Works Published in 2014
Displaying all 18 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction
Journal of the American Heart Association, 3(5), 001260.
Source: NC State University Libraries
Added: April 24, 2021
2014 journal article
Functional properties of bone marrow-derived MSC-based engineered cartilage are unstable with very long-term in vitro culture
Journal of Biomechanics, 47(9), 2173–2182.
author keywords: Mesenchymal stem cells; Chondrogenesis; Three-dimensional culture; Cartilage; Mechanical properties
MeSH headings : Animals; Bone Marrow Cells / cytology; Cartilage / cytology; Cartilage / metabolism; Cattle; Cell Survival; Cells, Cultured; Chondrocytes / cytology; Chondrogenesis; Femur; Glycosaminoglycans / metabolism; Hydrogels; Mesenchymal Stem Cells / cytology; Sepharose; Tissue Engineering / methods; Tissue Scaffolds
TL;DR:
Data suggest that, even within a controlled in vitro environment that is conducive to chondrogenesis, there may be an innate instability in the MSC phenotype that is independent of scaffold composition, and may ultimately limit their application in functional cartilage repair.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: December 19, 2020
2014 journal article
Maximizing cartilage formation and integration via a trajectory-based tissue engineering approach
Biomaterials, 35(7), 2140–2148.
author keywords: Tissue engineering; Hyaluronic acid; Hydrogels; Cartilage; Integration; Maturation
MeSH headings : Animals; Cartilage / growth & development; Cattle; Tissue Engineering
TL;DR:
It is shown that integration to cartilage in-vitro is not correlated to the maturation state of TE constructs, but rather their maturation rate, providing a proof-of-concept for the use of TB-TE to enhance treatment outcomes following cartilage injury.
(via Semantic Scholar)
Source: Crossref
Added: December 19, 2020
2014 journal article
Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells
STEM CELLS, 32(9), 2397–2406.
author keywords: Cardiosphere-derived cells; Cardiomyocyte; Proliferation; Paracrine factors; Cell-cell communication; beta 1 integrin
MeSH headings : Animals; Cell Communication / physiology; Cell Differentiation / physiology; Cells, Cultured; Humans; Integrin beta1 / metabolism; Male; Mice; Mice, SCID; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats
TL;DR:
The hypothesis that cell‐cell contact plays a role in mediating the observed therapeutic benefits of CDCs, above and beyond conventional paracrine effects, is tested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
5 DISRUPTION OF THE HIGH MOBILITY GROUP AT-HOOK 2 (HMGA2) GENE IN SWINE REDUCES POSTNATAL GROWTH
Reproduction, Fertility and Development, 26(1), 117.
TL;DR:
The approach described here will result in a valuable large-animal model of dwarfism, but also in a tool to reduce the size of existing transgenic and nontransgenic swine lines, which will increase the receptivity of valuable transgenic lines by the biomedical community.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2014 journal article
The Influence of MgO Nanoparticles on the Osseointegration of Polycaprolactone - Sodium Alginate Hydrogel Interfaces
British Journal of Applied Science & Technology, 4(1), 79–88.
Ed(s): M. Vimalan
TL;DR:
It is suggested that MgO nanoparticle improves the cell viability of a sodium alginate (SA) hydrogel, but it is detrimental for the osseointegration of PCL-SA hydrogels constructs.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: January 5, 2020
2014 journal article
Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling
Stem Cells, 32, 2397–2406.
Source: NC State University Libraries
Added: July 28, 2019
2014 journal article
Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction
Journal of the American College of Cardiology, 63(2), 110–122.
author keywords: cardiosphere-derived cells; myocardial infarction; myocardial regeneration
MeSH headings : Aged; Biopsy; Coronary Vessels; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Ventricles / pathology; Heart Ventricles / physiopathology; Humans; Injections, Intra-Arterial; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction / complications; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Recovery of Function; Stem Cell Transplantation / methods; Time Factors; Transplantation, Autologous; Treatment Outcome; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / physiopathology; Ventricular Dysfunction, Left / surgery; Ventricular Function, Left / physiology
TL;DR:
Preliminary indications of bioactivity include decreased scar size, increased viable myocardium, and improved regional function of infarctedMyocardium at 1 year post-treatment, which are consistent with therapeutic regeneration and merit further investigation in future trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair
JACC: Heart Failure, 2(1), 49–61.
