Works Published in 2004

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Displaying all 14 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2004 journal article

Development of fetuses from in vitro produced and cloned bovine embryos

Journal of Animal Science, 82(Supplement 13), E53–E62.

By: C. Farin n, P. Farin n & J. Piedrahita n

MeSH headings : Animals; Cattle / embryology; Cattle / genetics; Cattle / growth & development; Cloning, Organism / adverse effects; Cloning, Organism / veterinary; Embryo Culture Techniques / veterinary; Embryo Transfer / adverse effects; Embryo Transfer / veterinary; Embryonic Development / genetics; Embryonic Development / physiology; Female; Fertilization in Vitro / adverse effects; Fertilization in Vitro / veterinary; Fetal Development / genetics; Fetal Development / physiology; Gene Expression Regulation, Developmental / physiology; Male; Pregnancy
TL;DR: The effects of in vitro production and cloning on bovine embryo and fetal development are examined, including abnormalities in the development of fetuses, placentas, and offspring following transfer of cloned embryos. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: October 29, 2021

2004 journal article

35 Analysis of epigenetic modifications and genomic imprinting in nuclear transfer derived Bos Gaurus x B. Taurus Concepti

Reproduction, Fertility and Development, 16(2), 140.

By: S. Dindot*, P. Farin, C. Farin, J. Alexander, E. Crosier, S. Walker*, C. Long*, J. Piedrahita*

TL;DR: The use of a bovine interspecies model for the assessment and characterization of epigenetic modifications and genomic imprinting in 40-day-old female nuclear transfer (NT)-derived fetuses and placentas and methylation analysis of the XIST Differentially Methylated Region indicates that cloning is associated with increased levels of methylation in selected genomic regions in the chorion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 4, 2021

2004 journal article

67ORGAN WEIGHT VARIATION IN CLONED PIGS

Reproduction, Fertility and Development, 16(2), 155.

By: J. Piedrahita*, S. Walker* & G. Zaunbrecher*

TL;DR: Both absolute and corrected weights indicated that there is a high degree of variation in some of the organs among a group of identical clones, indicating that some organs in cloned animals have a high level of weight variability. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2004 journal article

343NUCLEAR LOCALIZATION SIGNAL AND CELL SYNCHRONY ENHANCES GENE TARGETING EFFICIENCY IN FETAL BOVINE FIBROBLASTS

Reproduction, Fertility and Development, 16(2), 291.

By: B. Mir & J. Piedrahita*

TL;DR: Evidence is presented that the use of a nuclear localization signal (nls) and S-phase cell cycle synchronization by thymidine block enhances targeting efficiency at the hypoxanthine phosphoribosyl transferase locus in primary fetal bovine fibroblasts. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2004 journal article

Computer-aided tissue engineering: application to biomimetic modelling and design of tissue scaffolds

Biotechnology and Applied Biochemistry, 39(1), 49.

By: W. Sun*, B. Starly*, A. Darling* & C. Gomez*

author keywords: bone scaffold; computer-aided design (CAD); computer-aided tissue engineering (CATE); tissue engineering; tissue scaffold design
MeSH headings : Biocompatible Materials / chemical synthesis; Biomechanical Phenomena; Biomimetics / methods; Bone Substitutes; Computer-Aided Design; Membranes, Artificial; Models, Anatomic; Tissue Engineering / methods
TL;DR: A general CATE‐based process for biomimetic modelling, anatomic reconstruction, computer‐assisted‐design of tissue scaffold, quantitative‐computed‐tomography characterization, finite element analysis and freeform extruding deposition for fabrication of scaffold is presented. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2004 journal article

Computer Aided Tissue Engineering for Modeling and Design of Novel Tissue Scaffolds

Computer-Aided Design and Applications, 1(1-4), 633–640.

By: J. Nam, B. Starly*, A. Darling & W. Sun

TL;DR: Some of the salient applications of CATE are presented, particularly in the modeling and design of scaffolds with controlled internal and external architecture; with vascular channels of different sizes; with modular and interconnecting subunits; with multi-layered heterogeneous dense and compact regions. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2004 journal article

Computer-aided tissue engineering: overview, scope and challenges

Biotechnology and Applied Biochemistry, 39(1), 29.

By: W. Sun*, A. Darling*, B. Starly* & J. Nam*

author keywords: cell printing; computer-aided tissue engineering; organ printing; solid freeform fabrication; tissue engineering; tissue scaffold
MeSH headings : Animals; Artificial Organs; Biocompatible Materials / chemical synthesis; Blood Vessels / physiology; Computer-Aided Design; Humans; Micromanipulation; Models, Biological; Tissue Engineering / methods; Tissue Transplantation / methods
TL;DR: Methodologies of development of CATE modelling from high‐resolution non‐invasive imaging and image‐based three‐dimensional reconstruction, and various reconstructive techniques for CAD‐based tissue modelling generation will be described. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2004 journal article

Conservation of genomic imprinting at the XIST, IGF2, and GTL2 loci in the bovine

Mammalian Genome, 15(12), 966–974.

