Works Published in 2009
Displaying works 21 - 40 of 148 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice
American Journal of Physiology-Gastrointestinal and Liver Physiology, 297(3), G461–G470.
author keywords: crypt fission; apoptosis; Paneth cells; goblet cells; Lgr5
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / toxicity; Apoptosis / drug effects; Cell Lineage; Cell Proliferation / drug effects; Doublecortin-Like Kinases; Doxorubicin / administration & dosage; Doxorubicin / toxicity; Female; Injections, Intraperitoneal; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestine, Small / drug effects; Intestine, Small / metabolism; Intestine, Small / pathology; Jejunum / drug effects; Jejunum / pathology; Leukocyte Common Antigens / analysis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Serine-Threonine Kinases / metabolism; RNA, Messenger / metabolism; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology; Time Factors; beta Catenin / metabolism
TL;DR:
Together these data suggest that, following Dox-induced injury, expansion of intestinal stem cells occurs during mucosal repair, and appears to be predominantly the +4 stem cell population rather than those of the crypt base.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: July 20, 2019
2009 journal article
Early but not late administration of glucagon-like peptide-2 following ileo-cecal resection augments putative intestinal stem cell expansion
American Journal of Physiology-Gastrointestinal and Liver Physiology, 296(3), G643–G650.
author keywords: intestinal adaptation
MeSH headings : Animals; Cecum / pathology; Cecum / surgery; Cell Division / drug effects; Glucagon-Like Peptide 2 / metabolism; Glucagon-Like Peptide 2 / pharmacology; Ileum / pathology; Ileum / surgery; Insulin-Like Growth Factor I / metabolism; Intestinal Diseases / pathology; Intestinal Diseases / surgery; Male; Mice; Mice, Inbred C57BL; Phosphorylation / drug effects; Postoperative Complications / drug therapy; Postoperative Complications / pathology; Proteins / metabolism; Stem Cells / cytology; Time Factors; Weight Gain / drug effects; beta Catenin / metabolism
TL;DR:
This study shows that, in mice, GLP-2 promotes jejunal pISC expansion only in the period immediately following ICR, associated with increased IGF-I and accelerated adaptive increases in mucosal mass.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2009 journal article
P58IPK: A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection
PLoS Pathogens, 5(5), e1000438.
Ed(s): R. Andino
MeSH headings : Animals; Apoptosis / genetics; Eukaryotic Initiation Factor-2 / metabolism; HSP40 Heat-Shock Proteins / genetics; HSP40 Heat-Shock Proteins / metabolism; Immunity, Innate; Inflammation; Influenza A virus / pathogenicity; Influenza A virus / physiology; Interferon-beta / genetics; Interferon-beta / metabolism; Interleukin-6 / genetics; Interleukin-6 / metabolism; Lung / metabolism; Lung / pathology; Lung / virology; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / metabolism; Orthomyxoviridae Infections / mortality; Orthomyxoviridae Infections / virology; Phosphorylation; Virus Replication / genetics; eIF-2 Kinase / metabolism
TL;DR:
It is reported that infection of P58IPK knockout mice with influenza virus resulted in increased lung pathology, immune cell apoptosis, PKR activation, and mortality, and it is suggested that P 58IPK represents a new class of molecule, a cellular inhibitor of the host defense (CIHD), as P56IPK is activated during virus infection to inhibit virus-induced apoptosis and inflammation to prolong host survival, even while prolonging viral replication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2009 journal article
Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events
BMC Genomics, 10(1), 270.
MeSH headings : Animals; Cell Line, Tumor; Gene Expression Profiling; Hepatocytes / metabolism; Hepatocytes / parasitology; Host-Parasite Interactions / genetics; Liver / metabolism; Liver / parasitology; Malaria / genetics; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Plasmodium berghei; Sporozoites; Time Factors
TL;DR:
The data reveal that host cell infection by Plasmodium sporozoites leads to a coordinated and sequential set of biological events, ranging from the initial stage of stress response up to the engagement of host metabolic processes and the maintenance of cell viability throughout infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2009 journal article
Virus–host interactions: from systems biology to translational research
Current Opinion in Microbiology, 12(4), 432–438.
MeSH headings : Gene Expression Regulation; Gene Expression Regulation, Viral; Gene Knockdown Techniques; Genomics / methods; Host-Pathogen Interactions; Humans; MicroRNAs / genetics; MicroRNAs / metabolism; Proteomics / methods; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Sequence Analysis, DNA / methods; Systems Biology / methods; Virus Diseases / immunology; Virus Diseases / virology; Virus Physiological Phenomena; Viruses / immunology
TL;DR:
New high-throughput technologies, a new philosophy for studying virus-host interactions, and the potential of systems biology to facilitate bench-to-bedside research and create novel strategies to combat disease are highlighted.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2009 journal article
Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers
BMC Genomics, 10(1), 373.
