Tobias Ernst Kaeser

Also known as: Tobias Käser; Toby Kaeser

Immunology, Chlamydia, Vaccine development, Food allergy, Animal model

I studied biology at the Eberhard Karls University Tübingen (Germany) with a focus on molecular biology, virology and microbiology. Having become interested in immunology, I decided to perform my Diploma thesis and subsequently my PhD thesis at an immunological institute and thus joined the Institute of Immunology at the Vetmeduni Vienna. The focus of my theses was the characterisation of porcine regulatory T cells (Tregs). My following postdoctoral work was delving deeper into the function of Tregs, focusing on their part in Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. Besides, I was trying to identify new markers for several T-helper cell subsets in swine and to improve flow cytometry for veterinary medicine. Thereby, we became able to characterize porcine T-helper cell subsets and Tregs phenotypically and functionally by up to eight-color flow cytometry. In addition, I was an active member of the Austrian Society of Cytometry and participated in the planning and in the execution of basic and advanced courses and seminars. In September 2013, I moved to Saskatoon, Canada to work at VIDO to extend my knowledge on host-pathogen interactions. We were using the pig as a large animal model to study the cellular immune response on intracellular chlamydia infection. Joining this well-recognized institute gave me the ability to broaden my skills including the isolation and culture of bacteria and host cells, immunohistochemistry, and confocal microscopy. The insight into a new institution with various up-to-date methods and a wide experience with vaccine development made this decision a great success. In June 2016, I started as an Assistant Professor in swine immunology at the College of Veterinary Medicine at the North Carolina State University in Raleigh, North Carolina. My lab focuses on swine health and using the pig as an animal model for biomedical research. We currently study the development of immunological memory to the major pig virus PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) and use the pig as a model to study chlamydia infections and food allergy. In 2023, I started my new position as Assistant Professor in Immunology at the University of Veterinary Medicine (vetmeduni) Vienna. Here I plan to continue my work towards the development of a vaccine against Chlamydia trachomatis as well as my research on food allergy and PRRSV. Other Experience and Professional Memberships International Society Memberships - Member, American Association of Veterinary Immunologists (AAVI) - Member, Edward Jenner Vaccine Society - Member, Chlamydia Basic Research Society - Member, German Society of Immunology (DGfI) - Member, Austrian Society for Cytometry (ÖGfZ) Editorial Roles and Board Positions - Frontiers Microbiology: Associate Editor - Frontiers Immunology: Editorial Board member – section Comparative Immunology - Molecular Immunology: Editorial Board member Ad hoc review work for 17 international journals and funding agencies including Funding agencies: - National Institutes of Health (NIH, USA) - US Department of Agriculture (USDA, USA) - National Pork Board (USA) - NSERC (Natural Sciences and Engineering Research Council, Canada) - BBSRC (Biotechnology and Biological Sciences Research Council, UK) - WWTF (Vienna Science and Technology Fund, Austria) Journals (selected): - Frontiers in Immunology - Frontiers in Microbiology - PLOS One - Vaccine - Veterinary Research - Veterinary Immunol. Immunopathol. - Cytometry Part A - Helyion - Microbes and Infection Honors 2021/22:Nomination for Faculty Scholar of NC State University 2021: Recipient of the “Goodnight Early Career Innovators” Award 2021: Nomination for the Zoetis Distinguished Veterinary Teacher Award 2019: Invitation to hold the keynote lecture “2019 Michael P. Murtaugh Memorial Lecture in Immunology” lecture at the NA PRRS Symposium (Chicago, IL): “The adaptive immune response to PRRSV” 2015-2018: Participation in the “Vaccine and Edward Jenner Vaccine Society Young Investigator Program (YIP)” 2010: Successful application for participation at the “60th Lindau Nobel Laureate Meeting”, Lindau (GER) 2010: Successful application for the Post-Doc program sponsored by the Vetmeduni Vienna on the project “Role of Tregs in PRRSV infected swine” 2009: “Most-cited junior scientist 2008” award of the Vetmeduni Vienna

Works (40)

Updated: March 16th, 2024 05:00

2023 journal article

Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination

Vaccines, 11(3), 594.

