Works Published in 2021
Displaying works 1 - 20 of 38 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 article
Non-destructive quality monitoring of 3D printed tissue scaffolds via dielectric impedance spectroscopy and supervised machine learning
49TH SME NORTH AMERICAN MANUFACTURING RESEARCH CONFERENCE (NAMRC 49, 2021), Vol. 53, pp. 636–643.
author keywords: biofabrication; non-destructive quality monitoring; supervised machine learning; dielectric impedance spectroscopy; tissue engineering
doi.org (publisher)
Sources: Web Of Science, NC State University Libraries
Added: October 24, 2022
2021 article
Hybrid Blockchain Architecture for Cloud Manufacturing-as-a-service (CMaaS) Platforms with Improved Data Storage and Transaction Efficiency
49TH SME NORTH AMERICAN MANUFACTURING RESEARCH CONFERENCE (NAMRC 49, 2021), Vol. 53, pp. 594–605.
author keywords: blockchain; smart contracts; distributed database; time series; regression; lstm; gas price prediction
TL;DR:
A Random Forest regressor based time series inference model has been shown to exhibit superior performance in the prediction of Ethereum gas price, that allows the CMaaS to avoid executing transactions in periods of high gas prices within the Ethereum ecosystem.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 24, 2022
2021 journal article
Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair
ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779.
author keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury
MeSH headings : Animals; Disease Models, Animal; Endothelial Cells / drug effects; Endothelial Cells / pathology; Extracellular Vesicles / chemistry; Fibroblasts / drug effects; Fibroblasts / pathology; Mesenchymal Stem Cells / chemistry; Mesenchymal Stem Cells / cytology; Mice; Myocardial Infarction / drug therapy; Myocardial Infarction / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Nanoparticles / chemistry; Particle Size; Surface Properties
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: February 21, 2022
2021 article
Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology
Hsu, Y., Huang, K., & Cheng, K. (2021, December 22). ADVANCED BIOLOGY.
author keywords: cardiac hypertrophy; cardiomyogenesis; heart failure; regeneration
MeSH headings : Biology; Heart Failure / therapy; Humans; Prognosis; Regeneration; Stroke Volume; Ventricular Function, Left
TL;DR:
In this review, numerous mediators involved in the pathogenesis of HF are summarized and the recent challenges and development in cardiac regenerative therapy that hold opportunities for future research and clinical translation are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2022
2021 journal article
Characterizing the Effects of Synergistic Thermal and Photo-Cross-Linking during Biofabrication on the Structural and Functional Properties of Gelatin Methacryloyl (GeIMA) Hydrogels
ACS BIOMATERIALS SCIENCE & ENGINEERING, 7(11), 5175–5188.
author keywords: GelMA; thermo-reversible cross-linking; photo-cross-linking; biofabrication; tissue engineering; CryoSEM; qPCR
MeSH headings : Biocompatible Materials; Gelatin; Humans; Hydrogels; Methacrylates; Tissue Engineering
TL;DR:
The finding that hydrogels processed at higher temperature possessed lower structural fidelity but resulted in more cell elongation and greater anisotropy over time demonstrate the significant impact of GelMA material formulation and processing conditions on the structural and functional properties of the hydrogel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Source: Web Of Science
Added: November 29, 2021
2021 journal article
A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs
MED, 2(11), 1253-+.
MeSH headings : Animals; Cell- and Tissue-Based Therapy; Heart; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells; Myocardial Infarction / surgery; Rats; Swine
TL;DR:
A fluid-driven heart pouch with a memory-shaped microfabricated lattice structure inspired by origami allowed minimally invasive delivery of the pouch to the heart with two small incisions and can be refilled multiple times with the therapeutic of choice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: November 29, 2021
2021 article
Age- and sex-specific differences in ACL and ACL bundle size during adolescent growth
Cone, S. G., Barnes, R. H., Howe, D., Fordham, L. A., Fisher, M. B., & Spang, J. T. (2021, November 2). JOURNAL OF ORTHOPAEDIC RESEARCH.
