Works Published in 2020
Displaying works 1 - 20 of 24 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2020 journal article
Witness Box Protocol: Automatic machine identification and authentication in industry 4.0
COMPUTERS IN INDUSTRY, 123.
author keywords: Cybersecurity; Smart manufacturing; Manufacturing fingerprinting; Cyber physical systems; Digital supply Chain traceability
TL;DR:
This paper introduces a machine fingerprinting scheme named as the ‘Witness Box Protocol’ (WBP) that exploits the physical properties of manufacturing machines and their surroundings to create a unique biometric like fingerprint that simplifies asset management within a large enterprise or distributed network comprising of thousands of machines in a Manufacturing-as-a-Service (MaaS) paradigm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 19, 2021
2020 journal article
Automating the Search and Discovery of Manufacturing Service Providers to Enable a Digital Supply Chain Network
SMART AND SUSTAINABLE MANUFACTURING SYSTEMS, 4(3), 276–280.
author keywords: coronavirus disease; manufacturing search engine optimization; schema.org vocabulary extensions; blockchain
TL;DR:
This technical note outlines solution pathways that can help ease the search and discovery process of connecting clients and manufacturing service providers through digitally enabled technologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021
2020 review
Recent Development in Therapeutic Cardiac Patches
[Review of ]. FRONTIERS IN CARDIOVASCULAR MEDICINE, 7.
author keywords: biomaterials; cardiac patch; myocardial infarction; cell therapy; cardiac tissue regeneration
TL;DR:
This review will present the most state-of-the-art cardiac patches and analysis their compositional details, and the recent advances to obtain scaffold biomaterials will be highlighted, including synthetic and natural materials.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 4, 2021
2020 journal article
Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy
BIOMEDICAL OPTICS EXPRESS, 11(11), 6181–6196.
TL;DR:
3D microscopic analysis was performed on an intact cochlea of newborn and juvenile pigs with a volume up to ∼ 250 mm3 using the BoneClear tissue clearing technique, which renders the bone transparent, to support the growing effort to regenerate cochlear tissues and assist with basic research to advance cures for hearing impairments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 11, 2020
2020 journal article
Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs
ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320.
author keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model
MeSH headings : Animals; Microvessels; Myocardial Infarction / therapy; Myocytes, Cardiac; Neovascularization, Physiologic; Rats; Stromal Cells; Swine
TL;DR:
It is shown that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 11, 2020
2020 journal article
Biomechanical evaluation of an autologous flexor digitorum lateralis graft to augment the surgical repair of gastrocnemius tendon laceration in a canine ex vivo model
VETERINARY SURGERY, 49(8), 1545–1554.
MeSH headings : Animals; Autografts / physiology; Biomechanical Phenomena; Cadaver; Dogs / injuries; Dogs / surgery; Lacerations / surgery; Lacerations / veterinary; Muscle, Skeletal / surgery; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / transplantation; Transplantation, Autologous / veterinary
TL;DR:
Use of FDL tendon augmentation for GT laceration may increase repair site strength and resist gap formation better than 3LP core suture use alone and increase yield, peak, and failure forces by twofold, 2.3-fold and 2.2-fold compared with core 3LP alone while preventing the occurrence of gap formation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 24, 2020
2020 journal article
In Vitro Validation of Transgene Expression in Gene-Edited Pias Using CRISPR Transcriptional Activators
CRISPR JOURNAL, 3(5), 409–418.
MeSH headings : Animals; Animals, Genetically Modified / genetics; CRISPR-Associated Protein 9 / genetics; CRISPR-Associated Protein 9 / metabolism; Cells, Cultured; Clustered Regularly Interspaced Short Palindromic Repeats; Gene Editing / methods; Gene Expression; Nuclear Transfer Techniques; RNA, Guide, Kinetoplastida / genetics; RNA, Guide, Kinetoplastida / metabolism; Swine; Trans-Activators / genetics; Trans-Activators / metabolism; Transgenes
TL;DR:
It is shown that CRISPR-dCas9 transcriptional activators can be used to validate functional transgene insertion in nonexpressing easily cultured cells such as fibroblasts and is a tool that could be used across disciplines and animal species to save time and resources by verifying expected outcomes of gene edits before generating live animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 24, 2020
2020 journal article
Decentralized cloud manufacturing-as-a-service (CMaaS) platform architecture with configurable digital assets
JOURNAL OF MANUFACTURING SYSTEMS, 56, 157–174.
author keywords: Cybermanufacturing; Blockchain; Smart contracts; Distributed digital thread; Cloud manufacturing
TL;DR:
The design, implementation and validation of middleware software architectures which aim to directly connect client users with manufacturing service providers while improving transparency, data integrity, data provenance and retaining data ownership to its creators are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science; OpenAlex)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 journal article
Influence of barbed epitendinous suture combined with a core locking-loop sutures to repair experimental flexor tendon lacerations
VETERINARY SURGERY, 49(8), 1590–1599.
