Translational Predictive Biology

Works Published in 2014

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Displaying works 1 - 20 of 21 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2014 conference paper

The implementation of acoustic angiography for microvascular and angiogenesis imaging

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Presented at the 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

By: P. Dayton *, R. Gessner*, L. Phillips*, S. Shelton* , K. Martin*, M. Lee *, F. Foster *

Event: 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging; Ultrasound Imaging and Elastography
TL;DR: Because microbubbles are strictly an intravascular agent, this approach enables visualization of microvascular morphology with unique clarity, providing insight into angiogenesis associated with tumor development. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 3, 2023

2014 journal article

CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction

Journal of the American Heart Association, 3(5), 001260.

By: K. Cheng, A. Ibrahim, M. Hensley, B. Sun, W. Liu, R. Smith, E. Marban

Source: NC State University Libraries
Added: April 24, 2021

2014 journal article

Functional properties of bone marrow-derived MSC-based engineered cartilage are unstable with very long-term in vitro culture

Journal of Biomechanics, 47(9), 2173–2182.

By: M. Farrell*, M. Fisher*, A. Huang *, J. Shin*, K. Farrell* & R. Mauck *

author keywords: Mesenchymal stem cells; Chondrogenesis; Three-dimensional culture; Cartilage; Mechanical properties
MeSH headings : Animals; Bone Marrow Cells / cytology; Cartilage / cytology; Cartilage / metabolism; Cattle; Cell Survival; Cells, Cultured; Chondrocytes / cytology; Chondrogenesis; Femur; Glycosaminoglycans / metabolism; Hydrogels; Mesenchymal Stem Cells / cytology; Sepharose; Tissue Engineering / methods; Tissue Scaffolds
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Periodontal Regeneration and Treatments; Knee injuries and reconstruction techniques
TL;DR: Data suggest that, even within a controlled in vitro environment that is conducive to chondrogenesis, there may be an innate instability in the MSC phenotype that is independent of scaffold composition, and may ultimately limit their application in functional cartilage repair. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2014 journal article

Maximizing cartilage formation and integration via a trajectory-based tissue engineering approach

Biomaterials, 35(7), 2140–2148.

By: M. Fisher*, E. Henning*, N. Söegaard*, G. Dodge *, D. Steinberg* & R. Mauck *

author keywords: Tissue engineering; Hyaluronic acid; Hydrogels; Cartilage; Integration; Maturation
MeSH headings : Animals; Cartilage / growth & development; Cattle; Tissue Engineering
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Knee injuries and reconstruction techniques; Periodontal Regeneration and Treatments
TL;DR: It is shown that integration to cartilage in-vitro is not correlated to the maturation state of TE constructs, but rather their maturation rate, providing a proof-of-concept for the use of TB-TE to enhance treatment outcomes following cartilage injury. (via Semantic Scholar)
Source: Crossref
Added: December 19, 2020

2014 journal article

Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells

STEM CELLS, 32(9), 2397–2406.

By: Y. Xie *, A. Ibrahim, K. Cheng*, Z. Wu *, W. Liang, K. Malliaras, B. Sun, W. Liu ...

author keywords: Cardiosphere-derived cells; Cardiomyocyte; Proliferation; Paracrine factors; Cell-cell communication; beta 1 integrin
MeSH headings : Animals; Cell Communication / physiology; Cell Differentiation / physiology; Cells, Cultured; Humans; Integrin beta1 / metabolism; Male; Mice; Mice, SCID; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / metabolism; Rats
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Congenital heart defects research; Pluripotent Stem Cells Research
TL;DR: The hypothesis that cell‐cell contact plays a role in mediating the observed therapeutic benefits of CDCs, above and beyond conventional paracrine effects, is tested. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2014 journal article

5 DISRUPTION OF THE HIGH MOBILITY GROUP AT-HOOK 2 (HMGA2) GENE IN SWINE REDUCES POSTNATAL GROWTH

Reproduction, Fertility and Development, 26(1), 117.