By: A. Kick n, A. Grete*, E. Crisci n, G. Almond n & T. Käser n

co-author countries: Austria 🇦🇹 United States of America 🇺🇸
author keywords: vaccination; PRRSV; correlates of protection; humoral immunity; IgG; neutralizing antibodies; T cell; IFN-gamma
Sources: ORCID, Web Of Science, Crossref
Added: March 7, 2023

2022 journal article

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(-/-)IL2RG(y/-) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

FRONTIERS IN VETERINARY SCIENCE, 9.

By: R. Sper n, J. Proctor n, O. Lascina n, L. Guo n, K. Polkoff n, T. Kaeser n, S. Simpson n, L. Borst n ...

co-author countries: United States of America 🇺🇸
author keywords: severe combined immunodeficiency; pig; xenotransplantation; allotransplantation; hematopoietic; RAG2; IL2RG; transgenic
Sources: Web Of Science, ORCID
Added: November 14, 2022

2022 journal article

Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine

Frontiers in Microbiology, 13.

By: J. Proctor n, I. Wolf n, D. Brodsky n, L. Cortes n, A. Frias-De-Diego n, G. Almond n, E. Crisci n, T. Negrão Watanabe n, J. Hammer*, T. Käser n

co-author countries: United States of America 🇺🇸

Contributors: E. Crisci n

author keywords: porcine reproductive and respiratory syndrome virus (PRRSV); correlates of protection (CoP); vaccination; swine; immunity; pig
Sources: Web Of Science, ORCID, Crossref
Added: September 25, 2022

2022 journal article

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

FRONTIERS IN ALLERGY, 3.

By: L. Cortes n, D. Brodsky n, C. Chen, T. Pridgen n, J. Odle n, D. Snider n, G. Cruse n, A. Putikova* ...

co-author countries: United States of America 🇺🇸
author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
Sources: Web Of Science, ORCID
Added: September 25, 2023

2021 journal article

Host-Pathogen Interactions of Chlamydia trachomatis in Porcine Oviduct Epithelial Cells

PATHOGENS, 10(10).

co-author countries: United States of America 🇺🇸
author keywords: Chlamydia trachomatis; porcine oviduct epithelial cell; developmental cycle; innate immune response; claudin-4; tight junctions
Sources: ORCID, Web Of Science
Added: October 6, 2021

2021 journal article

Maternal Autogenous Inactivated Virus Vaccination Boosts Immunity to PRRSV in Piglets

VACCINES, 9(2).

co-author countries: United States of America 🇺🇸
author keywords: maternal vaccination; autogenous inactivated vaccine; transfer of immunity; humoral immune response; cell-mediated immune response; T cells; PRRSV; swine; IFN-gamma producing B cells; CD4 T-EMRA cells
Sources: ORCID, Web Of Science
Added: February 1, 2021

2021 journal article

Swine as biomedical animal model for T-cell research-Success and potential for transmittable and non-transmittable human diseases

MOLECULAR IMMUNOLOGY, 135, 95–115.

co-author countries: United States of America 🇺🇸
author keywords: Pig Animal model; T cells; Vaccine development; Infectious disease; Virus; Bacteria; Parasites; Allergy; Cancer; Transplantation
MeSH headings : Animals; Biomedical Research; Communicable Diseases / immunology; Disease Models, Animal; Haplorhini; Mice; Swine; Swine Diseases / immunology; T-Lymphocytes / immunology
Sources: ORCID, Web Of Science
Added: April 18, 2021

2020 article

Maternal Autogenous Inactivated Virus Vaccination Boosts the Piglet Humoral and Cell-Mediated Immunity to PRRSV via Transfer of Neutralizing Antibodies and Interferon-Gamma Producing B Cells

Kick, A. R., Wolfe, Z. C., Amaral, A. F., Cortes, L. M., Almond, G. W., Crisci, E., … Käser, T. (2020, December 3). (Vol. 12). Vol. 12.

By: A. Kick, Z. Wolfe, A. Amaral, L. Cortes, G. Almond, E. Crisci*, P. Gauger, J. Pittman, T. Käser

Source: ORCID
Added: December 3, 2020

2020 journal article

Mucosal Vaccination with UV-Inactivated Chlamydia suis in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ+ Effector Memory Cells

Vaccines, 8(3), 353.

By: A. Amaral n, K. Rahman*, A. Kick n, L. Cortes n, J. Robertson n, B. Kaltenboeck*, V. Gerdts*, C. O'Connell* ...

