Works Published in 2019
Displaying works 41 - 60 of 71 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2019 journal article
Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species
SCIENCE TRANSLATIONAL MEDICINE, 11(499).
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism; Adolescent; Adult; Aged; Animals; Anti-Retroviral Agents / pharmacology; CD3 Complex / metabolism; Female; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / virology; Gene Expression Regulation, Viral / drug effects; HIV / drug effects; HIV / genetics; Humans; Macaca mulatta; Male; Mice; Middle Aged; RNA, Viral / genetics; RNA, Viral / metabolism; Simian Immunodeficiency Virus / drug effects; Simian Immunodeficiency Virus / genetics; Species Specificity; T-Lymphocytes / drug effects; Young Adult
TL;DR:
There may be gut regions with little to no exposure to antiretroviral drugs, which may result in low-level HIV replication contributing to HIV persistence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 5, 2019
2019 journal article
Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411(19), 4673–4682.
Contributors: X. Zheng *, F. Smith*, N. Aly*, J. Cai *, R. Smith *, A. Patterson *, E. Baker n
author keywords: Ion mobility spectrometry; Bile acids; Collisional cross sections
MeSH headings : Bile Acids and Salts / chemistry; Bile Acids and Salts / standards; Copper / chemistry; Humans; Ion Mobility Spectrometry / methods; Isomerism; Molecular Structure; Reference Standards; Zinc / chemistry
TL;DR:
In the DTIMS-MS analyses of 12 isomer groups, BAs with smaller m/z values were easily separated in either their deprotonated or sodiated forms (or both).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 29, 2019
2019 journal article
Evaluation of optimal model parameters for prediction of methane generation from selected US landfills
WASTE MANAGEMENT, 91, 120–127.
author keywords: Landfills; Landfill gas; Methane; Gas collection efficiency; LandGEM
MeSH headings : Air Pollutants; Gases; Methane; Refuse Disposal; Waste Disposal Facilities
TL;DR:
Methane collection data from 21 U.S. landfills were used to estimate the best fit k by inverse modeling of measured methane collection data in consideration of a time-varying gas collection efficiency, and show that there is wide variation in the best estimate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 22, 2019
2019 journal article
Label-Free Quantitative Proteomics of Enriched Nuclei from Sugarcane (Saccharum ssp) Stems in Response to Drought Stress
PROTEOMICS, 19(14).
author keywords: drought; RNA regulation; Saccharum spp; shotgun proteomics; transcription factors
MeSH headings : Droughts; Gene Expression Regulation, Plant; Plant Proteins / metabolism; Proteomics; Saccharum / metabolism
TL;DR:
The integration of nuclei enrichment sample preparation with the shotgun proteomic approach results in great coverage of the sugarcane stem proteome with 5381 protein groups identified, indicating that drought affects negatively the cell wall metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 22, 2019
2019 journal article
Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases
Toxicology and Applied Pharmacology, 379, 114674.
Contributors: M. Kosnik n & D. Reif n
author keywords: Data integration; Risk assessment; New approach methodologies; Gene-environment interactions
MeSH headings : Animals; Databases, Factual; Datasets as Topic; Environmental Exposure / adverse effects; Environmental Exposure / statistics & numerical data; Gene-Environment Interaction; Genetic Predisposition to Disease / etiology; Genetic Predisposition to Disease / genetics; Genetic Variation; High-Throughput Screening Assays; Humans; Information Storage and Retrieval; Risk Assessment / methods; Toxicology / methods
TL;DR:
This work presents an approach that systematically links multiple data sources to relate chemical risk values to diseases and gene-disease variants and develops a new value that estimates the risk of these associations toward differential population responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: July 17, 2019
2019 journal article
Effects of Co-occurring Species Present in Swine Lagoons on Adsorption of Copper on Eggshell
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH, 13(4), 613–622.
author keywords: Adsorption; Eggshell; Copper; Swine lagoons; Acetate; Ammonia
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 15, 2019
2019 journal article
Cheminformatics approach to exploring and modeling trait-associated metabolite profiles
JOURNAL OF CHEMINFORMATICS, 11.
author keywords: Metabolomics; Data mining; Cheminformatics; Molecular fragmentation; Statistics; Visualization; Chemical structure
TL;DR:
A novel cheminformatics-based approach capable of identifying predictive, interpretable, and reproducible trait-metabolite relationships that could ultimately facilitate biological understanding and advance research based on metabolomics data, especially with respect to the identification of novel biomarkers.
