Swine Immunology, Chlamydia, Vaccine development
I studied biology at the Eberhard Karls University Tübingen (Germany) with a focus on molecular biology, virology and microbiology. Having become interested in immunology, I decided to perform my Diploma thesis and subsequently my PhD thesis at an immunological institute and thus joined the Institute of Immunology at the Vetmeduni Vienna. The focus of my theses was the characterisation of porcine regulatory T cells (Tregs). My following postdoctoral work was delving deeper into the function of Tregs, focusing on their part in Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. Besides, I was trying to identify new markers for several T-helper cell subsets in swine and to improve flow cytometry for veterinary medicine. Thereby, we became able to characterize porcine T-helper cell subsets and Tregs phenotypically and functionally by up to eight-color flow cytometry. In addition, I was an active member of the Austrian Society of Cytometry and participated in the planning and in the execution of basic and advanced courses and seminars. In September 2013, I moved to Saskatoon, Canada to work at VIDO to extend my knowledge on host-pathogen interactions. We were using the pig as a large animal model to study the cellular immune response on intracellular chlamydia infection. Joining this well-recognized institute gave me the ability to broaden my skills including the isolation and culture of bacteria and host cells, immunohistochemistry, and confocal microscopy. The insight into a new institution with various up-to-date methods and a wide experience with vaccine development made this decision a great success. In June 2016, I started as an Assistant Professor in swine immunology at the College of Veterinary Medicine at the North Carolina State University in Raleigh, North Carolina. My lab focuses on swine health and using the pig as an animal model for biomedical research. We currently study the development of immunological memory to the major pig virus PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) and use the pig as a model to study chlamydia infections and food allergy. Other Experience and Professional Memberships International Society Memberships - Member, American Association of Veterinary Immunologists (AAVI) - Member, Edward Jenner Vaccine Society - Member, Chlamydia Basic Research Society - Member, German Society of Immunology (DGfI) - Member, Austrian Society for Cytometry (ÖGfZ) Editorial Roles and Board Positions - AAVI Board member - Guest editor for “Vaccine” - Veterinary Science and Research editorial board member Ad hoc review work for 17 international journals and funding agencies including - USDA/APHIS - National Pork Board - NSERC - PLOS One - Vaccine - Frontiers Immunology - Veterinary Research - Veterinary Immunol. Immunopathol. - Cytometry Part A - Helyion - Microbes and Infection Honors 2015: Successful application for the three year “Vaccine and Edward Jenner Vaccine Society Young Investigator Program (YIP)” (http://www.journals.elsevier.com/vaccine/tobias-kaser/) 2010: Successful application for participation at the „60th Lindau Nobel Laureate Meeting“, Lindau (GER) 2010: Successful application for the Post-Doc program sponsored by the Vetmeduni Vienna on the project “Role of Tregs in PRRSV infected swine” 2009: “Most-cited junior scientist 2008” award of the Vetmeduni Vienna 2007/2009: Poster awards at the New Year’s reception of the Vetmeduni Vienna
Maternal Autogenous Inactivated Virus Vaccination Boosts the Piglet Humoral and Cell-Mediated Immunity to PRRSV via Transfer of Neutralizing Antibodies and Interferon-Gamma Producing B Cells
Kick, A. R., Wolfe, Z. C., Amaral, A. F., Cortes, L. M., Almond, G. W., Crisci, E., … Käser, T. (2020, December 3). (Vol. 12). Vol. 12.
2020 journal article
Mucosal Vaccination with UV-Inactivated Chlamydia suis in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ+ Effector Memory Cells
2019 journal article
Expression of T-Bet, Eomesodermin, and GATA-3 Correlates With Distinct Phenotypes and Functional Properties in Porcine gamma delta T Cells
FRONTIERS IN IMMUNOLOGY, 10.
2016 journal article
Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs
PLOS ONE, 11(5), e0155676.
Ed(s): N. Câmara
2015 journal article
PRRSV-infected monocyte-derived dendritic cells express high levels of SLA-DR and CD80/86 but do not stimulate PRRSV-naïve regulatory T cells to proliferate
Veterinary Research, 46(1).
2015 journal article
The systemic multiplication of Gallibacterium anatis in experimentally infected chickens is promoted by immunosuppressive drugs which have a less specific effect on the depletion of leukocytes
Veterinary Immunology and Immunopathology, 166(1-2), 22–32.
2013 journal article
Immunohistochemical characterization of type II pneumocyte proliferation after challenge with type I porcine reproductive and respiratory syndrome virus
Journal of Comparative Pathology, 149(2-3), 322–330.
Grouping Pig-Specific Responses to Mitogen with Similar Responder Animals may Facilitate the Interpretation of Results Obtained in an Out-Bred Animal Model
Pasternak, J. A., Hon Ng, S. L., Käser, T., Meurens, F., & Wilson, H. L. Journal of Vaccines and Vaccination, 5, 1–9.
2016 - present
2013 - 2016
2010 - 2013
2006 - 2010
1999 - 2004