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: chlamydia trachomatis; chlamydia suis; large animal model; swine; translational research; vaccine development; TriAdj; vaccination; immunology; T cells; effector memory
Source: ORCID
Added: July 7, 2020

2019 journal article

Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine gamma delta T Cells

FRONTIERS IN IMMUNOLOGY, 10.

By: I. Rodriguez-Gomez*, S. Talker*, T. Kaeser, M. Stadler*, L. Reiter*, A. Ladinig*, J. Milburn*, S. Hammer* ...

co-author countries: Austria 🇦🇹
author keywords: gamma delta T cells; swine; pig; T-bet; Eomes; GATA-3
MeSH headings : Animals; GATA3 Transcription Factor / biosynthesis; GATA3 Transcription Factor / immunology; Phenotype; Receptors, Antigen, T-Cell, gamma-delta / immunology; Swine / immunology; T-Box Domain Proteins / biosynthesis; T-Box Domain Proteins / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism
Sources: Web Of Science, ORCID
Added: March 25, 2019

2019 journal article

The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

Viruses, 11(9), 796.

By: A. Kick n, A. Amaral n, L. Cortes n, J. Fogle n, E. Crisci n, G. Almond n, T. Käser n

co-author countries: United States of America 🇺🇸
author keywords: PRRSV; T cells; adaptive immunity; treg; thelper; Cytotoxic proliferation; TCR-gamma delta; IFN-gamma
MeSH headings : Adaptive Immunity; Animals; Kinetics; Lung / immunology; Lung / virology; Lymph Nodes / immunology; Lymph Nodes / virology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / pathology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / growth & development; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / pathogenicity; Receptors, Antigen, T-Cell, gamma-delta / metabolism; Receptors, Lymphocyte Homing / metabolism; Swine; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / virology; T-Lymphocytes / immunology; T-Lymphocytes / virology; Vaccines, Attenuated; Viral Vaccines / immunology; Viremia / immunology; Viremia / virology
Source: ORCID
Added: August 30, 2019

2018 journal article

Contribution of the swine model in the study of human sexually transmitted infections

Infection, Genetics and Evolution, 66, 346–360.

co-author countries: Canada 🇨🇦 Denmark 🇩🇰 France 🇫🇷 United States of America 🇺🇸
author keywords: Pig model; Chlamydia trachomatis; Trichomonas vaginalis; Neisseria gonorrhoeae; Hepatitis viruses; Herpesviruses
MeSH headings : Animals; Disease Models, Animal; Disease Susceptibility; Female; Hormones / metabolism; Humans; Male; Sex Factors; Sexually Transmitted Diseases / etiology; Sexually Transmitted Diseases / metabolism; Sexually Transmitted Diseases / prevention & control; Swine
Source: ORCID
Added: February 11, 2019

2018 journal article

Expression of pattern recognition receptors in porcine uterine epithelial cells in vivo and in culture

Veterinary Immunology and Immunopathology, 202, 1–10.

By: G. Hamonic*, J. Pasternak*, N. Forsberg*, T. Käser n & H. Wilson*

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
author keywords: Epithelial; Toll-like receptor; Pattern recognition receptor; Innate immunity; Pig; Uterus
MeSH headings : Acetylmuramyl-Alanyl-Isoglutamine / pharmacology; Animals; Cells, Cultured; Cytokines / metabolism; Epithelial Cells / immunology; Epithelial Cells / metabolism; Female; Immunity, Innate; Lipopolysaccharides / pharmacology; Oligodeoxyribonucleotides / pharmacology; Poly I-C / pharmacology; Real-Time Polymerase Chain Reaction; Receptors, Pattern Recognition / metabolism; Swine; Toll-Like Receptor 3 / metabolism; Toll-Like Receptor 9 / metabolism; Toll-Like Receptors / metabolism; Uterus / cytology
Sources: Crossref, ORCID
Added: February 18, 2020

2018 journal article

First Insights Into Within Host Translocation of the Bacillus cereus Toxin Cereulide Using a Porcine Model

FRONTIERS IN MICROBIOLOGY, 9.