By: J. Chung  n, X. Zhang  n, B. Colins n, K. Howard, S. Simpson  n, C. Salmon, S. Koh  n, R. Sper  n, C. Byrd, J. Piedrahita n 

topics (OpenAlex): Animal Genetics and Reproduction; Genomics and Chromatin Dynamics; Cancer-related molecular mechanisms research
TL;DR: The approach described here will result in a valuable large-animal model of dwarfism, but also in a tool to reduce the size of existing transgenic and nontransgenic swine lines, which will increase the receptivity of valuable transgenic lines by the biomedical community. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2014 journal article

The Influence of MgO Nanoparticles on the Osseointegration of Polycaprolactone - Sodium Alginate Hydrogel Interfaces

British Journal of Applied Science & Technology, 4(1), 79–88.

By: M. Khandaker, M. Vaughan & B. Starly 

Ed(s): M. Vimalan

topics (OpenAlex): Bone Tissue Engineering Materials; Hydrogels: synthesis, properties, applications; biodegradable polymer synthesis and properties
TL;DR: It is suggested that MgO nanoparticle improves the cell viability of a sodium alginate (SA) hydrogel, but it is detrimental for the osseointegration of PCL-SA hydrogels constructs. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2014 journal article

Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction

Journal of the American College of Cardiology, 63(2), 110–122.

By: K. Malliaras, R. Makkar, R. Smith, K. Cheng*, E. Wu *, R. Bonow *, L. Marbán, A. Mendizabal * ...

author keywords: cardiosphere-derived cells; myocardial infarction; myocardial regeneration
MeSH headings : Aged; Biopsy; Coronary Vessels; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Ventricles / pathology; Heart Ventricles / physiopathology; Humans; Injections, Intra-Arterial; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Infarction / complications; Myocardial Infarction / physiopathology; Myocardial Infarction / surgery; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Recovery of Function; Stem Cell Transplantation / methods; Time Factors; Transplantation, Autologous; Treatment Outcome; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / physiopathology; Ventricular Dysfunction, Left / surgery; Ventricular Function, Left / physiology
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Cardiac Structural Anomalies and Repair
TL;DR: Preliminary indications of bioactivity include decreased scar size, increased viable myocardium, and improved regional function of infarctedMyocardium at 1 year post-treatment, which are consistent with therapeutic regeneration and merit further investigation in future trials. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair

JACC: Heart Failure, 2(1), 49–61.

By: K. Cheng*, K. Malliaras, R. Smith *, D. Shen *, B. Sun, A. Blusztajn*, Y. Xie, A. Ibrahim ...

author keywords: cardiosphere-derived cells; heart failure; myocardial infarction; patient characteristics; stromal cell-derived factor 1
MeSH headings : Adult; Aged; Animals; Cardiomyopathies / physiopathology; Extracellular Matrix; Female; Graft Survival / physiology; Heart / physiology; Heart Failure / physiopathology; Humans; Intercellular Signaling Peptides and Proteins / metabolism; Male; Mice, SCID; Middle Aged; Myocardial Infarction / physiopathology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Oxidative Stress / physiology; Regeneration / physiology; Stem Cell Transplantation / methods; Stem Cells / physiology; Transplantation, Autologous
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Congenital heart defects research; Mesenchymal stem cell research
TL;DR: CDCs from advanced HF patients exhibit augmented potency in ameliorating ventricular dysfunction post-MI, possibly through SDF-1–mediated mechanisms. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block

Journal of the American College of Cardiology, 64(24), 2575–2585.