(via Semantic Scholar)
jcheminf.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 15, 2019
2019 journal article
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
NATURE COMMUNICATIONS, 10.
MeSH headings : ADAM17 Protein / antagonists & inhibitors; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Benchmarking; Biomarkers, Tumor / genetics; Cell Line, Tumor; Computational Biology / methods; Computational Biology / standards; Datasets as Topic; Drug Antagonism; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Drug Synergism; Genomics / methods; Humans; Molecular Targeted Therapy / methods; Mutation; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics / methods; Pharmacogenetics / standards; Phosphatidylinositol 3-Kinases / genetics; Phosphoinositide-3 Kinase Inhibitors; Treatment Outcome
TL;DR:
A large drug combination screen across cancer cell lines is provided to benchmark crowdsourced methods and to computationally predict drug synergies, and genomic rationale for synergy predictions are identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 1, 2019
2019 article
Challenges in Identifying the Dark Molecules of Life
ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 12, Vol. 12, pp. 177–199.
Contributors: M. Monge *, J. Dodds n, E. Baker n , A. Edison* & F. Fernaacutendez
author keywords: metabolomics; metabolite identification; chromatography; ion mobility; tandem mass spectrometry; nuclear magnetic resonance spectroscopy
MeSH headings : Animals; Chromatography, Liquid / methods; Humans; Ion Mobility Spectrometry / methods; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Metabolome; Metabolomics / methods
TL;DR:
The state-of-the-art in metabolite identification with specific applications in metabolomics is critically discussed and how technologies such as mass spectrometry, ion mobility, chromatography, and nuclear magnetic resonance currently contribute to this challenging task.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2019
2019 journal article
High Temperature Co-pyrolysis Thermal Air Activation Enhances Biochar Adsorption of Herbicides from Surface Water
ENVIRONMENTAL ENGINEERING SCIENCE, 36(6), 710–723.
author keywords: 2; 4-D; adsorption; aerobic pyrolysis; biochar; simazine
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2019
2019 review
Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples
[Review of ]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 116, 292–299.
Contributors: K. Burnum-Johnson *, X. Zheng *, J. Dodds n, J. Ash n, D. Fourches n, C. Nicora *, J. Wendler*, T. Metz *
author keywords: Ion mobility spectrometry; Mass spectrometry; Omics; Proteomics; Lipidomics; Metabolomics; Glycomics; Exposomics
TL;DR:
Ion mobility spectrometry has shown great utility in salvaging molecular information for low abundance molecules of interest when high concentration contaminant ions are present in the sample by reducing detector suppression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2019
2019 journal article
Inappropriate Citation of Vaccine Article.
The Journal of Infectious Diseases.
MeSH headings : Humans; Smallpox; Vaccination; Vaccines / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: June 19, 2019
2019 journal article
Animal production, insecticide use and self-reported symptoms and diagnoses of COPD, including chronic bronchitis, in the Agricultural Health Study
ENVIRONMENT INTERNATIONAL, 127, 764–772.
author keywords: Epidemiology; Occupational health; Environmental health; Pesticide
MeSH headings : Adult; Animal Husbandry; Animals; Bronchitis, Chronic / epidemiology; Farmers; Female; Humans; Insecticides / toxicity; Logistic Models; Male; Middle Aged; Occupational Exposure; Odds Ratio; Prevalence; Pulmonary Disease, Chronic Obstructive / chemically induced; Pulmonary Disease, Chronic Obstructive / epidemiology; Risk Factors; United States / epidemiology
TL;DR:
Animal production work, including insecticide use, was positively associated with chronic bronchitis symptoms; but not consistently with COPD diagnosis alone; the results support the need for further investigation into the role of animal production-related exposures in the etiology of COPD and better respiratory protection for agricultural workers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 journal article
Does Granular Activated Carbon with Chlorination Produce Safer Drinking Water? From Disinfection Byproducts and Total Organic Halogen to Calculated Toxicity
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 53(10), 5987–5999.