By: T. Bauer*, W. Sipos*, T. Stark*, T. Kaeser, C. Knecht*, R. Brunthaler*, A. Saalmueller, T. Hofmann*, M. Ehling-Schulz*

co-author countries: Austria 🇦🇹 Germany 🇩🇪 United States of America 🇺🇸
Sources: NC State University Libraries, ORCID
Added: November 19, 2018

2017 journal article

Challenges and efforts in vaccine development and distribution

Vaccine.

co-author countries: United States of America 🇺🇸

Contributors: T. Käser n

MeSH headings : Biomedical Research; Health Resources; Humans; Influenza Vaccines; Influenza, Human; Pandemics
Source: ORCID
Added: February 11, 2019

2017 journal article

Chlamydia suis and Chlamydia trachomatis induce multifunctional CD4 T cells in pigs

Vaccine, 35(1), 91–100.

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸

Contributors: T. Käser n, J. Pasternak*, M. Delgado-Ortega*, G. Hamonic*, K. Lai*, J. Erickson*, S. Walker*, J. Dillon*, V. Gerdts*, F. Meurens*

author keywords: Chlamydia suis; Chlamydia trachomatis; Animal model; Swine; Vaccine development; One Health
MeSH headings : Administration, Intravaginal; Animals; Antibodies, Bacterial / blood; Antibody Formation; CD4-Positive T-Lymphocytes / immunology; Chlamydia / immunology; Chlamydia / pathogenicity; Chlamydia Infections / immunology; Chlamydia Infections / microbiology; Chlamydia Infections / pathology; Chlamydia Infections / veterinary; Cytokines / metabolism; Host-Pathogen Interactions; Immunity, Cellular; Immunity, Humoral; Swine; Time Factors
Source: ORCID
Added: February 11, 2019

2016 journal article

Expression of T-bet, Eomesodermin and GATA-3 in porcine αβ T cells

Developmental and Comparative Immunology, 60, 115–126.

co-author countries: Austria 🇦🇹
author keywords: T-bet; GATA-3; Eomesodermin; Swine; alpha beta T cells
Source: ORCID
Added: February 11, 2019

2016 journal article

Extended semen for artificial insemination in swine as a potential transmission mechanism for infectious Chlamydia suis

Theriogenology, 86(4), 949–956.

co-author countries: Canada 🇨🇦 France 🇫🇷
author keywords: Artificial insemination; Biosecurity; Chlamydia; Herd health; Semen; Semen extender
MeSH headings : Animals; Chlamydia / isolation & purification; Insemination, Artificial / veterinary; Semen / microbiology; Semen Analysis / veterinary; Semen Preservation; Staining and Labeling; Swine / physiology; Time Factors
Sources: ORCID, Crossref
Added: February 11, 2019

2016 journal article

Flow cytometry as an improved method for the titration of Chlamydiaceae and other intracellular bacteria

Cytometry Part A, 89(5), 451–460.

By: T. Käser*, J. Pasternak*, G. Hamonic*, M. Rieder*, K. Lai*, M. Delgado-Ortega*, V. Gerdts*, F. Meurens*

co-author countries: Canada 🇨🇦 France 🇫🇷

Contributors: T. Käser*, J. Pasternak*, G. Hamonic*, M. Rieder*, K. Lai*, M. Delgado-Ortega*, V. Gerdts*, F. Meurens*

author keywords: Chlamydiaceae; Chlamydia suis; intracellular bacteria; titration; flow cytometry; FCM
MeSH headings : Cell Line; Chlamydiaceae / isolation & purification; Epithelial Cells / microbiology; Flow Cytometry / methods; Humans; Microscopy; Reproducibility of Results; Sensitivity and Specificity
Source: ORCID
Added: February 11, 2019

2016 journal article

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs

PLOS ONE, 11(5), e0155676.

By: A. Bähr*, T. Käser*, E. Kemter*, W. Gerner*, M. Kurome*, W. Baars*, N. Herbach*, K. Witter* ...

co-author countries: Austria 🇦🇹 Germany 🇩🇪 Japan 🇯🇵

Contributors: A. Bähr*, T. Käser*, E. Kemter*, W. Gerner*, M. Kurome*, W. Baars*, N. Herbach*, K. Witter* ...

