Kannapolis Research

MeSH headings : Diterpenes / chemistry; Diterpenes / isolation & purification; Euphorbiaceae / chemistry; Models, Molecular; Molecular Structure; Plant Oils / chemistry; Wood

TL;DR: Diosphenol 2 and nor-lactone 5 exhibited significant potency in bioassays for cytotoxic activity against leukemia cells (L1210). (via Semantic Scholar)

author keywords: protease; protease inhibitors; therapeutic application; clinical trials; approved drugs

MeSH headings : Animals; Communicable Diseases / enzymology; Diabetes Mellitus / enzymology; Fungi / enzymology; Humans; Inflammation / enzymology; Neoplasms / enzymology; Peptides / pharmacology; Plant Extracts / pharmacology; Protease Inhibitors / pharmacology; Viruses / enzymology

TL;DR: Modulation of protease activity with synthetic peptidomimetic inhibitors has proven to be clinically useful for treating human immunodeficiency virus and hypertension and shows potential for medicinal application in cancer, obesity, cardiovascular, inflammatory, neurodegenerative diseases, and various infectious and parasitic diseases. (via Semantic Scholar)

author keywords: Garcinia kola; tyrosinase; biflavanones; high-speed counter-current chromatography (HSCCC)

MeSH headings : Countercurrent Distribution / methods; Flavonoids / chemistry; Flavonoids / isolation & purification; Garcinia kola / chemistry; Molecular Structure; Peptides / chemistry; Peptides / isolation & purification; Reproducibility of Results; Seeds / chemistry

TL;DR: In continuation of the search for bioactive natural products that can be used for the treatment of dermatological disorders associated with melanin hyperpigmentation, 50 extracts/fractions from 21 families of medicinal plants from West and Central Africa were evaluated for inhibitory activity against tyrosinase. (via Semantic Scholar)

author keywords: phosphoenolpyruvate carboxykinase; polyphenols; diabetes

MeSH headings : Animals; Artemisia / chemistry; Cell Line, Tumor; Chalcones / analysis; Chalcones / isolation & purification; Chalcones / pharmacology; Chromones / analysis; Chromones / isolation & purification; Chromones / pharmacology; Cyclic AMP / analogs & derivatives; Cyclic AMP / pharmacology; Dexamethasone / pharmacology; Enzyme Inhibitors / pharmacology; Flavonoids / analysis; Flavonoids / isolation & purification; Flavonoids / pharmacology; Gene Expression / drug effects; Gluconeogenesis / drug effects; Glucose / metabolism; Hypoglycemic Agents / analysis; Hypoglycemic Agents / isolation & purification; Hypoglycemic Agents / pharmacology; Insulin / pharmacology; Morpholines / pharmacology; Phenols / analysis; Phenols / isolation & purification; Phenols / pharmacology; Phosphoenolpyruvate Carboxykinase (GTP) / genetics; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation / drug effects; Plant Extracts / pharmacology; Plant Shoots / chemistry; Polyphenols; Proto-Oncogene Proteins c-akt / metabolism; Pyrazoles / pharmacology; Pyrimidines / pharmacology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Thionucleotides / pharmacology

TL;DR: Results indicate that the isolated compounds may be responsible for much of the glucose-lowering activity of the Artemisia dracunculus extract, which was reported to decrease PEPCK mRNA expression in STZ-induced diabetic rats. (via Semantic Scholar)

TL;DR: Locus-specific imprinting is found in both maize and Arabidopsis and mechanisms by which the parental alleles are distinguished from one another are focused on. (via Semantic Scholar)

MeSH headings : DNA Methylation; Gene Silencing; Genomic Imprinting; Histones / metabolism; Models, Genetic; Plant Development; Plants / embryology; Plants / genetics; Polycomb-Group Proteins; Repressor Proteins / genetics; Repressor Proteins / physiology; Seeds / genetics; Seeds / growth & development

TL;DR: Endosperm gene imprinting can be uncoupled from seed development when fertilization of the central cell is prevented, thereby preventing parthenogenic development of the endosperm. (via Semantic Scholar)