5656.

By: Z. Wang n , H. Hamedi n, F. Zhang  n, A. El-Shafei n , A. Brown n , J. Gluck n , M. King n 

author keywords: hernia mesh; polypropylene; plasma; surface grafting; antibacterial; fibroblast
MeSH headings : Humans; Surgical Mesh / adverse effects; Polypropylenes; Hernia, Ventral / drug therapy; Anti-Bacterial Agents / pharmacology
topics (OpenAlex): Surgical Sutures and Adhesives; Hernia repair and management; Reconstructive Surgery and Microvascular Techniques
TL;DR: A polypropylene mesh with antibacterial properties was developed and grafted onto the mesh surface using pentaerythritol tetraacrylate as the cross-linker since it is able to engage all four functional groups to form a high-density cross-linked network. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: November 30, 2022

2021 journal article

Cleaner production of mulberry spun silk yarns via a shortened and gassing-free production route

Journal of Cleaner Production, 278, 123690.

By: R. Yin n , Y. Xiang *, Z. Zhang *, X. Tao *, J. Gluck n , K. Chiu, W. Lam

author keywords: Mulberry spun silk; Yarn properties; Gassing process; Modified ring spinning; 3D structural configuration
topics (OpenAlex): Silk-based biomaterials and applications; Textile materials and evaluations; Dyeing and Modifying Textile Fibers
Source: ORCID
Added: September 8, 2020

2020 journal article

Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications

Bioengineering, 7(3), 105.

By: T. Suh *, A. Amanah * & J. Gluck* 

author keywords: tissue engineering; cardiac tissue engineering; engineered heart tissue; electrospinning; scaffolds; cardiomyocytes; induced pluripotent stem cells
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Pluripotent Stem Cells Research
TL;DR: The requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts are presented. (via Semantic Scholar)
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Source: ORCID
Added: September 14, 2020

2017 journal article

Biochemical and biomechanical properties of the pacemaking sinoatrial node extracellular matrix are distinct from contractile left ventricular matrix.

PloS One, 12(9).

By: J. Gluck* , A. Herren *, S. Yechikov*, H. Kao *, A. Khan *, B. Phinney *, N. Chiamvimonvat *, J. Chan *, D. Lieu *

Contributors: J. Gluck* , A. Herren *, S. Yechikov*, H. Kao *, A. Khan *, B. Phinney *, N. Chiamvimonvat *, J. Chan *, D. Lieu *

MeSH headings : Animals; Basement Membrane / chemistry; Basement Membrane / metabolism; Basement Membrane / ultrastructure; Biological Clocks / physiology; Biomechanical Phenomena; Collagen / metabolism; Collagen / ultrastructure; Elasticity; Elastin / metabolism; Elastin / ultrastructure; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Fibronectins / metabolism; Fibronectins / ultrastructure; Fluorescent Antibody Technique; Heart Ventricles / chemistry; Heart Ventricles / metabolism; Heart Ventricles / ultrastructure; Mass Spectrometry; Microscopy, Atomic Force; Microscopy, Electrochemical, Scanning; Myocytes, Cardiac / chemistry; Myocytes, Cardiac / metabolism; Proteome; Proteomics; Sinoatrial Node / chemistry; Sinoatrial Node / metabolism; Sinoatrial Node / ultrastructure; Swine; Tensile Strength
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Cardiac Structural Anomalies and Repair
TL;DR: Findings provide the criteria for a suitable matrix scaffold for engineering biopacemakers and suggest that resident pacemaking cardiomyocytes are enclosed in fibrillar collagens that can withstand greater tensile strength while the surrounding elastin-rich regions may undergo deformation to reduce the mechanical strain in these cells. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2017 journal article

Dedifferentiated Adipocytes Improve Heart Function Post-Myocardial Infarction

Journal of Regenerative Medicine.