Ed(s): N. Câmara

MeSH headings : Abatacept / metabolism; Animals; Animals, Genetically Modified; Antigen-Presenting Cells / metabolism; Cloning, Organism; Conserved Sequence; Crosses, Genetic; Female; Fertilization in Vitro; Humans; Lymph Nodes / pathology; Lymphocyte Activation / immunology; Male; Promoter Regions, Genetic / genetics; Protein Binding; Reproduction / genetics; Sus scrofa / genetics; Sus scrofa / immunology; T-Lymphocytes / immunology
Sources: ORCID, Crossref
Added: February 11, 2019

2015 journal article

Natural and inducible Tregs in swine: Helios expression and functional properties

Developmental and Comparative Immunology, 49(2), 323–331.

co-author countries: Austria 🇦🇹
author keywords: Regulatory T cells; nTregs; iTregs; Helios; CD4(+); Pig
MeSH headings : Amino Acid Sequence; Animals; Biomarkers; CD3 Complex / biosynthesis; Cell Differentiation / immunology; Cell Line; Cell Proliferation; Cells, Cultured; Coculture Techniques; Forkhead Transcription Factors / metabolism; HEK293 Cells; Humans; Ikaros Transcription Factor / immunology; Interferon-gamma / biosynthesis; Interleukin-10 / metabolism; Interleukin-2 / immunology; Leukocytes, Mononuclear / immunology; Lymphocyte Activation / immunology; Molecular Sequence Data; Swine; T-Lymphocytes, Regulatory / cytology; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / immunology; Transforming Growth Factor beta / metabolism
Source: ORCID
Added: February 11, 2019

2015 journal article

PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate

Veterinary Research, 46(1).

co-author countries: Austria 🇦🇹 Spain 🇪🇸

Contributors: I. Rodríguez-Gómez*, T. Käser*, J. Gómez-Laguna, B. Lamp*, L. Sinn*, T. Rümenapf*, L. Carrasco*, A. Saalmüller*, W. Gerner*

MeSH headings : Animals; B7-1 Antigen / immunology; B7-1 Antigen / metabolism; B7-2 Antigen / immunology; B7-2 Antigen / metabolism; Dendritic Cells / immunology; Dendritic Cells / metabolism; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II / immunology; Histocompatibility Antigens Class II / metabolism; Monocytes / metabolism; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / physiology; Swine; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
Sources: ORCID, Crossref
Added: February 11, 2019

2015 journal article

Porcine retinal cell line VIDO R1 and Chlamydia suis to modelize ocular chlamydiosis

Veterinary Immunology and Immunopathology, 166(3-4), 95–107.

By: T. Käser*, T. Cnudde*, G. Hamonic*, M. Rieder*, J. Pasternak*, K. Lai*, S. Tikoo*, H. Wilson*, F. Meurens*

co-author countries: Canada 🇨🇦 France 🇫🇷

Contributors: T. Käser*, T. Cnudde*, G. Hamonic*, M. Rieder*, J. Pasternak*, K. Lai*, S. Tikoo*, H. Wilson*, F. Meurens*

author keywords: Pig; Retina; Innate immune response; Chlamydia suis
MeSH headings : Animals; Cell Line; Chlamydia / physiology; Chlamydia Infections / microbiology; Chlamydia Infections / veterinary; Chlamydia trachomatis / physiology; Cytokines / metabolism; Disease Models, Animal; Eye Infections, Bacterial / microbiology; Eye Infections, Bacterial / veterinary; Humans; Real-Time Polymerase Chain Reaction / veterinary; Retina / cytology; Retina / microbiology; Swine; Trachoma / microbiology
Source: ORCID
Added: February 11, 2019

2015 journal article

The systemic multiplication of Gallibacterium anatis in experimentally infected chickens is promoted by immunosuppressive drugs which have a less specific effect on the depletion of leukocytes

Veterinary Immunology and Immunopathology, 166(1-2), 22–32.

co-author countries: Austria 🇦🇹
author keywords: Gallibacterium anatis; Chickens; Leukocyte quantification; Non-selective Immunosuppression
MeSH headings : Animals; Bacterial Load; Chickens / immunology; Corticosterone / pharmacology; Immunosuppressive Agents / pharmacology; Leukocyte Count; Leukocytes / drug effects; Pasteurellaceae / physiology; Pasteurellaceae Infections / veterinary; Poultry Diseases / immunology; Poultry Diseases / microbiology; Spleen / microbiology
Source: ORCID
Added: February 11, 2019

2014 journal article

The porcine innate immune system: An update

Developmental and Comparative Immunology, 45(2), 321–343.