By: E. Cingolani, V. Ionta *, K. Cheng*, A. Giacomello*, H. Cho & E. Marbán

author keywords: arrhythmias; cardiac tissue engineering; gap junctions; heart conduction system
MeSH headings : Animals; Atrioventricular Block / pathology; Atrioventricular Block / physiopathology; Atrioventricular Block / surgery; Cell Transplantation / methods; Cells, Cultured; Electromagnetic Fields; Heart Conduction System / pathology; Heart Conduction System / physiopathology; Heart Conduction System / surgery; Heart Ventricles / pathology; Immunoconjugates / pharmacology; In Vitro Techniques; Magnets; Models, Cardiovascular; Myocytes, Cardiac / pathology; Rats; Rats, Sprague-Dawley; Sarcoglycans / immunology; Sarcoglycans / pharmacology; Tissue Engineering
topics (OpenAlex): Cardiac pacing and defibrillation studies; Cardiac Arrhythmias and Treatments; Cardiac Valve Diseases and Treatments
TL;DR: An EECT can re-establish electrical conduction in the heart and could, in principle, be used not only to treat cardiac arrhythmias but also to repair other organs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy

European Heart Journal, 36(12), 751–762.

By: M. Aminzadeh*, E. Tseliou *, B. Sun*, K. Cheng*, K. Malliaras *, R. Makkar *, E. Marban *

author keywords: Cardiomyopathy; Heart failure; Cell transplantation
MeSH headings : Animals; Apoptosis / physiology; CREB-Binding Protein / metabolism; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / therapy; Cell Differentiation; Cell Lineage; Disease Models, Animal; Doxorubicin / pharmacology; Fibrosis; Graft Survival; Heart Failure / pathology; Heart Failure / physiopathology; Heart Failure / therapy; Injections, Intralesional; Male; Mice, Transgenic; Myocarditis / physiopathology; Myocardium / pathology; Myocytes, Cardiac / transplantation; Oxidative Stress / physiology; Protein Kinase C / metabolism; Signal Transduction; Stem Cell Transplantation / methods; Ventricular Remodeling / physiology
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Mesenchymal stem cell research; Congenital heart defects research
TL;DR: The ability to impact favourably on disease progression in non-ischaemic heart failure heralds new potential therapeutic applications of CDCs, which reverse fundamental abnormalities in cell signalling, prevent adverse remodelling, and improve survival in a mouse model of DCM. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

Stem Cell Reports, 2(5), 606–619.

By: A. Ibrahim *, K. Cheng* & E. Marbán *

MeSH headings : Albumins / pharmacology; Aniline Compounds / pharmacology; Animals; Benzylidene Compounds / pharmacology; Cell Differentiation; Cell Proliferation; Cell- and Tissue-Based Therapy; Cells, Cultured; Disease Models, Animal; Exosomes / metabolism; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Mice, SCID; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardial Infarction / therapy; Myocardial Infarction / veterinary; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Neovascularization, Physiologic; Polyesters / pharmacology; Rats; Rats, Sprague-Dawley; Regeneration
topics (OpenAlex): Extracellular vesicles in disease; Cardiovascular Effects of Exercise; Tissue Engineering and Regenerative Medicine
TL;DR: Exosomes secreted by human CDCs are identified as key mediators of CDC-induced regeneration, while highlighting the potential utility of exosomes as cell-free therapeutic candidates. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 21, 2019

2014 journal article

Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5).

By: K. Cheng n, A. Ibrahim *, M. Hensley  n, D. Shen *, B. Sun*, R. Middleton *, W. Liu *, R. Smith *, E. Marban *

author keywords: cardiosphere-derived cells; CD90; ckit; myocardial infarction
MeSH headings : Analysis of Variance; Animals; Apoptosis / physiology; Biomarkers / analysis; Cell Differentiation / physiology; Cell Transplantation / methods; Cells, Cultured; Disease Models, Animal; Heart Function Tests; Humans; Male; Mice; Mice, SCID; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / transplantation; Prospective Studies; Proto-Oncogene Proteins c-kit / metabolism; Regeneration / physiology; Role; Sensitivity and Specificity; Thy-1 Antigens / metabolism; Treatment Outcome
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Mesenchymal stem cell research; Congenital heart defects research
TL;DR: It is shown, surprisingly, that c‐kit expression has no relationship to CDCs' therapeutic efficacy in humans, and depletion of c‐Kit+ cells does not undermine the structural and functional benefits of CDCs in a mouse model of myocardial infarction. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 article

Optimization of Contrast-to-tissue Ratio and Role of Bubble Destruction in Dual-Frequency Contrast-Specific "Acoustic Angiography" Imaging

2014 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), pp. 1774–1777.