Jessica Gluck

topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Cardiac Fibrosis and Remodeling; Pluripotent Stem Cells Research
TL;DR: This study is the first to report that the transplantation of mDFAT cells into a murine model of MI can preserve cardiac function up to eight weeks after the onset of infarction, suggesting a potential role for DFAT cells as a therapeutic pluripotent cell source in cardiovascular tissue repair. (via Semantic Scholar)
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Source: ORCID
Added: August 20, 2019

2016 journal article

Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology.

Stem Cells (Dayton, Ohio), 11(11), 2670–2680.

By: S. Yechikov*, R. Copaciu*, J. Gluck* , W. Deng *, N. Chiamvimonvat *, J. Chan *, D. Lieu *

Contributors: S. Yechikov*, R. Copaciu*, J. Gluck* , W. Deng *, N. Chiamvimonvat *, J. Chan *, D. Lieu *

author keywords: Human induced pluripotent stem cells; Cardiomyocyte subtype; Electrophysiology; Pacemaker
MeSH headings : Action Potentials / physiology; Biomarkers / metabolism; Cell Differentiation; Cell Line; Cell Lineage / genetics; Electrophysiology; Gene Expression; Heart Atria / cytology; Heart Atria / metabolism; Heart Conduction System / cytology; Heart Conduction System / metabolism; Heart Ventricles / cytology; Heart Ventricles / metabolism; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / genetics; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism; Immunohistochemistry; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / metabolism; LIM-Homeodomain Proteins / genetics; LIM-Homeodomain Proteins / metabolism; Muscle Proteins / genetics; Muscle Proteins / metabolism; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Organ Specificity; Potassium Channels / genetics; Potassium Channels / metabolism; Single-Cell Analysis / methods; Transcription Factors / genetics; Transcription Factors / metabolism
topics (OpenAlex): Pluripotent Stem Cells Research; Neuroscience and Neural Engineering; Cardiac electrophysiology and arrhythmias
TL;DR: expression of proposed pacemaker‐specific markers—hyperpolarization‐activated cyclic nucleotide‐modulated (HCN)4 channel and Islet (Isl)1)—at the protein level in all three hiPSC‐derived cardiomyocyte subtypes are revealed. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2014 journal article

Effect of fiber orientation of collagen-based electrospun meshes on human fibroblasts for ligament tissue engineering applications.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 1(1), 39–46.

By: S. Full*, C. Delman *, J. Gluck* , R. Abdmaulen*, R. Shemin* & S. Heydarkhan-Hagvall*

Contributors: S. Full*, C. Delman *, J. Gluck* , R. Abdmaulen*, R. Shemin* & S. Heydarkhan-Hagvall*

author keywords: electrospinning; polylactic-co-glycolic acid; polyurethane; collagen I; ligament tissue engineering
MeSH headings : Collagen Type I / chemistry; Elastic Modulus; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Lactic Acid / chemistry; Ligaments; Materials Testing; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Polyurethanes / chemistry; Tissue Engineering; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Knee injuries and reconstruction techniques; Bone Tissue Engineering Materials
TL;DR: The effectiveness of electrospun PLGA scaffolds as a suitable candidate for regenerative medicine, capable of being manipulated and combined with other polymers to create three-dimensional microenvironments with adjustable tensile properties to mimic native tissues is demonstrated. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2014 journal article

Microenvironment influences vascular differentiation of murine cardiovascular progenitor cells.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 11(8), 1730–1739.

By: J. Gluck* , C. Delman *, J. Chyu*, W. MacLellan *, R. Shemin* & S. Heydarkhan-Hagvall*

Contributors: J. Gluck* , C. Delman *, J. Chyu*, W. MacLellan *, R. Shemin* & S. Heydarkhan-Hagvall*

author keywords: cell differentiation; vascular; progenitor cells; stem cells; scaffolds; extracellular matrix
MeSH headings : Animals; Blood Vessel Prosthesis; Cell Differentiation; Cells, Cultured; Cellular Microenvironment; Endothelial Cells / cytology; Endothelial Cells / metabolism; Extracellular Matrix / chemistry; Mice; Myocardium / cytology; Myocardium / metabolism; Myocytes, Smooth Muscle / cytology; Myocytes, Smooth Muscle / metabolism; Stem Cells / cytology; Stem Cells / metabolism; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; 3D Printing in Biomedical Research
TL;DR: The study characterized the contributions of both ECM proteins and the addition of a 3D culture system to continued vascular differentiation and demonstrated the capability bioengineer a CPC-derived vascular graft. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2013 journal article

Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations

ISRN Tissue Engineering.