By: K. Mair*, C. Sedlak*, T. Käser*, A. Pasternak*, B. Levast*, W. Gerner*, A. Saalmüller*, A. Summerfield ...

co-author countries: Austria 🇦🇹 Canada 🇨🇦

Contributors: K. Mair*, C. Sedlak*, T. Käser*, A. Pasternak*, B. Levast*, W. Gerner*, A. Saalmüller*, A. Summerfield ...

author keywords: Pig; Innate response; Animal model; Innate immune cells
MeSH headings : Animals; Immunity, Innate; Inflammation / immunology; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Pattern Recognition / immunology; Sus scrofa / immunology; Swine / immunology; Swine Diseases / immunology
Source: ORCID
Added: February 11, 2019

2013 journal article

Effect of Two Strains of PRRSV on the Expression of Differentiation Antigens of Monocyte-derived Dendritic Cells

Journal of Comparative Pathology, 148(1), 51.

By: I. Rodríguez-Gómez*, A. Burgara-Estrella*, E. Mateu*, J. Gómez-Laguna, L. Carrasco*, A. Saalmüller, T. Käser

co-author countries: Spain 🇪🇸
Sources: Crossref, ORCID
Added: December 22, 2020

2013 journal article

Human Placental Alkaline Phosphatase as a Tracking Marker for Bone Marrow Mesenchymal Stem Cells

BioResearch Open Access, 2(5), 346–355.

By: E. Balmayor*, M. Flicker*, T. Käser*, A. Saalmüller* & R. Erben*

co-author countries: Austria 🇦🇹
author keywords: model organisms for research; stem cells; tissue engineering
Sources: Crossref, ORCID
Added: July 20, 2019

2013 journal article

Immunohistochemical characterization of type II pneumocyte proliferation after challenge with type I porcine reproductive and respiratory syndrome virus

Journal of Comparative Pathology, 149(2-3), 322–330.

By: G. Balka*, A. Ladinig*, M. Ritzmann*, A. Saalmüller*, W. Gerner*, T. Käser*, C. Jakab*, M. Rusvai*, H. Weißenböck*

co-author countries: Austria 🇦🇹 Germany 🇩🇪 Hungary 🇭🇺

Contributors: G. Balka*, A. Ladinig*, M. Ritzmann*, A. Saalmüller*, W. Gerner*, T. Käser*, C. Jakab*, M. Rusvai*, H. Weißenböck*

author keywords: pig; PRRSV; TTF-1; type II pneumocyte
MeSH headings : Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Porcine Reproductive and Respiratory Syndrome / metabolism; Porcine Reproductive and Respiratory Syndrome / pathology; Porcine respiratory and reproductive syndrome virus; Reverse Transcriptase Polymerase Chain Reaction; Swine
Source: ORCID
Added: February 11, 2019

2013 journal article

Phenotypic maturation of porcine NK- and T-cell subsets

Developmental and Comparative Immunology, 40(1), 51–68.

By: S. Talker*, T. Käser*, K. Reutner*, C. Sedlak*, K. Mair*, H. Koinig*, R. Graage*, M. Viehmann* ...

co-author countries: Austria 🇦🇹

Contributors: S. Talker*, T. Käser*, K. Reutner*, C. Sedlak*, K. Mair*, H. Koinig*, R. Graage*, M. Viehmann* ...

author keywords: Swine; T-cell subsets; NK cells; Phenotypic maturation
MeSH headings : Animals; Animals, Newborn; Cell Differentiation; Immunologic Memory; Immunophenotyping; Killer Cells, Natural / immunology; Receptors, Antigen, T-Cell, gamma-delta / metabolism; Swine / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology
Source: ORCID
Added: February 11, 2019

2012 journal article

Current knowledge on porcine regulatory T cells

Veterinary Immunology and Immunopathology, 148(1-2), 136–138.

By: T. Käser, W. Gerner, K. Mair, S. Hammer, M. Patzl & A. Saalmüller

Contributors: T. Käser, W. Gerner, K. Mair, S. Hammer, M. Patzl & A. Saalmüller

author keywords: Foxp3; Regulatory T cells; Tregs; Swine
MeSH headings : Animals; Forkhead Transcription Factors / immunology; Humans; Immune Tolerance / immunology; Swine / immunology; T-Lymphocytes, Regulatory / immunology
Source: ORCID
Added: February 11, 2019

2012 journal article

Porcine T-helper and regulatory T cells exhibit versatile mRNA expression capabilities for cytokines and co-stimulatory molecules

Cytokine, 60(2), 400–409.