By: B. Lindsey *, J. Rojas*, K. Martin*, S. Shelton*  & P. Dayton*

author keywords: superharmonic; microbubble; high frequency ultrasound; cavitation; dual-frequency; contrast-to-tissue ratio
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging; Ultrasound Imaging and Elastography
TL;DR: This work examines the imaging parameters for optimizing contrast-to-tissue ratio (CTR) for dual-frequency imaging and the relationship between bubble destruction and broadband harmonic signal production and indicates that superharmonic signals having the broadest bandwidth and highest energy are associated with shell fragmentation. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy

PLOS ONE, 9(12).

By: K. Yee, K. Malliaras, H. Kanazawa, E. Tseliou, K. Cheng n, D. Luthringer, C. Ho*, K. Takayama * ...

MeSH headings : Administration, Cutaneous; Animals; Cardiomyopathies / complications; Cardiomyopathies / immunology; Cardiomyopathies / pathology; Cardiomyopathies / therapy; Catheters; Cicatrix / complications; Cicatrix / pathology; Dilatation; Endocardium / pathology; Female; Injections; Magnetic Resonance Imaging; Male; Myocardial Ischemia / complications; Myocardial Ischemia / immunology; Myocardial Ischemia / pathology; Myocardial Ischemia / therapy; Myocytes, Cardiac / cytology; Myocytes, Cardiac / transplantation; Regeneration; Spheroids, Cellular / cytology; Spheroids, Cellular / transplantation; Survival Analysis; Sus scrofa; Transplantation, Homologous / adverse effects
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Transplantation: Methods and Outcomes; Cardiac Structural Anomalies and Repair
TL;DR: Dose-optimized injection of allogeneic cardiospheres is safe, decreases scar size, increases viable myocardium, and attenuates cardiac dilatation in porcine chronic ischemic cardiomyopathy, consistent with therapeutic regeneration. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Acoustic Characterization of Contrast-to-issue Ratio and Axial Resolution for Dual-Frequency Contrast-Specific Acoustic Angiography Imaging

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 61(10), 1668–1687.

By: B. Lindsey *, J. Rojas *, K. Martin*, S. Shelton*  & P. Dayton*

MeSH headings : Angiography / methods; Animals; Cattle; Contrast Media / chemistry; Iliac Artery / diagnostic imaging; Mice; Microbubbles; Muscles / diagnostic imaging; Particle Size; Pressure; Rats; Rats, Inbred F344; Signal Processing, Computer-Assisted; Signal-To-Noise Ratio; Transducers; Ultrasonography, Interventional / instrumentation; Ultrasonography, Interventional / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging; Ultrasound Imaging and Elastography
TL;DR: CTR dependence on transmit frequency and peak pressure were confirmed through in vivo imaging in two rodents and may lead to improved imaging of vascular remodeling in superficial or luminal cancers such as those of the breast, prostate, and colon. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

Vascular channels formed by subpopulations of PECAM1+ melanoma cells

Nature Communications, 5(1).

By: J. Dunleavey *, L. Xiao *, J. Thompson *, M. Kim *, J. Shields*, S. Shelton n , D. Irvin*, V. Brings * ...