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 review
Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)
[Review of ]. JOURNAL OF ENDOCRINOLOGY, 241(2), R65–R80.
author keywords: vitamin D deficiency; DOHAD; metabolic disorders; autism; neurobehavioral disorders; animal models
TL;DR:
A detailed review and perspective of evidence for the role of maternal VDD in offspring long term health, particularly as it relates to Developmental Origins of Health and Disease (DOHaD), and evidence implicating epigenetic mechanisms as a mediator of this link is explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 journal article
Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish
Nanotoxicology, 4, 1—15.
Contributors: L. Truong *, T. Zaikova*, B. Baldock*, M. Balik-Meisner n, K. To n, D. Reif n , Z. Kennedy *, J. Hutchison *, R. Tanguay *
author keywords: Size-dependency; gold nanoparticles; zebrafish; uptake; ligands
MeSH headings : Animals; Gold / toxicity; Metal Nanoparticles / toxicity; Particle Size; Zebrafish
TL;DR:
The results indicate that larger NPs may be the most toxic on a per particle basis and highlight the importance of using particle number and surface area, in addition to mass, when evaluating the size-dependent bioactivity of NPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2019 journal article
Predicting Ion Mobility Collision Cross-Sections Using a Deep Neural Network: DeepCCS
ANALYTICAL CHEMISTRY, 91(8), 5191–5199.
Contributors: P. Plante *, É. Francovic-Fontaine*, J. May *, J. McLean *, E. Baker n , F. Laviolette *, M. Marchand*, J. Corbeil *
MeSH headings : Algorithms; Deep Learning; Ion Mobility Spectrometry; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolomics; Neural Networks, Computer
TL;DR:
This article successfully developed and trained a prediction model for CCS values requiring only information about a compound's SMILES notation and ion type and was able to outperform all currently available CCS prediction algorithms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 13, 2019
2019 journal article
An algorithm for quantitatively estimating non-occupational pesticide exposure intensity for spouses in the Agricultural Health Study
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 29(3), 344–357.
MeSH headings : Adult; Agriculture; Algorithms; Environmental Exposure / analysis; Farmers; Female; Humans; Male; Pesticides / analysis; Spouses; Surveys and Questionnaires
TL;DR:
A quantitative, active ingredient-specific algorithm for cumulative (adult, married lifetime) non-occupational pesticide exposure intensity for spouses of farmers who applied pesticides in the Agricultural Health Study (AHS) is developed and will facilitate improved etiologic analyses in the AHS spouses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2019
2019 journal article
Evidence for Aryl hydrocarbon Receptor-Mediated Inhibition of Osteoblast Differentiation in Human Mesenchymal Stem Cells
TOXICOLOGICAL SCIENCES, 167(1), 145–156.
author keywords: aryl hydrocarbon receptor; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD; mesenchymal stem cell; osteoblast differentiation; skeletal toxicity; bone toxicity
MeSH headings : Basic Helix-Loop-Helix Transcription Factors / agonists; Cell Differentiation / drug effects; Fibroblast Growth Factor 9 / genetics; Fibroblast Growth Factors / genetics; Humans; Ligands; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / metabolism; Osteogenesis / drug effects; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / agonists; Up-Regulation
TL;DR:
Experimental evidence from this study suggests that AhR transactivation likely attenuates osteoblast differentiation in multipotent hBMSCs, and underscores the use of primary human MSCs to evaluate osteoinductive or osteotoxic potential of chemical and pharmacologic agents in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2019
2019 journal article
Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years
PLOS ONE, 14(3).
Contributors: M. Kosnik n, D. Reif n , D. Lobdell*, T. Astell-Burt *, X. Feng *, J. Hader*, J. Hoppin n
Ed(s): W. Cheungpasitporn
MeSH headings : Adolescent; Adult; Aged; Air Pollution / adverse effects; Female; Health Services Accessibility; Humans; Kidney Failure, Chronic / epidemiology; Male; Middle Aged; Prevalence; Proportional Hazards Models; Risk Factors; Socioeconomic Factors; United States / epidemiology; Water Quality; Young Adult
TL;DR:
The results demonstrate the importance of considering multiple factors when studying ESRD survival and future efforts should consider additional components of the broader environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 9, 2019
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