Works Published in 2008
Displaying works 41 - 60 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2008 journal article
An interlaboratory study of perfluorinated alkyl compound levels in human plasma
Environmental Research, 107(2), 152–159.
Contributors: M. Longnecker*, C. Smith *, G. Kissling*, J. Hoppin* , J. Butenhoff*, E. Decker*, D. Ehresman*, M. Ellefson*
author keywords: perfluorinated alkyl compounds; interlaboratory study; persistent organic pollutants; interdisciplinary studies; research design; epidemiologic methods
MeSH headings : Adult; Biomarkers / blood; Environmental Monitoring / standards; Environmental Pollutants / analysis; Female; Fluorocarbons / blood; Humans; Male; Pregnancy
TL;DR:
Considering the degree of between-subject variation in levels among people in background-exposed populations, the results indicate that biomarker-based epidemiologic studies of associations with health could have reasonable precision.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Cancer incidence among pesticide applicators exposed to trifluralin in the Agricultural Health Study
Environmental Research, 107(2), 271–276.
Contributors: D. Kang *, S. Park *, L. Beane-Freeman *, C. Lynch *, C. Knott*, D. Sandler *, J. Hoppin* , M. Dosemeci*
author keywords: agriculture; trifluralin; pesticides; cancer; occupational exposure
MeSH headings : Adult; Agriculture; Female; Herbicides / toxicity; Humans; Incidence; Male; Middle Aged; Neoplasms / epidemiology; Neoplasms / etiology; Occupational Exposure; Prospective Studies; Trifluralin / toxicity; United States
TL;DR:
Although there was a possible link between trifluralin exposure and colon cancer, small numbers and inconsistencies in dose-response and subgroup analyses indicate that this may be a chance finding.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Hearing Loss Among Licensed Pesticide Applicators in the Agricultural Health Study
Journal of Occupational and Environmental Medicine, 50(7), 817–826.
Contributors: J. Crawford, J. Hoppin* , M. Alavanja, A. Blair, D. Sandler & F. Kamel
MeSH headings : Adult; Agriculture; Commerce; Health Surveys; Hearing Loss / chemically induced; Hearing Loss / epidemiology; Humans; Licensure; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure; Odds Ratio; Organophosphates; Pesticides / adverse effects
TL;DR:
Although control for exposure to noise or other neurotoxicants was limited, this study extends previous reports suggesting that organophosphate exposure increases risk of hearing loss.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Chlorothalonil exposure and cancer incidence among pesticide applicator participants in the agricultural health study
Environmental Research, 108(3), 400–403.
Contributors: A. Mozzachio*, J. Rusiecki *, J. Hoppin* , R. Mahajan*, R. Patel*, L. Beane-Freeman *, M. Alavanja*
author keywords: Chlorothalonil; Pesticides; Fungicides; Cancer; Agriculture
MeSH headings : Agriculture / statistics & numerical data; Cohort Studies; Fungicides, Industrial / toxicity; Humans; Neoplasms / chemically induced; Neoplasms / epidemiology; Nitriles / toxicity; North Carolina / epidemiology; Occupational Exposure / analysis; Prospective Studies
TL;DR:
Chlorothalonil was not associated with overall cancer incidence, nor did the authors find any association with colon, lung, and prostate cancers--the only cancers for which they had sufficient numbers to explore associations.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Evaluation of Freeze–Thaw Cycles on Stored Plasma in the Biobank of the Norwegian Mother and Child Cohort Study
Cell Preservation Technology, 6(3), 223–229.
Contributors: L. Paltiel*, K. Rønningen *, H. Meltzer *, S. Baker* & J. Hoppin*
TL;DR:
Human plasma can go through several freeze-thaw cycles before analysis without influencing sample integrity for the selected analytes, according to a quality control study using pooled EDTA-plasma.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study
Cancer Causes & Control, 19(10), 1401–1407.
Contributors: D. Greenburg*, J. Rusiecki *, S. Koutros *, M. Dosemeci*, R. Patel*, C. Hines*, J. Hoppin* , M. Alavanja*
author keywords: Captan; Cancer; Agricultural Health Study; Cohort; Prospective; Pesticide; Fungicide; CAS number 133-06-2
MeSH headings : Adult; Agricultural Workers' Diseases / epidemiology; Captan / adverse effects; Cohort Studies; Confidence Intervals; Follow-Up Studies; Fungicides, Industrial / adverse effects; Humans; Incidence; Iowa / epidemiology; Life Style; Male; Middle Aged; Neoplasms / classification; Neoplasms / epidemiology; Neoplasms / etiology; North Carolina / epidemiology; Occupational Exposure / adverse effects; Poisson Distribution; Prevalence; Prospective Studies; Risk Factors; Surveys and Questionnaires; Time Factors
TL;DR:
This study is limited by low numbers of observed cancer cases and follow-up time, it does not provide evidence of an increased risk for the development of cancer at the investigated sites, and no association between the highest tertile of captan exposure and development of all cancers was observed.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
Depression and Pesticide Exposures among Private Pesticide Applicators Enrolled in the Agricultural Health Study
Environmental Health Perspectives, 116(12), 1713–1719.