MeSH headings : Angiogenesis Inhibitors / chemistry; Animals; Cell Line, Tumor; Female; Flow Cytometry; Green Fluorescent Proteins / metabolism; Humans; Melanoma / metabolism; Melanoma, Experimental / metabolism; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic / metabolism; Platelet Endothelial Cell Adhesion Molecule-1 / metabolism; RNA, Small Interfering / metabolism; Skin Neoplasms / metabolism; Transcription Factor AP-2 / metabolism; Up-Regulation; Vascular Endothelial Growth Factor A / metabolism; Vascular Endothelial Growth Factor Receptor-2 / metabolism
topics (OpenAlex): Extracellular vesicles in disease; Nanoplatforms for cancer theranostics; Neuropeptides and Animal Physiology
TL;DR: VM-competent subpopulations, rather than all cells within a tumour, may instigate VM, supplant host-derived endothelium, and form PECAM1-dependent conduits that are not diminished by neutralizing VEGF. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Stem Cells and Regenerative Medicine in Domestic and Companion Animals: A Multispecies Perspective

Reproduction in Domestic Animals, 49, 2–10.

By: N. Gonçalves, C. Ambrósio & J. Piedrahita n 

MeSH headings : Adult; Animals; Animals, Domestic / embryology; Cats; Dogs; Embryonic Stem Cells; Horses; Humans; Induced Pluripotent Stem Cells; Mice; Pets / embryology; Rats; Regenerative Medicine / trends; Stem Cells
topics (OpenAlex): Pluripotent Stem Cells Research; Animal Genetics and Reproduction; Tissue Engineering and Regenerative Medicine
TL;DR: A range of stem cells are reviewed, from ESC to induced pluripotent stem cells, and their potential application in the field of regenerative medicine is discussed. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction

BIOMATERIALS, 35(30), 8528–8539.

By: A. Vandergriff n, T. Hensley n, E. Henry n, D. Shen *, S. Anthony n, J. Zhang *, K. Cheng n

author keywords: Cardiac stem cells; Magnetic targeting; Myocardial infarction; Ferumoxytol; MRI; Superparamagnetic iron oxide nanoparticles
MeSH headings : Animals; Apoptosis / drug effects; Cell Movement / drug effects; Cell Proliferation / drug effects; Cell Survival / drug effects; Female; Ferrosoferric Oxide / pharmacology; Ferrosoferric Oxide / therapeutic use; Finite Element Analysis; Heart Function Tests; Heparin / pharmacology; Humans; Inflammation / pathology; Iron Overload / pathology; Magnetic Phenomena; Male; Myocardial Infarction / pathology; Myocardial Infarction / physiopathology; Myocardial Infarction / therapy; Myocardium / pathology; Nanoparticles / therapeutic use; Nanoparticles / ultrastructure; Neovascularization, Physiologic / drug effects; Protamines / pharmacology; Rats; Rats, Inbred WKY; Spheroids, Cellular / drug effects; Spheroids, Cellular / pathology
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Mesenchymal stem cell research
TL;DR: FHP labeling is safe to cardiac stem cells and facilitates magnetically-targeted stem cell delivery into the heart which leads to augmented cell engraftment and therapeutic benefit, and magnetic targeting increased cardiac retention of transplanted FHP-rCDCs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

Nature Communications, 5(1).

By: K. Cheng*, D. Shen *, M. Hensley  n, R. Middleton *, B. Sun*, W. Liu *, G. De Couto *, E. Marbán *

MeSH headings : Animals; Antibodies; Bone Marrow Cells / metabolism; Bone Marrow Transplantation / methods; Cell Movement; Ferrosoferric Oxide / therapeutic use; Iron; Leukocytes, Mononuclear / metabolism; Magnets; Myocardial Infarction / therapy; Myocytes, Cardiac / metabolism; Nanotechnology / methods; Rats; Regeneration; Stem Cells
topics (OpenAlex): Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications; Pluripotent Stem Cells Research
TL;DR: The authors use magnetic iron nanoparticles conjugated with antibodies that bind therapeutic cells and cardiomyocytes to treat myocardial ischemia/reperfusion injury in rats and show that targeting to the heart is enhanced upon local application of a magnetic field. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

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