author keywords: ACL; bundles; growth; MRI; pediatrics
MeSH headings : Adolescent; Animals; Anterior Cruciate Ligament / diagnostic imaging; Anterior Cruciate Ligament Injuries; Child; Female; Humans; Magnetic Resonance Imaging / methods; Male; Models, Animal; Retrospective Studies
TL;DR:
Findings in the length and cross‐sectional area (CSA) of the ACL and its primary bundles in adolescent human subjects may point toward biomechanical changes in the adolescent human ACL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: November 15, 2021
2021 article
Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins
Gaffney, L. S., Davis, Z. G., Mora-Navarro, C., Fisher, M. B., & Freytes, D. O. (2021, November 2). TISSUE ENGINEERING PART A.
author keywords: extracellular matrix; engineered tissues; myotendinous junction; paxillin
MeSH headings : Collagen / metabolism; Collagen Type I / metabolism; Culture Media, Conditioned; Extracellular Matrix / metabolism; Hydrogels; Muscles; Paxillin / metabolism; Tendons / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 15, 2021
2021 article
Sex-specific biomechanics and morphology of the anterior cruciate ligament during skeletal growth in a porcine model
Howe, D., Cone, S. G., Piedrahita, J. A., Collins, B., Fordham, L. A., Griffith, E. H., … Fisher, M. B. (2021, November 9). JOURNAL OF ORTHOPAEDIC RESEARCH.
author keywords: anterior cruciate ligament; knee; porcine model; skeletal growth
MeSH headings : Adolescent; Aged; Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Child; Female; Humans; Joint Instability; Knee Joint; Male; Swine; Tibia
TL;DR:
A porcine model is used to investigate the sex-specific morphology and biomechanics of the ACL and its bundles throughout skeletal growth and has implications for age and sex‐specific surgical intervention strategies and suggests the need for human studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: November 15, 2021
2021 article
A genetic algorithm for order acceptance and scheduling in additive manufacturing
Kapadia, M. S., Uzsoy, R., Starly, B., & Warsing, D. P., Jr. (2021, October 23). INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH, Vol. 10.
author keywords: Order acceptance scheduling; genetic algorithms; additive manufacturing; statistical optimum estimation; batch machine scheduling
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021
2021 journal article
A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation
FRONTIERS IN ONCOLOGY, 11.
author keywords: angiopellosis; circulating tumor cell cluster; tumor cell extravasation; cancer exodus hypothesis; metastasis; osteosarcoma
TL;DR:
Together, the results provide a novel experimental framework to study discrete steps in the metastatic process and identify the versican/ECM network dysregulation as a potential contributor to osteosarcoma circulating tumor cell metastasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 26, 2021
2021 journal article
A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency
THERANOSTICS, 11(18), 8894–8908.
author keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility
MeSH headings : Animals; Apoptosis; Cell-Derived Microparticles / metabolism; Disease Models, Animal; Female; Hydrogels / pharmacology; Infertility, Female / therapy; Mesenchymal Stem Cell Transplantation / methods; Mesenchymal Stem Cells / metabolism; Ovary / pathology; Primary Ovarian Insufficiency / therapy; Rats; Rats, Sprague-Dawley; Regenerative Medicine / methods; Secretome; Stem Cells / metabolism; Tissue Scaffolds
TL;DR:
In a rat model of POI, implantation of ORP rescued fertility by restoring sexual hormone secretion, estrus cycle duration, and follicle development and represents a cell-free, off-the-shelf, and clinically feasible treatment for POI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: October 12, 2021
2021 journal article
Patch grafting, strategies for transplantation of organoids into solid organs such as liver
BIOMATERIALS, 277.
author keywords: Liver; Biliary tree; Stem/progenitors; Cell therapies; Grafting; Matrix-metalloproteinases (MMPs); Hyaluronans
MeSH headings : Animals; Cell Differentiation; Hepatocytes; Liver; Organoids; Stem Cells; Swine
TL;DR:
RNA-seq analyses revealed that engraftment correlated with expression of matrix-metalloproteinases (MMPs), especially secreted isoforms that were found expressed strongly by organoids, less so by MSCs, and minimally, if at all, by adult cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 4, 2021
2021 article
Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation
Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). BIOELECTRICITY.