By: T. Käser, A. Müllebner, R. Hartl, S. Essler, A. Saalmüller & J. Catharina Duvigneau

Contributors: T. Käser, A. Müllebner, R. Hartl, S. Essler, A. Saalmüller & J. Catharina Duvigneau

author keywords: T-helper cells; Tregs; Cytokines; qPCR; Swine
MeSH headings : Animals; Antigens, CD / genetics; Antigens, CD / metabolism; Cytokines / genetics; Cytokines / metabolism; Flow Cytometry; Gene Expression Regulation; RNA, Messenger / metabolism; Sus scrofa / genetics; Sus scrofa / immunology; T-Lymphocytes, Helper-Inducer / metabolism; T-Lymphocytes, Regulatory / metabolism
Source: ORCID
Added: February 11, 2019

2011 journal article

Porcine regulatory T cells: Mechanisms and T-cell targets of suppression

Developmental & Comparative Immunology, 35(11), 1166–1172.

co-author countries: Austria 🇦🇹
author keywords: Foxp3; Regulatory T cells; Swine
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; Cell Communication; Forkhead Transcription Factors / biosynthesis; Forkhead Transcription Factors / metabolism; Immune Tolerance; Interleukin-10 / biosynthesis; Interleukin-10 / immunology; Interleukin-2 / biosynthesis; Interleukin-2 / immunology; Interleukin-2 / metabolism; Lymphocyte Activation; Receptors, Antigen, T-Cell, gamma-delta / immunology; Receptors, Antigen, T-Cell, gamma-delta / metabolism; Swine / immunology; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Helper-Inducer / metabolism; T-Lymphocytes, Regulatory / cytology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
Sources: ORCID, Crossref
Added: February 11, 2019

2009 journal article

Characterization of CD79α+CD21− B cells in swine

Veterinary Immunology and Immunopathology, 128(1-3), 274.

co-author countries: Austria 🇦🇹
Sources: Crossref, ORCID
Added: December 22, 2020

2009 journal article

Molecular characterisation of porcine Forkhead-box p3 (Foxp3)

Veterinary Immunology and Immunopathology, 132(2-4), 275–281.

co-author countries: Austria 🇦🇹

Contributors: K. Bolzer*, T. Käser*, A. Saalmüller* & S. Hammer*

author keywords: Foxp3; Porcine; Sus scrofa; Swine; Regulatory T cells
MeSH headings : Amino Acid Sequence; Animals; Antibody Specificity; Base Sequence; Cattle; Cell Line; Cross Reactions; DNA Primers / genetics; DNA, Complementary / genetics; Forkhead Transcription Factors / chemistry; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / immunology; Humans; Mice; Rats; Recombinant Proteins / genetics; Recombinant Proteins / immunology; Sequence Homology, Amino Acid; Species Specificity; Swine / genetics; Swine / immunology; T-Lymphocytes, Regulatory / immunology; Transfection
Source: ORCID
Added: February 11, 2019

2009 journal article

Porcine T lymphocytes and NK cells - An update

Developmental and Comparative Immunology, 33(3), 310–320.

co-author countries: Austria 🇦🇹
author keywords: Swine; T cells; NK cells
MeSH headings : Animals; Antigens, Differentiation / immunology; Antigens, Differentiation / metabolism; CD8 Antigens / immunology; CD8 Antigens / metabolism; Cytokines / metabolism; Genes, MHC Class II / immunology; Killer Cells, Natural / cytology; Killer Cells, Natural / immunology; Killer Cells, Natural / metabolism; Lymphocyte Activation; Natural Killer T-Cells / cytology; Natural Killer T-Cells / immunology; Natural Killer T-Cells / metabolism; Receptors, Antigen, T-Cell, alpha-beta / immunology; Receptors, Antigen, T-Cell, alpha-beta / metabolism; Receptors, Antigen, T-Cell, gamma-delta / immunology; Receptors, Antigen, T-Cell, gamma-delta / metabolism; Swine / immunology; T-Lymphocyte Subsets / cytology; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism
Source: ORCID
Added: February 11, 2019