Contributors: C. Beseler *, L. Stallones *, J. Hoppin* , M. Alavanja*, A. Blair*, T. Keefe*, F. Kamel*
author keywords: cumulative exposure; depression; farm applicators; pesticides; pesticide poisoning
MeSH headings : Adult; Agriculture; Depression / chemically induced; Humans; Iowa; Middle Aged; North Carolina; Occupational Exposure; Pesticides / toxicity; Surveys and Questionnaires
TL;DR:
This study is unique in reporting that depression is also associated with chronic pesticide exposure in the absence of a physician-diagnosed poisoning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2008 journal article
An Evaluation of Information Content as a Metric for the Inference of Putative Conserved Noncoding Regions in DNA Sequences Using a Genetic Algorithms Approach
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 5(1), 1–14.
author keywords: evolutionary computing; genetic algorithms; biology; genetics
MeSH headings : Algorithms; Animals; Base Sequence; Computational Biology / methods; Confidence Intervals; Conserved Sequence / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Enhancer Elements, Genetic / genetics; Glutathione Transferase / genetics; Humans; Models, Genetic; Regulatory Sequences, Nucleic Acid / genetics; Sequence Alignment; Sequence Analysis, DNA / methods; Sex-Determining Region Y Protein / genetics
TL;DR:
Results indicate that IC does not identify highly conserved regions and, thus, is not the appropriate metric for this task, whereas variations on IC, as well as the original metric, succeed in identifying putative Conserved regions.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2008 journal article
The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study
BMC Medical Genomics, 1(1).
TL;DR:
Analysis of curated data for the chemical arsenic provides insight into the biological functions and molecular networks affected by exposure to arsenic, including stress response, apoptosis, cell cycle, and specific protein signaling pathways.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 10, 2019
2008 journal article
A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia
Blood, 113(14), 3226–3234.
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Adaptor Proteins, Signal Transducing / physiology; CD28 Antigens / metabolism; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / pathology; Cytotoxicity, Immunologic / genetics; Endothelial Cells / immunology; Endothelial Cells / pathology; Extracellular Signal-Regulated MAP Kinases / metabolism; Humans; K562 Cells; Leukemia, Large Granular Lymphocytic / genetics; Leukemia, Large Granular Lymphocytic / immunology; Leukemia, Large Granular Lymphocytic / metabolism; Leukemia, Large Granular Lymphocytic / pathology; Membrane Proteins / genetics; Membrane Proteins / metabolism; Membrane Proteins / physiology; Phosphatidylinositol 3-Kinases / metabolism; Pulmonary Artery / immunology; Pulmonary Artery / pathology; Receptors, Immunologic / genetics; Receptors, Immunologic / metabolism; Receptors, Immunologic / physiology; Receptors, Natural Killer Cell / metabolism; Signal Transduction / genetics; Tumor Cells, Cultured
TL;DR:
Results shown suggest that inhibitors of DAP10 and DAP12 or other proteins involved in this signaling pathway will be attractive therapeutic targets for the treatment of LGLL and other autoimmune diseases and syndromes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, Crossref
Added: May 17, 2019
2008 journal article
Genetic basis for adverse events after smallpox vaccination.
Journal of Infectious Diseases, 198(1), 16–22.
Contributors: D. Reif* , B. McKinney *, A. Motsinger*, S. Chanock *, K. Edwards *, M. Rock*, J. Moore, J. Crowe Jr.
MeSH headings : Adult; Female; Genetic Predisposition to Disease; Genotype; Humans; Interferon Regulatory Factor-1 / genetics; Interleukin-4 / genetics; Male; Methylenetetrahydrofolate Reductase (NADPH2) / genetics; Polymorphism, Single Nucleotide; Smallpox Vaccine / adverse effects; Vaccination / adverse effects
TL;DR:
Genetic polymorphisms in genes expressing an enzyme previously associated with adverse reactions to a variety of pharmacologic agents (MTHFR) and an immunological transcription factor (IRF1) were associated with AEs after smallpox vaccination in 2 independent study samples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2008 journal article
Genetic basis for adverse events after smallpox vaccination (Journal of Infectious Diseases (2008) 198, (16-22))
Journal of Infectious Diseases, 198(5).