Jessica Gluck

topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; 3D Printing in Biomedical Research
TL;DR: It is shown here that the three-dimensionality of a hyaluronan-based hydrogel greatly induces a CPC population, as marked by Flk-1, and that the 3D microenvironment potently induces a progenitor cell state. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2012 journal article

Stem Cell Extracellular Matrix Interactions in Three- Dimensional System via Integrins

Journal of Regenerative Medicine.

Jessica Gluck

topics (OpenAlex): Cellular Mechanics and Interactions; Cell Adhesion Molecules Research; 3D Printing in Biomedical Research
TL;DR: This work has characterized integrin expression of undifferentiated mES cells and established a system of evaluating the ECM-integrin interactions in three-dimension (3D) using electrospun scaffolds. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2011 journal article

Hybrid coaxial electrospun nanofibrous scaffolds with limited immunological response created for tissue engineering

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 99B(1), 180–190.

By: J. Gluck* , P. Rahgozar *, N. Ingle n , F. Rofail*, A. Petrosian*, M. Cline*, M. Jordan *, K. Roos* ...

Contributors: J. Gluck* , P. Rahgozar *, N. Ingle n , F. Rofail*, A. Petrosian*, M. Cline*, M. Jordan *, K. Roos* ...

author keywords: coaxial; electrospinning; polycaprolactone; polyurethane; gelatin; tissue engineering
MeSH headings : Animals; Biocompatible Materials / chemistry; Biocompatible Materials / metabolism; Electrochemical Techniques / methods; Foreign-Body Reaction / immunology; Gelatin / chemistry; Implants, Experimental; Materials Testing; Mice; NIH 3T3 Cells; Nanofibers / chemistry; Nanofibers / ultrastructure; Polyesters / chemistry; Polymers / chemical synthesis; Polymers / chemistry; Polymers / metabolism; Polyurethanes / chemistry; Porosity; Stress, Mechanical; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Bone Tissue Engineering Materials
TL;DR: The results show the advantages of combining both natural and synethic polymers to create a coaxial scaffold capable of withstanding dynamic culture conditions and encourage cellular migration to the interior of the scaffold for tissue-engineering applications. (via Semantic Scholar)
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Sources: ORCID, Crossref, NC State University Libraries
Added: August 20, 2019

2011 journal article

Recapitulation of the embryonic cardiovascular progenitor cell niche.

Biomaterials, 4.

By: K. Schenke-Layland *, A. Nsair*, H. Van*, E. Angelis*, J. Gluck* , M. Votteler*, J. Goldhaber *, H. Mikkola *, M. Kahn *, W. Maclellan *

Contributors: K. Schenke-Layland *, A. Nsair*, B. Van Handel*, E. Angelis*, J. Gluck* , M. Votteler*, J. Goldhaber *, H. Mikkola *, M. Kahn *, W. MacLellan *

author keywords: Extracellular matrix; Cardiac tissue engineering; Stem cell; Scaffold; Heart
MeSH headings : Animals; Cardiovascular System / embryology; Cell Differentiation / physiology; Cell Line; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Extracellular Matrix / metabolism; Female; Flow Cytometry; Fluorescent Antibody Technique; Heart / embryology; Humans; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Confocal; Pregnancy; beta Catenin / metabolism
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Congenital heart defects research; Electrospun Nanofibers in Biomedical Applications
TL;DR: This study characterized the cardiovascular progenitor cell (CPC) niche in developing human and mouse hearts, identifying signaling pathways and extracellular matrix (ECM) proteins that are crucial for CPC maintenance and expansion and demonstrates that collagen IV (ColIV) and β-catenin-dependent signaling are essential for maintaining and expanding undifferentiated CPCs. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2011 journal article

The effect of vitronectin on the differentiation of embryonic stem cells in a 3D culture system.