author keywords: cardiosphere-derived cells; heart failure; myocardial infarction; patient characteristics; stromal cell-derived factor 1
MeSH headings : Adult; Aged; Animals; Cardiomyopathies / physiopathology; Extracellular Matrix; Female; Graft Survival / physiology; Heart / physiology; Heart Failure / physiopathology; Humans; Intercellular Signaling Peptides and Proteins / metabolism; Male; Mice, SCID; Middle Aged; Myocardial Infarction / physiopathology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Oxidative Stress / physiology; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology; Transplantation, Autologous
TL;DR:
CDCs from advanced HF patients exhibit augmented potency in ameliorating ventricular dysfunction post-MI, possibly through SDF-1–mediated mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block
Journal of the American College of Cardiology, 64(24), 2575–2585.
author keywords: arrhythmias; cardiac tissue engineering; gap junctions; heart conduction system
MeSH headings : Animals; Atrioventricular Block / pathology; Atrioventricular Block / physiopathology; Atrioventricular Block / surgery; Cell Transplantation / methods; Cells, Cultured; Electromagnetic Fields; Heart Conduction System / pathology; Heart Conduction System / physiopathology; Heart Conduction System / surgery; Heart Ventricles / pathology; Immunoconjugates / pharmacology; In Vitro Techniques; Magnets; Models, Cardiovascular; Myocytes, Cardiac / pathology; Rats; Rats, Sprague-Dawley; Sarcoglycans / immunology; Sarcoglycans / pharmacology; Tissue Engineering
TL;DR:
An EECT can re-establish electrical conduction in the heart and could, in principle, be used not only to treat cardiac arrhythmias but also to repair other organs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy
European Heart Journal, 36(12), 751–762.
author keywords: Cardiomyopathy; Heart failure; Cell transplantation
MeSH headings : Animals; Apoptosis / physiology; CREB-Binding Protein / metabolism; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / therapy; Cell Differentiation; Cell Lineage; Disease Models, Animal; Doxorubicin / pharmacology; Fibrosis; Graft Survival; Heart Failure / pathology; Heart Failure / physiopathology; Heart Failure / therapy; Injections, Intralesional; Male; Mice, Transgenic; Myocarditis / physiopathology; Myocardium / pathology; Myocytes, Cardiac / transplantation; Oxidative Stress / physiology; Protein Kinase C / metabolism; Signal Transduction; Stem Cell Transplantation / methods; Ventricular Remodeling / physiology
TL;DR:
The ability to impact favourably on disease progression in non-ischaemic heart failure heralds new potential therapeutic applications of CDCs, which reverse fundamental abnormalities in cell signalling, prevent adverse remodelling, and improve survival in a mouse model of DCM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy
Stem Cell Reports, 2(5), 606–619.
MeSH headings : Albumins / pharmacology; Aniline Compounds / pharmacology; Animals; Benzylidene Compounds / pharmacology; Cell Differentiation; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Disease Models, Animal; Exosomes / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Mice, SCID; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardial Infarction / therapy; Myocardial Infarction / veterinary; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Polyesters / pharmacology; Rats; Rats, Sprague-Dawley; Regeneration
TL;DR:
Exosomes secreted by human CDCs are identified as key mediators of CDC-induced regeneration, while highlighting the potential utility of exosomes as cell-free therapeutic candidates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 21, 2019
2014 journal article
Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5).
author keywords: cardiosphere-derived cells; CD90; ckit; myocardial infarction
MeSH headings : Analysis of Variance; Animals; Apoptosis / physiology; Biomarkers / analysis; Cell Differentiation / physiology; Cell Transplantation / methods; Cells, Cultured; Disease Models, Animal; Heart Function Tests; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / transplantation; Prospective Studies; Proto-Oncogene Proteins c-kit / metabolism; Regeneration / physiology; Role; Sensitivity and Specificity; Thy-1 Antigens / metabolism; Treatment Outcome
TL;DR:
It is shown, surprisingly, that c‐kit expression has no relationship to CDCs' therapeutic efficacy in humans, and depletion of c‐Kit+ cells does not undermine the structural and functional benefits of CDCs in a mouse model of myocardial infarction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy
PLOS ONE, 9(12).