author keywords: converse piezoelectric effect; mechanical stimulation; bone regeneration
TL;DR:
The potential of the converse piezoelectric effect to enhance bone regeneration is highlighted by discussing the activation of beneficial cellular pathways, the properties of piezOElectric biomaterials, and the potential for the more effective administration of the Converse pieZoelectrics effect using wireless control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: October 4, 2021
2021 journal article
Dynamic matching with deep reinforcement learning for a two-sided Manufacturing-as-a-Service (MaaS) marketplace
MANUFACTURING LETTERS, 29, 11–14.
author keywords: Cloud manufacturing; Cyber-enabled manufacturing; Resource allocation; Two-sided matching; Dynamic and stochastic knapsack problem (DSKP); Cloud based design and manufacturing (CBDM)
TL;DR:
Empirical simulations demonstrate that DRL has considerably better performance compared to four baselines and demonstrates a learning approach for near real-time decision making for suppliers participating in a MaaS marketplace.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 4, 2021
2021 journal article
Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury
NANO TODAY, 39.
author keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells
TL;DR:
It is found that encapsulation by the platelet membranes induces macropinocytosis, enhancing the cellular uptake of exosomes by endothelial cells and cardiomyocytes strikingly and boosting the cardiac targeting ability of hybrid exosome in a mice model with myocardial infarction injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: September 7, 2021
2021 article
Generation and Manipulation of Exosomes
CARDIAC REGENERATION, Vol. 2158, pp. 295–305.
author keywords: Exosome generation; Exosome manipulation; Myocardial infarction; Cardiac homing peptide; Platelet membrane; Intravenous injection
MeSH headings : Animals; Blood Platelets / chemistry; Cell Culture Techniques / methods; Cell Fractionation / methods; Cell Membrane / chemistry; Cell Membrane / metabolism; Exosomes / ultrastructure; Humans; Mice; Molecular Targeted Therapy; Myocardium / cytology; Peptides / analysis; Peptides / metabolism; Rats; Technology, Pharmaceutical / methods; Ultracentrifugation; Ultrasonic Waves
TL;DR:
Generation of exosomes from biopsy, isolation ofExosomes by centrifugal ultrafiltration method, and approaches for manipulation of cardiac homing exosome by chemical engineering for the treatment of myocardial infarction are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 30, 2021
2021 article
Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis
MELANOMA, Vol. 2265, pp. 417–425.
author keywords: Circulating tumor cells; Metastasis; Intravital microscopy; Cancer Exodus Hypothesis; Extravasation; Angiopellosis; Zebrafish; Tumor infusion; Light sheet microscopy; Tumor cell isolation
MeSH headings : Animals; Animals, Genetically Modified; Cell Line, Tumor; Endothelial Cells / metabolism; Endothelial Cells / pathology; Intravital Microscopy; Melanoma, Experimental / metabolism; Melanoma, Experimental / pathology; Neoplasm Metastasis; Neoplastic Cells, Circulating / metabolism; Neoplastic Cells, Circulating / pathology; Zebrafish
TL;DR:
The use of intravital microscopy techniques to image and isolate both extravasating melanoma CTCs and the extravasation-participating endothelial cells can be used as a means to study cancer metastasis and as a screening tool for anticancer therapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 30, 2021
2021 journal article
A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction
ACS NANO, 15(7), 11099–11111.
author keywords: MSC; exosome; spray; myocardial infarction; heart repair
MeSH headings : Mice; Swine; Animals; Exosomes; Myocardial Infarction / therapy; Mesenchymal Stem Cells; Heart; Disease Models, Animal
TL;DR:
In a mouse model of acute myocardial infarction, EXOS improved cardiac function and reduced fibrosis, and promoted endogenous angiomyogenesis in the post-injury heart, indicating that EXOS is a promising strategy to deliver therapeutic exosomes for heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 23, 2021
2021 review
Exosome therapeutics for COVID-19 and respiratory viruses
[Review of ]. VIEW, 2(3).
author keywords: COVID-19; exosomes; respiratory viruses; SARS-CoV-2
TL;DR:
The relationship between exosomes and respiratory viruses is reviewed, potential exosome therapeutics for viral infections are described, and progress toward clinical translation for lung‐derived exosomal therapeutics is summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 19, 2021
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