Biomaterials, 3(7), 2032–2040.

By: S. Heydarkhan-Hagvall*, J. Gluck* , C. Delman *, M. Jung *, N. Ehsani*, S. Full*, R. Shemin*

Contributors: S. Heydarkhan-Hagvall*, J. Gluck* , C. Delman *, M. Jung *, N. Ehsani*, S. Full*, R. Shemin*

author keywords: Extracellular matrix; Niche; Cardiovascular tissue engineering; Stem cell; Scaffold
MeSH headings : Animals; Biocompatible Materials / metabolism; Cell Culture Techniques / methods; Cell Differentiation / physiology; Cell Proliferation; Cells, Cultured; Collagen Type IV / metabolism; Embryonic Stem Cells / cytology; Embryonic Stem Cells / physiology; Extracellular Matrix / metabolism; Fibronectins / metabolism; Heart / embryology; Humans; Laminin / metabolism; Mice; Myocardium / cytology; Tissue Engineering / methods; Vascular Endothelial Growth Factor Receptor-2 / genetics; Vascular Endothelial Growth Factor Receptor-2 / metabolism; Vitronectin / metabolism
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; 3D Printing in Biomedical Research
TL;DR: The results show the importance of defined culture systems in vitro for studying the guided differentiation of pluripotent embryonic stem cells in the field of cardiovascular tissue engineering and regenerative medicine. (via Semantic Scholar)
Source: ORCID
Added: August 20, 2019

2009 journal article

The use of three-dimensional nanostructures to instruct cells to produce extracellular matrix for regenerative medicine strategies

Biomaterials, 30(27), 4665–4675.

By: K. Schenke-Layland *, F. Rofail*, S. Heydarkhan*, J. Gluck* , N. Ingle n , E. Angelis*, C. Choi *, W. MacLellan * ...

Contributors: K. Schenke-Layland *, F. Rofail*, S. Heydarkhan*, J. Gluck* , N. Ingle n , E. Angelis*, C. Choi *, W. MacLellan * ...

MeSH headings : Adipose Tissue / cytology; Biological Assay; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Extracellular Matrix Proteins / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Fluorescence; Humans; Nanostructures / chemistry; Photons; Polyesters / pharmacology; Porosity / drug effects; Regenerative Medicine / methods; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / ultrastructure; Tissue Scaffolds
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Graphene and Nanomaterials Applications
TL;DR: This study developed novel hybrid constructs composed of both strong biosynthetic materials and natural human ECM proteins that exhibited excellent biomechanical properties with fiber and pore sizes that allowed attachment and migration of adipose tissue-derived stem cells. (via Semantic Scholar)
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Sources: ORCID, NC State University Libraries, Crossref, NC State University Libraries
Added: August 6, 2018

Employment

Updated: August 20th, 2019 13:41

2019 - present

NC State University Raleigh , NC, US
Assistant Professor Textile Engineering, Chemistry & Science

2017 - 2019

Precise Bio Winston Salem, NC, US
Research Scientist

2016 - 2017

Discovery Place Science Charlotte, NC, US
Manager

2013 - 2016

UC Davis Health System Sacramento, CA, US
Postdoctoral Fellow Internal Medicine: Cardiovascular

Education

Updated: April 3rd, 2014 15:18

2008 - 2013

University of California Los Angeles Los Angeles, CA, US
PhD Molecular, Cellular & Integrative Physiology

2007 - 2008

University of California Los Angeles Los Angeles, CA, US
MS Biomedical Engineering

2005 - 2007

North Carolina State University Raleigh, NC, US
MS Textile Apparel, Technology & Management

2002 - 2005

North Carolina State University Raleigh, NC, US
BS Textile Technology

Funding History

Funding history based on the linked ORCID record. Updated: February 10th, 2025 12:45

grant July 1, 2022 - June 30, 2025
Biologically-derived tissue engineered cardiac patch
American Heart Association

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