MeSH headings : Administration, Cutaneous; Animals; Cardiomyopathies / complications; Cardiomyopathies / immunology; Cardiomyopathies / pathology; Cardiomyopathies / therapy; Catheters; Cicatrix / complications; Cicatrix / pathology; Dilatation; Endocardium / pathology; Female; Injections; Magnetic Resonance Imaging; Male; Myocardial Ischemia / complications; Myocardial Ischemia / immunology; Myocardial Ischemia / pathology; Myocardial Ischemia / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Spheroids, Cellular / cytology; Spheroids, Cellular / transplantation; Survival Analysis; Sus scrofa; Transplantation, Homologous / adverse effects
TL;DR:
Dose-optimized injection of allogeneic cardiospheres is safe, decreases scar size, increases viable myocardium, and attenuates cardiac dilatation in porcine chronic ischemic cardiomyopathy, consistent with therapeutic regeneration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Stem Cells and Regenerative Medicine in Domestic and Companion Animals: A Multispecies Perspective
Reproduction in Domestic Animals, 49, 2–10.
MeSH headings : Adult; Animals; Animals, Domestic / embryology; Cats; Dogs; Embryonic Stem Cells; Horses; Humans; Induced Pluripotent Stem Cells; Mice; Pets / embryology; Rats; Regenerative Medicine / trends; Stem Cells
TL;DR:
A range of stem cells are reviewed, from ESC to induced pluripotent stem cells, and their potential application in the field of regenerative medicine is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 journal article
Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction
BIOMATERIALS, 35(30), 8528–8539.
author keywords: Cardiac stem cells; Magnetic targeting; Myocardial infarction; Ferumoxytol; MRI; Superparamagnetic iron oxide nanoparticles
MeSH headings : Animals; Apoptosis / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Ferrosoferric Oxide / pharmacology; Ferrosoferric Oxide / therapeutic use; Finite Element Analysis; Heart Function Tests; Heparin / pharmacology; Humans; Inflammation / pathology; Iron Overload / pathology; Magnetic Phenomena; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Nanoparticles / therapeutic use; Nanoparticles / ultrastructure; Neovascularization, Physiologic / drug effects; Protamines / pharmacology; Rats; Rats, Inbred WKY; Spheroids, Cellular / drug effects; Spheroids, Cellular / pathology
TL;DR:
FHP labeling is safe to cardiac stem cells and facilitates magnetically-targeted stem cell delivery into the heart which leads to augmented cell engraftment and therapeutic benefit, and magnetic targeting increased cardiac retention of transplanted FHP-rCDCs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting
Nature Communications, 5(1).
MeSH headings : Animals; Antibodies; Bone Marrow Cells / metabolism; Bone Marrow Transplantation / methods; Cell Movement; Ferrosoferric Oxide / therapeutic use; Iron; Leukocytes, Mononuclear / metabolism; Magnets; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Nanotechnology / methods; Rats; Regeneration; Stem Cells
TL;DR:
The authors use magnetic iron nanoparticles conjugated with antibodies that bind therapeutic cells and cardiomyocytes to treat myocardial ischemia/reperfusion injury in rats and show that targeting to the heart is enhanced upon local application of a magnetic field.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 review
From "ES-like" cells to induced pluripotent stem cells: A historical perspective in domestic animals
[Review of ]. THERIOGENOLOGY, 81(1), 103–111.
author keywords: Pluripotent stem cells; Reprogramming; Large animals; Induced pluripotent stem cells
MeSH headings : Animals; Animals, Domestic / embryology; Animals, Domestic / physiology; Cattle; Dogs; Embryonic Stem Cells; Genomic Instability; Induced Pluripotent Stem Cells; Regenerative Medicine; Swine / physiology
TL;DR:
A historical perspective of the isolation of various types of pluripotent stem cells in domesticated animals is provided and the latest progress and limitations in the derivation and application of iPSCs are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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