MeSH headings : Adolescent; Adult; Aged; Computational Biology / methods; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Hepacivirus / physiology; Hepatitis C / genetics; Hepatitis C / metabolism; Humans; Liver / metabolism; Liver / virology; MicroRNAs / genetics; MicroRNAs / metabolism; Middle Aged; Models, Genetic; Oligonucleotide Array Sequence Analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Analysis, RNA / methods; Young Adult
TL;DR:
The utility of the approach to obtain new insights into post-transcriptional gene regulation at the miRNA level in complex human diseases is demonstrated as the framework for future experimental analyses is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2009 journal article
Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes
PLoS Pathogens, 5(10), e1000604.
Ed(s): M. Diamond
MeSH headings : Animals; Bronchi / pathology; Bronchi / virology; Disease Outbreaks; Gene Expression; Gene Expression Profiling; In Situ Nick-End Labeling; Inflammation / genetics; Inflammation / virology; Influenza A Virus, H1N1 Subtype / immunology; Influenza A Virus, H5N1 Subtype / immunology; Macaca; Oligonucleotide Array Sequence Analysis; Orthomyxoviridae Infections / genetics; Orthomyxoviridae Infections / immunology; Orthomyxoviridae Infections / virology; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
Compared pathology and global gene expression profiles in bronchial tissue from macaques infected with either the reconstructed 1918 pandemic virus or the highly pathogenic avian H5N1 virus A/Vietnam/1203/04 suggest that the severity of disease in 1918 virus-infected macaques is a consequence of the early up-regulation of cell death and inflammatory related genes, in which additive or synergistic effects likely dictate the severityof tissue damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2009 journal article
The Alpha/Beta Interferon Receptor Provides Protection against Influenza Virus Replication but Is Dispensable for Inflammatory Response Signaling
Journal of Virology, 84(4), 2027–2037.
MeSH headings : Animals; Apoptosis / genetics; Base Sequence; Cells, Cultured; DNA, Viral / genetics; Dogs; Host-Pathogen Interactions / immunology; Inflammation / immunology; Inflammation / virology; Influenza A virus / genetics; Influenza A virus / immunology; Influenza A virus / pathogenicity; Influenza A virus / physiology; Mice; Mice, Knockout; NF-kappa B / metabolism; Orthomyxoviridae Infections / genetics; Orthomyxoviridae Infections / immunology; Receptor, Interferon alpha-beta / deficiency; Receptor, Interferon alpha-beta / genetics; Receptor, Interferon alpha-beta / physiology; STAT1 Transcription Factor / metabolism; Signal Transduction; Toll-Like Receptor 3 / metabolism; Virulence; Virus Replication / immunology; eIF-2 Kinase / metabolism
TL;DR:
Familiarity studies have identified potential pathways, via interferon regulatory factor 3 (IRF3) activation or Hoxa13, Polr2a, Nr4a1, or Ing1 induction, that contribute to this redundancy.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019
2009 journal article
Vesicle formation and endocytosis: function, machinery, mechanisms, and modeling.
Antioxidants & Redox Signaling, 11(6), 1301–1312.
Contributors: N. Parkar*, B. Akpa* , L. Nitsche*, L. Wedgewood*, A. Place*, M. Sverdlov *, O. Chaga*, R. Minshall *
MeSH headings : Animals; Caveolae / metabolism; Caveolae / ultrastructure; Cell Membrane / metabolism; Cell Membrane / ultrastructure; Clathrin / metabolism; Endocytosis / genetics; Endocytosis / physiology; Humans; Models, Biological; Signal Transduction / physiology; Transport Vesicles / metabolism; Transport Vesicles / physiology; Transport Vesicles / ultrastructure
TL;DR:
This review of endocytosis broadly discusses the structural and signaling proteins that compose the molecular machinery governing endocytic vesicle formation (budding, invagination, and fission from the membrane), with some regard for the specificity observed in certain cell types and species.
(via Semantic Scholar)
Source: ORCID
Added: May 18, 2019
2009 journal article
Developmental and tissue-specific expression of NITRs
Immunogenetics, 62(2), 117–122.
author keywords: Innate immunity; Lymphocytes; Natural killer receptors
MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Female; Gene Expression Regulation, Developmental; Organ Specificity; Ovary / metabolism; Receptors, Immunologic / genetics; Receptors, Immunologic / immunology; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / immunology; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology
TL;DR:
The expression of multiple NITR genes in the zebrafish ovary and during embryogenesis is demonstrated and all 14 families of NITRs are shown to be expressed in the lymphocyte lineage, but not in the myeloid lineage, consistent with the hypothesis that N ITRs function as NKRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: NC State University Libraries, Crossref
Added: May 17, 2019
2009 chapter
Therapeutic Drug Monitoring
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology & Therapeutics (9th ed.). Wiley Blackwell, John Wiley & Sons.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Drugs that Affect the Respiratory System
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Drugs Affecting Gastrointestinal Function
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Immunosuppressive Drugs and Cyclosporine
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Antifungal and Antiviral Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Fluoroquinolone Antimicrobial Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Aminoglycoside Antibiotics
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Tetracycline Antibiotics
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
2009 chapter
Beta-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed.). Ames, Iowa, USA: Wiley-Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: April 17, 2019
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