2008 journal article

Detection of Foxp3 protein expression in porcine T lymphocytes

Veterinary Immunology and Immunopathology, 125(1-2), 92–101.

co-author countries: Austria 🇦🇹
author keywords: Foxp3; regulatory T cells; swine
MeSH headings : Animals; Antibodies, Monoclonal / chemistry; Antibodies, Monoclonal / immunology; Antibody Specificity; Blotting, Southern / veterinary; Blotting, Western / veterinary; CD4 Antigens / biosynthesis; CD4 Antigens / immunology; CD8 Antigens / biosynthesis; CD8 Antigens / immunology; Cross Reactions; Flow Cytometry / veterinary; Forkhead Transcription Factors / biosynthesis; Forkhead Transcription Factors / genetics; Interleukin-2 Receptor alpha Subunit / biosynthesis; Interleukin-2 Receptor alpha Subunit / immunology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Swine / blood; Swine / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / immunology
Source: ORCID
Added: February 11, 2019

2008 journal article

Detection of intracellular antigens in porcine PBMC by flow cytometry: A comparison of fixation and permeabilisation reagents

Veterinary Immunology and Immunopathology, 121(3-4), 251–259.

Contributors: W. Gerner*, T. Käser*, M. Pintarič*, S. Groiß* & A. Saalmüller*

author keywords: intracellular antigen; swine; fixation; permeabilisation; flow cytometry
MeSH headings : Animals; CD79 Antigens / blood; CD79 Antigens / immunology; Flow Cytometry / methods; Flow Cytometry / veterinary; Interferon-gamma / blood; Interferon-gamma / immunology; Ki-67 Antigen / blood; Ki-67 Antigen / immunology; Leukocytes, Mononuclear / chemistry; Leukocytes, Mononuclear / immunology; Perforin / blood; Perforin / immunology; Swine / blood; Swine / immunology; Tissue Fixation / methods; Tissue Fixation / veterinary
Source: ORCID
Added: February 11, 2019

2008 journal article

Phenotypic and functional characterisation of porcine CD4+CD25high regulatory T cells

Veterinary Immunology and Immunopathology, 122(1-2), 153–158.

co-author countries: Austria 🇦🇹
author keywords: regulatory T cells; swine; foxp3; T lymphocytes
MeSH headings : Animals; Forkhead Transcription Factors / analysis; Immunophenotyping; Interleukin-10 / biosynthesis; Swine / immunology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / physiology
Source: ORCID
Added: February 11, 2019

manuscript

A TriAdj-Adjuvanted Chlamydia trachomatis CPAF Protein Vaccine Is Highly Immunogenic in Pigs.

Tobias Kaeser

Source: ORCID
Added: March 15, 2024

journal article

Grouping Pig-Specific Responses to Mitogen with Similar Responder Animals may Facilitate the Interpretation of Results Obtained in an Out-Bred Animal Model

Pasternak, J. A., Hon Ng, S. L., Käser, T., Meurens, F., & Wilson, H. L. Journal of Vaccines and Vaccination, 5, 1–9.

By: J. Pasternak, S. Hon Ng, T. Käser, F. Meurens & H. Wilson

Source: NC State University Libraries
Added: July 11, 2019

Employment

Updated: September 20th, 2022 12:05

2016 - 2022

NC State University Raleigh, NC, US
Assistant Professor in Swine Immunology College of Veterinary Medicine - Population Health and Pathobiology

2013 - 2016

University of Saskatchewan Saskatoon, SK, CA
PostDoc (Establishment of the pig as a model to study chlamydia infections) Vaccine and Infectious Disease Organization (VIDO-InterVac)

2010 - 2013

University of Veterinary Medicine Vienna Vienna, AT
PostDoc (Role of Tregs in Porcine Reproductive and Respiratory Syndrome Virus infections) Institute of Immunology

Education

Updated: August 17th, 2016 11:00

2006 - 2010

University of Veterinary Medicine Vienna Vienna, AT
PhD (Immunology) Institute of Immunology

1999 - 2004

Eberhard Karls Universität Tübingen Tubingen, Baden-Württemberg, DE
Diploma in Biology (Molecular Biology, Virology, Microbiology)

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