Works Published in 2011
Displaying all 17 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
The CADUCEUS (CArdiosphere-Derived aUtologous Stem CElls to Reverse ventricUlar dySfunction) Trial
Circulation, 124, 2365–2374.
Source: NC State University Libraries
Added: April 24, 2021
2011 journal article
Suture augmentation following ACL injury to restore the function of the ACL, MCL, and medial meniscus in the goat stifle joint
Journal of Biomechanics, 44(8), 1530–1535.
author keywords: Anterior cruciate ligament (ACL); Suture augmentation; Biomechanics; Robotic/UFS testing system
MeSH headings : Animals; Anterior Cruciate Ligament / surgery; Anterior Cruciate Ligament Injuries; Biomechanical Phenomena; Goats; Humans; Knee Injuries / pathology; Knee Injuries / surgery; Medial Collateral Ligament, Knee / injuries; Medial Collateral Ligament, Knee / surgery; Menisci, Tibial / surgery; Models, Anatomic; Robotics; Suture Techniques; Sutures; Tibia / pathology; Tibial Meniscus Injuries
TL;DR:
Suture augmentation may be helpful in combination with FTE approaches for ACL healing by providing the needed initial joint stability while lowering the loads on the MM.
(via Semantic Scholar)
Source: Crossref
Added: February 7, 2021
2011 journal article
Alpha1,3-galactosyltransferase knockout does not alter the properties of porcine extracellular matrix bioscaffolds
Acta Biomaterialia, 7(4), 1719–1727.
author keywords: Extracellular matrix; Bioscaffold; Growth factors; alpha Gal
MeSH headings : Animals; Anterior Cruciate Ligament / metabolism; Anterior Cruciate Ligament / pathology; Biomechanical Phenomena; Blotting, Western; Bromodeoxyuridine / metabolism; Cell Proliferation; Extracellular Matrix / metabolism; Extracellular Matrix / pathology; Fibroblast Growth Factor 2 / metabolism; Galactosyltransferases / deficiency; Galactosyltransferases / metabolism; Gene Knockout Techniques; Humans; Immunohistochemistry; Intestinal Mucosa / pathology; Reproducibility of Results; Sus scrofa; Tissue Scaffolds / chemistry; Transforming Growth Factor beta1 / metabolism; Urinary Bladder / pathology
TL;DR:
The multidisciplinary results suggest that genetic modification to eliminate the αGal epitopes in the ECM bioscaffolds had not altered the properties of these ECMBioscaffolding and, as such, they should retain their performance in tissue engineering in humans.
(via Semantic Scholar)
Source: Crossref
Added: February 7, 2021
2011 journal article
The effects of multiple freeze-thaw cycles on the biomechanical properties of the human bone-patellar tendon-bone allograft
Journal of Orthopaedic Research, 29(8), 1193–1198.
author keywords: anterior cruciate ligament reconstruction; bone-patellar tendon-bone allograft; multiple freeze-thaw cycles; biomechanics
MeSH headings : Adult; Aged; Biomechanical Phenomena; Bone-Patellar Tendon-Bone Grafting; Cryopreservation; Female; Freezing; Humans; Male; Middle Aged; Patellar Ligament
TL;DR:
It is suggested that the BPTB allografts used for anterior cruciate ligament reconstruction could potentially be re‐frozen without a loss in their biomechanical properties, given appropriate storage and care.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
Source: Crossref
Added: February 7, 2021
2011 journal article
Sustainment: A Growth Industry for Custom Manufacturing in the United States
Journal of Aviation and Aerospace Perspectives, 1(1), 5–16.
Source: NC State University Libraries
Added: December 24, 2020
2011 journal article
Virtual and Real: Using 3D Scanning, Modeling and Printing in Reconstructing a Juvenile Apatosaurus Skeleton
Journal of Vertebrate Paleontology, 31(Supplement 2).
Source: NC State University Libraries
Added: December 24, 2020
2011 journal article
336 TRANSGENIC Stra8-EYFP PIGS: A MODEL FOR DEVELOPING MALE GERM CELL TECHNOLOGIES
Reproduction, Fertility and Development, 23(1), 264.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2011 journal article
Perspectives on transgenic livestock in agriculture and biomedicine: an update
Reproduction, Fertility and Development, 23(1), 56.
author keywords: animal models; bioreactors; somatic cell nuclear transfer; spinal cord repair; xenotransplantation
MeSH headings : Agriculture / trends; Animals; Animals, Domestic; Animals, Genetically Modified; Biomedical Technology / trends; Nuclear Transfer Techniques / trends; Nuclear Transfer Techniques / veterinary; Pluripotent Stem Cells; Stem Cell Research
TL;DR:
The combination of advances in somatic cell nuclear transfer, the development of induced pluripotent stem cells and the completion of the sequencing of most livestock genomes ensures a bright and exciting future for this field, not only in livestock but also in companion animal species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2011 journal article
Experimental investigation on the operating variables of a near-field electrospinning process via response surface methodology
Journal of Manufacturing Processes, 13(2), 104–112.