By: S. Dindot*, K. Kent*, B. Evers*, N. Loskutoff, J. Womack* & J. Piedrahita n

MeSH headings : Alleles; Animals; Base Sequence; Cattle; DNA Methylation; Female; Gene Expression Regulation; Genomic Imprinting / genetics; Humans; Insulin-Like Growth Factor II / genetics; Male; Molecular Sequence Data; Placenta; Polymorphism, Single Nucleotide; Proteins / genetics; RNA, Long Noncoding; RNA, Untranslated / genetics; Sequence Homology, Nucleic Acid; Sheep
TL;DR: Conservation of genomic imprinting in the bovine is reported at the X chromosome inactivation–specific transcript (XIST), insulin-like growth factor 2 (IGF2), and gene trap locus 2 (GTL2) loci. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Nuclear localization signal and cell synchrony enhance gene targeting efficiency in primary fetal fibroblasts

Nucleic Acids Research, 32(3), e25–e28.

By: B. Mir n & J. Piedrahita n

MeSH headings : Animals; Azaguanine / pharmacology; Base Sequence; Cattle; Cell Division / drug effects; Cell Division / physiology; Cells, Cultured; Drug Resistance; Fetus; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Targeting / methods; Genetic Vectors / genetics; Hypoxanthine Phosphoribosyltransferase / genetics; Male; Molecular Sequence Data; Mutagenesis, Insertional; Nuclear Localization Signals / genetics
TL;DR: It was determined that while no targeted colonies were identified using a conventional targeting construct, an average of 1 per million targeted cells were identified when a nuclear localization signal (nls) was added to the construct and targeting efficiency increased 7-fold. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2004 journal article

Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses

Biology of Reproduction, 71(2), 470–478.

By: S. Dindot n, P. Farin n, C. Farin n, J. Romano*, S. Walker*, C. Long, J. Piedrahita n

MeSH headings : Animals; Cattle; Chimera / genetics; Cloning, Organism; DNA Methylation; DNA, Satellite; Embryonic Development; Epidermis / physiology; Epigenesis, Genetic / genetics; Exons; Female; Fibroblasts / physiology; Genomic Imprinting / genetics; Genotype; Insulin-Like Growth Factor II / genetics; Keratins / genetics; Nuclear Transfer Techniques; Placenta; Pregnancy; Promoter Regions, Genetic; Proteins / genetics; RNA, Long Noncoding; RNA, Untranslated / genetics
TL;DR: The use of a bovine interspecies model for the assessment and characterization of epigenetic modifications and genomic imprinting in Day 40-old female NT-derived fetuses and placenta indicates that the nuclear transfer process affects gene expression patterns in the trophectoderm- and inner cell mass-derived tissues to different extents. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2004 journal article

Cloning and transgenesis in mammals: Implications for xenotransplantation

AMERICAN JOURNAL OF TRANSPLANTATION, 4, 43–50.

By: J. Piedrahita n & B. Mir n

MeSH headings : Animals; Animals, Genetically Modified; Cloning, Organism; Embryo, Mammalian / cytology; Graft Rejection / etiology; Graft Rejection / immunology; Graft Rejection / prevention & control; Humans; Immune Tolerance; Immunosuppression Therapy; Nuclear Transfer Techniques; Stem Cells / cytology; Swine; Transplantation, Heterologous / immunology; Transplantation, Heterologous / methods; Transplantation, Heterologous / trends
TL;DR: Advances in transgenic manipulation and cloning in swine are reviewed and how the development of these two technologies is critical to the eventual utilization of the pig as a human organ donor. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Use of artificial androgen receptor coactivators to alter myoblast proliferation

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 91(3), 111–119.

author keywords: androgen receptor; muscle growth; coactivators
MeSH headings : Animals; Base Sequence; Cell Division / drug effects; DNA Primers; HeLa Cells; Humans; Muscle, Skeletal / cytology; Muscle, Skeletal / drug effects; Mutagenesis, Site-Directed; Rats; Receptors, Androgen / drug effects; Receptors, Androgen / metabolism
TL;DR: The ability of the mutated AR to act as an artificial coactivator to up-regulate androgen responsive genes is a useful tool for understanding the interaction of androgens and muscle growth. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Somatic cell cloning: The ultimate form of nuclear reprogramming?

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 15(5), 1140–1144.

By: J. Piedrahita*, B. Mir*, S. Dindot* & S. Walker*

MeSH headings : Animals; Cloning, Molecular / methods; Humans; Kidney Failure, Chronic / therapy; Stem Cell Transplantation / methods; Stem Cells / physiology
TL;DR: To make this a reality, techniques associated with cloning and genetic modifications in somatic cells need to be continued to be developed and optimized and have an effect beyond the area of nuclear transfer and assist with better methods for transdifferentiation of mammalian cells. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Comparative PRNP genotyping of US cattle sires for potential association with BSE

MAMMALIAN GENOME, 15(10), 828–833.

By: C. Seabury*, J. Womack*, J. Piedrahita n & J. Derr*

MeSH headings : Alleles; Amyloid / genetics; Animals; Cattle / genetics; Encephalopathy, Bovine Spongiform / genetics; Genetic Variation; Genotype; Germany; Polymorphism, Single Nucleotide; Prions; Promoter Regions, Genetic / genetics; Protein Precursors / genetics; United States
TL;DR: Forward primer sequences from published primer sets targeting indels within the putative bovine PRNP promoter, intron 1, and the 3′ UTR were synthesized with unique 5′ fluorescent labels and utilized to develop a rapid multiplexed PCR assay for identifying BSE-associated indels as well as facilitating polymorphism analyses and/or marker-assisted selection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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