Contributors: D. Reif , B. McKinney & A. Motsinger
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2008 journal article
A comparison of analytical methods for genetic association studies
Genet. Epidemiol., 32(8), 767â778.
Contributors: A. Motsinger-Reif n, D. Reif* , T. Fanelli* & M. Ritchie *
author keywords: genetic association study; epistasis; multifactor dimensionality reduction; grammatical evolution neural networks; focused interaction testing framework
MeSH headings : Data Interpretation, Statistical; Epistasis, Genetic; Genetic Linkage; Genetic Techniques; Genome; Humans; Models, Genetic; Models, Statistical; Models, Theoretical; Neural Networks, Computer; Phenotype; Probability; Regression Analysis; Software
TL;DR:
This study compares the performance of six analytical approaches to detect both main effects and gene‐gene interactions in a range of genetic models and demonstrates the strengths and weaknesses of each and illustrates the importance of continued methods development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2008 conference paper
A balanced accuracy fitness function leads to robust analysis using grammatical evolution neural networks in the case of class imbalance
Proceedings of the 10th annual conference on Genetic and evolutionary computation - GECCO '08, 353–354.
Contributors: N. Hardison n, D. Reif* , T. Fanelli*, M. Ritchie *, S. Dudek * & A. Motsinger-Reif n
TL;DR:
It is shown that when using classification error, class imbalance greatly decreases the power of GENN, and balanced error has replaced classification error in the GENN algorithm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2008 journal article
Assessing infection and immunity in zebrafish
Zebrafish, 5(3), 189–191.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: February 13, 2019
2008 journal article
The impact of vegetation on sedimentary organic matter composition and PAH desorption
ENVIRONMENTAL POLLUTION, 156(3), 928–935.
author keywords: Phragmites; PAHs; Desorption; Sediments; Phytoremediation
MeSH headings : Adsorption; Biodegradation, Environmental; Chrysenes / analysis; Gas Chromatography-Mass Spectrometry; Geologic Sediments / analysis; Humic Substances / analysis; Plants / metabolism; Polycyclic Aromatic Hydrocarbons / analysis; Polycyclic Aromatic Hydrocarbons / pharmacokinetics; Polymers; Pyrenes / analysis; Soil / analysis; Soil Pollutants / pharmacokinetics
TL;DR:
After several decades of plant colonization and growth (Phragmites australis), vegetated sediment fractions more extensively desorbed PAHs and had faster desorption kinetics than non-vegetation sediment fractions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Differences in sediment organic matter composition and PAH weathering between non-vegetated and recently vegetated fuel oiled sediments
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION, 10(6), 473–485.
author keywords: polycyclic aromatic hydrocarbon (PAH); C-14 accelerator mass spectrometry (AMS); Phragmites; cattails; willow trees
MeSH headings : Biodegradation, Environmental; Fuel Oils / analysis; Geologic Sediments / chemistry; Plant Roots; Poaceae / metabolism; Polycyclic Aromatic Hydrocarbons / chemistry; Salix / metabolism; Soil Pollutants / chemistry; Soil Pollutants / metabolism; Typhaceae / metabolism
TL;DR:
Polycyclic aromatic hydrocarbon attenuation in contaminated field sediments after only 2 years of plant growth is examined to hypothesized that bulk sediment and humin fractions with measurable increases in plant organic matter content would show measurable changes to PAH attenuation as indicated by more weathered PAH diagnostic ratios or reduced PAH concentrations.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
Workshop report - assessing infection and immunity in zebrafish
Zebrafish, 5, 189–191.
Source: NC State University Libraries
Added: August 6, 2018
2008 review
Hormonal regulation of metamorphosis and reproduction in ticks
[Review of ]. Frontiers in Bioscience, 13, 7250–7268.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Tackling the characterization of canine chromosomal breakpoints with an integrated in-situ/in-silico approach: The canine PAR and PAB
CHROMOSOME RESEARCH, 16(8), 1193–1202.
author keywords: Canis familiaris; chromosomal breakpoints; dog; PAR; PAB
MeSH headings : Animals; Chromosome Breakage; Chromosome Mapping / methods; Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian / genetics; Dogs / genetics; X Chromosome / genetics
TL;DR:
This study demonstrates the synergy of using a such a combined in-situ/in-silico approach to define chromosome breakpoints using the naturally occurring breakpoint present on all canine X chromosomes—the pseudoautosomal breakpoint (PAB).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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