MeSH headings : Animals; Cadaver; Dogs / injuries; Dogs / surgery; Lacerations / surgery; Lacerations / veterinary; Plastic Surgery Procedures / veterinary; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength
TL;DR:
Investigating the influence of barbed epitendinous sutures on the biomechanical properties and gap formation of repaired canine tendons found Stratafix barbed suture performed better as an ES compared with other barbedSutures and similarly to monofilament suture.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 28, 2020
2020 journal article
Effect of partial vs complete circumferential epitendinous suture placement on the biomechanical properties and gap formation of canine cadaveric tendons
VETERINARY SURGERY, 49(8), 1571–1579.
MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Dogs / injuries; Dogs / surgery; Plastic Surgery Procedures / veterinary; Suture Techniques / veterinary; Sutures / veterinary; Tendon Injuries / surgery; Tendon Injuries / veterinary; Tendons / surgery; Tensile Strength
TL;DR:
Addition of a complete circumferential ES with a single or double knotting technique increased the biomechanical strength of normal tendon repairs while reducing gap formation compared with partial ES placement alone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 7, 2020
2020 review
Advances of exosome isolation techniques in lung cancer
[Review of ]. MOLECULAR BIOLOGY REPORTS, 47(9), 7229–7251.
author keywords: Lung cancer; Exosome; Multi-vesicular bodies; Extracellular vesicles; MicroRNAs
MeSH headings : Biomarkers, Tumor / blood; Biomarkers, Tumor / isolation & purification; Cell-Free Nucleic Acids / blood; Cell-Free Nucleic Acids / isolation & purification; Circulating Tumor DNA / blood; Circulating Tumor DNA / isolation & purification; Exosomes / metabolism; Exosomes / pathology; Humans; Lung Neoplasms / blood; Lung Neoplasms / diagnosis; Lung Neoplasms / pathology
TL;DR:
This review summarizes the recent investigations regarding isolation and also the characterization of exosomes of LC cells, and discusses the noncoding RNAs as biomarkers and their applications in the diagnosis and prognosis of LC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 31, 2020
2020 article
Clinical xenotransplantation of the heart: At the watershed
Platt, J. L., Piedrahita, J. A., & Cascalho, M. (2020, August). JOURNAL OF HEART AND LUNG TRANSPLANTATION, Vol. 39, pp. 758–760.
MeSH headings : Animals; Heart; Heart Transplantation; Primates; Swine; Transplantation, Heterologous
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine
TISSUE ENGINEERING PART C-METHODS, 26(7), 364–374.
author keywords: 3D printing; melt blowing; fibers; scaffolds
MeSH headings : Animals; Biocompatible Materials / chemistry; Dogs; Hernia / therapy; Herniorrhaphy / methods; Polymers / chemistry; Printing, Three-Dimensional / instrumentation; Regenerative Medicine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The 3DMB system described in this study is modified from larger nonwovens manufacturing machinery to accommodate the lower volume, high-cost polymers used for tissue engineering and implantable biomedical devices and has a fiber collection component that uses adaptable robotics to create scaffolds with predetermined geometries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 journal article
Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling
SCIENCE ADVANCES, 6(30).
MeSH headings : Cells, Cultured; Exosomes; Hair; Hair Follicle; MicroRNAs / genetics; Regeneration; beta Catenin / genetics
TL;DR:
Results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment, and it was demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 10, 2020
2020 review
Exosome therapeutics for lung regenerative medicine
[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).
author keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell
TL;DR:
The uses of exosomes as a therapy and their roles in lung regenerative medicine, as well as current challenges in exosome therapies are underline.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 20, 2020
2020 journal article
Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis
NANO RESEARCH, 13(8), 2197–2202.
author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
TL;DR:
A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: June 29, 2020
2020 journal article
The bioprinting roadmap
BIOFABRICATION, 12(2).
author keywords: biofabrication; bioprinting; cell printing; in vitro biological models; disease models; organoids; organ-on-a-chip
MeSH headings : Animals; Bioprinting / methods; Bioprinting / trends; Humans; Tissue Engineering / instrumentation; Tissue Scaffolds / chemistry
TL;DR:
This bioprinting roadmap features salient advances in selected applications of the technique and highlights the status of current developments and challenges, as well as envisioned advances in science and technology, to address the challenges to the young and evolving technique.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 8, 2020
2020 review
Engineering better stem cell therapies for treating heart diseases
[Review of ]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8).
author keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation
TL;DR:
This review will provide a brief summary of stem cell therapies for ischemic heart disease, the investigation of mechanisms behind stem-cell based cardiac regeneration and also, what bioengineers can do and have been doing on the translational stage of stem Cell therapies for heart repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: May 26, 2020
2020 journal article
Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs
THERANOSTICS, 10(8), 3474–3487.
author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
TL;DR:
It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 30, 2020
2020 journal article
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
NATURE COMMUNICATIONS, 11(1).
MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR:
It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 23, 2020
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