Sources: Crossref, NC State University Libraries
Added: September 15, 2019
2011 journal article
A design for the additive manufacture of functionally graded porous structures with tailored mechanical properties for biomedical applications
Journal of Manufacturing Processes, 13(2), 160–170.
TL;DR:
This article discusses a design process for creating periodic cellular structures specifically targeted for biomedical applications and shows the compatibility and matched functional performance characteristics of highly porous parts at a safety factor of 5 and an effective reduction in weight.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 15, 2019
2011 journal article
Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities
Toxicology and Applied Pharmacology, 256(1), 62–72.
author keywords: Cell encapsulation; Alginate; 3D culture; HepG2; MCF-7; Co-culture
MeSH headings : Alginates / chemistry; Cell Line, Tumor; Cell Survival / drug effects; Cell Survival / physiology; Cells, Cultured; Coculture Techniques / methods; Drug Evaluation, Preclinical / methods; Drug-Related Side Effects and Adverse Reactions / metabolism; Hep G2 Cells; Humans; Hydrogels / chemistry; Liver / drug effects; Liver / metabolism; Toxicity Tests / methods
TL;DR:
An in vitro 3D co-culture platform provides a scalable and flexible approach to test multiple-cell types in a hybrid setting within standard cell culture plates which may open up novel 3D in vitro culture techniques to screen new chemical entity compounds.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 15, 2019
2011 journal article
The amelioration of cardiac dysfunction after myocardial infarction by the injection of keratin biomaterials derived from human hair
Biomaterials, 32(35), 9290–9299.
author keywords: Heart; Keratin; Scaffold; Angiogenesis; Cardiac tissue engineering
MeSH headings : Animals; Biocompatible Materials / administration & dosage; Biocompatible Materials / pharmacology; Blotting, Western; Disease Models, Animal; Female; Hair / chemistry; Heart / drug effects; Heart / physiopathology; Heart Function Tests / drug effects; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology; Inflammation / complications; Inflammation / pathology; Injections; Keratins / administration & dosage; Keratins / pharmacology; Mechanical Phenomena / drug effects; Myocardial Infarction / complications; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Pathologic / complications; Neovascularization, Pathologic / pathology; Paracrine Communication / drug effects; Rats; Rats, Sprague-Dawley; Tissue Scaffolds / chemistry; Ventricular Remodeling / drug effects
TL;DR:
Injection of keratin biomaterials promotes angiogenesis but does not exacerbate inflammation in the post-MI hearts, and the salient functional benefits, the simplicity of manufacturing and the potentially autologous nature of this biomaterial provide impetus for further translation to the clinic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 28, 2019
2011 journal article
Neural Cell 3D Microtissue Formation Is Marked by Cytokines' Up-Regulation
PLoS ONE, 6(10), e26821.
Ed(s): M. Wanunu
MeSH headings : Biomarkers; Cytokines / biosynthesis; Humans; Neural Stem Cells / cytology; Primary Cell Culture / methods; Tissue Engineering / methods; Up-Regulation
TL;DR:
A transcriptomic expression comparison among neural progenitor cells cultured on 2D substrates, 3D porous polystyrene scaffolds, and as 3D neurospheres suggests potential for any or a combination from this list to serve as three-dimensionality biomarkers.
(via Semantic Scholar)
Source: Crossref
Added: July 28, 2019
2011 journal article
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
BRITISH JOURNAL OF OPHTHALMOLOGY, 95(12), 1749–1754.
MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR:
These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 review
The Role of Imprinted Genes in Fetal Growth Abnormalities
[Review of ]. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 91(8), 682–692.
MeSH headings : Animals; Epigenesis, Genetic; Female; Fetal Development; Fetus / abnormalities; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Humans; Pregnancy; Pregnancy Complications / genetics
TL;DR:
Imprinting-associated disorders in humans and assisted reproductive technologies in animals have been shown to affect the epigenome of the early embryo and the expression of imprinted genes, and their role in disorders such as intrauterine growth restriction appears to be more complex.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways
PLACENTA, 32(2), 175–182.
author keywords: Placenta; Preeclampsia; Maternal hypertension; Sialic acid acetylesterase
MeSH headings : Acetylesterase / biosynthesis; Antigens, CD / biosynthesis; Endoglin; Female; Genome-Wide Association Study; Humans; Infant, Newborn; Inhibins / biosynthesis; Male; Pre-Eclampsia / etiology; Pre-Eclampsia / metabolism; Pregnancy; Protein Array Analysis; Receptors, Cell Surface / biosynthesis; Trophoblasts / physiology; Up-Regulation; Vascular Endothelial Growth Factor Receptor-1 / biosynthesis
TL;DR:
Evidence is found of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases, and changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeClampsia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 conference paper
Perspectives on transgenic livestock in agriculture and biomedicine: An update
Reproduction, Fertility and Development, 23(1), 56–63.
Source: NC State University Libraries
Added: August 6, 2018
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